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The Lead

How turkeys may be lifesavers

November 25, 2014 4:51 pm | by Todd Hollingshead, Brigham Young Univ. | News | Comments

While the turkey you eat on Thursday will bring your stomach happiness and could probably kick-start an afternoon nap, it may also save your life one day. That’s because the biological machinery needed to produce a potentially life-saving antibiotic is found in turkeys. Looks like there is one more reason to be grateful this Thanksgiving.

Trace Analysis of Carbon Dioxide in High-Purity Hydrofluorocarbon

November 25, 2014 4:15 pm | by Zhuangzhi “Max” Wang, Clifford M. Taylor, Shimadzu Scientific Instruments, Columbia, Md. | Articles | Comments

Fluorocarbon, a generic term for organic compounds with carbon-fluorine (C-F) bonding, is a...

Doctor behind "free radical" aging theory dies

November 25, 2014 2:02 pm | by By Josh Funk - Associated Press - Associated Press | News | Comments

Dr. Denham Harman, a renowned scientist who developed the most widely accepted theory on aging...

Angiogenesis drug could provide treatment for TB

November 25, 2014 9:27 am | by Karl Bates, Duke Univ. | News | Comments

The body responds to tuberculosis infection by locking the bacterial offenders into tiny...

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Pain in a dish

November 25, 2014 9:11 am | by Harvard Stem Cell Institute | News | Comments

After more than six years of intensive effort, and repeated failures that made the quest at times seem futile, Harvard Stem Cell Institute researchers at Boston Children’s Hospital and Harvard’s Dept. of Stem Cell and Regenerative Biology have successfully converted mouse and human skin cells into pain-sensing neurons that respond to a number of stimuli that cause acute and inflammatory pain.

Wireless electronic implants stop staph

November 25, 2014 8:41 am | by Kim Thurier, Tufts Univ. | News | Comments

Researchers at Tufts Univ., in collaboration with a team at the Univ. of Illinois at Urbana-Champaign, have demonstrated a resorbable electronic implant that eliminated bacterial infection in mice by delivering heat to infected tissue when triggered by a remote wireless signal. The silk and magnesium devices then harmlessly dissolved in the test animals. The technique had previously been demonstrated only in vitro.

Device could make large biological circuits practical

November 25, 2014 7:59 am | by David L. Chandler, MIT News Office | News | Comments

Researchers have made great progress in recent years in the design and creation of biological circuits: systems that, like electronic circuits, can take a number of different inputs and deliver a particular kind of output. But while individual components of such biological circuits can have precise and predictable responses, those outcomes become less predictable as more such elements are combined.

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Brain’s reaction to virtual reality

November 25, 2014 7:42 am | by Stuart Wolpert, Univ. of California, Los Angeles | News | Comments

Univ. of California, Los Angeles neurophysicists have found that space-mapping neurons in the brain react differently to virtual reality than they do to real-world environments. Their findings could be significant for people who use virtual reality for gaming, military, commercial, scientific or other purposes.

Google's latest: A spoon that steadies tremors

November 25, 2014 4:00 am | by By Martha Mendoza - AP National Writer - Associated Press | News | Comments

Just in time for the holidays, Google is throwing its money, brain power and technology at the humble spoon. Of course these spoons (don't call them spoogles) are a bit more than your basic utensil: Using hundreds of algorithms, they allow people with essential tremors and Parkinson's disease to eat without spilling.

Cell’s skeleton is never still

November 24, 2014 11:23 am | by Mike Williams, Rice Univ. | News | Comments

New computer models that show how microtubules age are the first to match experimental results and help explain the dynamic processes behind an essential component of every living cell, according to Rice Univ. scientists. The results could help scientists fine-tune medications that manipulate microtubules to treat cancer and other diseases. 

Nanoparticles infiltrate, kill cancer cells from within

November 24, 2014 11:06 am | by Melanie Titanic-Schefft, Univ. of Cincinnati | News | Comments

Conventional treatment seeks to eradicate cancer cells by drugs and therapy delivered from outside the cell, which may also affect (and potentially harm) nearby normal cells. In contrast to conventional cancer therapy, a Univ. of Cincinnati team has developed several novel designs for iron-oxide based nanoparticles that detect, diagnose and destroy cancer cells using photo-thermal therapy (PTT).

Bee brains offer insights into how human memories form

November 24, 2014 9:46 am | by Univ. of Queensland | News | Comments

Scientists have discovered that genes switch off as memories are being formed, allowing for new connections between nerve cells. The discovery could eventually lead to a key for treating conditions such as autism and dementia. Researchers studying honeybees during learning activities have shown that memory management in the bee brain is controlled by small genetic elements called microRNAs that help regulate gene expression.

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Life’s extremists may be an untapped source of antibacterial drugs

November 24, 2014 9:29 am | by David Salisbury, Vanderbilt Univ. | News | Comments

One of the most mysterious forms of life may turn out to be a rich and untapped source of antibacterial drugs. The mysterious life form is Archaea, a family of single-celled organisms that thrive in environments like boiling hydrothermal pools and smoking deep sea vents which are too extreme for most other species to survive.

Researchers study impact of power prosthetic failures on amputees

November 24, 2014 8:43 am | by Matt Shipman, News Services, North Carolina State Univ. | Videos | Comments

Powered lower limb prosthetics hold promise for improving the mobility of amputees, but errors in the technology may also cause some users to stumble or fall. New research examines exactly what happens when these technologies fail, with the goal of developing a new generation of more robust powered prostheses.

Robotics meet x-ray laser in cutting-edge biology studies

November 24, 2014 8:31 am | by SLAC Office of Communications | News | Comments

Scientists at SLAC National Accelerator Laboratory are combining the speed and precision of robots with one of the brightest x-ray lasers on the planet for pioneering studies of proteins important to biology and drug discovery. The new system uses robotics and other automated components to precisely maneuver delicate samples for study with the x-ray laser pulses at SLAC’s Linac Coherent Light Source.

For important tumor-suppressing protein, context is key

November 24, 2014 8:19 am | by Dan Krotz, Lawrence Berkeley National Laboratory | News | Comments

Scientists from Lawrence Berkeley National Laboratory have learned new details about how an important tumor-suppressing protein, called p53, binds to the human genome. As with many things in life, they found that context makes a big difference. The researchers mapped the places where p53 binds to the genome in a human cancer cell line.

U.S. looking past Ebola to prepare for next outbreak

November 23, 2014 8:59 am | by Lauran Neergaard - AP Medical Writer - Associated Press | News | Comments

The next Ebola or the next SARS. Maybe even the next HIV. Even before the Ebola epidemic in West Africa is brought under control, public health officials are girding for the next health disaster. Ebola sprang from one of those blind spots, in an area that lacks the health systems needed to detect an outbreak before it becomes a crisis.

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How mutant gene causes deafness

November 21, 2014 9:47 am | by The Scripps Research Institute | News | Comments

Scientists at The Scripps Research Institute (TSRI) have discovered how one gene is essential to hearing, uncovering a cause of deafness and suggesting new avenues for therapies. The new study, published in Neuron, shows how mutations in a gene called Tmie can cause deafness from birth. Underlining the critical nature of their findings, researchers were able to reintroduce the gene in mice and restore the process underpinning hearing.

Quantum mechanical calculations reveal the hidden states of enzyme active sites

November 21, 2014 8:37 am | by Princeton Univ. | News | Comments

Enzymes carry out fundamental biological processes such as photosynthesis, nitrogen fixation and respiration, with the help of clusters of metal atoms as "active" sites. But scientists lack basic information about their function because the states thought to be critical to their chemical abilities cannot be experimentally observed.

Biomarker could provide early warning of kidney disease in cats

November 21, 2014 8:27 am | by David Stauth, Oregon State Univ. | News | Comments

Researchers from Oregon State Univ. and other institutions have developed a new biomarker called “SDMA” that can provide earlier identification of chronic kidney disease in cats, which is one of the leading causes of their death. A new test based on this biomarker, when commercialized, should help pet owners and their veterinarians watch for this problem through periodic checkups, and treat it with diet or other therapies.

Researchers create first inhibitor for enzyme linked to certain cancers

November 21, 2014 7:49 am | by Univ. of California, Irvine | News | Comments

Recent studies showing acid ceramidase (AC) to be upregulated in melanoma, lung and prostate cancers have made the enzyme a desired target for novel synthetic inhibitor compounds. In Angewandte Chemie, scientists with the Univ. of California, Irvine School of Medicine and the Italian Institute of Technology describe the very first class of AC inhibitors that may aid in the efficacy of chemotherapies.

U.S. approves new, hard-to-abuse hydrocodone pill

November 20, 2014 6:00 pm | by Matthew Perrone - AP Health Writer - Associated Press | News | Comments

U.S. government health regulators on Thursday approved the first hard-to-abuse version of the painkiller hydrocodone, offering an alternative to a similar medication that has been widely criticized for lacking such safeguards. The FDA approved Purdue Pharma's Hysingla ER for patients with severe, round-the-clock pain that cannot be managed with other treatments.

Center Stage: The High Rollers of S&T Industry Honored at 2014 R&D 100 Awards

November 20, 2014 12:06 pm | by Lindsay Hock, Managing Editor | Award Winners

The R&D 100 Awards have a 50+ year history of recognizing excellence in innovation, earning the name the “Oscars of Invention." And at the annual event, the high rollers of the science and technology industry were honored on stage for their innovative, high-tech products and processes that are, or will, make a difference in our everyday lives.

Paper electronics could make health care more accessible

November 20, 2014 9:02 am | by American Chemical Society | News | Comments

Flexible electronic sensors based on paper have the potential to cut the price of a wide range of medical tools, from helpful robots to diagnostic tests. Scientists have now developed a fast, low-cost way of making these sensors by directly printing conductive ink on paper.

Unique sense of “touch” gives a prolific bacterium its ability to infect anything

November 20, 2014 8:49 am | by Morgan Kelly, Office of Communications, Princeton Univ. | Videos | Comments

New research has found that one of the world's most prolific bacteria manages to afflict humans, animals and even plants by way of a mechanism not before seen in any infectious microorganism—a sense of touch. This unique ability helps make the bacteria Pseudomonas aeruginosa ubiquitous, but it also might leave these antibiotic-resistant organisms vulnerable to a new form of treatment.

Many older brains have plasticity, but in a different place

November 20, 2014 8:38 am | by David Orenstein, Brown Univ. | News | Comments

A widely presumed problem of aging is that the brain becomes less flexible or plastic, and that learning may therefore become more difficult. A new study led by Brown Univ. researchers contradicts that notion with a finding that plasticity did occur in seniors who learned a task well, but it occurred in a different part of the brain than in younger people.

Government wants more clinical trial results made public

November 19, 2014 3:00 pm | by Lauran Neergaard - AP Medical Writer - Associated Press | News | Comments

The government proposed new rules Wednesday to make it easier for doctors and patients to learn if clinical trials of treatments worked or not. Thousands of Americans participate in clinical trials every year, testing new treatments, comparing old ones or helping to uncover general knowledge about health. Many of the studies are reported in scientific journals and trumpeted in the news.

Immune system surprise hints at new strategy for fighting HIV

November 19, 2014 10:53 am | by Bill Hathaway, Yale Univ. | News | Comments

The discovery of the innate immunity system’s role in mobilizing the body’s defenses against invading microorganisms has been long studied at Yale Univ. Now in Nature Immunology, Yale researchers have discovered a surprising twist to the story that may open a new avenue in the fight against HIV.

Biochemists build largest synthetic molecular “cage” ever

November 19, 2014 10:26 am | by Stuart Wolpert, Univ. of California, Los Angeles | News | Comments

Univ. of California, Los Angeles biochemists have created the largest-ever protein that self-assembles into a molecular “cage.” The research could lead to synthetic vaccines that protect people from the flu, HIV and other diseases. At a size hundreds of times smaller than a human cell, it also could lead to new methods of delivering pharmaceuticals inside of cells, or to the creation of new nanoscale materials.

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