Researchers have developed a concept to potentially improve delivery of drugs for cancer treatment using nanoparticles that concentrate and expand in the presence of higher acidity found in tumor cells. The concept involves using nanoparticles made of "weak polybases," compounds that expand when transported into environments mimicking tumor cells, which have a higher acidity than surrounding tissues.
The ultimate dream come true for material scientists is to have the ability to make materials that can take on properties and behaviors to best suit our needs. But scientists first must truly understand the properties of cluster assembly through the individual cluster. Now, material scientists will have greater insight into the organizing principles that allow for the design of nanoscopic materials with specific band gap energy.
A new coating technology developed at Massachusetts Institute of Technology, combined with a novel nanoparticle-manufacturing technology developed at the Univ. of North Carolina at Chapel Hill, may offer scientists a way to quickly mass-produce tailored nanoparticles that are specially coated for specific applications, including medicines and electronics.
Biomaterials are susceptible to microbial colonization, which is why silver is often added to reduce the adhesion rate of bacteria. However, a recent study by researchers in Portugal suggests that—in one material—increasing levels of silver may indirectly promote bacterial adhesion instead of decrease it.
Comic book hero Popeye swears by it. And so do generations of parents who “spoil” their children with spinach. But too much iron content in the blood can indicate acute inflammatory responses, which makes it an important medical diagnostic agent. Using nanoscale diamonds which feature defects, researchers in Europe have developed a new, sensitive biosensor for determination of iron content.
Commonly found in many fruits, vegetables, coffees, teas, and wines, antioxidants are generally regarded as healthy chemicals. However, the problem with using antioxidants in other products is that many of these molecules are not actually very stable. Scientists have recently developed a nanomaterial that protects other molecules from oxidation, and unlike previous attempts the new antioxidant has a long shelf life.
Nanoscopic crystals of silicon assembled like skyscrapers on wafer-scale substrates are being intensely studied as a possible breakthrough in highly efficient battery technologies. A researcher at Northeastern University has been using computational to understand the atomic-scale interactions between the growth of nanowires and new development in this area of technology: alloyed metal droplets.
When petroleum companies abandon an oil well, more than half the reservoir’s oil is usually left behind as too difficult to recover. Now, however, much of the residual oil can be recovered with the help of nanoparticles and a simple law of physics. A partnership of Norwegian and Chinese scientists has succeeded in recovering up to 50% of residual in North Sea rock samples.
Cheaper clean-energy technologies could be made possible thanks to a new discovery. A Penn State Univ. research team has found that an important chemical reaction that generates hydrogen from water is effectively triggered—or catalyzed—by a nanoparticle composed of nickel and phosphorus, two inexpensive elements that are abundant on Earth.
Light-emitting diodes, or LEDs, are the most efficient and environmentally friendly light bulbs on the market. But they come at a higher up-front price than other bulbs, especially the ones with warmer and more appealing hues. Researchers at the Univ. of Washington have created a material they say would make LED bulbs cheaper and greener to manufacture, driving down the price.
Gold bars may signify great wealth, but gold packs a much more practical punch when shrunk down to nanoscale. Unfortunately, unlocking its potential often requires complex synthesis techniques that produce delicate structures with sensitivity to heat. Now, scientists have discovered a process of creating uniquely structured gold-indium nanoparticles that combine high stability, great catalytic potential and a simple synthesis process.
A new study involving researchers at Sanford-Burnham Medical Research Center and the University of California, Santa Barbara, found that the shape of nanoparticles can enhance drug targeting. The study found that rod-shaped nanoparticles—or nanorods—as opposed to spherical nanoparticles, appear to adhere more effectively to the surface of endothelial cells that line the inside of blood vessels.
Current methods for particle trapping mainly rely on electrokinetic, magnetic, or optical force fields, which may not be compatible with biomolecules or biological systems. Researchers at the University of Illinois at Urbana-Champaign have developed a first-of-its-kind flow-based method for manipulating and confining single particles in free solution.
A sensor that relies on reflected light to analyze biomedical and chemical samples now has greater sensitivity, thanks to a carpet of gold nanoparticles. Other researchers have shown that gold nanoparticles can enhance the responsiveness surface plasmon resonance sensors (SPR), which magnifies reflected light intensity. Scientists in Singapore have now determined the ideal size of nanoparticle to improve these SPR sensors.
Scientists at the University of California, San Diego have designed tiny spherical particles to float easily through the bloodstream after injection, then assemble into a durable scaffold within diseased tissue. An enzyme produced by a specific type of tumor can trigger the transformation of the spheres into net-like structures that accumulate at the site of a cancer.
Growing thin films out of nanoparticles in ordered, crystalline sheets would be a boon for materials researchers, but the physics is tricky because particles of that size don’t form crystals the way individual atoms do. Using bigger particles as models, physicists have predicted some unusual properties of nanoparticle crystal growth.
Scientists in Missouri have successfully created nanoparticles made of a radioactive form of the element lutetium. By covering these particles with gold shells and attaching targeting agents, they have a tool that can seek out dangerous secondary lymphoma tumors. They recently demonstrated the nanoparticles can find the tumors without attaching to or damaging healthy cells.
Injectable nanoparticles developed at Massachusetts Institute of Technology may someday eliminate the need for patients with Type 1 diabetes to constantly monitor their blood-sugar levels and inject themselves with insulin. The nanoparticles were designed to sense glucose levels in the body and respond by secreting the appropriate amount of insulin.
According to recent research at Rice University, bovine serum albumin (BSA) forms a protein “corona” around gold nanoparticles that keeps them from aggregating, particularly in high-salt environments like seawater. The discovery could lead to improved biomedical applications and contribute to projects that use nanoparticles in harsh environments.
Nearly all drugs taken orally spike in concentration, decay quickly, and are only at their peak effectiveness for a short period of time. working on a solution―nanocapsules implanted beneath the skin that release pharmaceutical drugs through a nanochannel membrane and into the body at a sustained, steady rate. To design better nanochannels for a given drug, the team is hoping to use the International Space Station.
A new study by University of Georgia researchers documents a technological breakthrough: Synthetic high density lipoprotein (HDL) nanoparticles. A completely biodegradable synthetic version of the so-called good cholesterol, the nanoparticles represent a potential new detection and therapy regimen for atherosclerosis.
Ripening fruit, vegetables, and flowers release ethylene, which works as a plant hormone. Ethylene accelerates ripening, so other unripened fruit also begins to ripen—fruit and vegetables quickly spoil and flowers wilt. researchers in Japan have now introduced a new catalytic system for the fast and complete degradation of ethylene. This could keep the air in warehouses ethylene-free, keeping perishable products fresh longer.
Described as the "most beautiful experiment in physics," Richard Feynman emphasized how the diffraction of individual particles at a grating is an unambiguous demonstration of wave-particle duality and contrary to classical physics. A research team recently used carefully made fluorescent molecules and nanometric detection accuracy to provide clear and tangible evidence of the quantum behavior of large molecules in real time.
Researchers at the University of Illinois at Chicago have developed a way to introduce precisely four copper ions into a single quantum dot. The introduction of these “guest” ions opens up possibilities for fine-tuning the optical properties of the quantum dots and producing spectacular colors. When the crystallinity is perfect, they become very emissive and end up being the world’s best dye.
Researchers at the University of Bristol in the U.K. have led a new enquiry into how extremely small particles of silica (sand) can be used to design and construct artificial protocells in the laboratory. By attaching a thin polymer layer to the external surface of an artificial inorganic protocell built from silica nanoparticles, the scientists have potentially the problem of controlling membrane permeability.