Just as the invention of non-stick pans was a boon for chefs, a new type of nanoscale surface that bacteria can’t stick to holds promise for applications in the food processing, medical and even shipping industries. The technology uses an electrochemical process called anodization to create nanoscale pores that change the electrical charge and surface energy of a metal surface.
Scientists have developed the first ultra-thin, flexible device that sticks to skin like a rub-on tattoo and can detect a person’s glucose levels. The sensor, reported in a proof-of-concept study in Analytical Chemistry, has the potential to eliminate finger-pricking for many people with diabetes.
Scientists from The Scripps Research Institute have identified a novel synthetic compound that sharply inhibits the activity of a protein that plays an important role in in the progression of breast and pancreatic cancers. In the new study the scientists showed that the compound, known as SR1848, reduces the activity and expression of the cancer-related protein called “liver receptor homolog-1” or LRH-1.
Autism is a spectrum of closely related disorders diagnosed in patients who exhibit a shared core of symptoms, including delays in learning to communicate and interact socially. Early detection of autism in children is the key for treatments to be most effective and produce the best outcomes. Using advanced 3-D imaging and statistical analysis techniques, researchers identified facial measurements in children with autism.
Training of first responders on the hazards of actual radiological and nuclear threats has been challenged by the difficulties of adequately representing those threats. Training against such threats would involve using hazardous, highly radioactive materials, experiencing actual radiation doses in training, or require the distribution of radioactive material over a large geographical area.
DNA molecules provide the "source code" for life in humans, plants, animals and some microbes. But now researchers report an initial study showing that the strands can also act as a glue to hold together 3-D-printed materials that could someday be used to grow tissues and organs in the laboratory.
Sometimes the response to the outbreak of a disease can make things worse. The ability to anticipate when such overreactions might occur could help public health officials take steps to limit the dangers. Now a new computer model could provide a way of making such forecasts, based on a combination of data collected from hospitals, social media and other sources.
A group led by scientists has developed a new method for effectively extracting and analyzing cancer cells circulating in patients’ blood. Circulating tumor cells are cancer cells that break away from tumors and travel in the blood, looking for places in the body to grow new tumors called metastases. Capturing these rare cells would allow doctors to detect and analyze the cancer so they could tailor treatment for individual patients.
In a laboratory first, Duke Univ. researchers have grown human skeletal muscle that contracts and responds just like native tissue to external stimuli such as electrical pulses, biochemical signals and pharmaceuticals. The laboratory-grown tissue should soon allow researchers to test new drugs and study diseases in functioning human muscle outside of the human body.
Electroporation is a powerful technique in molecular biology. By using an electrical pulse to create a temporary nanopore in a cell membrane, researchers can deliver chemicals, drugs and DNA directly into a single cell. But existing electroporation methods require high electric field strengths and for cells to be suspended in solution, which disrupts cellular pathways and creates a harsh environment for sensitive primary cells.
A simple method to sense DNA, as well as potential biomarker proteins of cancer or other diseases such as Alzheimer's, may soon be within reach thanks to the work of a team of Yokohama National Univ. researchers in Japan. As the team reports in Applied Physics Letters, they created a photonic crystal nanolaser biosensor capable of detecting the adsorption of biomolecules based on the laser's wavelength shift.
The immune system is a complex network of many different cells working together to defend against invaders. Successfully fighting off an infection depends on the interactions between these cells. A new device developed by Massachusetts Institute of Technology engineers offers a much more detailed picture of that cellular communication.
New research has identified one of the key cancer-fighting mechanisms for sulforaphane, and suggests that this phytochemical may be able to move beyond cancer prevention and toward therapeutic use for advanced prostate cancer. Scientists said that pharmacologic doses in the form of supplements would be needed for actual therapies, beyond the amount of sulforaphane that would ordinarily be obtained from dietary sources such as broccoli.
A new study from Lund Univ. in Sweden indicates inherited viruses that are millions of years old play an important role in building up the complex networks that characterize the human brain. Researchers have long been aware endogenous retroviruses constitute around 5% of our DNA. For many years, they were considered junk DNA of no real use, a side effect of our evolutionary journey.
Chemists have made a significant advancement to directly functionalize C-H bonds in natural products by selectively installing new carbon-carbon bonds into highly complex alkaloids and nitrogen-containing drug molecules. C-H functionalization is a much more streamlined process than traditional organic chemistry, holding the potential to greatly reduce the time and number of steps needed to create derivatives of natural products.
Forget about it. Your brain is a memory powerhouse, constantly recording experiences in long-term memory. Those memories help you find your way through the world: Who works the counter each morning at your favorite coffee shop? How do you turn on the headlights of your car? What color is your best friend's house?
Washington State Univ. Spokane scientists have found a brain protein that boosts the healing power of sleep and speeds an animal's recovery from the flu. The research has determined that a brain-specific protein is uniquely involved in sleep responses triggered by the influenza virus in mice. Without the protein, animals develop more severe symptoms of infection and die at higher rates than regular or control mice.
In the midst of a worrisome flu season, health officials are pushing doctors to prescribe antiviral medicines. The Centers for Disease Control and Prevention on Friday sent a new alert to doctors, advising prompt use of Tamiflu and other antivirals for hospitalized flu patients and those at higher risk for complications like pneumonia.
People who have upbeat outlooks on life have significantly better cardiovascular health, suggests a new study that examined associations between optimism and heart health in more than 5,100 adults. Participants’ cardiovascular health was assessed using seven metrics: blood pressure, body mass index, fasting plasma glucose and serum cholesterol levels, dietary intake, physical activity and tobacco use.
Optogenetics, which uses light to control cellular events, is poised to become an important technology in molecular biology and beyond. The Reich Group in Univ. of California, Santa Barbara’s Dept. of Chemistry and Biochemistry has made a major contribution to this emergent field by developing a light-activated nanocarrier that transports proteins into cells and releases them on command.
For years, pathogens’ resistance to antibiotics has put them one step ahead of researchers, which is causing a public health crisis, according to Northeastern Univ. Distinguished Prof. Kim Lewis. But in new research, Lewis and his colleagues present a newly discovered antibiotic that eliminates pathogens without encountering any detectable resistance.
It has been taken for granted for over 50 years that the type of spectroscopy widely used to study hydrogen inside materials is not subject to any selection rules. In the joint theoretical and experimental study that appeared recently in Physical Review Letters, an international team of researchers showed that this near universally held view is incorrect for at least one important class of hydrogen-entrapping compounds.
A major barrier to finding a cure for HIV/AIDS is the presence of latent HIV in the cells of chronically infected individuals. But a team of Yale and Johns Hopkins researchers may have pinpointed a strategy for eliminating the residual virus. Despite treatment with antiretroviral therapy, HIV persists in patients in a latent reservoir.
Researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill have uncovered a novel approach to creating inhalable vaccines using nanoparticles that shows promise for targeting lung-specific diseases, such as influenza, pneumonia and tuberculosis.
Inflammation is a normal and often beneficial response to injury or infection. The swelling, heat and even pain are the body’s attempts to protect its soft tissue, remove offending objects, substances or microbes and initiate healing. However, persistent inflammation is often indicative of more serious conditions and can lead to problems of its own, including impaired healing, loss of function or even tissue death.