Biomedical engineering researchers have developed a new technique that uses adenosine-5’-triphosphate (ATP), the so-called “energy molecule,” to trigger the release of anti-cancer drugs directly into cancer cells. Early laboratory tests show it increases the effectiveness of drugs targeting breast cancer. The technique was developed by researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill.
In physics, there's small, and then there's nullity, as in zero-dimensional. Univ. of Cincinnati researchers have reached this threshold with a special structure, zero-dimensional quantum dots, that may someday lead to better ways of harnessing solar energy, stronger lasers or more sensitive medical diagnostic devices.
Cornell Univ. researchers have recently led what is probably the most comprehensive study to date of block copolymer nanoparticle self-assembly processes. The work is important, because using polymers to self-assemble inorganic nanoparticles into porous structures could revolutionize electronics.
It has long been known that free, ionic silver particles can be highly toxic to aquatic organisms. Yet we a lack of detailed knowledge about the doses required to trigger a response and how the organisms deal with the stress. To learn more about the cellular processes, scientists in Switzerland subjected algae to a range of silver concentrations. The results are reassuring, but the presence of other stressors could compound the problem.
Researchers from NIST and the FDA have demonstrated that they can make sensitive chemical analyses of minute samples of nanoparticles by, essentially, roasting them on top of a quartz crystal. The NIST-developed technique, "microscale thermogravimetric analysis," holds promise for studying nanomaterials in biology and the environment, where sample sizes often are quite small and larger-scale analysis won't work.
A light-activated drug delivery system for treating cancer is particularly promising to traditional chemotherapy methods because it can accomplish spatial and temporal control of drug release. To this end, scientists have developed a new type of nanoparticle that can absorb energy from tissue-penetrating light that releases drugs in cancer cells.
A tabletop device invented at Rice Univ. can tell how efficiently a nanoparticle would travel through a well and may provide a wealth of information for oil and gas producers. The device gathers data on how tracers, microscopic particles that can be pumped into and recovered from wells, move through deep rock formations that have been opened by hydraulic fracturing.
The scarcity of ultraviolet (UV) light in sunlight has held back the usefulness of titanium dioxide-based photocatalysts. Through the application of nanotechnology, researchers in Japan have recently succeeded in the development of better titanium dioxide-based material that can be activated by visible light. The solution lies in an array of nanoparticles that “simulate” the photoexcitation of UV light.
Clemson Univ. researchers have developed nanoparticles that can deliver drugs targeting damaged arteries, a non-invasive method to fight heart disease. Heart disease is the leading cause of death in the U.S., according to the Centers for Disease Control and Prevention. One of the standard ways to treat clogged and damaged arteries currently is to implant vascular stents, which hold the vessels open and release such drugs as paclitaxel.
An electrode designed like a pomegranate—with silicon nanoparticles clustered like seeds in a tough carbon rind—overcomes several remaining obstacles to using silicon for a new generation of lithium-ion batteries, say its inventors at Stanford Univ. and the SLAC National Accelerator Laboratory.
Inspired by tiny particles that carry cholesterol through the body, Massachusetts Institute of Technology chemical engineers have designed nanoparticles that can deliver snippets of genetic material that turn off disease-causing genes. This approach, known as RNA interference, holds great promise for treating cancer and other diseases. However, delivering enough RNA to treat the diseased tissue has proven difficult.
A Texas bioengineer has received a four-year, $1.4 million National Institutes of Health grant to create a nanoparticle system to shore up arterial walls following angioplasty and stenting procedures to treat coronary arterial disease. Kytai Nguyen discovered a way to use nanoparticles to help the arteries heal themselves more effectively.
Individual silver nanoparticles in solutions typically grow through single atom attachment, but when they reach a certain size they can link with other particles, according to a team which includes scientists at Pacific Northwest National Laboratory. This seemingly simple result has shifted a long-held scientific paradigm that did not consider kinetic models when explaining how nanoparticle ensembles formed.
By emitting photons from a quantum dot at the top of a micropyramid, researchers at Linköping Univ. in Sweden are creating a polarized light source for such things as energy-saving computer screens and wiretap-proof communications.
By letting DNA strands grow together with gold, scientists in Finland have developed a new concept for super-sensitive disease diagnostics. The method relies on growth of a DNA strand over a narrow gap between two electrodes in an electric circuit. The strand will only grow if a certain DNA molecule has bound to the surface of one electrode, which makes it possible to build diagnostic tests for detection of that specific DNA molecule.
More than 2,800 commercially available applications are now based on nanoparticles, but this influx of nanotechnology is not without risks, say researchers at Missouri Univ. of Science and Technology. They have been systematically studying the effects of transition metal oxide nanoparticles on human lung cells and have found that the nanoparticles’ toxicity to the cells increased as they moved right on the periodic table.
Silk and diamonds aren't just for ties and jewelry anymore. They're ingredients for a new kind of tiny glowing particle that could provide doctors and researchers with a novel technique for biological imaging and drug delivery. Just tens of nanometers across, the new particles are made of diamond, covered in silk and can be injected into living cells.
Transparent displays have a variety of potential applications. A number of technologies have been developed for such displays, but all have limitations. Now, researchers have come up with a new approach that can have significant advantages over existing systems, at least for certain kinds of applications: a wide viewing angle, simplicity of manufacture and potentially low cost and scalability.
Rice Univ. scientists have found they can control the bonds between atoms in a molecule. The molecule in question is carbon-60, also known as the buckminsterfullerene and the buckyball, discovered at Rice in 1985. The scientists found that it’s possible to soften the bonds between atoms by applying a voltage and running an electric current through a single buckyball.
Vaccines combat diseases and protect populations from outbreaks, but the life-saving technology leaves room for improvement. Vaccines usually are made en masse in centralized locations far removed from where they will be used. They are expensive to ship and keep refrigerated and they tend to have short shelf lives. However, Univ. of Washington engineers have developed hope for on-demand vaccines.
Developed by a team of researchers in Massachusetts and California, “nanotraps” are nanoparticles that act as viral traps using specific molecules found naturally within the human body. Initial testing on the treatments, which each use tiny, non-toxic particles that can be injected, inhaled, or eaten, has shown them to be effective and safe against a multitude of strains of disease.
Researchers have developed a technique for creating nanoparticles that carry two different cancer-killing drugs into the body and deliver those drugs to separate parts of the cancer cell where they will be most effective. The technique was developed by researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill.
Molecules anchored to the surfaces of nanoparticles modify and even control many characteristics of the particles, including how they interact with cells or react to light. Taking advantage of advanced instrumental capabilities, researchers have built a specially designed experimental cell to successfully deduce the how molecules of carboxylic acid, a common organic acid found in nature, bind to ceria nanoparticle surfaces.
The Ulsan National Institute of Science and Technology in Korea has developed a new method for the mass production of boron/nitrogen co-doped graphene nanoplatelets, which could lead to the fabrication of a graphene-based field-effect transistor with semiconducting nature. This opens up opportunities for practical use in electronic devices.
Researchers have created a new type of molecular motor made of DNA and demonstrated its potential by using it to transport a nanoparticle along the length of a carbon nanotube. The design was inspired by natural biological motors that have evolved to perform specific tasks critical to the function of cells.