The majority of wines are produced from around 20 different types of grape, all of which have their own typical aroma. This is due to the terpenes, a diverse category of chemical substances including cholesterol and estrogen. Scientists have now identified two enzymes that determine the terpene content, and thus the aroma intensity, of grapes. The findings could play an important role in the future development of grape varieties.
Texas health officials have confined four people to their home, under guard, after they had close contact with an Ebola patient hospitalized in Dallas, as disease detectives work to make sure the deadly virus doesn't spread in the U.S. Five things to know about containing the virus: 1. WHY ORDER...
A new Georgia Institute of Technology study shows that an intense workout of as little as 20 min can enhance episodic memory, also known as long-term memory for previous events, by about 10% in healthy young adults. The research isn’t the first to find that exercise can improve memory. But the study took a few new approaches, including testing memory after just single period of exercise.
The National Institutes of Health this week announced its first research grants through President Barack Obama’s BRAIN Initiative, including three awards to the Univ. of California, Berkeley, totaling nearly $7.2 million over three years. The projects are among 58 funded in this initial wave of NIH grants, involving 100 researchers and a total of $46 million in fiscal year 2014 dollars alone.
Cancer vaccines have recently emerged as a promising approach for killing tumor cells before they spread. But so far, most clinical candidates haven’t worked that well. Now, scientists have developed a new way to deliver vaccines that successfully stifled tumor growth when tested in laboratory mice. And the key is in the vaccine’s unique stealthy nanoparticles.
A collaboration has been announced between Agilent Technologies and the Univ. of Toronto’s Donnelly Centre for Cellular and Biomolecular Research to produce a comprehensive metabolomics multiple-reaction monitoring library and methodology, using Agilent’s Infinity 1290 UHPLC, 6460 triple quadrupole mass spectrometry system, and MassHunter Software. The goal is to accelerate quantification of hundreds of metabolically important compounds.
Despite being outlawed in 2012 in the U.S., the synthetic drugs known as "bath salts" are still readily available in some retail shops, on the Internet and on the streets. To help law enforcement, scientists are developing low-cost, disposable, mercury-free electrodes that could be the basis for the first portable, on-site testing device for identifying the drugs.
Inspired by a desire to help wounded soldiers, an international team has created a paint-on, see-through, “smart” bandage that glows to indicate a wound’s tissue oxygenation concentration. Because oxygen plays a critical role in healing, mapping these levels in severe wounds and burns can help to greatly improve the success of surgeries to restore limbs and physical functions.
Only a minority of suspicious mammograms actually leads to a cancer diagnosis, which results in lots of needless worry and spent time for women and their families. Ultrasound elastography could be an excellent screening tool but it requires a lot of skill and interpretation. In an effort to improve results, researchers in Michigan have developed a virtual “breast”, allowing medical professionals to practice in the laboratory.
The 52nd annual R&D 100 Awards event will present a series of panel discussions featuring today’s top technological minds revealing their secrets for innovation. Draw inspiration from these leading experts as they discuss technology-driven strategies for transforming your ideas into excellence.
The discovery of a gene mutation that causes a rare premature aging disease could lead to the development of drugs that block the rapid, unstoppable cell division that makes cancer so deadly. Scientists at the Univ. of Michigan recently discovered a protein mutation that causes the devastating disease dyskeratosis congenita, in which precious hematopoietic stem cells can't regenerate and make new blood.
Given a choice, most patients would prefer to take a drug orally instead of getting an injection. Unfortunately, many drugs, can’t be given as a pill because they get broken down in the stomach before they can be absorbed. To help overcome that obstacle, researchers have devised a novel drug capsule coated with tiny needles that can inject drugs directly into the lining of the stomach after swallowed.
Federal health officials on Tuesday confirmed the first case of Ebola diagnosed in the U.S., a patient who recently traveled from Liberia to Dallas and a sign of the far-reaching impact of the out-of-control epidemic in West Africa. The unidentified patient was critically ill and has been in isolation at Texas Health Presbyterian Hospital since Sunday, officials said.
Researchers at the Univ. of Michigan have described a new approach to discovering potential cancer treatments that requires a fraction of the time needed for more traditional methods. They used the platform to identify a novel antibody that is undergoing further investigation as a potential treatment for breast, ovarian and other cancers.
Over the past few years, a class of compounds called ADEPs (cyclic acyldepsipeptides) has emerged as a promising new weapon in the fight against drug-resistant bacteria. The compounds work by attaching themselves to a cellular enzyme called ClpP, which bacterial cells use to rid themselves of harmful proteins. With an ADEP attached, ClpP can’t function properly, and the bacterial cell dies.
Univ. of California, Santa Barbara’s Paul Atzberger, a professor in the Department of Mathematics and in mechanical engineering, often works in areas where mathematics plays an ever more important role in the discovery and development of new ideas. Most recently he has developed new mathematical approaches to gain insights into how proteins move around within lipid bilayer membranes.
Microbes have an amazing ability to feed on plant biomass and convert it into other chemical products. Tapping into this talent has the potential to revolutionize energy, medicine, environmental remediation and many other fields. The success of this effort hinges in part on metagenomics, the emerging technology that enables researchers to read all the individual genomes of a sample microbial community at once.
A mysterious space within a protein critical to photosynthesis is filled with fat molecules that influence both the protein’s architecture and electrical properties, according to two recent studies. Researchers studied the atomic structure of, and electrical interactions within, the cytochrome bf complex, a protein complex central to the transport of electrons within membranes of a plant cell, a critical step in photosynthesis.
Massachusetts Institute of Technology engineers have devised a way to rapidly test hundreds of different drug-delivery vehicles in living animals, making it easier to discover promising new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA and DNA, to human patients.
The 2nd Annual Pharma Data Analytics Conference will enable senior-level analytics professionals to improve the bottom line of their business through utilizing the potential of big data. Driven by single-track case study presentations from Pfizer, Celgene, Novartis, Merck and many others, this program will explore recent trends in the pharmaceutical environment, including the influence of analytics in the commercial space, data visualization tools and techniques and methodologies for forecasting across multiple business units.
How the brain ages is still largely an open question because this organ is mostly insulated from direct contact with other systems in the body. In recent research, scientists in Israel found evidence of a unique “signature” that may be the “missing link” between cognitive decline and aging. The scientists believe that this discovery may lead, in the future, to treatments that can slow or reverse cognitive decline in older people.
Years before they show any other signs of disease, pancreatic cancer patients have very high levels of certain amino acids in their bloodstream, according to a new study. This finding, which suggests that muscle tissue is broken down in the disease’s earliest stages, could offer new insights into developing early diagnostics for pancreatic cancer, which kills about 40,000 Americans every year.
An Oak Ridge National Laboratory team has unlocked the enzymatic synthesis process of rare sugars, which are useful in developing drugs with low side effects. In a recently published paper, the team reported the pioneering use of neutron and x-ray crystallography and HPC to study how the enzyme D-xylose isomerase, or XI, can cause a biochemical reaction in natural sugar to produce rare sugars.
Cryptophytes, complex single-cell algae that make up a lot of the ocean's phytoplankton, have, in the course of evolution, adapted their light-harvesting mechanisms to their environment and have thus become capable of utilizing green light. Researchers in Germany have recently been the first ones to reveal similarities and differences in the assembly of this light-harvesting machinery compared to cyanobacteria and red algae.
Almost all of today’s previously existing cell-sorting methods rely on what is called a single-cell analysis platform. A researcher in Hawaii took a different approach, inventing a bulk method that sorts different cell populations by tuning their solubility. Instead of targeting individual features, the measurement principle sorts cells by differentiating their characteristic surface free energies.