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The Lead

Flattening Yields Faster CT

August 20, 2014 2:14 pm | Award Winners

In 2012, more than 85 million computed tomography (CT) scans were performed in the U.S. Of these, 16% were thoracic scans. Up to now, this has been done manually and sequentially in what is a tedious, lengthy and error-prone process. Engineers at Siemens Corporate Technology and Siemens Healthcare, Computed Tomography have launched a new solution to save radiologists time and increase diagnostic confidence for thoracic bone assessment.

Could elastic bands monitor patients’ breathing?

August 20, 2014 11:39 am | News | Comments

Research published in ACS Nano identifies a new type of sensor that could monitor body...

Many patients don’t understand electronic lab results

August 20, 2014 10:48 am | by Laurel Thomas Gnagey, Univ. of Michigan | News | Comments

While it's becoming commonplace for patients to see the results of laboratory work...

Research paves way for development of cyborg moth “biobots”

August 20, 2014 9:46 am | by Matt Shipman, News Services, North Carolina State Univ. | News | Comments

North Carolina State Univ. researchers have developed methods for electronically manipulating...

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NMR using Earth’s magnetic field

August 20, 2014 8:19 am | by Rachel Berkowitz, Lawrence Berkeley National Laboratory | News | Comments

Earth’s magnetic field, a familiar directional indicator over long distances, is routinely probed in applications ranging from geology to archaeology. Now it has provided the basis for a technique which might, one day, be used to characterize the chemical composition of fluid mixtures in their native environments.

Biomarker in aggressive breast cancer identified

August 20, 2014 7:53 am | by Megan Fellman, Northwestern Univ. | News | Comments

Two Northwestern Univ. scientists have identified a biomarker strongly associated with basal-like breast cancer, a highly aggressive carcinoma that is resistant to many types of chemotherapy. The biomarker, a protein called STAT3, provides a smart target for new therapeutics designed to treat this often deadly cancer.

AstraZeneca says DOJ closes probe into drug trial

August 19, 2014 1:23 pm | by The Associated Press | News | Comments

British drugmaker AstraZeneca says the U.S. Dept. of Justice has closed its investigation into a clinical trial of the company's blood thinner Brilinta, and plans no further action. The company announced in October 2013 that federal officials were looking into the 18,000-patient study, which began in 2009.

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500-million-year reset for the immune system

August 19, 2014 10:22 am | News | Comments

Scientists at the Max Planck Institute of Immunobiology and Epigenetics re-activated expression of an ancient gene, which is not normally expressed in the mammalian immune system, and found that the animals developed a fish-like thymus. To the researchers' surprise, while the mammalian thymus is utilized exclusively for T cell maturation, the reset thymus produced not only T cells, but also served as a maturation site for B cells.

Our connection to content

August 19, 2014 9:34 am | by Rob Matheson, MIT News Office | News | Comments

It’s often said that humans are wired to connect: The neural wiring that helps us read the emotions and actions of other people may be a foundation for human empathy. But for the past eight years, MIT Media Lab spinout Innerscope Research has been using neuroscience technologies that gauge subconscious emotions by monitoring brain and body activity to show just how powerfully we also connect to media and marketing communications.

Bacterial nanowires not what scientists thought they were

August 19, 2014 8:28 am | by Robert Perkins, Univ. of Southern California | Videos | Comments

For the past 10 years, scientists have been fascinated by a type of “electric bacteria” that shoots out long tendrils like electric wires, using them to power themselves and transfer electricity to a variety of solid surfaces. A team led by scientists has now turned the study of these bacterial nanowires on its head, discovering that the key features in question are not pili as previously believed.

Worm virus details come to light

August 19, 2014 8:10 am | by Mike Williams, Rice Univ. | News | Comments

Rice Univ. scientists have won a race to find the crystal structure of the first virus known to infect the most abundant animal on Earth. The Rice laboratories of structural biologist Yizhi Jane Tao and geneticist Weiwei Zhong, with help from researchers at Baylor College of Medicine and Washington Univ., analyzed the Orsay virus that naturally infects a certain type of nematode, the worms that make up 80% of the living animal population.

Engineering new bone growth

August 19, 2014 7:56 am | by Anne Trafton, MIT News Office | News | Comments

Massachusetts Institute of Technology chemical engineers have devised a new implantable tissue scaffold coated with bone growth factors that are released slowly over a few weeks. When applied to bone injuries or defects, this coated scaffold induces the body to rapidly form new bone that looks and behaves just like the original tissue.

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Microchip reveals how tumor cells transition to invasion

August 18, 2014 11:06 am | by Kevin Stacey, Brown Univ. | News | Comments

Using a microengineered device that acts as an obstacle course for cells, researchers have shed new light on a cellular metamorphosis thought to play a role in tumor cell invasion throughout the body. The epithelial-mesenchymal transition (EMT) is a process in which epithelial cells, which tend to stick together within a tissue, change into mesenchymal cells, which can disperse and migrate individually.

Artificial cells act like the real thing

August 18, 2014 10:55 am | News | Comments

Imitation, they say, is the sincerest form of flattery, but mimicking the intricate networks and dynamic interactions that are inherent to living cells is difficult to achieve outside the cell. Now, as published in Science, Weizmann Institute scientists have created an artificial, network-like cell system that is capable of reproducing the dynamic behavior of protein synthesis.

Researchers develop molecular probes for the study of metals in brain

August 18, 2014 8:59 am | by Lynn Yarris, Lawrence Berkeley National Laboratory | News | Comments

The human brain harbors far more copper, iron and zinc than anywhere else in the body. Abnormally high levels of these metals can lead to disorders such as Alzheimer’s and Parkinson’s diseases. Chris Chang, a faculty chemist with Berkeley Lab’s Chemical Sciences Div., has spent the past several years developing new probes and techniques for imaging the molecular activity of these metals in the brain.

Disabilities in kids rise; not physical problems

August 18, 2014 2:19 am | by Lindsey Tanner - AP Medical Writer - Associated Press | News | Comments

Disabilities among U.S. children have increased slightly, with a bigger rise in mental and developmental problems in those from wealthier families, a 10-year analysis found. Disadvantaged kids still bear a disproportionate burden. The increases may partly reflect more awareness and recognition that conditions, including autism, require a specific diagnosis to receive special services, the researchers said.

Another Ebola problem: Finding its natural source

August 17, 2014 9:19 am | by Mike Stobbe - AP Medical Writers - Associated Press | News | Comments

A scary problem lurks beyond the frenzied efforts to keep people from spreading Ebola: No one knows exactly where the virus comes from or how to stop it from seeding new outbreaks. Ebola has caused two dozen outbreaks in Africa since it first emerged in 1976. It is coming from somewhere—probably bats—but experts agree they need to pinpoint its origins in nature.

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Report: CDC scientist kept quiet about flu blunder

August 15, 2014 12:23 pm | by Mike Stobbe - AP Medical Writer - Associated Press | News | Comments

An investigation into a potentially dangerous blunder at a government lab found that a scientist kept silent about the accident and revealed it only after other employees noticed something fishy. Officials on Friday released the results of an internal probe into the accident, which happened in January at the Centers for Disease Control and Prevention in Atlanta.

New way to treat solid tumors

August 15, 2014 11:12 am | News | Comments

An international team of scientists has shown that an antibody against the protein EphA3, found in the micro-environment of solid cancers, has anti-tumor effects. As EphA3 is present in normal organs only during embryonic development but is expressed in blood cancers and in solid tumors, this antibody-based approach may be a suitable candidate treatment for solid tumors.

Scientists fold RNA origami from a single strand

August 15, 2014 11:07 am | News | Comments

RNA origami is a new method,  developed by researchers from Denmark and California, for organizing molecules on the nanoscale. Using just a single strand of RNA, many complicated shapes can be fabricated by this technique. Unlike existing methods for folding DNA molecules, RNA origamis are produced by enzymes and they simultaneously fold into pre-designed shapes.

The beetle’s white album

August 15, 2014 9:31 am | News | Comments

The physical properties of the ultra-white scales on certain species of beetle could be used to make whiter paper, plastics and paints, while using far less material than is used in current manufacturing methods. Current technology is not able to produce a coating as white as these beetles can in such a thin layer, and spectroscopic analyses are revealing how this colorization is achieved through a dense complex network of chitin.

9/11 dust cloud may have caused widespread pregnancy issues

August 15, 2014 9:00 am | News | Comments

Previous research into the health impacts of in utero exposure to the 9/11 dust cloud on birth outcomes has shown little evidence of consistent effects. But according to a new paper pregnant women living near the World Trade Center during 9/11 experienced higher-than-normal negative birth outcomes. These mothers were more likely to give birth prematurely and deliver babies with low birth weights.

New gene editing method may help correct muscular dystrophy

August 15, 2014 8:56 am | News | Comments

Researchers in Texas have successfully used a new gene editing method to correct a mutation that leads to Duchenne muscular dystrophy (DMD) in a mouse model of the condition. The technique is called CRISPR/Cas9-mediated genome editing, and can precisely remove a mutation in DNA, allowing the body’s DNA repair mechanisms to replace it with a normal copy of the gene.

Scientists racing to test Ebola vaccines in humans

August 14, 2014 6:22 pm | by Matthew Perrone - Associated Press - Associated Press | News | Comments

Scientists are racing to begin the first human safety tests of two experimental Ebola vaccines, but it won't be easy to prove that the shots and other potential treatments in the pipeline really work. There are no proven drugs or vaccines for Ebola, a disease so rare that it's been hard to attract investments in countermeasures. But the current outbreak in West Africa is fueling new efforts to speed Ebola vaccine and drug development.

Non-invasive method controls size of molecules passing blood-brain barrier

August 14, 2014 4:38 pm | News | Comments

A new technique has demonstrated for the first time that the size of molecules penetrating the blood-brain barrier can be controlled using acoustic pressure. The innovative ultrasound approach uses acoustic pressure to let molecules through, and may help treatment for central nervous system diseases like Parkinson’s and Alzheimer’s.

Inside the cell, an ocean of buffeting waves

August 14, 2014 1:22 pm | by Caroline Perry, Harvard Univ. | News | Comments

Conventional wisdom holds that the cytoplasm of mammalian cells is a viscous fluid, with organelles and proteins suspended within it, jiggling against one another and drifting at random. However, a new biophysical study led by researchers at Harvard Univ. challenges this model and reveals that those drifting objects are subject to a very different type of environment.

Immune cells get cancer-fighting boost from nanomaterials

August 14, 2014 9:00 am | by Rase McCry, Yale Univ. | News | Comments

Scientists at Yale Univ. have developed a novel cancer immunotherapy that rapidly grows and enhances a patient’s immune cells outside the body using carbon nanotube-polymer composites; the immune cells can then be injected back into a patient’s blood to boost the immune response or fight cancer.

Nanotech invention improves effectiveness of the “penicillin of cancer”

August 14, 2014 8:01 am | by Jared Sagoff, Argonne National Laboratory | News | Comments

By combining magnetic nanoparticles with one of the most common and effective chemotherapy drugs, Argonne National Laboratory researchers have created a way to deliver anti-cancer drugs directly into the nucleus of cancer cells. They have created nano-sized bubbles, or “micelles,” that contain magnetic nanoparticles of iron oxide and cisplatin, a conventional chemotherapy drug also known as “the penicillin of cancer.”

Single gene controls jet lag

August 14, 2014 7:52 am | News | Comments

Scientists at the Salk Institute for Biological Studies have identified a gene that regulates sleep and wake rhythms. The discovery of the role of this gene, called Lhx1, provides scientists with a potential therapeutic target to help night-shift workers or jet lagged travelers adjust to time differences more quickly. The results, published in eLife, can point to treatment strategies for sleep problems caused by a variety of disorders.

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