Biologists have discovered a vulnerability of brain cancer cells that could be exploited to develop more-effective drugs against brain tumors. The study found that a subset of glioblastoma tumor cells is dependent on a particular enzyme that breaks down the amino acid glycine. Without this enzyme, toxic metabolic byproducts build up inside the tumor cells, and they die.
Complex organic molecules discovered in infant star system: hints that prebiotic chemistry is universalApril 8, 2015 2:21 pm | by National Radio Astronomy Observatory | News | Comments
For the first time, astronomers have detected the presence of complex organic molecules, the building blocks of life, in a protoplanetary disk surrounding a young star, suggesting once again that the conditions that spawned our Earth and Sun are not unique in the universe.
Just as some people seem built to run marathons and have an easier time going for miles without tiring, others are born with a knack for memorizing things, from times tables to trivia facts. These two skills are not so different as it turns out. Salk scientists and collaborators have discovered that physical and mental activities rely on a single metabolic protein that controls the flow of blood and nutrients throughout the body.
A great deal of public attention in the past couple of years has been showered on complexes of bacterial proteins known as “CRISPR-Cas” for their potential use as a tool for editing DNA. Now, researchers with the Lawrence Berkeley National Laboratory are reporting that CRISPR-Cas complexes could also serve as an engineering tool for RNA, the molecule that translates DNA’s genetic instructions into the production of proteins.
Yale Univ. scientists are using new chemical tools to identify and understand molecules in the human gut that alter DNA and regulate inflammatory bowel diseases and colorectal cancers. In a recent article, researchers describe the chemical structures of 32 such molecules from the bacterial colibactin pathway, found in select strains of E. coli in the gut.
Consumers are one step closer to benefiting from packaging that could give simple text warnings when food is contaminated with deadly pathogens like E. coli and Salmonella, and patients could soon receive real-time diagnoses of infections such as C. difficile right in their doctors' offices, saving critical time and trips to the lab.
The self-organization properties of DNA-like molecular fragments four billion years ago may have guided their own growth into repeating chemical chains long enough to act as a basis for primitive life, says a new study by the Univ. of Colorado Boulder and the Univ. of Milan.
Separating circulating cancer cells from blood cells for diagnostic, prognostic and treatment purposes may become much easier using an acoustic separation method and an inexpensive, disposable chip, according to a team of engineers from Penn State Univ.
Rice Univ. researchers are developing a highly accurate, touch-free system that uses a video camera to monitor patients’ vital signs just by looking at their faces. The technique isn’t new, but engineering researchers in Rice’s Scalable Health Initiative are making it work under conditions that have so far stumped earlier systems.
Northwestern Medicine scientists have identified a small RNA molecule called miR-182 that can suppress cancer-causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor. While standard chemotherapy drugs damage DNA to stop cancer cells from reproducing, the new method stops the source that creates those cancer cells: genes that are overexpressing certain proteins.
There are few times in life when one should aim for suboptimal performance, but new research at Rice Univ. suggests scientists who study metabolism and its role in evolution should look for signs of just that. A study published in BMC Systems Biology details a computational method called corsoFBA.
Calico, a company whose mission is to harness advanced technologies to increase understanding of the biology that controls human lifespan, and UC San Francisco have partnered on an innovative project to develop potential therapies for cognitive decline.
Scientists know that depression affects the brain, but they still don’t know why some people respond to treatment and others do not. Now UCLA researchers have shown for the first time in a large cohort of patients that electroconvulsive therapy, or ECT, changes certain areas of the brain that play a role in how people feel, learn and respond to positive and negative environmental factors.
Stem cells hold great promise for treating a number of diseases, in part because they have the unique ability to differentiate, specializing into any one of the hundreds of cell types that comprise the human body. Harnessing this potential, though, is difficult.
Researchers discovered a new protein involved in the process that determines the fate of cells under stress and whether they fight to survive or sacrifice themselves for the greater good. A protein named HYPE orchestrates a response to misfolded proteins within the cell, mistakes which increase when a cell is under stress from disease or injury.
In the 1970s, epidemiologists found that workers in factories using vinyl chloride had unusually high rates of a rare form of liver cancer called angiosarcoma. Biologists later identified a mutation that appears to be associated with this cancer, which originates in cells of the blood vessels that feed the liver.
Purdue Univ. researchers have identified a new class of chemical insecticides that could provide a safer, more selective means of controlling mosquitoes that transmit key infectious diseases such as dengue, yellow fever and elephantiasis. Known as dopamine receptor antagonists, the chemicals beat out the neurotransmitter dopamine to lock into protein receptors that span the mosquito cell membrane.
Therapeutic agents intended to reduce dental plaque and prevent tooth decay are often removed by saliva and the act of swallowing before they can take effect. But a team of researchers has developed a way to keep the drugs from being washed away. Dental plaque is made up of bacteria enmeshed in a sticky matrix of polymers, a polymeric matrix, that is firmly attached to teeth.
Analyzing people’s keystrokes as they type on a computer keyboard can reveal a great deal of information about the state of their motor function, according to a new study. In the study, the researchers found that their algorithm for analyzing keystrokes could distinguish between typing done in the middle of the night, when sleep deprivation impairs motor skills, and typing performed when fully rested.
The protein haptoglobin boosts inflammation in transplanted hearts, reducing their survival, according to a study led by Yale Univ. researchers. The finding may help identify new anti-inflammatory therapies to enhance organ transplant survival.
Complex brain disorders, such as autism or schizophrenia, still puzzle scientists because their causes lie hidden in early events of brain development, which are still poorly understood. This is about to change thanks to research by Univ. of Toronto Profs. Ben Blencowe and Sabine Cordes, who have developed a powerful model that will allow researchers to better understand the physiology behind many disorders.
Many studies show that video gamers perform better than non-gamers on certain visual tasks, like managing distractors and identifying targets, but a small new Brown Univ. study provides gamers with some cognitive bonus points. The study results suggest that gaming not only improves their visual skill but also may improve their learning ability for those skills.
When weighing the pluses and minuses of your skin add this to the plus column: Your skin, like that of all vertebrates, is remarkably resistant to tearing. Now, a collaboration of researchers at Lawrence Berkeley National Laboratory and the Univ. of California, San Diego, has shown why.
Researchers at the National Univ. of Singapore have discovered that the inherent handedness of molecular structures directs the behavior of individual cells and confers them the ability to sense the difference between left and right. This is a significant step forward in the understanding of cellular biology.
Memory and as well as connections between brain cells were restored in mice with a model of Alzheimer’s given an experimental cancer drug, Yale School of Medicine researchers reported in the Annals of Neurology. The drug, AZD05030, developed by Astra Zeneca proved disappointing in treating solid tumors but appears to block damage triggered during the formation of amyloid-beta plaques, a hallmark of Alzheimer’s disease.