Since the first test-tube baby was born more than three decades ago, in vitro fertilization has evolved into a highly sophisticated lab procedure. Now, scientists are going back to basics and testing a simpler method that could cost as little as $265 and use basic laboratory equipment that could fit inside a shoebox.
Traditionally, dentists have made dental impressions by having patients bite down on a moldable silicone material. Such impressions, however, can be uncomfortable and inaccurate. In the early 2000s, a group of researchers from Massachusetts Institute of Technology and Harvard Univ. began working to commercialize a novel handheld scanner that could digitally capture 3-D images of the inside of a patient’s mouth.
Researchers in Switzerland have developed a “guide” that can be used to precisely predict the number of proteins a given gene will produce under varying conditions. Each gene has a segment of DNA at its beginning called a promoter, and the researchers generated more than 200 of them, integrated them into a yeast genome, and conducted comparative analysis that generated a model. This work will help biologists to engineer cells.
When people have a brain injury so severe that they can't squeeze a loved one's hand or otherwise respond, there are few good ways to tell if they have any lingering awareness or are in a vegetative state. Now researchers have created a technique using a magnetic coil and an electroencephalogram to allow them to peek inside the brain and measure varying levels of consciousness.
The Wyss Institute for Biologically Inspired Engineering at Harvard Univ. has received a $5.6 million grant award from the U.S. Food and Drug Administration to use its Organs-on-Chips technology to test human physiological responses to radiation. The project will investigate if the microfluidic devices lined by living human cells can be used instead of animals to evaluate the efficacy and safety of medical treatments for radiation sickness.
A recent invention at Purdue Univ. could improve therapy selection for personalized cancer care. Researchers have created a technique called BioDynamic Imaging that measures the activity inside cancer biopsies, or samples of cells. It allows technicians to assess the efficacy of drug combinations, called regimens, on personal cancers.
Lawrence Berkeley National Laboratory scientists have helped to develop a tiny chip that has big potential for quickly determining whether someone has been exposed to dangerous levels of ionizing radiation. The first-of-its-kind chip has an array of nanosensors that measure the concentrations of proteins that change after radiation exposure.
Abbott’s Absorb bioresorbable vascular scaffold was named one of R&D Magazine’s 2013 top 100 technologies as part of its 51st annual R&D 100 Awards. The Absorb bioresorbable vascular scaffold, similar to a small mesh tube, is designed to open a blocked heart vessel and restore blood flow to the heart.
Researchers at Columbia Univ. Medical Center, working with their collaborators at the Hospital for Special Surgery, have created a fleet of molecular “robots” that can home in on specific human cells and mark them for drug therapy or destruction. The nanorobots—a collection of DNA molecules, some attached to antibodies—were designed to seek a specific set of human blood cells and attach a fluorescent tag to the cell surfaces.
Stem cell therapy is in its infancy, but has the potential to change the way we treat cancer and other diseases by replacing damaged or diseased cells with healthy ones. Identifying the right cells to use is the challenge, and scientists in the U.K. have found a way to use gold nanoprobes with surface enhanced Raman spectroscopy to differentiate the nearly identical cells.
A team of scientists in South Korea have recently developed the most precise method ever used to accomplish a typically messy, clumsy process: inserting DNA into living cells. It combines two high-tech laboratory techniques and allows the researchers to precisely poke holes on the surface of a single cell with a high-powered femtosecond laser and then gently tug a piece of DNA through it using optical tweezers.
China’s biomedical sector is rapidly transforming itself from a manufacturing base to an innovation hub, investing billions of dollars and setting up innovation centers in a bid to catch up with the west by the end of the 12th Five-Year Plan, according to Lux Research.
At Battelle, supporting America’s military personnel is woven into the fabric of its business. In that pursuit, a team consisting of Battelle, NxStage Medical Inc. and Aethlon Medical has won a contract from DARPA to develop an innovative, new medical device that may save the lives of soldiers—and civilians as well—by treating sepsis.
Univ. of Maryland Ventures announced agreements between Univ. of Maryland, Baltimore and five different life sciences companies across the Baltimore/Washington metropolitan region. The companies include Rexahn Pharmaceuticals, Plasmonix, IGI Technologies, A&G Pharmaceuticals and BioAssay Works.
Early in 2012, a team of scientists reported the development of a postage stamp-sized microchip capable of sorting cells through a technique, known as cell rolling, that mimics a natural mechanism in the body. The device successfully separated leukemia cells from cell cultures, but could not extract cells directly from blood. Now the group has developed a new microchip that can quickly separate white blood cells from samples of whole blood.
One of the major driving forces for developing new sensors and detectors is in medical applications. This includes the integration of fiber optic sensors, smart sensors, silicon micromachined sensors and thin-film devices. Smart sensors are devices that incorporate electronic logic, control or signal processing functions and therefore offer enhanced measurement capabilities, information quality and functional performance.
The human cell represents the smallest functional unit of life. All tissues in the body are composed of multiple cell types, typically arranged in a 3-D architecture that is relevant to the functions they carry out. Since cells were first isolated and grown in the laboratory environment, biologists and engineers have pursued the utilization of these tiny building blocks in the reconstruction and regeneration of functional tissue.
Certain bacteria, including Staphylococcus aureus, have the ability to deploy tiny darts. This biological weapon kills the host cell by piercing the membrane. Researchers have unlocked, piece by piece, this intriguing little machine and found an assembly of proteins that, in unfolding at the right time, takes the form of a spur.
“Are we there yet?” As anyone who has traveled with young children knows, maintaining focus on distant goals can be a challenge. A new study from Massachusetts Institute of Technology suggests how the brain achieves this task, and indicates that the neurotransmitter dopamine may signal the value of long-term rewards.
Engineers at the Univ. of California, Berkeley have built a device that could speed up medical imaging without breaking the bank. The key ingredient? An engine lubricant called molybdenum disulfide, or MoS2, which has been sold in auto parts shops for decades.
Reaching a clinic in time to receive an early diagnosis for cancer—when the disease is most treatable—is a global problem. And now a team of Chinese researchers proposes a global solution: have a user-friendly diagnostic device travel to the patient, anywhere in the world.
A study at the Univ. of Utah finds that more than 60% of antibiotic prescriptions are for types that kill multiple kinds of bacteria. Unfortunately, in more than 25% of cases such prescriptions are useless because the infection stems from a virus, which cannot be treated with antibiotics. This overuse of antibiotics has a number of downsides.
Massachusetts Institute of Technology researchers have developed a new endoscopy technology that could make it easier for doctors to detect precancerous lesions in the colon. Early detection of such lesions has been shown to reduce death rates from colorectal cancer, which kills about 50,000 people per year in the U.S.
A recent publication evaluates the latest advances toward using a protein called resilin in nanosprings, biorubbers, biosensors and other applications. This remarkable protein is rubber-like and enables dragonflies, grasshoppers and other insects to flap their wings, jump and chirp. Resilin could have major potential uses in medicine.
Many drugs such as agents for cancer or autoimmune diseases have nasty side effects because while they kill disease-causing cells, they also affect healthy cells. Now a new study has demonstrated a technique for developing more targeted drugs, by using molecular “robots” to hone in on more specific populations of cells.