Researchers from North Carolina State University have, for the first time, successfully coated polymer implants with a bioactive film. The discovery should improve the success rate of such implants. The polymer used in these implants, called PEEK, does not bond well with bone or other tissues in the body. This can result in the implant rubbing against surrounding tissues, which can lead to medical complications and the need for additional surgeries.
Many medically minded researchers are in hot pursuit of designs that will allow drug-carrying nanoparticles to navigate tissues and the interiors of cells, but University of Michigan engineers have discovered that these particles have another hurdle to overcome: escaping the bloodstream. According to their work, the immune system can't get rid of some of the promising drug carriers quickly.
Biomembranes consist of a mosaic of individual, densely packed lipid molecules. These molecules are formed inside the cells. But how do these building blocks move to the correct part of the membrane? Researchers in Germany have discovered the bilayer structural mechanism that demonstrates how this is done.
A team of materials scientists at Harvard University and the University of Exeter have invented a new fiber that changes color when stretched. Inspired by nature, the researchers identified and replicated the unique structural elements that create the bright iridescent blue color of a tropical plant's fruit.
Researchers in Switzerland have designed tiny vessels that are capable of releasing active agents in the body. These “nanovehicles” are made from a liposome just 100 to 200 nm in diameter. By attaching magnetic iron oxide nanoparticles to the surface, scientists are able to target the vessel, heating it up to release the drug.
Scientists at Arizona State University are celebrating their recent success on the path to understanding what makes the fiber that spiders spin—weight for weight—at least five times as strong as piano wire. They have found a way to obtain a wide variety of elastic properties of the silk of several intact spiders' webs using a sophisticated but non–invasive laser light scattering technique.
Bacterial biofilms, which diseased groupings of cells found in 80% of infections, are a significant health hazard and one of the biggest headaches for hospitals and their constant battle against disease. Researchers from IBM, with the help of scientists in Singapore, revealed today a synthetic antimicrobial hydrogel that can break through diseased biofilms and completely eradicate drug-resistant bacteria upon contact. It is the first hydrogel to be biodegradable, biocompatible, and non-toxic.
In a small study recently conducted at Johns Hopkins Medicine, researchers reported increased healthy tissue growth after surgical repair of damaged cartilage if they put a “hydrogel” scaffolding into the wound to support and nourish the healing process. Physicians encourage cartilage growth by punching tiny holes in bone near the injured cartilage. This stimulates the patients’ stem cells to grow.
Mussels can be a mouthwatering meal, but the chemistry that lets mussels stick to underwater surfaces may also provide a highly adhesive wound closure and more effective healing from surgery. Researchers have incorporated the chemical structure from the mussel's adhesive protein into the design of an injectable synthetic polymer. The bioadhesives adhere well in wet environments, have controlled degradability, and improved biocompatibility.
A University of British Columbia researcher has helped create a gel—based on the mussel's knack for clinging to rocks, piers, and boat hulls-that can be painted onto the walls of blood vessels and stay put, forming a protective barrier with potentially life-saving implications.
A nanomaterial engineered by researchers at Duke University can help regulate chloride levels in nerve cells that contribute to chronic pain, epilepsy, and traumatic brain injury. The findings were demonstrated in individual nerve cells as well as in the brains of mice and rats, and may have future applications in intracranial or spinal devices to help treat neural injuries.
Anyone unfortunate enough to encounter a porcupine’s quills knows that once they go in, they are extremely difficult to remove. Researchers at Massachusetts Institute of Technology and Brigham and Women’s Hospital now hope to exploit the porcupine quill’s unique properties to develop new types of adhesives, needles and other medical devices.
Just like the bones that hold up your body, your cells have their own scaffolding that holds them up. This scaffolding, known as the extracellular matrix, or ECM, not only props up cells but also provides attachment sites, or "sticky spots," to which cells can bind, just as bones hold muscles in place. A new study by researchers in the U.S. and the U.K. found these sticky sports are distributed randomly throughout the ECM in the body, an important discovery with implications for researchers trying to figure out how to grow stems cells in the laboratory in ways that most closely mimic biology.
Researchers at Rice University have found a way to kill some diseased cells and treat others in the same sample at the same time. The process, which uses tunable plasmonic nanobubbles previously invented in the laboratory of Dmitri Lapotko, is activated by a pulse of laser light and leaves neighboring healthy cells untouched.
A new form of contraception could take an unexpected shape: electrically spun cloth with nanometer-sized fibers. These fibers, designed by a University of Washington team, can dissolve and release drugs, providing a cheap and discreet platform for protecting against unintended pregnancy, as well as HIV infection.
Tufts University School of Engineering researchers have demonstrated silk-based implantable optics that offer significant improvement in tissue imaging while simultaneously enabling photothermal therapy, administering drugs, and monitoring drug delivery. The devices also lend themselves to a variety of other biomedical functions.
Colloidal suspensions of metal nanoparticles in water passes too easily through commonly used macroporous polymeric membranes. To handle these nanofluids, researchers have built a membrane equipped functionalized proteins that can act as filters for nanoscaled particles in aqueous solutions. Such a nano-sieve could act as a catalyzer or could capture solar energy.
Scientists in Japan have developed a high activity gold nanoparticle catalyst that simplifies the function of enzymes in capturing substances. This new type of catalyst mimics enzyme function on the surface of cell membranes, which capture molecules of designated lengths and shapes. The findings indicate that gold nanoparticles thus equipped could support biological activities as a catalyst in the reactions of the living body.
A research project in Europehas the aim of building bone implants that have been sourced from wood. The wood serves as a scaffolding that transforms to a ceramic identical to the mineral part of bone tissue: hydroxyapatite. The researchers believe the approach could appear in a clinical setting within ten years.
Researchers in Spain have improved the antimicrobial properties of medical textiles using an enzymatic pre-treatment combined with simultaneous deposition of nanoparticles and biopolymers under ultrasonic irradiation. The technique is used to create completely sterile antimicrobial textiles that help prevent hospital-acquired infections.
At this week’s Frontiers in Optics 2012, physicists are presenting possible applications based on research that uses natural spider silk to catch light. Recent findings could present an eco-friendly alternative to glass or plastic fiber optics: the traditional materials for manipulating light. Silk-enabled implantable biosensors, lasers, and microchips could result.
University of Akron polymer scientists and biologists have discovered that a certain house spider—in order to more efficiently capture different types of prey—performs an uncommon feat. It tailors one glue to demonstrate two adhesive strengths: firm and weak. The researchers who made the finding are already working toward developing a synthetic adhesive that mimics this design strategy.
Tiny, fully biocompatible electronic devices that are able to dissolve harmlessly into their surroundings after functioning for a precise amount of time have been created by a research team led by biomedical engineers. Dubbed "transient electronics," the new class of silk-silicon devices promises a generation of medical implants that never need surgical removal, as well as environmental monitors and consumer electronics that can become compost rather than trash.
If you throw a ball underwater, you'll find that the smaller it is, the faster it moves: A larger cross-section greatly increases the water's resistance. Now, a team of researchers has figured out a way to use this basic principle, on a microscopic scale, to carry out biomedical tests that could eventually lead to fast, compact, and versatile medical testing devices.
Fabricating precise biomolecular structures at extremely small scales is critical to the progress of nanotechnology. Traditionally this has been accomplished through the use of rubber stamps with tiny features which are covered with molecular inks and then stamped onto substrate surfaces, creating molecular patterns. However, when using this technique at the nanoscale, molecules tend to diffuse on the surface both during and after stamping, blurring the patterns. Now, a team of researchers have turned this "soft lithography" process on its head.