A bit of pressure from a new shrinking, sponge-like gel is all it takes to turn transplanted unspecialized cells into cells that lay down minerals and begin to form teeth. The bioinspired gel material could one day help repair or replace damaged organs, such as teeth and bone, and possibly other organs as well.
Protein from a small, tasty mollusk inspired Michigan Technological Univ.’s Bruce P. Lee to...
A group of Washington State Univ. researchers has developed a chewing gum-like battery material...
A Duke Univ. research team has developed a better recipe for synthetic replacement cartilage in joints. Combining two innovative technologies, the team found a way to create artificial replacement tissue that mimics both the strength and suppleness of native cartilage. Articular cartilage is the tissue on the ends of bones where they meet at joints in the body.
A research team in France has invented an adhesion method that creates a strong bond between two gels by spreading on their surface a solution containing nanoparticles. Until now, there was no entirely satisfactory method of obtaining adhesion between two gels or two biological tissues. The bond is resistant to water and uses no polymers or chemical reactions.
Rice Univ. bioengineers have developed a hydrogel scaffold for craniofacial bone tissue regeneration that starts as a liquid, solidifies into a gel in the body and liquefies again for removal. The material developed in a Rice laboratory is a soluble liquid at room temperature that can be injected to the point of need. At body temperature, it turns into a gel to help direct the formation of new bone to replace that damaged by injury.
Scientists are reporting development of a squishy gel that, when compressed at a key location such as a painful knee joint, releases anti-inflammatory medicine. The new material could someday deliver medications when and where osteoarthritis patients need it most.
To gauge whether suspects involved in accidents or routine traffic stops have been driving drunk, police officers pair field sobriety tests with breathalyzers. Most breathalyzers are expensive and unable to test for precise concentrations of alcohol. Offering a better solution, Italian researchers have developed a novel idea for an inexpensive, portable breathalyzer.
Tissues designed with pre-formed vascular networks are known to promote rapid vascular integration with the host. Generally, prevascularization has been achieved by seeding or encapsulating endothelial cells, but these methods are slow. Hydrogels have also been tried, but a new technique developed in Singapore uses hydrogels with a new patterning process to quickly incorporate different cell types separately into different fibers.
Some animals, like the octopus and cuttlefish, transform their shape based on environment. For decades, researchers have worked toward mimicking similar biological responses in non-living organisms, as it would have significant implications in the medical arena. Now, researchers at the Univ. of Pittsburgh have demonstrated such a biomimetic response using hydrogels.
Stanford Univ. scientists have dramatically improved the performance of lithium-ion batteries by creating novel electrodes made of silicon and conducting polymer hydrogel, a spongy material similar to that used in contact lenses and other household products. The scientists developed a new technique for producing low-cost, silicon-based batteries with potential applications for a wide range of electrical devices.
It’s a familiar scenario—a patient receives a medical implant and days later, the body attacks the artificial valve or device, causing complications to an already compromised system. Expensive medical devices and surgeries often are thwarted by the body’s natural response to attack something in the tissue that appears foreign. Now, University of Washington engineers have demonstrated in mice a way to prevent this sort of response.
Coating medical supplies with an antimicrobial material is one approach that bioengineers are using to combat the increasing spread of multidrug-resistant bacteria. A research team in Singapore has now developed a highly effective antimicrobial coating based on cationic polymers. The coating can be applied to medical equipment, such as catheters.
Surfactant molecules, which are commonly found in soaps and detergents, have two main parts, a head and a tail, that help them break down and penetrate grease and oil. A research team has recently built a palm-sized microfluidics tool that passes water, detergent, and salt through tiny posts, producing a viscous, elastic gel that requires fewer surfactant molecules.
Gelatin sets by forming a solid matrix full of random, liquid-filled pores—much like a saturated sponge. It turns out that a similar process also happens in some metallic glasses, substances whose molecular behavior has now been clarified by new Massachusetts Institute of Technology research detailing the “setting” of these metal alloys.
Scientists in China say they have developed the world's lightest material, which they expect to play an important role in tackling pollution. Call graphene aerogel, or simply carbon aerogel, the new material has a density of just 0.16 milligrams per cubic centimeter, a sixth that of air. It is derived from a gel, with the liquid component replaced by a gas. It appears in solid state with extremely low density.
A research team at the National Institute of Materials Science in Japan has recently developed a gel material which is capable of releasing drugs in response to pressure applied by the patient. Three fingers applying force to the site of the gel produces an effect for up to three days. They built the new drug from two materials already used in pharmaceuticals: a saccharide and a natural component of algae.
Bacterial biofilms, which diseased groupings of cells found in 80% of infections, are a significant health hazard and one of the biggest headaches for hospitals and their constant battle against disease. Researchers from IBM, with the help of scientists in Singapore, revealed today a synthetic antimicrobial hydrogel that can break through diseased biofilms and completely eradicate drug-resistant bacteria upon contact. It is the first hydrogel to be biodegradable, biocompatible, and non-toxic.
In a small study recently conducted at Johns Hopkins Medicine, researchers reported increased healthy tissue growth after surgical repair of damaged cartilage if they put a “hydrogel” scaffolding into the wound to support and nourish the healing process. Physicians encourage cartilage growth by punching tiny holes in bone near the injured cartilage. This stimulates the patients’ stem cells to grow.
Self-moving gels can give synthetic materials the ability to "act alive" and mimic primitive biological communication, University of Pittsburgh researchers have found. In a recently published paper, the Pitt research team demonstrates that a synthetic system can reconfigure itself through a combination of chemical communication and interaction with light.
Building a tunnel made up of both hard and soft materials to guide the reconnection of severed nerve endings may be the first step toward helping patients who have suffered extensive nerve trauma regain feeling and movement, according to a team of biomedical engineers.
A painstaking effort to create a biocompatible patch to heal infant hearts is paying off at Rice University and Texas Children’s Hospital. The proof is in a petri dish in Jeffrey Jacot's laboratory, where a small slab of gelatinous material beats with the rhythm of a living heart.
A University of British Columbia researcher has helped create a gel—based on the mussel's knack for clinging to rocks, piers, and boat hulls-that can be painted onto the walls of blood vessels and stay put, forming a protective barrier with potentially life-saving implications.
A bit reminiscent of the Terminator T-1000, a new material created by Cornell University researchers is so soft that it can flow like a liquid and then, strangely, return to its original shape. Rather than liquid metal, it is a hydrogel, a mesh of organic molecules with many small empty spaces that can absorb water like a sponge. It qualifies as a "metamaterial" with properties not found in nature and may be the first organic metamaterial with mechanical metaproperties.
Gels that can be injected into the body, carrying drugs or cells that regenerate damaged tissue, hold promise for treating many types of disease. However, these injectable gels don't always maintain their solid structure once inside the body. Massachusetts Institute of Technology chemical engineers have now designed an injectable gel that responds to the body's high temperature by forming a reinforcing network that makes the gel much more durable, allowing it to function over a longer period of time.
They're soft, biocompatible, about 7 mm long, and able to walk by themselves. Miniature "bio-bots" developed at the University of Illinois are making tracks in synthetic biology. Designing non-electronic biological machines has been a riddle that scientists at the interface of biology and engineering have struggled to solve. These bio-bots demonstrate the Illinois team's ability to forward-engineer functional machines using only hydrogel, heart cells, and a 3D printer.
Bioengineers at Harvard University have developed a gel-based sponge that can be molded to any shape, loaded with drugs or stem cells, compressed to a fraction of its size, and delivered via injection. Once inside the body, it pops back to its original shape and gradually releases its cargo, before safely degrading.
Smart scaffolding that can guide cells, proteins, and small-molecule drugs to make new tissue and repair damage inside the body is in the works at Rice University. Scientists at Rice and the Texas A&M Health Science Centery Baylor College of Dentistry received a $1.7 million, five-year grant from the National Institutes of Health (NIH) to develop a hydrogel that can be injected into a patient to form an active biological scaffold.
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