An Oak Ridge National Laboratory team has unlocked the enzymatic synthesis process of rare sugars, which are useful in developing drugs with low side effects. In a recently published paper, the team reported the pioneering use of neutron and x-ray crystallography and HPC to study how the enzyme D-xylose isomerase, or XI, can cause a biochemical reaction in natural sugar to produce rare sugars.
Researchers may soon have a better idea of how tiny particles of pollution are formed in the atmosphere. These particles, called aerosols, are hazardous to human health and contribute to climate change, but researchers know little about how their properties are shaped by chemical reactions in the atmosphere. Unraveling this chemistry could someday lead to more effective policies to protect human health and the Earth’s climate.
One of the big frustrations of surgery is that little indicates whether the patient is a fast or slow healer, someone who feels normal in a week or is out of work for a month with lingering pain and fatigue. Now Stanford Univ. researchers have discovered that right after surgery, patients' blood harbors clues about how fast they'll bounce back. And it has to do with the activity of certain immune cells that play a key role in healing.
A new wearable medical device can quickly alert a person if they are having cardiovascular trouble or if it’s simply time to put on some skin moisturizer, reports a Northwestern Univ. and Univ. of Illinois at Urbana-Champaign study. The small device, approximately five centimeters square, can be placed directly on the skin and worn 24/7 for around-the-clock health monitoring.
Platelets, the tiny cell fragments whose job it is to stop bleeding, are very simple. They don’t have a cell nucleus. But they can “feel” the physical environment around them, researchers at Emory Univ. and Georgia Tech have discovered. Platelets respond to surfaces with greater stiffness by increasing their stickiness, the degree to which they “turn on” other platelets and other components of the clotting system, the researchers found.
Scientists have scoured cow rumens and termite guts for microbes that can efficiently break down plant cell walls for the production of next-generation biofuels, but some of the best microbial candidates actually may reside in the human lower intestine, researchers report. Their studyis the first to use biochemical approaches to confirm the hypothesis that microbes in the human gut can digest fiber.
Purdue Univ. researchers have discovered the structure of the enzyme that makes cellulose, a finding that could lead to easier ways of breaking down plant materials to make biofuels and other products and materials. The research also provides the most detailed glimpse to date of the complicated process by which cellulose is produced.
Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. A team of Massachusetts Institute of Technology (MIT) researchers has now hijacked that delivery system for a different purpose: administering cancer drugs.
The liver provides critical functions, such as ridding the body of toxins, but its failure can be deadly, and there are few options for fixing it. A promising alternative in development is transplanting liver cells made using adult stem cells, but the only source identified until now has been bone marrow. Recently, scientists identified another, more convenient, source of adult stem cells that could be used for this purpose:tonsils.
Researchers in the Netherlands have managed to open nanovesicles in a reversible process and close them using a magnet. Previously, these vesicles had been “loaded” with a drug and opened elsewhere using a chemical process, such as osmosis. The magnetic method, which is repeatable, is the first to demonstrate the viability of another method.
Antarctic fish that manufacture their own "antifreeze" proteins to survive in the icy Southern Ocean also suffer an unfortunate side effect: The protein-bound ice crystals that accumulate inside their bodies resist melting even when temperatures warm. Ice that doesn't melt at its normal melting point is referred to as "superheated”, and the phenomenon was an unexpected discovery by scientists in Oregon and Illinois.
This short course will provide practical training in the field of cell culture, bioreactor operation, bioprocess paradigm and separation technology. It will also increase understanding of the industrial food and drug fermentation biotechnology through simulation, sterilization technologies and clinical implications, as well as related research done across different countries, universities and industries.
A Rice Univ. team led by bioengineer Jeffrey Jacot and chemical engineer and chemist Matteo Pasquali have created new pediatric heart-defect patches infused with conductive single-walled carbon nanotubes that allow electrical signals to pass unhindered. The nanotubes overcome a limitation of current patches in which pore walls hinder the transfer of electrical signals between cardiomyocytes, the heart muscle’s beating cells.
Achieving complete breakdown of plant biomass for energy conversion in industrialized bioreactors remains a complex challenge, but new research shows that termite fungus farmers solved this problem more than 30 million years ago. The new insight reveals that the great success of termite farmers as plant decomposers is due to division of labor.
Using an optical microstructure and gold nanoparticles, scientists have amplified the interaction of light with DNA to the extent that they can now track interactions between individual DNA molecule segments. In doing so, they have approached the limits of what is physically possible. This optical biosensor for single unlabelled molecules could also be a breakthrough in the development of biochips:
Each year, new strains of bacteria emerge that resist even the most powerful antibiotics, but scientists have discovered very few new classes of antibiotics in the past decade. Engineers have now turned a powerful new weapon on these superbugs. Using a gene-editing system that can disable any target gene, they have shown that they can selectively kill bacteria carrying harmful genes that confer antibiotic resistance or cause disease.
Synthetic molecules hold great potential for revealing key processes that occur in cells, but the trial-and-error approach to their design has limited their effectiveness. Christina Smolke at Stanford Univ. has introduced a new computer model that could provide better blueprints for building synthetic genetic tools.
Shellfish such as mussels and barnacles secrete very sticky proteins that help them cling to rocks or ship hulls, even underwater. Inspired by these natural adhesives, a team of Massachusetts Institute of Technology engineers has designed new materials that could be used to repair ships or help heal wounds and surgical incisions.
Researchers at the Salk Institute have discovered an on-and-off “switch” in cells that may hold the key to healthy aging. This switch, which involves the enzyme telomerase, points to a way to encourage healthy cells to keep dividing and generating, for example, new lung or liver tissue, even in old age.
Biochemists in California have developed a program that predicts the placement of chemical marks that control the activity of genes based on sequences of DNA. By comparing sequences with and without epigenomic modification, the researchers identified DNA patterns associated with the changes. They call this novel analysis pipeline Epigram and have made both the program and the DNA motifs they identified openly available to other scientists.
A new, ultrasensitive biosensor made from graphene has been used to detect molecules that indicate an increased risk of developing cancer. The biosensor has been shown to be more than five times more sensitive than bioassay tests currently in use, and was able to provide results in a matter of minutes, opening up the possibility of a rapid, point-of-care diagnostic tool for patients.
There's some truth to the effectiveness of folk remedies, according to findings by a team from Detroit Medical Center. Dr. Sonal Saraiya and her colleagues in Michigan found that packing strips of cured pork in the nose of a child who suffers from uncontrollable, life-threatening nosebleeds can stop the hemorrhaging. The discovery won a 2014 Ig Nobel prize, the annual award for sometimes inane, but often practical, scientific discoveries.
Mathematics might be able to reduce the need for invasive biopsies in patients suffering kidney damage related to the autoimmune disease lupus. In a new study, researchers developed a math model that can predict the progression from nephritis, or kidney inflammation, to interstitial fibrosis, scarring in the kidney that current treatments cannot reverse. A kidney biopsy is the only existing way to reach a definitive diagnosis.
For decades, researchers have tried to develop broadly effective vaccines to prevent the spread of illnesses such as HIV, malaria and tuberculosis. While limited progress has been made along these lines, there are still no licensed vaccinations available that can protect most people from these devastating diseases. So what are immunologists to do when vaccines just aren't working?
No matter how many times it’s demonstrated, it’s still hard to envision bacteria as social, communicating creatures. But by using a signaling system called “quorum sensing,” these single-celled organisms radically alter their behavior to suit their population. In short, some bacteria “know” how many of them are present, and act accordingly.
One sip of a perfectly poured glass of wine leads to an explosion of flavors in your mouth. Researchers in Denmark have now developed a nanosensor that can mimic what happens in your mouth when you drink wine. The sensor, which uses gold nanoparticles to act as a “mini-mouth”, measures how you experience the sensation of dryness in the wine.
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