Many cancer patients survive treatment only to have a recurrence within a few years. Recurrences and tumor spreading are likely due to cancer stem cells that can be tough to kill with conventional cancer drugs. But now researchers have designed nanoparticles that specifically target these hardy cells to deliver a drug. The nanoparticle treatment, reported in ACS Nano, worked far better than the drug alone in mice.
The liquid is dark red, a mixture of fat and blood, and Dr. Mark Berman pumps it out of the...
Pre-eclampsia is a disease that affects 5 to 8% of pregnancies in America. Complications from...
Stem cells hold great promise for treating a number of diseases, in part because they have the unique ability to differentiate, specializing into any one of the hundreds of cell types that comprise the human body. Harnessing this potential, though, is difficult.
Scientists have coaxed stem cells to grow the first three-dimensional mini lungs. Previous research has focused on deriving lung tissue from flat cell systems or growing cells onto scaffolds made from donated organs.
Univ. of California, Berkeley, scientists have identified a new molecular pathway critical to aging, and confirmed that the process can be manipulated to help make old blood like new again. The researchers found that blood stem cells’ ability to repair damage caused by inappropriate protein folding in the mitochondria, a cell’s energy station, is critical to their survival and regenerative capacity.
Stem cells can have a strong sense of identity. Taken out of their home in the hair follicle, and grown in culture, these cells remain true to themselves. After waiting in limbo, these cultured cells become capable of regenerating follicles and other skin structures once transplanted back into skin. It’s not clear just how these stem cells retain their ability to produce new tissue and heal wounds, even under extraordinary conditions.
Imagine a pair of twins that everyone believed to be estranged, who turn out to be closer than anyone knew. A genetic version of this heartwarming tale might be taking place in our cells. We and other mammals have two copies of each gene, one from each parent. Each copy, or "allele," was thought to remain physically apart from the other in the cell nucleus, but a new study finds that alleles can and do pair up in mammalian cells.
Researchers have, for the first time, successfully converted adult human skin cells into neurons of the type that regulate appetite, providing a patient-specific model for studying the neurophysiology of weight control and testing new therapies for obesity. To make the neurons, human skin cells were first genetically reprogrammed to become induced pluripotent stem (iPS) cells.
Scientists have discovered that the human brain can produce new neurons, but exactly how those cells are produced and what purpose they serve are not well understood. Now a study by Yale Univ. researchers shows that key developmental factors that control the formation of blood vessels are also necessary for activating brain stem cells.
After using optical tweezers to squeeze a tiny bead attached to the outside of a human stem cell, researchers now know how mechanical forces can trigger a key signaling pathway in the cells. The squeeze helps to release calcium ions stored inside the cells and opens up channels in the cell membrane that allow the ions to flow into the cells, according to the study led by Univ. of California, San Diego bioengineer Yingxiao Wang.
In 2008, the World Health Organization announced a global effort to eradicate malaria, which kills about 800,000 people every year. As part of that goal, scientists are trying to develop new drugs that target the malaria parasite during the stage when it infects the human liver, which is crucial because some strains of malaria can lie dormant in the liver for several years before flaring up.
A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. The cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. Using this marker, the researchers found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes.
Electroporation is a powerful technique in molecular biology. By using an electrical pulse to create a temporary nanopore in a cell membrane, researchers can deliver chemicals, drugs and DNA directly into a single cell. But existing electroporation methods require high electric field strengths and for cells to be suspended in solution, which disrupts cellular pathways and creates a harsh environment for sensitive primary cells.
The immune system is a complex network of many different cells working together to defend against invaders. Successfully fighting off an infection depends on the interactions between these cells. A new device developed by Massachusetts Institute of Technology engineers offers a much more detailed picture of that cellular communication.
Univ. of California, Irvine scientists studying the role of circadian rhythms in skin stem cells found that this clock plays a key role in coordinating daily metabolic cycles and cell division. Their research, which appears in Cell Reports, shows, for the first time, how the body’s intrinsic day-night cycles protect and nurture stem cell differentiation.
In a recent study, Univ. of California, Los Angeles scientists have shown that two genes not previously known to be involved with the immune system play a crucial role in how progenitor stem cells are activated to fight infection. This discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for diseases.
New research from Rice Univ. and the Univ. of Texas MD Anderson Cancer Center shows how ovarian tumors co-opt a specific type of adult stem cell from abdominal tissues to fuel their growth. The research, published online in Cancer Research, suggests a new way to target aggressive ovarian cancers by disrupting the metabolic processes that allow them to thrive.
After more than six years of intensive effort, and repeated failures that made the quest at times seem futile, Harvard Stem Cell Institute researchers at Boston Children’s Hospital and Harvard’s Dept. of Stem Cell and Regenerative Biology have successfully converted mouse and human skin cells into pain-sensing neurons that respond to a number of stimuli that cause acute and inflammatory pain.
Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General (MGH) and Boston Children’s hospitals (BCH) for the first time have used a relatively new gene-editing technique to create what could prove to be an effective technique for blocking HIV from invading and destroying patients’ immune systems.
In the first study of its kind, Rice Univ. researchers have mapped how information flows through the genetic circuits that cause cancer cells to become metastatic. The research reveals a common pattern in the decision-making that allows cancer cells to both migrate and form new tumors.
When most animals begin life, cells immediately begin accepting assignments to become a head, tail or a vital organ. However, mammalian cells become the protective placenta or to commit to forming the baby. It’s during this critical first step that research from Michigan State Univ. has revealed key discoveries. The results provide insights into where stem cells come from, and could advance research in regenerative medicine.
While megakaryocytes are best known for producing platelets that heal wounds, these "mega" cells found in bone marrow also play a critical role in regulating stem cells according to new research from the Stowers Institute for Medical Research. The study is the first to show that hematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes).
Within our fat lives a variety of cells with the potential to become bone, cartilage or more fat if properly prompted. This makes adipose tissue, in theory, a readily available reservoir for regenerative therapies such as bone healing if doctors can get enough of those cells and compel them to produce bone. In a new study, scientists demonstrate a new method for extracting a wide variety of potential bone-producing cells from human fat.
A 7-year-project to develop a barcoding and tracking system for tissue stem cells has revealed previously unrecognized features of normal blood production: New data from Harvard Stem Cell Institute scientists at Boston Children's Hospital suggests, surprisingly, that the billions of blood cells that we produce each day are made not by blood stem cells, but rather their less pluripotent descendants, called progenitor cells.
The liver provides critical functions, such as ridding the body of toxins, but its failure can be deadly, and there are few options for fixing it. A promising alternative in development is transplanting liver cells made using adult stem cells, but the only source identified until now has been bone marrow. Recently, scientists identified another, more convenient, source of adult stem cells that could be used for this purpose:tonsils.
Biochemists in California have developed a program that predicts the placement of chemical marks that control the activity of genes based on sequences of DNA. By comparing sequences with and without epigenomic modification, the researchers identified DNA patterns associated with the changes. They call this novel analysis pipeline Epigram and have made both the program and the DNA motifs they identified openly available to other scientists.
It’s one of the highest-profile cases of scientific fraud in memory: In 2005, South Korean researcher Woo-Suk Hwang and colleagues made international news by claiming that they had produced embryonic stem cells from a cloned human embryo using nuclear transfer. But within a year, the work had been debunked, soon followed by findings of fraud. South Korea put a moratorium on stem cell research funding.
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