The discovery of the innate immunity system’s role in mobilizing the body’s defenses against invading microorganisms has been long studied at Yale Univ. Now in Nature Immunology, Yale researchers have discovered a surprising twist to the story that may open a new avenue in the fight against HIV.
Univ. of California, Los Angeles biochemists have created the largest-ever protein that self-assembles into a molecular “cage.” The research could lead to synthetic vaccines that protect people from the flu, HIV and other diseases. At a size hundreds of times smaller than a human cell, it also could lead to new methods of delivering pharmaceuticals inside of cells, or to the creation of new nanoscale materials.
Energy storage devices and computer screens may seem worlds apart, but they're not. When Assoc. Prof. Qi Hua Fan set out to make a less expensive supercapacitor for storing renewable energy, he developed a new plasma technology that will streamline the production of display screens.
Scientists have made high-resolution x-ray laser images of an intact cellular structure much faster and more efficiently than ever possible before. The results are an important step toward atomic-scale imaging of intact biological particles, including viruses and bacteria. The technique was demonstrated at the Linac Coherent Light Source at the SLAC National Accelerator Laboratory.
A major challenge faced by the pharmaceutical industry has been how to rationally design and select protein molecules to create effective biologic drug therapies while reducing unintended side effects—a challenge that has largely been addressed through costly guess–and–check experiments. Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard Univ. offer a new approach.
Truth shines a light into dark places. But sometimes to find that truth in the first place, it’s better to stay in the dark. That’s what recent findings at NIST show about methods for testing the safety of nanoparticles. It turns out that previous tests indicating that some nanoparticles can damage our DNA may have been skewed by inadvertent light exposure in the lab.
Reducing greenhouse gas (GHG) emissions, which result from the burning of fossil fuels, also reduces the incidence of health problems from particulate matter (PM) in these emissions. A team of scientists has calculated that the economic benefit of reduced health impacts from GHG reduction strategies in the U.S. range between $6 and $14 billion annually in 2020, depending on how the reductions are accomplished.
In a showdown of black hole versus G2—a cloud of gas and dust—it looks like G2 won. Recent research shows that G2 came within 30 billion km of the super-massive black hole at the center of our galaxy, yet managed to escape from the gravitational pull of the black hole.
Researchers at the Univ. of Michigan have discovered how a previously unknown hormone serves as a messenger from fat cells to the liver and are investigating the potential of developing a new treatment for metabolic disorders. Jiandie Lin of the Life Sciences Institute described how in mice the hormone, NRG4, is secreted by so-called brown fat cells and communicates with the liver to regulate the conversion of sugar into fat.
For such humble creatures, single-celled paramecia have remarkable sensory systems. Give them a sharp jab on the nose, they back up and swim away. Jab them in the behind, they speed up their swimming to escape. But according to new research, when paramecia encounter flat surfaces, they’re at the mercy of the laws of physics.
A coalition of companies and aid groups announced plans Tuesday to test experimental drugs and collect blood plasma from Ebola survivors to treat new victims of the disease in West Africa. Plasma from survivors contains antibodies, substances the immune system makes to fight the virus.
An ultra-high-resolution NASA computer model has given scientists a stunning new look at how carbon dioxide in the atmosphere travels around the globe. Plumes of carbon dioxide in the simulation swirl and shift as winds disperse the greenhouse gas away from its sources. The simulation also illustrates differences in carbon dioxide levels in the northern and southern hemispheres.
Scientists at The Scripps Research Institute have identified weak spots on the surface of Ebola virus that are targeted by the antibodies in ZMapp, the experimental drug cocktail administered to several patients during the recent Ebola outbreak. The study provides a revealing 3-D picture of how the ZMapp antibodies bind to Ebola virus.
Testing for ovarian cancer or the presence of a particular chemical could be almost as simple as distinguishing an F sharp from a B flat, thanks to a new microscopic acoustic device that has been dramatically improved by scientists at Argonne National Laboratory. The device, known as a surface acoustic wave (SAW) sensor, detects frequency changes in waves that propagate through its crystalline structure.
Massachusetts Institute of Technology chemists have developed new nanoparticles that can simultaneously perform magnetic resonance imaging (MRI) and fluorescent imaging in living animals. Such particles could help scientists to track specific molecules produced in the body, monitor a tumor’s environment, or determine whether drugs have successfully reached their targets.
A team of New York Univ. and Univ. of Barcelona physicists has developed a method to control the movements occurring within magnetic materials, which are used to store and carry information. The breakthrough could simultaneously bolster information processing while reducing the energy necessary to do so.
The race to make computer components smaller and faster and use less power is pushing the limits of the properties of electrons in a material. Photonic systems could eventually replace electronic ones, but the fundamentals of computation, mixing two inputs into a single output, currently require too much space and power when done with light.
Rice Univ. scientists have invented a novel cathode that may make cheap, flexible dye-sensitized solar cells practical. The Rice laboratory of materials scientist Jun Lou created the new cathode, one of the two electrodes in batteries, from nanotubes that are seamlessly bonded to graphene and replaces the expensive and brittle platinum-based materials often used in earlier versions.
Silicon is the second-most-abundant element in the Earth's crust. When purified, it takes on a diamond structure, which is essential to modern electronic devices—carbon is to biology as silicon is to technology. A team of Carnegie scientists has synthesized an entirely new form of silicon, one that promises even greater future applications.
Researchers from the Univ. of Cambridge have developed artificial muscles which can learn and recall specific movements, the first time that motion control and memory have been combined in a synthetic material. The muscles, made from smooth plastic, could eventually be used in a applications where mimicking the movement of natural muscle would be an advantage, such as robotics, aerospace, exoskeletons and biomedical applications.
Physicists at Australian National Univ. have engineered a spiral laser beam and used it to create a whirlpool of hybrid light-matter particles called polaritons. The ability to control polariton flows in this way could aid the development of completely novel technology to link conventional electronics with new laser and fiber-based technologies.
Lawrence Livermore National Laboratory researchers have developed an efficient method to measure residual stress in metal parts produced by powder-bed fusion additive manufacturing. This 3-D printing process produces metal parts layer by layer using a high-energy laser beam to fuse metal powder particles.
Researchers at the Univ. of California, Los Angeles Henry Samueli School of Engineering and Applied Science have developed a more efficient way to turn methanol into useful chemicals, such as liquid fuels, and that would also reduce carbon dioxide emissions. Methanol, which is a product of natural gas, is well-known as a common “feedstock” chemical.
Researchers at the Univ. of Southampton have demonstrated how glass can be manipulated to create electronic devices that will be smaller, faster and consume less power. The researchhas the potential to allow faster, more efficient electronic devices; further shrinking the size of our phones, tablets and computers and reducing their energy consumption by turning waste heat into power.
For the first time, scientists have vividly mapped the shapes and textures of high-order modes of Brownian motions—in this case, the collective macroscopic movement of molecules in microdisk resonators—researchers at Case Western Reserve Univ. report. To do this, they used a record-setting scanning optical interferometry technique.