A team at Purdue Univ. has used gold nanoparticles to target and bind to fragments of genetic material known as BRCA1 messenger RNA splice variants, which can indicate the presence and stage of breast cancer. The number of these synthetic DNA “tails” in a cell can be determined in a living cell by examining the specific signal that light produces when it interacts with the gold nanoparticles.
It's a familiar trope in science fiction: In enemy territory, activate your cloaking device. And...
Physicist Wei Chen at Univ. of Texas at Arlington’s Center for Security Advances Via...
When considering potential drug delivery vehicles, liposomes are an important option and have already been approved for use with a number of therapeutic formulations. Liposomes are comprised of phospholipids and may be single- or multi-layered, can be produced in different sizes and have a hydrophilic interior and hydrophobic shell. They are biodegradable, non-toxic and capable of encapsulating both hydrophilic and hydrophobic materials.
Nanotechnology has unlocked new pathways for targeted drug delivery, including the use of nanocarriers that can transport cargoes of small-molecule therapeutics to specific locations in the body. Researchers have recently demonstrated that processing can have significant influence on the size of nanocarriers for targeted drug delivery. It was previously assumed that once a nanocarrier is created, it maintains its size and shape anywhere.
The unique properties of engineered nanoparticles have created intense interest in their environmental behavior. Due to the increased use of nanotechnology in consumer products, industrial applications and health care technology, nanoparticles are more likely to enter the environment. For this reason, it’s not only important to know the type, size and distribution of nanoparticles, but it’s also crucial to understand their impact.
Delivering chemotherapy drugs in nanoparticle form could help reduce side effects by targeting the drugs directly to the tumors. In recent years, scientists have developed nanoparticles that deliver one or two chemotherapy drugs, but it has been difficult to design particles that can carry any more than that in a precise ratio. Now Massachusetts Institute of Technology chemists have devised a new way to build such nanoparticles.
Thousands of consumer products contain nanoparticles added by manufacturers to improve texture, kill microbes or enhance shelf life, among other purposes. However, several studies have shown that some of these engineered nanoparticles can be toxic to cells. A new study from Massachusetts Institute of Technology and the Harvard School of Public Health suggests that certain nanoparticles can also harm DNA.
Using magnetically controlled nanoparticles to force tumor cells to "self-destruct" sounds like science fiction, but could be a future part of cancer treatment, according to new research.
Chemotherapeutic drugs excel at fighting cancer, but they're not so efficient at getting where they need to go. Now, researchers are developing a better delivery method by encapsulating the drugs in nanoballoons – which are tiny modified liposomes that, upon being struck by a red laser, pop open and deliver concentrated doses of medicine.
Researchers have discovered that microscopic "bubbles" are safe and effective storage lockers for harmful isotopes that emit ionizing radiation for treating tumors.
A new microfluidic method for evaluating drugs commonly used for preventing heart attacks has found that while aspirin can prevent dangerous blood clots in some at-risk patients, it may not be effective in all patients with narrowed arteries. The study, a first in the examination of heart attack prevention drugs, used a device that simulated blood flowing through narrowed coronary arteries to assess effects of anti-clotting drugs.
Even in a crowded room full of background noise, the human ear is remarkably adept at tuning in to a single voice—a feat that has proved remarkably difficult for computers to match. A new analysis of the underlying mechanisms, conducted by researchers at Massachusetts Institute of Technology, has provided insights that could ultimately lead to better machine hearing, and perhaps to better hearing aids as well.
Biomedical engineering researchers have developed a new technique that uses adenosine-5’-triphosphate (ATP), the so-called “energy molecule,” to trigger the release of anti-cancer drugs directly into cancer cells. Early laboratory tests show it increases the effectiveness of drugs targeting breast cancer. The technique was developed by researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill.
A light-activated drug delivery system for treating cancer is particularly promising to traditional chemotherapy methods because it can accomplish spatial and temporal control of drug release. To this end, scientists have developed a new type of nanoparticle that can absorb energy from tissue-penetrating light that releases drugs in cancer cells.
Clemson Univ. researchers have developed nanoparticles that can deliver drugs targeting damaged arteries, a non-invasive method to fight heart disease. Heart disease is the leading cause of death in the U.S., according to the Centers for Disease Control and Prevention. One of the standard ways to treat clogged and damaged arteries currently is to implant vascular stents, which hold the vessels open and release such drugs as paclitaxel.
Inspired by tiny particles that carry cholesterol through the body, Massachusetts Institute of Technology chemical engineers have designed nanoparticles that can deliver snippets of genetic material that turn off disease-causing genes. This approach, known as RNA interference, holds great promise for treating cancer and other diseases. However, delivering enough RNA to treat the diseased tissue has proven difficult.
Shape is thought to play an important role in the effectiveness of cells grown to repair or replace damaged tissue in the body. To help design new structures that enable cells to "shape up," researchers at NIST have come up with a way to measure, and more importantly, classify, the shapes cells tend to take in different environments.
A Texas bioengineer has received a four-year, $1.4 million National Institutes of Health grant to create a nanoparticle system to shore up arterial walls following angioplasty and stenting procedures to treat coronary arterial disease. Kytai Nguyen discovered a way to use nanoparticles to help the arteries heal themselves more effectively.
Our cells produce thousands of proteins, but more than one-third of these proteins can fulfill their function only after migrating to the outside of the cell. While it is known that protein migration occurs with the help of various “nanomotors” that push proteins out of the cell, little is known about their precise mechanical functioning. New research reveals the inner workings of one such nanomotor, called SecA, with new clarity.
Designing nanomedicine to combat diseases is a hot area of scientific research, primarily for treating cancer, but very little is known in the context of atherosclerotic disease. Scientists have engineered a microchip coated with blood vessel cells to learn more about the conditions under which nanoparticles accumulate in the plaque-filled arteries of patients with atherosclerosis, the underlying cause of myocardial infarction and stroke.
People infected with HIV can stave off the symptoms of AIDS thanks to drug cocktails that mainly target three enzymes produced by the virus, but resistant strains pop up periodically. Researchers have now focused on a fourth protein, Nef, that hijacks host proteins and is essential to HIV’s lethality. By blocking the part of a key host protein to which Nef binds, it may be possible to slow or stop HIV.
Silk and diamonds aren't just for ties and jewelry anymore. They're ingredients for a new kind of tiny glowing particle that could provide doctors and researchers with a novel technique for biological imaging and drug delivery. Just tens of nanometers across, the new particles are made of diamond, covered in silk and can be injected into living cells.
Vaccines combat diseases and protect populations from outbreaks, but the life-saving technology leaves room for improvement. Vaccines usually are made en masse in centralized locations far removed from where they will be used. They are expensive to ship and keep refrigerated and they tend to have short shelf lives. However, Univ. of Washington engineers have developed hope for on-demand vaccines.
Researchers have developed a technique for creating nanoparticles that carry two different cancer-killing drugs into the body and deliver those drugs to separate parts of the cancer cell where they will be most effective. The technique was developed by researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill.
Rice Univ. researchers have developed a noninvasive technology that accurately detects low levels of malaria infection through the skin in seconds with a laser scanner. The “vapor nanobubble” technology requires no dyes or diagnostic chemicals, and there is no need to draw blood. A preclinical study shows that Rice’s technology detected even a single malaria-infected cell among a million normal cells with zero false-positive readings.
As represented in this Forecast, the life science industry includes biopharmaceuticals, medical instruments and devices, animal/agricultural bioscience and commercial research and testing. However, the industry’s R&D spending is driven primarily by the mass and research intensity of the biopharmaceutical sector, which accounts for nearly 85% of all expenditures.
Drugs delivered by nanoparticles hold promise for targeted treatment of many diseases, including cancer. However, the particles have to be injected into patients, which has limited their usefulness so far. Now, researchers have developed a new type of nanoparticle that can be delivered orally and absorbed through the digestive tract, allowing patients to simply take a pill instead of receiving injections.
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