Like a slumbering dragon, HIV can lay dormant in a person’s cells for years, evading medical treatments only to wake up and strike at a later time, quickly replicating itself and destroying the immune system. Scientists at the Salk Institute have uncovered a new protein that participates in active HIV replication. The new protein, called Ssu72, is part of a switch used to awaken HIV-1 from its slumber.
In early drug discovery, you need a starting point. In a new research paper published in PLOS-Neglected Tropical Diseases, a team of researchers present hundreds of such starting points for potentially treating Human African trypanosomiasis, or sleeping sickness, a deadly disease that affects thousands of people annually.
Google executive Alan Eustace broke the sound barrier and set several skydiving records over the southern New Mexico desert early Friday after taking a big leap from the edge of space. Eustace's supersonic jump was part of a project by Paragon Space Development Corp., which has been working secretly for years to develop a self-contained commercial spacesuit that would allow people to explore some 20 miles above the Earth's surface.
Lasers are so deeply integrated into modern technology that their basic operations would seem well understood. CD players, medical diagnostics and military surveillance all depend on lasers. Re-examining longstanding beliefs about the physics of these devices, Princeton Univ. engineers have now shown that carefully restricting the delivery of power to certain areas within a laser could boost its output by many orders of magnitude.
Starting Monday, millions of people who have avoided colon cancer screening can get a new home test that's noninvasive and doesn't require the icky preparation most other methods do. The test is the first to look for cancer-related DNA in stool. But deciding whether to get it is a more complex choice than ads for "the breakthrough test ... that's as easy as going to the bathroom" make it seem.
Adherent cells, the kind that form the architecture of all multicellular organisms, are engineered with precise forces that allow them to move around and stick to things. When these cells are put into a petri dish with a variety of substrates they can sense the differences in the surfaces and they will “crawl” toward the stiffest one. Chemists have devised a method using DNA-based tension probes to measure and map these phenomena.
Researchers at Virginia Commonwealth Univ. have discovered that most of the electrolytes used in lithium-ion batteries are superhalogens, and that the vast majority of these electrolytes contain toxic halogens. At the same time, the researchers also found that the electrolytes in lithium-ion batteries could be replaced with halogen-free electrolytes that are both nontoxic and environmentally friendly.
Traditional forms of temperature measurement, such as thermocouples and spot pyrometers, often don’t offer the resolution or speed required to fully characterize high-speed thermal applications. This article explores the advantages of high-speed thermal measurement with infrared cameras.
In many areas of the developing world, there’s limited access to electricity, and many places have never had any type of power infrastructure. This presents a challenge for aid workers and doctors. In the recent past, vaccines that needed to be stored at cold, relatively constant temperatures couldn’t be taken into the remote areas where they were needed most.
Researchers in the U.K. have found a new way to make nanostructured carbon using the waste product sawdust. By cooking sawdust with a thin coating of iron at 700 C, they have discovered that they can create carbon with a structure made up of many tiny tubes. These tubes are one thousand times smaller than an average human hair.
Helium is a famously unreactive gas but when cooled to just above absolute zero it becomes a superfluid, a strange form of liquid. An Anglo-Austrian team has used this liquid to develop a completely new way of forming charged particles. The team’s key discovery is that helium atoms can acquire an excess negative charge which enables them to become aggressive new chemical reagents.
Certain quantum physical phenomena in matter can only be clearly visualized in the presence of extreme magnetic fields. Physicists in Germany are developing a new high field magnet based on a hybrid design conceived in the U.S. On Oct. 16, 2014, scientists with the High Field Magnet project reported consistent magnetic fields of 26 T, higher than 25-T goal originally conceived.
Scientists have been able to manufacture 3-D isotropic metamaterials, but up to now only on a very small scale. Now, in a significant breakthrough, scientists from RIKEN, in collaboration with colleagues in Taiwan, have succeeded in creating a large metamaterial up to 4-mm-square in size that is essentially isotropic, using a type of metamaterial element called a split-ring resonator.
Sandia National Laboratories has begun laboratory-based characterization of TransPower’s GridSaver, the largest grid energy storage system analyzed at Sandia’s Energy Storage Test Pad in Albuquerque. Sandia will evaluate the 1 MW, lithium-ion grid energy storage system for capacity, power, safety and reliability. The laboratory also will investigate the system’s frequency regulation.
When a solid material is immersed in a liquid, the liquid immediately next to its surface differs from that of the bulk liquid at the molecular level. This interfacial layer is critical to our understanding of a diverse set of phenomena. When the solid surface is charged, it can drive further changes in the interfacial liquid. However, elucidating the molecular structure at the solid-liquid interface under these conditions is difficult.
Researchers at the New York Univ. Polytechnic School of Engineering have broken new ground in the development of proteins that form specialized fibers used in medicine and nanotechnology. For as long as scientists have been able to create new proteins that are capable of self-assembling into fibers, their work has taken place on the nanoscale. For the first time, this achievement has been realized on the microscale.
New achievements in synthetic biology, which will allow complex cellular recognition reactions to proceed outside of living cells, will dare scientists to dream big: There could one day be inexpensive, shippable and accurate test kits that use saliva or a drop of blood to identify specific disease or infection.
At first glance, the static, greyscale display created by a group of researchers in Hong Kong might not catch the eye of a thoughtful consumer in a market saturated with flashy, colorful electronics. But a closer look at the specs could change that: the ultra-thin LCD screen is capable of holding 3-D images without a power source, making it a compact, energy-efficient way to display visual information.
For as long as scientists have been able to create new proteins that are capable of self-assembling into fibers, scientists’ work has taken place on the nanoscale. For the first time, this achievement has been realized on the microscale, a leap of magnitude in size that presents significant new opportunities for using engineered protein fibers.
An international team of scientists have become the first to successfully reach temperatures below -272.15 C, which is just above absolute zero, using magnetic molecules. The effort, which avoids the use of helium, depends on a form of gadolinium that appropriately has a structure resembling a snowflake.
A few short years ago, the idea of a practical manufacturing process based on getting molecules to organize themselves in useful nanoscale shapes seemed far-fetched. Recent work at NIST, Massachusetts Institute of Technology and IBM Almaden Research Center suggest this capability isn’t far off, however, by demonstrating self-assembly of thin films on a polymer template that creates precise rows just 10 nm wide.
Bio-engineers are working on the development of biological computers: biological material that can be integrated into cells to change their functions. Researchers in Europe have now developed a biological circuit that controls the activity of individual sensor components using internal "timer". This circuit prevents a sensor from being active when not required by the system; when required, it can be activated via a control signal.
Major leaks from oil and gas pipelines have led to home evacuations, explosions, millions of dollars in lawsuit payouts and valuable natural resources escaping into the air, ground and water. But scientists say they have developed a new software-based method that finds leaks even when they’re small, which could help prevent serious incidents and save money for customers and industry.
The AN/AAR-57 Common Missile Warning System (CMWS) helps protect Army aircraft from attack by shoulder-launched missiles and other threats. To keep this defensive system operating at maximum effectiveness, the Army periodically updates the software on the more than 1,000 AN/AAR-57 units in use around the world.
Though it garners few headlines, carbonic acid, the hydrated form of carbon dioxide, is critical to both the health of the atmosphere and the human body. However, because it exists for only a fraction of a second before changing into a mix of hydrogen and bicarbonate ions, carbonic acid has remained an enigma. A new study has yielded new information about carbonic acid with important implications for geological and biological concerns.