For four decades, polychlorinated biphenyls (PCBs) and heavy metals from nearby manufacturing plants flowed into New Bedford Harbor, creating one of the EPA’s largest Superfund cleanup sites. It’s also the site of an evolutionary puzzle: small Atlantic killifish are not only tolerating the toxic conditions in the harbor, they seem to be thriving there. In a new paper, researchers may have an explanation for their genetic resistance to PCBs.
The Food and Drug Administration on Wednesday approved a cancer drug from Pharmacyclics and Janssen Biotech Inc. for a new use against a rare blood and bone marrow disease. The agency said it approved Imbruvica for patients with chronic lymphocytic leukemia who have already tried at least one other therapy.
A Canadian study that many experts say has major flaws has revived a debate about the value of mammograms. The study suggests that these screening x-rays do not lower the risk of dying of breast cancer while finding many tumors that do not need treatment. The study gives longer follow-up on nearly 90,000 women who were given either a breast exam by a nurse to check for lumps plus a mammogram or the breast exam alone.
To improve their chances of success, in vitro fertilization clinics need to assess the viability of the sperm they use. Now doctors may soon have a new technique to help them sort the good sperm cells from the less viable ones: a tracking system, developed by a team of researchers from four European institutions, that takes 3-D movies of living sperm.
Once the snow melts, the bee population will be back in business pollinating and making honey. A new study by scientists in Canada reveals that some these bees use bits of plastic bags and plastic building materials to construct their nests. The discovery reveals how urban bee populations have adapted to a human-dominated world.
Researchers at NIST have developed a new method for accurately measuring a key process governing a wide variety of cellular functions that may become the basis for a health checkup for living cells. The NIST technique measures changes in a living cell's internal redox (reduction-oxidation) potential, a chemistry concept that expresses the favorability of reactions in which molecules or atoms either gain or lose electrons.
Univ. of California, Berkeley researchers have shown that chronic stress generates long-term changes in the brain that may explain why people suffering chronic stress are prone to mental problems such as anxiety and mood disorders later in life. Their findings could lead to new therapies to reduce the risk of developing mental illness after stressful events.
A majority of federal health experts said Tuesday that new research is not strong enough to conclude that naproxen, the pain reliever in Aleve and many other medications, is safer on the heart than rival drugs used by millions of Americans to treat arthritis and everyday aches and pains. The Food and Drug Administration advisory panel voted against the conclusion that naproxen has a lower risk of heart attack than ibuprofen.
These findings won’t appear on any Hallmark card, but romantic love tends to activate the same reward areas of the brain as cocaine, research has shown. Now Yale School of Medicine researchers studying meditators have found that a more selfless variety of love, a deep and genuine wish for the happiness of others without expectation of reward, actually turns off the same reward areas that light up when lovers see each other.
Researchers have introduced a unique microrobotic technique to assemble the components of complex materials, the foundation of tissue engineering and 3-D printing. Tissue engineering and 3-D printing have become vitally important to the future of medicine for many reasons. The shortage of available organs for transplantation, for example, leaves many patients on waiting lists for life-saving treatment.
Computational biologists in Austria have recently shown that the common practice of averaging is not always a good thing when it comes to analyzing protein crystal structures. A study shows that protein structures could be more dynamic and heterogeneous than current methods of x-ray analysis suggest.
Plant growth is orchestrated by a spectrum of signals from hormones within a plant. A major group of plant hormones called cytokinins originate in the roots of plants, and their journey to growth areas on the stem and in leaves stimulates plant development. Though these phytohormones have been identified in the past, the molecular mechanism responsible for their transportation within plants was previously poorly understood. Until now.
Inspired by tiny particles that carry cholesterol through the body, Massachusetts Institute of Technology chemical engineers have designed nanoparticles that can deliver snippets of genetic material that turn off disease-causing genes. This approach, known as RNA interference, holds great promise for treating cancer and other diseases. However, delivering enough RNA to treat the diseased tissue has proven difficult.
Federal health experts are taking a second look this week at the heart safety of pain medications used by millions of Americans to treat arthritis and other everyday aches and pains. The Food and Drug Administration holds a two-day meeting beginning Monday to examine the latest research on anti-inflammatory medicines called NSAIDS, which serve as the backbone of U.S. pain treatment.
On the eve of the 25th World AIDS Day (December 2014), President Barack Obama expressed hope to our nation, proclaiming that an “AIDS-free generation is within our reach.” During his speech, Obama expressed how our nation has made significant strides toward strengthening scientific investments, building effective HIV/AIDS education and prevention programs and bringing together public and private stakeholders.
In 2011, biologists at Caltech demonstrated a highly effective method for delivering HIV-fighting antibodies to mice—a treatment that protected the mice from infection by a laboratory strain of HIV delivered intravenously. Now the researchers have shown that the same procedure is just as effective against a strain of HIV found in the real world, even when transmitted across mucosal surfaces.
The lipid-rich membranes of cells are largely impermeable to proteins, but evolution has provided a way through—in the form of transmembrane tunnels. A new study in Germany shows in unmatched detail what happens as proteins pass through such a pore.
Shape is thought to play an important role in the effectiveness of cells grown to repair or replace damaged tissue in the body. To help design new structures that enable cells to "shape up," researchers at NIST have come up with a way to measure, and more importantly, classify, the shapes cells tend to take in different environments.
Some of the world's biggest drugmakers are playing a larger role in anti-doping efforts at this year's Winter Olympics: They're providing information on drugs that once would have been considered proprietary trade secrets. GlaxoSmithKline, Amgen and Roche are among the drugmakers that have begun sharing data about experimental drugs as part of an effort to stay one step ahead of drug cheats.
For more than two years, researchers have been investigating melanopsin, a retina pigment capable of sensing light changes in the environment, informing the nervous system and synchronizing it with the day/night rhythm. They have found that this pigment is potentially more sensitive to light than its more famous counterpart rhodopsin, the pigment that allows night vision.
When people see a skunk, the reaction usually is “Eww,” but when they see a group of meerkats peering around, they often think “Aww.” Why some animals use noxious scents while others live in social groups to defend themselves against predators is the question that biologists in California have sought to answer through a comprehensive analysis of predator-prey interactions among carnivorous mammals and birds of prey.
A team of physicists have used statistical mechanics and mathematical modeling to shed light on something known as epigenetic memory, which allows an organism to create a biological memory of some variable condition, such as quality of nutrition or temperature. The model highlights the "engineering" challenge a cell must constantly face during molecular recognition.
A one-letter change in the human genetic code can sometimes mean the difference between health and a serious disease. But replicating these tiny changes in human stem cells has proven challenging. Scientists at the Gladstone Institutes have found a way to efficiently edit the human genome one letter at a time, not only boosting researchers' ability to model human disease, but also paving the way for new therapies.
In research that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute have developed a potentially general approach to design drugs from genome sequence. As a proof of principle, they identified a highly potent compound that causes cancer cells to attack themselves and die.
Optogenetics allows scientists to control neurons’ electrical activity with light by engineering them to express light-sensitive proteins, called opsins. Most opsins respond to light in the blue-green range. Now, a team has discovered an opsin that is sensitive to red light, which allows researchers to independently control the activity of two populations of neurons at once, enabling much more complex studies of brain function.