A light-activated drug delivery system for treating cancer is particularly promising to traditional chemotherapy methods because it can accomplish spatial and temporal control of drug release. To this end, scientists have developed a new type of nanoparticle that can absorb energy from tissue-penetrating light that releases drugs in cancer cells.
Clemson Univ. researchers have developed nanoparticles that can deliver drugs targeting damaged...
Inspired by tiny particles that carry cholesterol through the body, Massachusetts Institute of...
Shape is thought to play an important role in the...
A Texas bioengineer has received a four-year, $1.4 million National Institutes of Health grant to create a nanoparticle system to shore up arterial walls following angioplasty and stenting procedures to treat coronary arterial disease. Kytai Nguyen discovered a way to use nanoparticles to help the arteries heal themselves more effectively.
Our cells produce thousands of proteins, but more than one-third of these proteins can fulfill their function only after migrating to the outside of the cell. While it is known that protein migration occurs with the help of various “nanomotors” that push proteins out of the cell, little is known about their precise mechanical functioning. New research reveals the inner workings of one such nanomotor, called SecA, with new clarity.
Designing nanomedicine to combat diseases is a hot area of scientific research, primarily for treating cancer, but very little is known in the context of atherosclerotic disease. Scientists have engineered a microchip coated with blood vessel cells to learn more about the conditions under which nanoparticles accumulate in the plaque-filled arteries of patients with atherosclerosis, the underlying cause of myocardial infarction and stroke.
People infected with HIV can stave off the symptoms of AIDS thanks to drug cocktails that mainly target three enzymes produced by the virus, but resistant strains pop up periodically. Researchers have now focused on a fourth protein, Nef, that hijacks host proteins and is essential to HIV’s lethality. By blocking the part of a key host protein to which Nef binds, it may be possible to slow or stop HIV.
Silk and diamonds aren't just for ties and jewelry anymore. They're ingredients for a new kind of tiny glowing particle that could provide doctors and researchers with a novel technique for biological imaging and drug delivery. Just tens of nanometers across, the new particles are made of diamond, covered in silk and can be injected into living cells.
Vaccines combat diseases and protect populations from outbreaks, but the life-saving technology leaves room for improvement. Vaccines usually are made en masse in centralized locations far removed from where they will be used. They are expensive to ship and keep refrigerated and they tend to have short shelf lives. However, Univ. of Washington engineers have developed hope for on-demand vaccines.
Researchers have developed a technique for creating nanoparticles that carry two different cancer-killing drugs into the body and deliver those drugs to separate parts of the cancer cell where they will be most effective. The technique was developed by researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill.
Rice Univ. researchers have developed a noninvasive technology that accurately detects low levels of malaria infection through the skin in seconds with a laser scanner. The “vapor nanobubble” technology requires no dyes or diagnostic chemicals, and there is no need to draw blood. A preclinical study shows that Rice’s technology detected even a single malaria-infected cell among a million normal cells with zero false-positive readings.
As represented in this Forecast, the life science industry includes biopharmaceuticals, medical instruments and devices, animal/agricultural bioscience and commercial research and testing. However, the industry’s R&D spending is driven primarily by the mass and research intensity of the biopharmaceutical sector, which accounts for nearly 85% of all expenditures.
Drugs delivered by nanoparticles hold promise for targeted treatment of many diseases, including cancer. However, the particles have to be injected into patients, which has limited their usefulness so far. Now, researchers have developed a new type of nanoparticle that can be delivered orally and absorbed through the digestive tract, allowing patients to simply take a pill instead of receiving injections.
Researchers from North Carolina State Univ. and Duke Univ. have developed nanoscale “patches” that can be used to sensitize targeted cell receptors, making them more responsive to signals that control cell activity. The finding holds promise for promoting healing and facilitating tissue engineering research.
A new nanotechnology-based technique for regulating blood sugar in diabetics may give patients the ability to release insulin painlessly using a small ultrasound device, allowing them to go days between injections—rather than using needles to give themselves multiple insulin injections each day. The technique was developed by researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill.
An interdisciplinary team of University of Pennsylvania researchers has already developed a technique for controlling liquid crystals by means of physical templates and elastic energy, rather than the electromagnetic fields that manipulate them in televisions and computer monitors. They envision using this technique to direct the assembly of other materials, such as nanoparticles.
A two-year collaboration between the Chan and the Rocheleau labs at the Institute of Biomaterials & Biomedical Engineering has led to the development of a new microfluidics screening platform that can accurately predict the way nanoparticles will behave in a living body.
An aggressive form of breast cancer known as “triple negative” is very difficult to treat: Chemotherapy can shrink such tumors for a while, but in many patients they grow back and gain resistance to the original drugs. To overcome that resistance, chemical engineers have designed nanoparticles that carry the cancer drug doxorubicin, as well as short strands of RNA that can shut off one of the genes that cancer cells use to escape the drug.
The combination of heat, chemotherapeutic drugs and an innovative delivery system based on nanotechnology may significantly improve the treatment of ovarian cancer while reducing side effects from toxic drugs, researchers at Oregon State Univ. report in a new study. The findings, so far done only in a laboratory setting, show that this one-two punch of mild hyperthermia and chemotherapy can kill 95% of ovarian cancer cells.
Comparable to nanoscale Navy Seals, Cornell Univ. scientists have merged tiny gold and iron oxide particles to work as a team, then added antibody guides to steer the team through the bloodstream toward colorectal cancer cells. And in a nanosecond, the alloyed allies then kill the bad guys, cancer cells, with absorbed infrared heat.
Life-threatening blood clots can form in anyone who sits on a plane for a long time, is confined to bed while recovering from surgery, or takes certain medications. There is no fast and easy way to diagnose these clots, which often remain undetected until they break free and cause a stroke or heart attack. However, new technology from Massachusetts Institute of Technology may soon change that.
Scientists at Rice Univ. are enhancing the natural antioxidant properties of an element found in a car’s catalytic converter to make it useful for medical applications. The team created small, uniform spheres of cerium oxide and gave them a thin coating of fatty oleic acid to make them biocompatible.
Many viruses infect humans through mucosal surfaces. To help fight these viruses, scientists are working on vaccines that can establish a defense at mucosal surfaces. Vaccines can be delivered to the lungs via an aerosol spray, but are often cleared away before they can provoke an immune response. To overcome that, engineers have developed a new type of nanoparticle that protects the vaccine long enough to generate a strong immune response.
Microscopic, bottle-like structures with corks that melt at precisely controlled temperatures could potentially release drugs inside the body or fragrances onto the skin, according to a recently published study. Typical drug delivery systems act more like sponges than bottles. The researchers hope that the new system may allow for greater control of drug delivery.
Getting biomolecules past the body’s numerous defenses requires innovations such as drug-delivering nanoparticles. Polylactic acid (PLA) is a potential candidate because it is non-toxic, biodegradable, and spontaneously assembles into tiny structures under the right conditions. Researchers in Singapore have developed a robust method to synthesize PLA nanoparticles using copolymer technology and a rigid “nanocage” made from silicon.
Cells are very good at protecting their precious contents. As a result, it’s very difficult to penetrate their membrane walls without damaging or destroying the cell. One effective way of doing so, discovered in 2008, is to use nanoparticles of pure gold, coated with a thin layer of a special polymer. But nobody knew exactly why this combination worked so well, or how it made it through the cell wall, until now.
Massachusetts Institute of Technology chemical engineers have discovered that arrays of billions of nanoscale sensors have unique properties that could help pharmaceutical companies produce drugs more safely and efficiently. Using these sensors, the researchers were able to characterize variations in the binding strength of antibody drugs, which hold promise for treating cancer and other diseases.
Researchers at the Univ. of Georgia are developing a new treatment technique that uses nanoparticles to reprogram immune cells so they are able to recognize and attack cancer. The human body operates under a constant state of martial law. Chief among the enforcers charged with maintaining order is the immune system. The immune system is good at its job, but it's not perfect.
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