A team led by the Lawrence Livermore National Laboratory scientists has created a new kind of ion channel consisting of short carbon nanotubes, which can be inserted into synthetic bilayers and live cell membranes to form tiny pores that transport water, protons, small ions and DNA. These carbon nanotube “porins” have significant implications for future health care and bioengineering applications.
Houston Methodist Research Institute scientists will receive about $1.25 million from the Center...
A group of scientists in Florida have combined medicine and advanced nanotechnological...
In a design that mimics a hard-to-duplicate texture of starfish shells, Univ. of Michigan...
Nanomedicines consisting of nanoparticles for targeted drug delivery to specific tissues and cells offer new solutions for cancer diagnosis and therapy. Understanding the interdependency of physiochemical properties of nanomedicines, in correlation to their biological responses and functions, is crucial for their further development of as cancer-fighters.
Like discriminating thieves, prostate cancer tumors scavenge and hoard copper that is an essential element in the body. But such avarice may be a fatal weakness. Researchers at Duke Medicine have found a way to kill prostate cancer cells by delivering a trove of copper along with a drug that selectively destroys the diseased cells brimming with the mineral, leaving non-cancer cells healthy.
Some people might consider mucus an icky bodily secretion best left wrapped in a tissue, but to a group of researchers in North Carolina, snot is an endlessly fascinating subject. The team has developed a way to use gold nanoparticles and light to measure the stickiness of the slimy substance that lines our airways. The new method could help doctors better monitor and treat lung diseases such as cystic fibrosis.
Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs. The new system is DNA-based, which means it is biocompatible and less toxic to patients than systems that use synthetic materials.
When Illinois researchers set out to investigate a method to control how DNA moves through a tiny sequencing device, they didn’t know they were about to witness a display of molecular gymnastics. Fast, accurate and affordable DNA sequencing is the first step toward personalized medicine.
Cancer vaccines have recently emerged as a promising approach for killing tumor cells before they spread. But so far, most clinical candidates haven’t worked that well. Now, scientists have developed a new way to deliver vaccines that successfully stifled tumor growth when tested in laboratory mice. And the key is in the vaccine’s unique stealthy nanoparticles.
Researchers in the Netherlands have managed to open nanovesicles in a reversible process and close them using a magnet. Previously, these vesicles had been “loaded” with a drug and opened elsewhere using a chemical process, such as osmosis. The magnetic method, which is repeatable, is the first to demonstrate the viability of another method.
A Rice Univ. team led by bioengineer Jeffrey Jacot and chemical engineer and chemist Matteo Pasquali have created new pediatric heart-defect patches infused with conductive single-walled carbon nanotubes that allow electrical signals to pass unhindered. The nanotubes overcome a limitation of current patches in which pore walls hinder the transfer of electrical signals between cardiomyocytes, the heart muscle’s beating cells.
A self-assembling nanoparticle designed by a Univ. of Connecticut (UConn) professor is the key component of a potent new malaria vaccine that is showing promise in early tests. For years, scientists trying to develop a malaria vaccine have been stymied by the malaria parasite’s ability to transform itself and “hide” in the liver and red blood cells of an infected person to avoid detection by the immune system.
Cancerous brain tumors are notorious for growing back despite surgical attempts to remove them, and for leading to a dire prognosis for patients. But scientists are developing a new way to try to root out malignant cells during surgery so fewer or none get left behind to form new tumors. The technology relies on a Raman scanner that can read injected nanoprobes.
DARPA’s new Electrical Prescriptions (ElectRx) program was among the initiatives the White House highlighted this week as President Barack Obama addressed the need for new and more effective strategies for improving the health of service members, veterans and others. ElectRx goes beyond medication, aiming to explore neuromodulation of organ functions to help the human body heal itself.
Laboratory-grown replacement organs have moved a step closer with the completion of a new study. Scientists have grown a fully functional organ from transplanted laboratory-created cells in a living animal for the first time. They have created a thymus, an organ next to the heart that produces immune cells known as T cells that are vital for guarding against disease.
There’s a certain type of biomolecule built like a nano-Christmas tree. Called a glycoconjugate, it’s many branches are bedecked with sugary ornaments. It’s those ornaments that get all the glory. That’s because, according to conventional wisdom, the glycoconjugate’s lowly “tree” basically holds the sugars in place as they do the important work of reacting with other molecules.
A multidisciplinary team of scientists from the Univ. of California, Los Angeles and Stanford Univ. has used a naturally occurring nanoparticle called a vault to create a novel drug delivery system that could lead to advances in the treatment of cancer and HIV. Their findings could lead to cancer treatments that are more effective with smaller doses and to therapies that could potentially eradicate the HIV virus.
Scientists at Yale Univ. have developed a novel cancer immunotherapy that rapidly grows and enhances a patient’s immune cells outside the body using carbon nanotube-polymer composites; the immune cells can then be injected back into a patient’s blood to boost the immune response or fight cancer.
By combining magnetic nanoparticles with one of the most common and effective chemotherapy drugs, Argonne National Laboratory researchers have created a way to deliver anti-cancer drugs directly into the nucleus of cancer cells. They have created nano-sized bubbles, or “micelles,” that contain magnetic nanoparticles of iron oxide and cisplatin, a conventional chemotherapy drug also known as “the penicillin of cancer.”
Gene-based personalized medicine has many possibilities for diagnosis and targeted therapy, but one big bottleneck: the expensive and time-consuming DNA sequencing process. Now, researchers at the Univ. of Illinois at Urbana-Champaign have found that nanopores in the material molybdenum disulfide (MoS2) could sequence DNA more accurately, quickly and inexpensively than anything yet available.
A smart technology which involves smuggling gold nanoparticles into brain cancer cells has proven highly effective in lab-based tests in the U.K. The technique could eventually be used to treat glioblastoma multiforme, which is the most common and aggressive brain tumor in adults, and notoriously difficult to treat.
Some of the most damaging brain diseases can be traced to irregular blood delivery in the brain. Now, Stanford Univ. chemists have employed lasers and carbon nanotubes to capture an unprecedented look at blood flowing through a living brain. The technique was developed for mice but could one day be applied to humans, potentially providing vital information in the study of stroke and migraines.
About one in four older adults suffers from chronic pain. Many of those people take medication, usually as pills. But this is not an ideal way of treating pain: Patients must take medicine frequently, and can suffer side effects, since the contents of pills spread through the bloodstream to the whole body. Now researchers have refined a technique that could enable pain medication to be released directly to specific parts of the body.
An Israeli and German research team have succeeded in creating a tiny screw-shaped propeller that can move in a gel-like fluid, mimicking the environment inside a living organism. The filament that makes up the propeller, made of silica and nickel, is only 70 nm in diameter. The entire propeller is just 400 nm long.
A new study has investigated the effects of small but finite inertia on the propulsion of micro- and nano-scale swimming machines. Scientists have found that the direction of propulsion made possible by such inertia is opposite to that induced by a viscoelastic fluid. The findings could help to optimize the design of swimming machines to improve their mobility in medical applications.
Cancerous tumors protect themselves by tricking the immune system into accepting everything as normal, even while cancer cells are dividing and spreading. One pioneering approach to combat this effect is to use nanoparticles to jumpstart the body's ability to fight tumors. Recent combines these therapeutic nanoparticles with heat to stimulate the immune system.
A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells. A new study from Massachusetts Institute of Technology materials scientists reveals that these nanoparticles enter cells by taking advantage of a route normally used in vesicle-vesicle fusion, a crucial process that allows signal transmission between neurons.
Scientists have designed a new self-assembling nanoparticle that targets tumors, to help doctors diagnose cancer earlier. The new nanoparticle, developed by researchers in the U.K., boosts the effectiveness of magnetic resonance imaging scanning by specifically seeking out receptors that are found in cancerous cells.
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