Researchers have demonstrated a promising new way to increase the effectiveness of radiation in killing cancer cells. The approach involves gold nanoparticles tethered to acid-seeking compounds called pHLIPs. The pHLIPs (pH low-insertion peptides) home in on high acidity of malignant cells, delivering their nanoparticle passengers straight to the cells’ doorsteps.
A new device developed by Univ. of California, Los Angeles, engineers and doctors may eventually...
Therapeutic agents intended to reduce dental plaque and prevent tooth decay are often removed by...
Scientists have developed tiny nanoneedles that have successfully prompted parts of the body to...
Carbon nanotube fibers invented at Rice Univ. may provide a way to communicate directly with the brain. The fibers have proven superior to metal electrodes for deep brain stimulation and to read signals from a neuronal network. Because they provide a two-way connection, they show promise for treating patients with neurological disorders while monitoring the real-time response of neural circuits in areas that control movement and mood.
Acne, a scourge of adolescence, may be about to meet its ultra-high-tech match. By using a combination of ultrasound, gold-covered particles and lasers, researchers from Univ. of California, Santa Barbara and Sebacia have developed a targeted therapy that could potentially lessen the frequency and intensity of breakouts, relieving acne sufferers the discomfort and stress of dealing with severe and recurring pimples.
Materials resulting from chemical bonding of glucosamine, a type of sugar, with fullerenes, kind of nanoparticles known as buckyballs, might help to reduce cell damage and inflammation occurring after stroke. A team from the Max Planck Institute in Germany has tested this on mice, opening the door to potential new drugs for the cerebrovascular accident.
Researchers at Massachusetts Institute of Technology have developed a method to stimulate brain tissue using external magnetic fields and injected magnetic nanoparticles: a technique allowing direct stimulation of neurons, which could be an effective treatment for a variety of neurological diseases, without the need for implants or external connections.
A research team from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions has identified a new class of drugs that in animal models dramatically slows the aging process—alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan.
Animal study shows that a nanoparticle applied at the time of surgery slowly releases needed medicine to reduce risk of rejection after eye surgery.
Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back. A new nanodevice developed by Massachusetts Institute of Technology researchers can help overcome that by first blocking the gene that confers drug resistance, then launching a new chemotherapy attack against the disarmed tumors.
Univ. of Manchester scientists have used graphene to target and neutralize cancer stem cells while not harming other cells. This new development opens up the possibility of preventing or treating a broad range of cancers, using a non-toxic material.
Researchers at McGill Univ. have developed a new, low-cost method to build DNA nanotubes block-by-block, a breakthrough that could help pave the way for scaffolds made from DNA strands to be used in applications such as optical and electronic devices or smart drug delivery systems. Many researchers, including the McGill team, have previously constructed nanotubes using a method that relies on spontaneous assembly of DNA in solution.
Chemical engineers have designed a new type of self-healing hydrogel that could be injected through a syringe. Such gels, which can carry one or two drugs at a time, could be useful for treating cancer, macular degeneration, or heart disease, among other diseases, the researchers say.
With a low price tag and mild flavor, tilapia has become a staple dinnertime fish for many Americans. Now it could have another use: helping to heal our wounds. In ACS Applied Materials & Interfaces, scientists have shown that a protein found in this fish can promote skin repair in rats without an immune reaction, suggesting possible future use for human patients.
Scientists have shown that gold nanotubes have many applications in fighting cancer: internal nanoprobes for high-resolution imaging, drug delivery vehicles and agents for destroying cancer cells. The study, published in Advanced Functional Materials, details the first successful demonstration of the biomedical use of gold nanotubes in a mouse model of human cancer.
Despite having a diameter tens of thousands of times smaller than a human hair, nanopores could be the next big thing in DNA sequencing. By zipping DNA molecules through these tiny holes, scientists hope to one day read off genetic sequences in the blink of an eye. Now, researchers from Brown Univ. have taken the potential of nanopore technology one step further.
For years, treating scratches and burns to the eyes has usually involved dropping medicine onto the eyes several times a day, sometimes for weeks: a treatment that lends itself to missed doses and other side effects. But scientists are now reporting a novel, drug-releasing wafer that patients can put directly on their affected eyes just once a day. The team says the device works better than drops and could help patients recover faster.
As nanomachine design rapidly advances, researchers are moving from wondering if the nanomachine works to how long it will work. This is an especially important question as there are so many potential applications, for instance, for medical uses, including drug delivery, early diagnosis, disease monitoring, instrumentation and surgery.
It’s technology so advanced that the machine capable of using it doesn’t yet exist. Using two biocompatible parts, Univ. at Buffalo researchers and their colleagues have designed a nanoparticle that can be detected by six medical imaging techniques: computed tomography (CT) scanning, positron emission tomography (PET) scanning, photoacoustic imaging, fluorescence imaging, upconversion imaging and Cerenkov luminescence imaging.
Rice Univ. scientists have found the balance necessary to aid healing with high-tech hydrogel. The team created a new version of the hydrogel that can be injected into an internal wound and help it heal while slowly degrading as it is replaced by natural tissue. Hydrogels are used as a scaffold upon which cells can build tissue. The new hydrogel overcomes a host of issues that have kept them from reaching their potential to treat injuries.
More efficient medical treatments could be developed thanks to a new method for triggering the rearrangement of chemical particles. The new method, developed at the Univ. of Warwick, uses two “parent” nanoparticles that are designed to interact only when in proximity to each other and trigger the release of drug molecules contained within both.
New York Univ. Polytechnic School of Engineering professors have been collaborating with researchers from Peking Univ. on a new test strip that is demonstrating great potential for the early detection of certain heart attacks. The new colloidal gold test strip can test for cardiac troponin I (cTn-I) detection.
Optogenetics, which uses light to control cellular events, is poised to become an important technology in molecular biology and beyond. The Reich Group in Univ. of California, Santa Barbara’s Dept. of Chemistry and Biochemistry has made a major contribution to this emergent field by developing a light-activated nanocarrier that transports proteins into cells and releases them on command.
Researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill have uncovered a novel approach to creating inhalable vaccines using nanoparticles that shows promise for targeting lung-specific diseases, such as influenza, pneumonia and tuberculosis.
An international team of researchers has developed a drug delivery technique that utilizes graphene strips as “flying carpets” to deliver two anticancer drugs sequentially to cancer cells, with each drug targeting the distinct part of the cell where it will be most effective. The technique was found to perform better than either drug in isolation when tested in a mouse model targeting a human lung cancer tumor.
Researchers at Oregon State Univ. have developed a new way to selectively insert compounds into cancer cells—a system that will help surgeons identify malignant tissues and then, in combination with phototherapy, kill any remaining cancer cells after a tumor is removed. It’s about as simple as, “If it glows, cut it out.” And if a few malignant cells remain, they’ll soon die.
Stroke victims could have more time to seek treatment that could reduce harmful effects on the brain, thanks to tiny blobs of gelatin that could deliver the medication to the brain noninvasively. Univ. of Illinois researchers found that gelatin nanoparticles could be laced with medications for delivery to the brain, and that they could extend the treatment window for when a drug could be effective.
Lindsey Vonn. Derrick Rose. Tom Brady. Mickey Mantle. They have all fallen victim to the dreaded pop of the knee. Connecting the femur to the tibia, the anterior cruciate ligament (ACL) rupture is one of the most devastating injuries in sports. No other injury has sidelined more athletes for a season or even the rest of a career.
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