Doctors may one day be able to control a patient's HIV infection in a new way: injecting swarms of germ-fighting antibodies, two new studies suggest. In monkeys, that strategy sharply reduced blood levels of a cousin of HIV. The results also gave tantalizing hints that someday the tactic might help destroy the AIDS virus in its hiding places in the body, something current drugs cannot do.
Taking inspiration from the human immune system, researchers at Lawrence Berkeley National Laboratory have created a new material that can be programmed to identify an endless variety of molecules. The new material resembles tiny sheets of Velcro, each just one-hundred nanometers across. But instead of securing your sneakers, this molecular Velcro mimics the way natural antibodies recognize viruses and toxins.
A brain stimulation technique that is used to treat tough cases of depression could be considerably improved with a new headpiece designed by Univ. of Michigan engineers. Computer simulations showed that the headpiece—a square array of 64 circular metallic coils—could one day help researchers and doctors hit finer targets in the brain that are twice as deep as they can reach today, and without causing pain.
Advances in computer storage have created collections of data so huge that researchers often have trouble uncovering critical patterns in connections among individual items, making it difficult for them to realize fully the power of computing as a research tool. Now, computer scientists at Princeton Univ. have developed a method that offers a solution to this data overload.
A lens with ten times the resolution of any current lens, making it a powerful new tool for the biological sciences, has been developed by researchers at the Univ. of Sydney. The lens was created using fiber-optic manufacturing technology, and is a metamaterial, or a material with completely new properties not found in nature.
In a pair of studies that exploit the genetic sequencing of the “missing link” cold virus, rhinovirus C, scientists at the Univ. of Wisconsin-Madison have constructed a 3-D model of the pathogen that shows why there is no cure yet for the common cold. The new cold virus model was built in silico, drawing on advanced bioinformatics and the genetic sequences of 500 rhinovirus C genomes, which provided 3-D coordinates of the viral capsid.
The ability to shrink laboratory-scale processes to automated chip-sized systems would revolutionize biotechnology and medicine. One of the challenges of lab-on-a-chip technology is the need for miniaturized pumps to move solutions through microchannels. A super-thin silicon membrane developed at the Univ. of Rochester could now make it possible to shrink the power source, paving the way for diagnostic devices the size of a credit card.
Accurate and rapid testing for drug toxicity just became easier, thanks to a half-dozen Rice Univ. student interns working at Houston-based startup Nano3D Biosciences (n3D). The bioengineering and nanoscale physics students just wrapped up a year-long effort to aid the company in developing a new method for conducting high-throughput, in vitro cytotoxicity assays.
The editors of R&D Magazine and Laboratory Design are now accepting entries to the 48th international Laboratory of the Year competition. This annual award recognizes the best new and renovated laboratories that combine all aspects of the building into a superior working environment. The entry deadline is January 31, 2014 (11:59p.m. Eastern Standard Time).
Nanomaterials are the heart of the smaller, better electronics developed during the last decade, as well as new materials, medical diagnostics, energy storage and clean water. However, exposure to nanomaterials may have unintended consequences for human health and the environment. As a resource, Virginia Tech has joined the Woodrow Wilson International Center for Scholars to renew and expand the Nanotechnology Consumer Product Inventory.
Structures that put a spin on light reveal tiny amounts of DNA with 50 times better sensitivity than the best current methods, a collaboration between the Univ. of Michigan and Jiangnan Univ. in China has shown. Highly sensitive detection of DNA can help with diagnosing patients, solving crimes and identifying the origins of biological contaminants such as a pathogen in a water supply.
Dark matter, believed by physicists to outweigh all the normal matter in the universe by more than five to one, is by definition invisible. But certain features associated with dark matter might be detectable, according to some of the many competing theories describing this elusive matter. Now scientists have developed a tool that could test some of these predictions and thus prove, or disprove, one of the leading theories.
Cosmochemists at the Univ. of California, San Diego have solved a long-standing mystery in the formation of the solar system: Oxygen, the most abundant element in Earth’s crust, follows a strange, anomalous pattern in the oldest, most pristine rocks, one that must result from a different chemical process than the well-understood reactions that form minerals containing oxygen on Earth.
Making hydrogen easily and cheaply is a dream goal for clean, sustainable energy. Bacteria have been doing exactly that for billions of years, and now chemists at the Univ. of California, Davis and Stanford Univ. are revealing how they do it, and perhaps opening ways to imitate them.
The effects of gravity are relevant when building houses or flying airplanes, but biologists have generally accepted that the average cell is too small for gravity to play a role in how it is built or behaves. A finding by Princeton Univ. researchers now shows gravity imposes a size constraint on cells. The results provide a novel reason why most animal cells are small and of similar size.
Researchers at Massachusetts Institute of Technology have succeeded in producing and measuring a coupling of photons and electrons on the surface of an unusual type of material called a topological insulator. This type of coupling had been predicted by theorists, but never observed.
Cancer researchers from Rice Univ. have deciphered the operating principles of a genetic switch that cancer cells use to decide when to metastasize and invade other parts of the body. The study found that the on-off switch’s dynamics also allows a third choice that lies somewhere between “on” and “off.” The extra setting both explains previously confusing experimental results and opens the door to new avenues of cancer treatment.
Lawrence Berkeley National Laboratory researchers at the Advanced Light Source (ALS) have invented a new technique for studying the process by which certain errors in the genetic code are detected and repaired. The technique is based on a combination of hybrid nanomaterials and SAXS imaging at the ALS SIBYLS beamline.
Doctors now have convincing evidence that they put HIV into remission, hopefully for good, in a Mississippi baby born with the AIDS virus—a medical first that is prompting a new look at how hard and fast such cases should be treated. The case was reported earlier this year but some doctors were skeptical that the baby was really infected rather than testing positive because of exposure to virus in the mom's blood.
In remote regions of the world where electricity is hard to come by and scientific instruments are even scarcer, conducting medical tests at a doctor’s office or medical laboratory is rarely an option. Scientists are now reporting progress toward an inexpensive point-of-care, paper-based device to fill that void with no electronics required.
Researchers in electrical and computer engineering at the Univ. of California, Santa Barbara have introduced and modeled an integrated circuit design scheme in which transistors and interconnects are monolithically patterned seamlessly on a sheet of graphene. The demonstration offers possibilities for ultra-energy-efficient, flexible and transparent electronics.
Researchers from North Carolina State Univ., the Univ. of North Carolina at Chapel Hill and Laser Zentrum Hannover have discovered that a naturally occurring compound can be incorporated into 3-D printing processes to create medical implants out of non-toxic polymers. The compound is riboflavin, which is better known as vitamin B2.
As microelectronics get smaller and smaller, one of the biggest challenges to packing a smartphone or tablet with maximum processing power and memory is the amount of heat generated by the tiny “switches” at the heart of the device. A complex metal-oxide film could help reduce the voltage required to switch electronic signals, and thus the excessive energy they require.
When it comes to designing extremely water-repellent surfaces, shape and size matter. That's the finding of a group of scientists at Brookhaven National Laboratory, who investigated the effects of differently shaped, nanoscale textures on a material's ability to force water droplets to roll off without wetting its surface.
Spraying a plant hormone on broccoli—already one of the planet’s most nutritious foods—boosts its cancer-fighting potential, and researchers say they have new insights on how that works. They published their findings, which could help scientists build an even better, more healthful broccoli.