HIV is adept at eluding immune system responses because the protein it uses to infect cells is constantly changing. Now a team of researchers including scientists from Yale Univ. have stripped the cloak from this master of disguise, providing a high-resolution image of this surface spike protein and monitoring how it constantly changes its shape, information that suggests new ways to attack the virus through drugs and vaccines.
Spectroscopic chemical sensing has great promise, but current technologies lack sensitivity and broad spectral coverage. DARPA’s Spectral Combs from UV to THz (SCOUT) program aims to overcome these limitations. The goal is to develop chip-sized, optical frequency combs that accurately identify even tiny traces of dangerous biological and chemical substances several football fields away, DARPA is now soliciting proposals for a solution.
A long-sought goal of creating particles that can emit a colorful fluorescent glow in a biological environment, and that could be precisely manipulated into position within living cells, has been achieved by a team of researchers at Massachusetts Institute of Technology and several other institutions. The new technology could make it possible to track the position of the nanoparticles as they move within the body or inside a cell.
New research involving scientists in the U.S. and Israel offers new insight into the lethal interaction between cancer cells and the immune system's communications network. The study authors devised a new computer program that models a specific channel of cell-to-cell communication involving exosomes that both cancer and immune cells harness to communicate with other cells. This “cyberwarfare” model reveals three distinct states of cancer.
An emerging class of electrically conductive plastics called "radical polymers” may bring low-cost, transparent solar cells, flexible and lightweight batteries, and ultrathin antistatic coatings for consumer electronics and aircraft. Researchers have established the solid-state electrical properties of one such polymer, called PTMA, which is about 10 times more electrically conductive than common semiconducting polymers.
Researchers have developed a new method for harvesting the energy carried by particles known as “dark” spin-triplet excitons with close to 100% efficiency, clearing the way for hybrid solar cells which could far surpass current efficiency limits. To date, this type of energy transfer had only been shown for “bright” spin-singlet excitons.
Tuberculosis is caused by a bacterium that infects the lungs of an estimated 8.6 million people worldwide. The fight against the disease is hampered by the fact that treatment requires a long time and that the bacterium often develops multi-drug resistance. Scientists have used a sensitive screening assay to test new compounds that can be used against the bacterium, and have discovered two small molecules that show remarkable promise.
Researchers at NIST and the Univ. of Michigan have demonstrated a technique based on the quantum properties of atoms that directly links measurements of electric field strength to the International System of Units. The new method could improve the sensitivity, precision and ease of tests and calibrations of antennas, sensors, and biomedical and nano-electronic systems and facilitate the design of novel devices.
Within our fat lives a variety of cells with the potential to become bone, cartilage or more fat if properly prompted. This makes adipose tissue, in theory, a readily available reservoir for regenerative therapies such as bone healing if doctors can get enough of those cells and compel them to produce bone. In a new study, scientists demonstrate a new method for extracting a wide variety of potential bone-producing cells from human fat.
Astronomers have detected a pulsating dead star that appears to be burning with the energy of 10 million suns, making it the brightest pulsar ever detected. The pulsar—a rotating, magnetized neutron star—was found in the galaxy Messier 82 (M82), a relatively close galactic neighbor that’s 12 million light-years from Earth.
The first person diagnosed with Ebola in the U.S. died Wednesday despite intense but delayed treatment, and the government announced it was expanding airport examinations to guard against the spread of the deadly disease. The checks will include taking the temperatures of hundreds of travelers arriving from West Africa at five major American airports.
IBM revealed details about new projects for its Watson cognitive computing software as it opened its New York headquarters. The company has been developing business uses for Watson with clients since it announced in January it was investing more than $1 billion in the technology, including about $100 million in startup companies working on Watson projects.
It is estimated that as many as half of patients taking cancer drugs experience a decrease in mental sharpness, but what causes “chemo brain” has eluded scientists. In the study involving a sea snail that shares many of the same memory mechanisms as humans and a drug used to treat cancer, scientists in Texas identified memory mechanisms blocked by the drug. Then, they were able to counteract the mechanisms by administering another agent.
A study suggests that do-it-yourself flu vaccine might be possible. Researchers found that military folks who squirted a nasal vaccine up their noses were as well-protected as others who got it from health workers. The study leader says there is no reason that ordinary people could not be taught to give the vaccine, especially for children who might be less scared if they received it from mom or dad.
Researchers at NIST have demonstrated a laser-based imaging system that creates high-definition 3-D maps of surfaces from as far away as 10.5 m. The method, which combines a form of laser detection and ranging that is sensitive enough to detect weak reflected light with the ranging accuracy made possible by frequency combs, may be useful in diverse fields, including precision machining and assembly, as well as in forensics.
Researchers have discovered that some common messenger molecules in human cells double as hormones when bound to a protein that interacts with DNA. The finding could bring to light a class of previously unknown hormones and lead to new ways to target diseases—including cancers and a host of hormone-related disorders.
Increasing the oil content of plant biomass could help fulfill the nation's increasing demand for renewable energy feedstocks. But many of the details of how plant leaves make and break down oils have remained a mystery. Now a series of detailed genetic studies conducted at Brookhaven National Laboratory reveals previously unknown biochemical details about those metabolic pathways.
Two Americans and a German scientist won the 2014 Nobel Prize in chemistry Wednesday for finding ways to make microscopes more powerful than previously thought possible. Working independently of each other, U.S. researchers Eric Betzig and William Moerner and Stefan Hell of Germany shattered previous limits on the resolution of optical microscopes by using molecules that glow on command to peer inside tiny components of life.
Anyone who has blown a bubble and seen how quickly it pops has first-hand experience on the major challenge in creating stable foams. At its most basic level, foam is a bunch of bubbles squished together. Liquid foams, a state of matter that arises from tiny gas bubbles dispersed in a liquid, are familiar in everyday life, from beer to bathwater. They also are important in commercial products and processes.
Scientists have been laboring to detect cancer and a host of other diseases in people using promising new biomarkers called “exosomes.” Indeed, Popular Science magazine named exosome-based cancer diagnostics one of the 20 breakthroughs that will shape the world this year. Exosomes could lead to less invasive, earlier detection of cancer, and sharply boost patients’ odds of survival.
Metabolic networks are mathematical models of every possible sequence of chemical reactions available to an organ or organism, and they’re used to design microbes for manufacturing processes or to study disease. Based on both genetic analysis and empirical study, they can take years to assemble. Unfortunately, a new analytic tool suggests that many of those models may be wrong.
Ebola's victims may include a dog named Excalibur. Officials in Madrid got a court order to euthanize the pet of a Spanish nursing assistant with Ebola because of the chance the animal might spread the disease. At least one major study suggests that dogs can be infected with the deadly virus without having symptoms. But whether or how likely they are to spread it to people is less clear.
It’s a well-known phenomenon in electronics: Shining light on a semiconductor, such as the silicon used in computer chips and solar cells, will make it more conductive. But now researchers have discovered that in a special semiconductor, light can have the opposite effect, making the material less conductive instead. This new mechanism of photoconduction could lead to next-generation excitonic devices.
JEOL has introduced an easy-to-use, smart solution for high-sensitivity elemental analysis in a new benchtop EDXRF spectrometer. The JSX-1000S ElementEye analyzes major to trace components on most sample types, including solids, powders and liquids, with little or no sample preparation.
Osram Opto Semiconductors has developed a new optical sensor for automatic fitness tracking. The SFH 7050 is Osram’s first integrated optical sensor. It is designed for use in mobile devices, such as smart watches and fitness armbands. The sensor contains three light emitting diodes with different wavelengths, based on highly efficient chip technology.