Researchers have discovered that the so-called HOPE method allows tissue samples to be treated such that they do not only meet the requirements of clinical histology, but can still be characterized later on by modern methods of proteomics, a technique that analyzes all proteins at once. This differs from the traditional formalin-based approach that cross-links protein molecules.
Beckman Coulter Diagnostics has announced a strategic partnership with hc1.co of Indianapolis to help laboratories turn large amounts of clinical data into actionable insights. The new technology combines Beckman Coulter’s clinical diagnostic systems with hc1.com’s software-as-a-service product, Healthcare Relationship Cloud.
Engineers have demonstrated thin, soft stick-on patches that stretch and move with the skin and incorporate commercial, off-the-shelf chip-based electronics for sophisticated wireless health monitoring.
Scientists have published the first study explaining in detail how viruses reprogram the metabolism of the cells they invade to promote continued viral growth within an organism.
Pharmaceutical researchers in California, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using near-infrared light to activate polymeric drug-delivering nanoparticles and other targeted therapeutic substances inside the body. This discovery represents a major innovation; up to now only a handful of strategies using light-triggered release from nanoparticles have been reported.
Researchers have reported they can generate human motor neurons from stem cells much more quickly and efficiently than previous methods allowed. The new method involves adding critical signaling molecules to precursor cells a few days earlier than previous methods specified. This increases the proportion of healthy motor neurons derived from stem cells (from 30 to 70%) and cuts in half the time required to do so.
Combatting the tissue degrading enzymes that cause lasting damage following a heart attack is tricky. Each patient responds to a heart attack differently and damage can vary from one part of the heart muscle to another, but existing treatments can’t be fine-tuned to deal with this variation. Univ. of Pennsylvania researchers have developed a way to address this problem via a material that can be applied directly to the damaged heart tissue.
Wounds may heal more quickly if exposed to low-intensity vibration, report researchers at the Univ. of Illinois at Chicago. The finding, in mice, may hold promise for the 18 million Americans who have type 2 diabetes, and especially the quarter of them who will eventually suffer from foot ulcers. Their wounds tend to heal slowly and can become chronic or worsen rapidly.
Researchers in Sweden have designed a paper filter which is capable of removing virus particles with the efficiency matching that of the best industrial virus filters. The paper filter, which is manufactured according to traditional paper making processes, consists of 100% high purity cellulose nanofibers directly derived from nature.
A new study gives a big boost to fixing a bad aortic valve, the heart's main gate, without open-heart surgery. Survival rates were better one year later for people who had a new valve placed through a tube into an artery instead. The results were reported at an American College of Cardiology conference in Washington and prompted some doctors to predict that in the near future, far fewer people will be having the traditional operation.
A new organ has been developed at George Washington Univ. to help return blood flow from veins lacking functional valves. A rhythmically contracting cuff made of cardiac muscle cells surrounds the vein acting as a 'mini heart' to aid blood flow through venous segments. The cuff can be made of a patient’s own adult stem cells, eliminating the chance of implant rejection.
A mathematical model created by Penn State Univ. researchers can predict with more than 90% accuracy the blood glucose levels of individuals with type 1 diabetes up to 30 min in advance of imminent changes in their levels, which is plenty of time to take preventative action. The model was estimated by the extended Kalman filtering technique and accounts for time-varying changes in glucose kinetics due to insulin and meal intake.
Call it “homo minutus”. A team at Los Alamos National Laboratory is developing four human organ constructs (liver, heart, lung and kidney) that will work together to serve as a drug and toxicity analysis system that can mimic the actual response of human organs. Called ATHENA, for Advanced Tissue-engineered Human Ectypal Network Analyzer, the system will fit neatly on a desk.
A new brain imaging study in Australia found a “stop mechanism” that determined brain signals telling the individual to stop drinking water when no longer thirsty. The study, which used magnetic resonance imaging, also gauged the brain effects of drinking more water than required.
The 3-D virtual reality cadaver floats in space like a hologram on an invisible gurney. Univ. of Michigan 3-D Lab employee Sean Petty stands a few inches away. Petty wears special glasses and pilots a joystick to arbitrarily slice away sections of the cadaver. He enlarges and turns the body for a better view of the detailed anatomy inside.
Adopted a common technique used in biochemistry, called agarose gel electrophoresis, researchers have investigated the damage to DNA that might have been caused by use of an atmospheric pressure plasma jet. This qualitative and quantitative study could ultimately lead to plasma-based tools for cancer therapy or hospital hygiene and other purposes.
A new microfluidic method for evaluating drugs commonly used for preventing heart attacks has found that while aspirin can prevent dangerous blood clots in some at-risk patients, it may not be effective in all patients with narrowed arteries. The study, a first in the examination of heart attack prevention drugs, used a device that simulated blood flowing through narrowed coronary arteries to assess effects of anti-clotting drugs.
Massachusetts Institute of Technology engineers have coaxed bacterial cells to produce biofilms that can incorporate non-living materials, such as gold nanoparticles and quantum dots. These “living materials” combine the advantages of live cells, which respond to their environment and produce complex biological molecules, with the benefits of nonliving materials, which add functions such as conducting electricity or emitting light.
When cancers become advanced, tumor cells from the primary tumor can enter the bloodstream and cause metastasis at another organ with deadly effect. While researching the biological implications of CTC spread, Creatv MicroTech researchers found a group of previously unreported cells associated with primary cancer spread. These macrophage-like cells could serve as biomarkers.
Duke Univ. engineers have devised a way to improve the efficiency of lithotripsy—the demolition of kidney stones using focused shock waves. After decades of research, all it took was cutting a groove near the perimeter of the shock wave-focusing lens and changing its curvature.
Even in a crowded room full of background noise, the human ear is remarkably adept at tuning in to a single voice—a feat that has proved remarkably difficult for computers to match. A new analysis of the underlying mechanisms, conducted by researchers at Massachusetts Institute of Technology, has provided insights that could ultimately lead to better machine hearing, and perhaps to better hearing aids as well.
Changing the texture and surface characteristics of a semiconductor material at the nanoscale can influence the way that neural cells grow on the material. The finding stems from a study performed by researchers at North Carolina State Univ., the Univ. of North Carolina at Chapel Hill and Purdue Univ., and may have utility for developing future neural implants.
The U.S. Food and Drug Administration said Tuesday it approved a Belgium-made nerve-stimulating headband as the first medical device to prevent migraine headaches. Agency officials said the device provides a new option for patients who can't tolerate migraine medications. The Cefaly device is a battery-powered plastic band worn across the forehead.
Smartphones are capable of giving us directions when we’re lost, sending photos and videos to our friends in mere seconds and, perhaps very soon, diagnose our diseases in real time. Researchers in Texas are developing a disease diagnostic system made of a glass slide and a porous film of gold that offers results that could be read using only a smartphone and a $20 lens attachment.
It's not just grandma with a new hip and your uncle with a new knee. More than two of every 100 Americans now have an artificial joint, doctors are reporting. Among those over 50, it's even more common: 5% have replaced a knee and more than 2%, a hip.