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New weapons against multi-drug resistance in tuberculosis

October 9, 2014 8:51 am | by Nik Papageorgiou, EPFL | News | Comments

Tuberculosis is caused by a bacterium that infects the lungs of an estimated 8.6 million people worldwide. The fight against the disease is hampered by the fact that treatment requires a long time and that the bacterium often develops multi-drug resistance. Scientists have used a sensitive screening assay to test new compounds that can be used against the bacterium, and have discovered two small molecules that show remarkable promise.

NIST quantum probe enhances electric field measurements

October 9, 2014 8:37 am | News | Comments

Researchers at NIST and the Univ. of Michigan have demonstrated a technique based on the quantum properties of atoms that directly links measurements of electric field strength to the International System of Units. The new method could improve the sensitivity, precision and ease of tests and calibrations of antennas, sensors, and biomedical and nano-electronic systems and facilitate the design of novel devices.

New way to extract bone-making cells from fat tissue

October 9, 2014 8:23 am | by David Orenstein, Brown Univ. | News | Comments

Within our fat lives a variety of cells with the potential to become bone, cartilage or more fat if properly prompted. This makes adipose tissue, in theory, a readily available reservoir for regenerative therapies such as bone healing if doctors can get enough of those cells and compel them to produce bone. In a new study, scientists demonstrate a new method for extracting a wide variety of potential bone-producing cells from human fat.

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Researchers detect brightest pulsar ever recorded

October 9, 2014 8:09 am | by Jennifer Chu, MIT News Office | News | Comments

Astronomers have detected a pulsating dead star that appears to be burning with the energy of 10 million suns, making it the brightest pulsar ever detected. The pulsar—a rotating, magnetized neutron star—was found in the galaxy Messier 82 (M82), a relatively close galactic neighbor that’s 12 million light-years from Earth.

Technology that controls brain cells with radio waves earns early BRAIN grant

October 8, 2014 12:30 pm | News | Comments

A proposal to develop a new way to remotely control brain cells from Sarah Stanley, a research associate in Rockefeller Univ.’s Laboratory of Molecular Genetics is among the first to receive funding from President Barack Obama’s BRAIN initiative. The project will make use of a technique called radiogenetics that combines the use of radio waves or magnetic fields with nanoparticles to turn neurons on or off.

Breakthrough allows researchers to watch molecules “wiggle”

October 8, 2014 12:11 pm | News | Comments

A new crystallographic technique, called fast time-resolved crystallography, developed in the U.K. is set to transform scientists’ ability to observe how molecules work. Although this method, also known as Laue crystallography, has previously been possible, it has required advanced instrumentation that is only available at three sites worldwide. Only a handful of proteins have been studied using the traditional technique.

Neuroscientists use snail research to help explain “chemo brain”

October 8, 2014 12:00 pm | News | Comments

It is estimated that as many as half of patients taking cancer drugs experience a decrease in mental sharpness, but what causes “chemo brain” has eluded scientists. In the study involving a sea snail that shares many of the same memory mechanisms as humans and a drug used to treat cancer, scientists in Texas identified memory mechanisms blocked by the drug. Then, they were able to counteract the mechanisms by administering another agent.

“Bellhops” in cell walls can double as hormones

October 8, 2014 9:29 am | by SLAC Office of Communications | Videos | Comments

Researchers have discovered that some common messenger molecules in human cells double as hormones when bound to a protein that interacts with DNA. The finding could bring to light a class of previously unknown hormones and lead to new ways to target diseases—including cancers and a host of hormone-related disorders.

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Researchers pump up oil accumulation in plant leaves

October 8, 2014 9:20 am | by Karen McNulty Walsh, Brookhaven National Laboratory | News | Comments

Increasing the oil content of plant biomass could help fulfill the nation's increasing demand for renewable energy feedstocks. But many of the details of how plant leaves make and break down oils have remained a mystery. Now a series of detailed genetic studies conducted at Brookhaven National Laboratory reveals previously unknown biochemical details about those metabolic pathways.

Three win Nobel for super-zoom microscopes

October 8, 2014 9:20 am | by Karl Ritter and Malin Rising, Associated Press | News | Comments

Two Americans and a German scientist won the 2014 Nobel Prize in chemistry Wednesday for finding ways to make microscopes more powerful than previously thought possible. Working independently of each other, U.S. researchers Eric Betzig and William Moerner and Stefan Hell of Germany shattered previous limits on the resolution of optical microscopes by using molecules that glow on command to peer inside tiny components of life.

New way to make foams could lead to lightweight, sustainable materials

October 8, 2014 8:30 am | by John Toon, Georgia Institute of Technology | News | Comments

Anyone who has blown a bubble and seen how quickly it pops has first-hand experience on the major challenge in creating stable foams. At its most basic level, foam is a bunch of bubbles squished together. Liquid foams, a state of matter that arises from tiny gas bubbles dispersed in a liquid, are familiar in everyday life, from beer to bathwater. They also are important in commercial products and processes.

Getting metabolism right

October 8, 2014 7:59 am | by Larry Hardesty, MIT News Office | News | Comments

Metabolic networks are mathematical models of every possible sequence of chemical reactions available to an organ or organism, and they’re used to design microbes for manufacturing processes or to study disease. Based on both genetic analysis and empirical study, they can take years to assemble. Unfortunately, a new analytic tool suggests that many of those models may be wrong.

Unconventional photoconduction in an atomically thin semiconductor

October 7, 2014 3:36 pm | by David L. Chandler, MIT | News | Comments

It’s a well-known phenomenon in electronics: Shining light on a semiconductor, such as the silicon used in computer chips and solar cells, will make it more conductive. But now researchers have discovered that in a special semiconductor, light can have the opposite effect, making the material less conductive instead. This new mechanism of photoconduction could lead to next-generation excitonic devices.

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DNA linked to how much coffee you drink

October 7, 2014 2:15 pm | by Malcolm Ritter, AP Science Writer | News | Comments

Scientists have long known that your DNA influences how much java you consume. Now a huge study has identified some genes that may play a role. Their apparent effect is quite small. But variations in such genes may modify coffee's effect on a person's health, and so genetic research may help scientists explore that.

Researchers demonstrate how direct fluid flow influences neuron growth

October 7, 2014 2:11 pm | News | Comments

Axons are the shafts of neurons, on the tips of which connections are made with other neurons or cells. In a new study in Texas, researchers were able to use microfluidic stimulations to change the path of an axon at an angle of up to 90 degrees. The publication adds insight to the long accepted idea that chemical cues are primarily responsible for axonal pathfinding during human development and nervous system regeneration.

Charge transport jamming in solar cells

October 7, 2014 2:08 pm | News | Comments

Conventional silicon solar cells could have an inexpensive competitor in the near future. Researchers in Europe have examined the working principle of a cell where an organic-inorganic perovskite compound acts as a light absorber. The scientists observed that charge carriers accumulate in a layer in these photovoltaic elements. If this jam can be dissolved, the already considerable efficiency of these solar cells could be further improved.

Quantum entanglement made tangible

October 7, 2014 2:00 pm | by Nik Papageorgiou, EPFL | News | Comments

Scientists at EPFL in Switzerland have designed a first-ever experiment for demonstrating quantum entanglement in the macroscopic realm. Unlike other such proposals, the experiment is relatively easy to set up and run with existing semiconductor devices.

Researchers turn computers into powerful allies in the fight against AIDS

October 7, 2014 9:54 am | News | Comments

Until now, researchers searching for compounds that have the potential to become a new HIV drug have been hampered by slow computers and inaccurate prediction models. Now, researchers in Denmark have developed an effective model based on quantum mechanics and molecular mechanics that has found, out of a half-million compounds, 14 of interest in just weeks.

Green tea-based “missiles” kill cancer cells more effectively

October 7, 2014 9:47 am | News | Comments

Green tea has long been known for its anti-oxidant, anti-cancer, anti-aging and anti-microbial properties. A group of researchers from the Institute of Bioengineering and Nanotechnology in Singapore has taken the health benefits of green tea to the next level by using one of its ingredients, the antioxidant epigallocatechin gallate, to develop a drug delivery system that kills cancer cells more efficiently.

Droplets made to order

October 7, 2014 9:33 am | by David L. Chandler, MIT | News | Comments

Massachusetts Institute of Technology researchers have developed a new way of creating surfaces on which droplets of any desired shape can spontaneously form. They say this approach could lead to new biomedical assay devices and light-emitting diode display screens, among other applications. The new work represents the first time that scientists can control the shape of the contact area of the droplets.

Three win medicine Nobel for discovering brain's GPS

October 7, 2014 9:28 am | by Karl Ritter and Jill Lawless, Associated Press | News | Comments

A U.S.-British scientist and a Norwegian husband-and-wife research team won the Nobel Prize in medicine for discovering the brain's navigation system—the inner GPS that helps us find our way in the world—a revelation that could lead to advances in diagnosing Alzheimer's. The research by John O'Keefe, May-Britt Moser and Edvard Moser represents a "paradigm shift" in neuroscience that could help researchers understand Alzheimer's disease.

Two Japanese, one American win Nobel for LED lights

October 7, 2014 9:10 am | by Karl Ritter and Malin Rising, Associated Press | Videos | Comments

Isamu Akasaki and Hiroshi Amano of Japan and U.S. scientist Shuji Nakamura won the 2014 Nobel Prize in physics for the invention of blue light-emitting diodes, a breakthrough that spurred the development of light-emitting diode (LED) technology. Scientists had struggled for decades to produce the blue diodes that are a crucial component in producing white light from LEDs when the three laureates made their breakthroughs in the early 1990s.

A quick look at electron-boson coupling

October 7, 2014 8:56 am | by Lynn Yarris, Lawrence Berkeley National Laboratory | News | Comments

Imagine being able to tune the properties of a solid material just by flashing pulses of light on it. That is one potential payoff of electrons and atoms interacting with ultrashort pulses of light. The technology of ultrafast spectroscopy is a key to understanding this phenomenon and now a new wrinkle to that technology, observations of electron self-energy, has been introduced by Lawrence Berkeley National Laboratory researchers.

Validation: Recognizing A Problem With Real-Time PCR Kits

October 7, 2014 7:49 am | by Keith Cockrum, Bio-Rad Laboratories | Bio-Rad Laboratories | Articles | Comments

Life Science researchers have become ever-more dependent on the industry for “kits” that are intended to execute research processes in the laboratory flawlessly. In recognition of this expectation, kit manufacturers now market nearly every product as “guaranteed” or “validated.” This practice has led the research community to feel secure that the products will perform as advertised.

Dialing It In

October 6, 2014 2:59 pm | by Ra’ef Mikhail, Edmund Optics | Articles | Comments

Optical system designers often need to evaluate the effect of different laser beam diameters during prototyping. Although it’s possible to do this by introducing several different beam expanders in sequence, or by stopping the beam down with apertures, variable-magnification beam expanders provide flexibility and performance in an easy-to-use package.

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