Researchers at Swinburne University of Technology have discovered an instability in gold nanoparticles that is critical for their application in future technology. Gold nanorods are important building blocks for future applications in solar cells, cancer therapy and optical circuitry.
Malaria parasites invade human red blood cells, which they bring to burst and infect others....
A new hybrid vehicle is under development. Its performance isn’t measured by the distance it...
Conventional treatment seeks to eradicate cancer cells by drugs and therapy delivered from...
Univ. of California, Los Angeles biochemists have created the largest-ever protein that self-assembles into a molecular “cage.” The research could lead to synthetic vaccines that protect people from the flu, HIV and other diseases. At a size hundreds of times smaller than a human cell, it also could lead to new methods of delivering pharmaceuticals inside of cells, or to the creation of new nanoscale materials.
Massachusetts Institute of Technology chemists have developed new nanoparticles that can simultaneously perform magnetic resonance imaging (MRI) and fluorescent imaging in living animals. Such particles could help scientists to track specific molecules produced in the body, monitor a tumor’s environment, or determine whether drugs have successfully reached their targets.
Stanching the free flow of blood from an injury remains a holy grail of clinical medicine. Controlling blood flow is a primary concern and first line of defense for patients and medical staff in many situations, from traumatic injury to illness to surgery. If control is not established within the first few minutes of a hemorrhage, further treatment and healing are impossible.
Nanomedicine is offering patients a growing arsenal of therapeutic drugs for a variety of diseases, but often at a cost of thousands of dollars a month. Generics could substantially reduce the price tag for patients—if only there were a well-defined way to make and regulate them. An article in Chemical & Engineering News (C&EN) details the challenges on the road to generic nanodrugs.
North Carolina State Univ. researchers have developed a potential new weapon in the fight against cancer: a daisy-shaped drug carrier that’s many thousands of times smaller than the period at the end of this sentence. Once injected into the bloodstream, millions of these “nanodaisies” sneak inside cancer cells and release a cocktail of drugs to destroy them from within.
Univ. of Virginia biomedical engineers are building an entire technology around tiny, microscopic bubbles– a technology that has the potential to play an important role in diagnosing as well as treating disease like stroke and cancer.
Antibodies, in charge of recognizing and homing in on molecular targets, are among the most useful tools in biology and medicine. Nanobodies—antibodies’ tiny cousins—can do the same tasks, for example marking molecules for research or flagging diseased cells for destruction. But, thanks to their comparative simplicity nanobodies offer the tantalizing prospect of being much easier to produce.
Stanford Univ. School of Medicine researchers have developed a new formula for delivering the therapeutic peptide apelin to heart tissue for treatment of hypertrophy, a hereditary disease commonly attributed to sudden death in athletes. The nanoscale delivery system, which dramatically increases the peptide’s stability, shows promise for treating heart disease in humans, the researchers said.
A team led by the Lawrence Livermore National Laboratory scientists has created a new kind of ion channel consisting of short carbon nanotubes, which can be inserted into synthetic bilayers and live cell membranes to form tiny pores that transport water, protons, small ions and DNA. These carbon nanotube “porins” have significant implications for future health care and bioengineering applications.
Houston Methodist Research Institute scientists will receive about $1.25 million from the Center for the Advancement of Science in Space to develop an implantable, nanochannel device that delivers therapeutic drugs at a rate guided by remote control. The device's effectiveness will be tested aboard the International Space Station and on Earth's surface.
A group of scientists in Florida have combined medicine and advanced nanotechnological engineering to create a smarter, more targeted therapy that could overcome the most lethal gynecologic cancer. The technology involves combining Taxol, a chemotherapy drug, with magneto-electric nanoparticles that can penetrate the blood-brain barrier.
In a design that mimics a hard-to-duplicate texture of starfish shells, Univ. of Michigan engineers have made rounded crystals that have no facets. The team calls the crystals "nanolobes". The nanolobes' shape and the way they're made have promising applications. The geometry could potentially be useful to guide light in advanced LEDs, solar cells and non-reflective surfaces.
Nanomedicines consisting of nanoparticles for targeted drug delivery to specific tissues and cells offer new solutions for cancer diagnosis and therapy. Understanding the interdependency of physiochemical properties of nanomedicines, in correlation to their biological responses and functions, is crucial for their further development of as cancer-fighters.
Like discriminating thieves, prostate cancer tumors scavenge and hoard copper that is an essential element in the body. But such avarice may be a fatal weakness. Researchers at Duke Medicine have found a way to kill prostate cancer cells by delivering a trove of copper along with a drug that selectively destroys the diseased cells brimming with the mineral, leaving non-cancer cells healthy.
Some people might consider mucus an icky bodily secretion best left wrapped in a tissue, but to a group of researchers in North Carolina, snot is an endlessly fascinating subject. The team has developed a way to use gold nanoparticles and light to measure the stickiness of the slimy substance that lines our airways. The new method could help doctors better monitor and treat lung diseases such as cystic fibrosis.
Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs. The new system is DNA-based, which means it is biocompatible and less toxic to patients than systems that use synthetic materials.
When Illinois researchers set out to investigate a method to control how DNA moves through a tiny sequencing device, they didn’t know they were about to witness a display of molecular gymnastics. Fast, accurate and affordable DNA sequencing is the first step toward personalized medicine.
Cancer vaccines have recently emerged as a promising approach for killing tumor cells before they spread. But so far, most clinical candidates haven’t worked that well. Now, scientists have developed a new way to deliver vaccines that successfully stifled tumor growth when tested in laboratory mice. And the key is in the vaccine’s unique stealthy nanoparticles.
Researchers in the Netherlands have managed to open nanovesicles in a reversible process and close them using a magnet. Previously, these vesicles had been “loaded” with a drug and opened elsewhere using a chemical process, such as osmosis. The magnetic method, which is repeatable, is the first to demonstrate the viability of another method.
A Rice Univ. team led by bioengineer Jeffrey Jacot and chemical engineer and chemist Matteo Pasquali have created new pediatric heart-defect patches infused with conductive single-walled carbon nanotubes that allow electrical signals to pass unhindered. The nanotubes overcome a limitation of current patches in which pore walls hinder the transfer of electrical signals between cardiomyocytes, the heart muscle’s beating cells.
A self-assembling nanoparticle designed by a Univ. of Connecticut (UConn) professor is the key component of a potent new malaria vaccine that is showing promise in early tests. For years, scientists trying to develop a malaria vaccine have been stymied by the malaria parasite’s ability to transform itself and “hide” in the liver and red blood cells of an infected person to avoid detection by the immune system.
Cancerous brain tumors are notorious for growing back despite surgical attempts to remove them, and for leading to a dire prognosis for patients. But scientists are developing a new way to try to root out malignant cells during surgery so fewer or none get left behind to form new tumors. The technology relies on a Raman scanner that can read injected nanoprobes.
DARPA’s new Electrical Prescriptions (ElectRx) program was among the initiatives the White House highlighted this week as President Barack Obama addressed the need for new and more effective strategies for improving the health of service members, veterans and others. ElectRx goes beyond medication, aiming to explore neuromodulation of organ functions to help the human body heal itself.
Laboratory-grown replacement organs have moved a step closer with the completion of a new study. Scientists have grown a fully functional organ from transplanted laboratory-created cells in a living animal for the first time. They have created a thymus, an organ next to the heart that produces immune cells known as T cells that are vital for guarding against disease.
There’s a certain type of biomolecule built like a nano-Christmas tree. Called a glycoconjugate, it’s many branches are bedecked with sugary ornaments. It’s those ornaments that get all the glory. That’s because, according to conventional wisdom, the glycoconjugate’s lowly “tree” basically holds the sugars in place as they do the important work of reacting with other molecules.
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