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The Lead

Nanodevice defeats drug resistance

March 3, 2015 7:30 am | by Anne Trafton, MIT News Office | News | Comments

Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back. A new nanodevice developed by Massachusetts Institute of Technology researchers can help overcome that by first blocking the gene that confers drug resistance, then launching a new chemotherapy attack against the disarmed tumors.

Graphene shows potential as anticancer therapeutic strategy

February 25, 2015 8:11 am | by Jamie Brown, Univ. of Manchester | News | Comments

Univ. of Manchester scientists have used graphene to target and neutralize cancer stem cells...

Building tailor-made DNA nanotubes step-by-step

February 24, 2015 8:10 am | by McGill Univ. | News | Comments

Researchers at McGill Univ. have developed a new, low-cost method to build DNA nanotubes block-...

New nanogel for drug delivery

February 19, 2015 9:04 am | by Anne Trafton, MIT News Office | News | Comments

Chemical engineers have designed a new type of self-healing hydrogel that could be injected...

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Making a better wound dressing

February 13, 2015 10:18 am | by American Chemical Society | News | Comments

With a low price tag and mild flavor, tilapia has become a staple dinnertime fish for many Americans. Now it could have another use: helping to heal our wounds. In ACS Applied Materials & Interfaces, scientists have shown that a protein found in this fish can promote skin repair in rats without an immune reaction, suggesting possible future use for human patients.

Gold nanotubes launch a three-pronged attack on cancer cells

February 13, 2015 9:10 am | by Sarah Reed, Univ. of Leeds | News | Comments

Scientists have shown that gold nanotubes have many applications in fighting cancer: internal nanoprobes for high-resolution imaging, drug delivery vehicles and agents for destroying cancer cells. The study, published in Advanced Functional Materials, details the first successful demonstration of the biomedical use of gold nanotubes in a mouse model of human cancer.

DNA “cage” could improve nanopore technology

February 10, 2015 10:51 am | by Kevin Stacey, Brown Univ. | News | Comments

Despite having a diameter tens of thousands of times smaller than a human hair, nanopores could be the next big thing in DNA sequencing. By zipping DNA molecules through these tiny holes, scientists hope to one day read off genetic sequences in the blink of an eye. Now, researchers from Brown Univ. have taken the potential of nanopore technology one step further.

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An end to the medicine dropper for eye injuries?

February 6, 2015 8:35 am | by American Chemical Society | News | Comments

For years, treating scratches and burns to the eyes has usually involved dropping medicine onto the eyes several times a day, sometimes for weeks: a treatment that lends itself to missed doses and other side effects. But scientists are now reporting a novel, drug-releasing wafer that patients can put directly on their affected eyes just once a day. The team says the device works better than drops and could help patients recover faster.

Nanoshuttle wear and tear: It’s the mileage, not the age

January 26, 2015 11:36 am | by Holly Evarts, Columbia Univ. | News | Comments

As nanomachine design rapidly advances, researchers are moving from wondering if the nanomachine works to how long it will work. This is an especially important question as there are so many potential applications, for instance, for medical uses, including drug delivery, early diagnosis, disease monitoring, instrumentation and surgery.

One nanoparticle, six types of medical imaging

January 21, 2015 8:22 am | by Charlotte Hsu, Univ. at Buffalo | News | Comments

It’s technology so advanced that the machine capable of using it doesn’t yet exist. Using two biocompatible parts, Univ. at Buffalo researchers and their colleagues have designed a nanoparticle that can be detected by six medical imaging techniques: computed tomography (CT) scanning, positron emission tomography (PET) scanning, photoacoustic imaging, fluorescence imaging, upconversion imaging and Cerenkov luminescence imaging.

Hydrogels deliver on blood-vessel growth

January 20, 2015 7:50 am | by Mike Williams, Rice Univ. | Videos | Comments

Rice Univ. scientists have found the balance necessary to aid healing with high-tech hydrogel. The team created a new version of the hydrogel that can be injected into an internal wound and help it heal while slowly degrading as it is replaced by natural tissue. Hydrogels are used as a scaffold upon which cells can build tissue. The new hydrogel overcomes a host of issues that have kept them from reaching their potential to treat injuries.

New “triggered-release” mechanism could improve drug delivery

January 16, 2015 11:58 am | by Tom Frew, International Press Officer, Univ. of Warwick | News | Comments

More efficient medical treatments could be developed thanks to a new method for triggering the rearrangement of chemical particles. The new method, developed at the Univ. of Warwick, uses two “parent” nanoparticles that are designed to interact only when in proximity to each other and trigger the release of drug molecules contained within both.

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Gold nanoparticles show promise for early detection of heart attacks

January 15, 2015 12:29 pm | by New York Univ. | News | Comments

New York Univ. Polytechnic School of Engineering professors have been collaborating with researchers from Peking Univ. on a new test strip that is demonstrating great potential for the early detection of certain heart attacks. The new colloidal gold test strip can test for cardiac troponin I (cTn-I) detection.

Solving a case of intercellular entrapment

January 9, 2015 7:51 am | by Julie Cohen, Univ. of California, Santa Barbara | News | Comments

Optogenetics, which uses light to control cellular events, is poised to become an important technology in molecular biology and beyond. The Reich Group in Univ. of California, Santa Barbara’s Dept. of Chemistry and Biochemistry has made a major contribution to this emergent field by developing a light-activated nanocarrier that transports proteins into cells and releases them on command.

New approach may lead to inhalable vaccines for influenza, pneumonia

January 8, 2015 9:29 am | by Matt Shipman, News Services, North Carolina State Univ. | News | Comments

Researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill have uncovered a novel approach to creating inhalable vaccines using nanoparticles that shows promise for targeting lung-specific diseases, such as influenza, pneumonia and tuberculosis.

“Flying carpet” technique uses graphene to deliver one-two punch of anticancer drugs

January 6, 2015 10:02 am | by Matt Shipman, News Services, North Carolina State Univ. | News | Comments

An international team of researchers has developed a drug delivery technique that utilizes graphene strips as “flying carpets” to deliver two anticancer drugs sequentially to cancer cells, with each drug targeting the distinct part of the cell where it will be most effective. The technique was found to perform better than either drug in isolation when tested in a mouse model targeting a human lung cancer tumor.

“Glowing” new nanotechnology guides cancer surgery

January 5, 2015 3:41 pm | by David Stauth, Oregon State Univ. | News | Comments

Researchers at Oregon State Univ. have developed a new way to selectively insert compounds into cancer cells—a system that will help surgeons identify malignant tissues and then, in combination with phototherapy, kill any remaining cancer cells after a tumor is removed. It’s about as simple as, “If it glows, cut it out.” And if a few malignant cells remain, they’ll soon die.

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Gelatin nanoparticles could deliver drugs to the brain

January 2, 2015 8:12 am | by Liz Ahlberg, Physical Sciences Editor, Univ. of Illinois, Urbana-Champaign | News | Comments

Stroke victims could have more time to seek treatment that could reduce harmful effects on the brain, thanks to tiny blobs of gelatin that could deliver the medication to the brain noninvasively. Univ. of Illinois researchers found that gelatin nanoparticles could be laced with medications for delivery to the brain, and that they could extend the treatment window for when a drug could be effective.

Nanotech used to engineer ACL replacements

January 2, 2015 7:50 am | by Amanda Morris, Northwestern Univ. | News | Comments

Lindsey Vonn. Derrick Rose. Tom Brady. Mickey Mantle. They have all fallen victim to the dreaded pop of the knee. Connecting the femur to the tibia, the anterior cruciate ligament (ACL) rupture is one of the most devastating injuries in sports. No other injury has sidelined more athletes for a season or even the rest of a career.

Landmark discovery in gold nanorod instability

December 18, 2014 3:14 pm | News | Comments

Researchers at Swinburne University of Technology have discovered an instability in gold nanoparticles that is critical for their application in future technology. Gold nanorods are important building blocks for future applications in solar cells, cancer therapy and optical circuitry.

Nanotechnology battles malaria parasites

December 10, 2014 8:04 am | News | Comments

Malaria parasites invade human red blood cells, which they bring to burst and infect others. Researchers at the University of Basel and the Swiss Tropical and Public Health Institute called nano imitations of host cell membranes have developed that deceive and trick the pathogen. This could lead to novel therapeutic and vaccine strategies against malaria and other infectious diseases.

A hybrid vehicle that delivers DNA

November 26, 2014 7:46 am | by Cory Nealon, Univ. at Buffalo | News | Comments

A new hybrid vehicle is under development. Its performance isn’t measured by the distance it travels, but rather the delivery of its cargo: vaccines that contain genetically engineered DNA to fight HIV, cancer, influenza and other maladies. The technology is a biomedical advancement that could help unleash the potential of DNA vaccines, which despite much research, have yet to make a significant impact in the treatment of major illnesses.

Nanoparticles infiltrate, kill cancer cells from within

November 24, 2014 11:06 am | by Melanie Titanic-Schefft, Univ. of Cincinnati | News | Comments

Conventional treatment seeks to eradicate cancer cells by drugs and therapy delivered from outside the cell, which may also affect (and potentially harm) nearby normal cells. In contrast to conventional cancer therapy, a Univ. of Cincinnati team has developed several novel designs for iron-oxide based nanoparticles that detect, diagnose and destroy cancer cells using photo-thermal therapy (PTT).

Biochemists build largest synthetic molecular “cage” ever

November 19, 2014 10:26 am | by Stuart Wolpert, Univ. of California, Los Angeles | News | Comments

Univ. of California, Los Angeles biochemists have created the largest-ever protein that self-assembles into a molecular “cage.” The research could lead to synthetic vaccines that protect people from the flu, HIV and other diseases. At a size hundreds of times smaller than a human cell, it also could lead to new methods of delivering pharmaceuticals inside of cells, or to the creation of new nanoscale materials.

Two sensors in one

November 18, 2014 8:10 am | by Anne Trafton, MIT News Office | News | Comments

Massachusetts Institute of Technology chemists have developed new nanoparticles that can simultaneously perform magnetic resonance imaging (MRI) and fluorescent imaging in living animals. Such particles could help scientists to track specific molecules produced in the body, monitor a tumor’s environment, or determine whether drugs have successfully reached their targets.

Bio-inspired bleeding control

November 13, 2014 4:12 pm | by Sonia Fernandez, Univ. of California, Santa Barbara | News | Comments

Stanching the free flow of blood from an injury remains a holy grail of clinical medicine. Controlling blood flow is a primary concern and first line of defense for patients and medical staff in many situations, from traumatic injury to illness to surgery. If control is not established within the first few minutes of a hemorrhage, further treatment and healing are impossible.

Regulatory, scientific complexity of generic nanodrugs could delay savings for patients

November 13, 2014 8:07 am | by American Chemical Society | News | Comments

Nanomedicine is offering patients a growing arsenal of therapeutic drugs for a variety of diseases, but often at a cost of thousands of dollars a month. Generics could substantially reduce the price tag for patients—if only there were a well-defined way to make and regulate them. An article in Chemical & Engineering News (C&EN) details the challenges on the road to generic nanodrugs.

Cancer-killing nanodaisies

November 12, 2014 8:31 am | by Alastair Hadden, North Carolina State Univ. | Videos | Comments

North Carolina State Univ. researchers have developed a potential new weapon in the fight against cancer: a daisy-shaped drug carrier that’s many thousands of times smaller than the period at the end of this sentence. Once injected into the bloodstream, millions of these “nanodaisies” sneak inside cancer cells and release a cocktail of drugs to destroy them from within.

Microbubbles can improve stroke treatment

November 6, 2014 10:25 am | by Charlie Feigenoff, Univ. of Virginia | News | Comments

Univ. of Virginia biomedical engineers are building an entire technology around tiny, microscopic bubbles– a technology that has the potential to play an important role in diagnosing as well as treating disease like stroke and cancer.     

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