A team of Yale Univ. researchers has developed a simple method that could significantly reduce the time and cost of probing gene expression on a large scale. The team created a tool that takes advantage of new high-throughput DNA sequencing technologies to make it easier to simultaneously measure gene activity in large numbers of cells or tissues.
A new simple tool developed by nanoengineers at the Univ. of California, San Diego, is opening...
Modern biology has attained deep knowledge of how cells work, but the mechanisms by which...
Tiny parasitic hookworms infect nearly half a billion people worldwide, almost exclusively in developing countries, causing health problems ranging from gastrointestinal issues to cognitive impairment and stunted growth in children. By sequencing and analyzing the genome of one particular hookworm species, Caltech researchers have uncovered new information that could aid the fight against these parasites.
With the aid of x-ray crystallography, researchers at the Univ. of Michigan have revealed the structures of two closely related enzymes that play essential roles in the body's ability to metabolize excess lipids, including cholesterol. The findings are an important step toward understanding and being able to therapeutically target disorders and drug side effects that cause lipids, including cholesterol, to build up in the body.
Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back. A new nanodevice developed by Massachusetts Institute of Technology researchers can help overcome that by first blocking the gene that confers drug resistance, then launching a new chemotherapy attack against the disarmed tumors.
A powerful genome editing tool may soon become even more powerful. Researchers with the Lawrence Berkeley National Laboratory have unlocked the key to how bacteria are able to “steal” genetic information from viruses and other foreign invaders for use in their own immunological memory system.
A new twist on an old tool lets scientists use light to study and control matter with 1,000 times better resolution and precision than previously possible. Physicists at the Univ. of Michigan have demonstrated "ponderomotive spectroscopy," an advanced form of a technique that was born in the 15th century when Isaac Newton first showed that white light sent through a prism breaks into a rainbow.
Researchers have, for the first time, successfully converted adult human skin cells into neurons of the type that regulate appetite, providing a patient-specific model for studying the neurophysiology of weight control and testing new therapies for obesity. To make the neurons, human skin cells were first genetically reprogrammed to become induced pluripotent stem (iPS) cells.
A study of how climate change has affected emperor penguins over the last 30,000 years found that only three populations may have survived during the last ice age, and that the Ross Sea in Antarctica was likely the refuge for one of these populations.
Scientists have captured the first detailed microscopy images of ultra-small bacteria that are believed to be about as small as life can get. The existence of ultra-small bacteria has been debated for two decades, but there hasn’t been a comprehensive electron microscopy and DNA-based description of the microbes until now.
Researchers have long sought an efficient way to untangle DNA in order to study its structure under a microscope. Now, chemists and engineers at KU Leuven have devised a strikingly simple and effective solution: They inject genetic material into a droplet of water and use a pipet tip to drag it over a glass plate covered with a sticky polymer.
A new drug that prompts cancer cells to self-destruct while sparing healthy cells is now entering phase I clinical trials in humans. The drug, called PAC-1, first showed promise in the treatment of pet dogs with spontaneously occurring cancers, and is still in clinical trials in dogs with osteosarcoma.
Current peanut allergy tests are not very reliable when it comes to diagnosing the severity of an individual’s allergic reaction, which can range from hives to life-threatening anaphylactic shock. With an estimated three million people in the U.S. allergic to peanuts and tree nuts, having a more precise and reliable allergy test could prevent hospitalizations and allow for better monitoring of individuals suffering from peanut allergies.
The makers of the nasal spray version of the flu vaccine say they now know why it didn't protect young children against swine flu—the doses got too warm. The spray FluMist works well for most flu strains, but small studies found it didn't work very well against the swine flu bug that first emerged in 2009.
Everyday experience and psychological studies alike tell us there are two different types of extroverts: The gregarious “people-persons” and the ambitious “go-getters”. A new study shows that these overlapping yet distinct personalities have commensurately overlapping yet distinct signatures in the anatomy of the brain.
Like the shape-shifting robots of "Transformers" fame, a unique class of proteins in the human body also has the ability to alter their configuration. These so-named intrinsically disordered proteins lack a fixed or ordered 3-D structure, which can be influenced by exposure to various chemicals and cellular modifications. A new study looked at a particular IDP called tau, which plays a critical role in human physiology.
With antibiotic resistance on the rise, scientists are looking for innovative ways to combat bacterial infections. The pathogen that causes conditions from strep throat to flesh-eating disease is among them, but scientists have now found a tool that could help them fight it: a drug approved to treat HIV. Their work, appearing in ACS Chemical Biology, could someday lead to new treatments.
Univ. of Manchester scientists have used graphene to target and neutralize cancer stem cells while not harming other cells. This new development opens up the possibility of preventing or treating a broad range of cancers, using a non-toxic material.
A chemical found in garlic can kill bacteria that cause life-threatening lung infections in people with cystic fibrosis, research suggests. The study is the first to show that the chemical, known as allicin, could be an effective treatment against a group of infectious bacteria that is highly resistant to most antibiotics.
Scientists around the world make use of cell culture techniques on a daily basis. Whether they happen to be working with primary cell cultures, secondary cultures or cell lines, they all face many of the same problems: slow growth, spontaneous differentiation, evaporation, contamination and a host of other issues that require troubleshooting.
Computational Model Reveals the Importance of Transitional Dynamics of “Memory Molecule” in Memory FormationFebruary 24, 2015 9:01 am | by Glen C. Rains | Articles | Comments
The dynamics of a molecule abundant in the synapse, Ca2+/Calmodulin dependent kinase type II (CaMKII), known as the “memory molecule”, are important in memory formation. Synapses are junctions connecting neurons and there’s increasing evidence they store memory when neurons are stimulated by the environment.
Oxytocin, sometimes referred to as the “love” or “cuddle” hormone, has a legendary status in popular culture due to its vital role in social and sexual behavior and long-term bonding. Now researchers from the Univ. of Sydney and the Univ. of Regensburg have discovered it also has a remarkable influence on the intoxicating effect of alcohol.
Researchers at the Univ. of North Carolina School of Medicine have found that the blood platelet protein Rasa3 is critical to the success of the common anti-platelet drug Plavix, which breaks up blood clots during heart attacks and other arterial diseases. The discovery details how Rasa3 is part of a cellular pathway crucial for platelet activity during clot formation.
Researchers at McGill Univ. have developed a new, low-cost method to build DNA nanotubes block-by-block, a breakthrough that could help pave the way for scaffolds made from DNA strands to be used in applications such as optical and electronic devices or smart drug delivery systems. Many researchers, including the McGill team, have previously constructed nanotubes using a method that relies on spontaneous assembly of DNA in solution.
When exposed to nitrogen fertilizer over a period of years, nitrogen-fixing bacteria called rhizobia evolve to become less beneficial to legumes, researchers report in a new study. These findings, reported in Evolution, may be of little interest to farmers, who generally grow only one type of plant and can always add more fertilizer to boost plant growth.
When diagnosing a case of Ebola, time is of the essence. However, existing diagnostic tests take at least a day or two to yield results, preventing health care workers from quickly determining whether a patient needs immediate treatment and isolation. A new test could change that: The device, a simple paper strip similar to a pregnancy test, can rapidly diagnose Ebola, as well as other viral hemorrhagic fevers.
An experimental antiviral drug shows some early, encouraging signs of effectiveness in its first human test against Ebola in West Africa, but only if patients get it when their symptoms first appear. A study of the drug, favipiravir, is still in early stages in West Africa, and too few people have been treated to really know whether the drug helps.
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