Cancerous brain tumors are notorious for growing back despite surgical attempts to remove them, and for leading to a dire prognosis for patients. But scientists are developing a new way to try to root out malignant cells during surgery so fewer or none get left behind to form new tumors. The technology relies on a Raman scanner that can read injected nanoprobes.
Because Brown Univ. biomedical engineering graduate student Molly Boutin needed to study how neural tissues grow from stem cells, she wanted to grow not just a cell culture, but a sphere-shaped one. Cells grow and interact more naturally in 3-D cultures than when they’re confined to thin slides or dishes.
Over the past several decades, malaria diagnosis has changed very little. After taking a blood sample from a patient, a technician smears the blood across a glass slide, stains it with a special dye and looks under a microscope for the Plasmodium parasite, which causes the disease. This approach gives an accurate count of how many parasites are in the blood, but is not ideal because there is potential for human error.
Cartilage lesions in joints often appear in older people as a result of degenerative processes, and appear in younger people after injuries and accidents. Such defects are difficult to repair and often require complicated surgery and long rehabilitation times. Researchers in Switzerland have reported that cells taken from the nasal septum are able to adapt to the environment of the knee joint and can thus repair articular cartilage defects.
Newborn jaundice: It’s one of the last things a parent wants to deal with, but it’s unfortunately a common condition in babies less than a week old. Skin that turns yellow can be a sure sign that a newborn is jaundiced and isn’t adequately eliminating the chemical bilirubin. But that discoloration is sometimes hard to see. Researchers have developed a smartphone application that checks for jaundice in newborns.
Like a protective tent over a colony of harmful bacteria, biofilms make the treatment of skin infections especially difficult. Microorganisms protected in a biofilm pose a significant health risk due to their antibiotic resistance and recalcitrance to treatment, and biofilm-protected bacteria account for 80% of total bacterial infections in humans and are 50 to 1,000 times more resistant to antibiotics than simpler bacterial infections.
"Do-it-yourself" blood pressure measurements and medicine changes work better than usual doctor-office care in some patients, a study of older adults in England found. Those who did their own readings at home and adjusted their medicine as needed had healthier blood pressure levels after a year than those who got standard doctors' care.
For the 2.2 million Americans battling glaucoma, the main course of action for staving off blindness involves weekly visits to eye specialists who monitor increasing pressure within the eye. Now researchers have developed an eye implant that could help stave off blindness caused by glaucoma. The tiny eye implant developed at Stanford Univ. could enable patients to take more frequent readings from the comfort of home.
Univ. of Illinois engineers are bringing a touch of color to glucose monitoring. The researchers developed a new continuous glucose monitoring material that changes color as glucose levels fluctuate, and the wavelength shift is so precise that doctors and patients may be able to use it for automatic insulin dosing—something now possible using current point measurements like test strips.
Researchers have devised a new way to separate cells by exposing them to sound waves as they flow through a tiny channel. Their device, about the size of a dime, could be used to detect the extremely rare tumor cells that circulate in cancer patients’ blood, helping doctors predict whether a tumor is going to spread.
Laboratory-grown replacement organs have moved a step closer with the completion of a new study. Scientists have grown a fully functional organ from transplanted laboratory-created cells in a living animal for the first time. They have created a thymus, an organ next to the heart that produces immune cells known as T cells that are vital for guarding against disease.
David Erickson, a professor at Cornell Univ., will receive a $3 million National Science Foundation grant over five years to adapt smartphones for health monitoring. The program, dubbed PHeNoM for Public Health, Nanotechnology, and Mobility, aims to deploy three systems that can have an immediate impact on personal healthcare.
In the past, immune cells were clearly divided into innate cells, which respond to attacks in a non-specific way, and adaptive cells, which learn to recognize new antigens and gain the ability to rapidly react to later attacks. Researchers at RIKEN in Japan have discovered that is not always the case, having found that killer T cells previously thought to be innate, and thus short-lived, can remain in the lung for up to nine months.
Laparoscopic Surgery was introduced with a goal to reduce morbidities associated with open surgical techniques. Twenty years later, although it has brought much better outcomes across a number of indicators, it still has some significant patient morbidities and mortality risks associated with it. Port site hernia is one such example. No ubiquitous global device-based standard of care developed has been accepted to deal with this issue. neoSurgical’s neoClose brings a simple, accurate technology/device-based solution that can be deployed in less than 30 sec.
Princeton Univ. researchers have developed a way to use a laser to measure people's blood sugar, and, with more work to shrink the laser system to a portable size, the technique could allow diabetics to check their condition without pricking themselves to draw blood.
Milliken and Company’s ASSIST Silver is a low-adherent antimicrobial dressing used primarily in burn care for the management of skin grafts. The dressing incorporates three primary features: Active Fluid Management (AFM) technology, an ionic silver antimicrobial and a low-adherent layer.
Globally, 22 million infants aren’t receiving basic vaccines and 1.5 million children will die each year from vaccine-preventable diseases before they reach age five. This challenge is further complicated by the fact that most vaccines must be refrigerated, and more than a billion people globally don’t have reliable access to electricity. Vaccination rates are lowest in remote and rural locations. As part of Intellectual Ventures’ Global Good program, Intellectual Venture Labs (IVL) approached Stratos Product Development for help in developing an insulated container to strengthen and extend vaccination services in developing countries.
Novilytic’s Noviplex Plasma Collection Card is a self-contained, blood-plasma sampling device used to volumetrically collect a plasma aliquot independent of whole blood application volumes. The Noviplex requires no power and circumvents requirements for venipuncture-phlebotomy training, needles, special vials and equipment, refrigeration and centrifugation normally associated with traditional plasma methods.
A team of researchers at Louisiana Tech Univ. has developed an innovative method for using affordable, consumer-grade 3-D printers and materials to fabricate custom medical implants that can contain antibacterial and chemotherapeutic compounds for targeted drug delivery.
Research published in ACS Nano identifies a new type of sensor that could monitor body movement and advance the future of global health care. Although body motion sensors already exist in different forms, they have not been widely used due to their complexity and cost of production.
While it's becoming commonplace for patients to see the results of laboratory work electronically, a new Univ. of Michigan study suggests that many people may not be able to understand what those numbers mean. The research found that people with low comprehension of numerical concepts—or numeracy—and low literacy skills were less than half as likely to understand whether a result was inside or outside the reference ranges.
Using a microengineered device that acts as an obstacle course for cells, researchers have shed new light on a cellular metamorphosis thought to play a role in tumor cell invasion throughout the body. The epithelial-mesenchymal transition (EMT) is a process in which epithelial cells, which tend to stick together within a tissue, change into mesenchymal cells, which can disperse and migrate individually.
An international team of scientists has shown that an antibody against the protein EphA3, found in the micro-environment of solid cancers, has anti-tumor effects. As EphA3 is present in normal organs only during embryonic development but is expressed in blood cancers and in solid tumors, this antibody-based approach may be a suitable candidate treatment for solid tumors.
A new technique has demonstrated for the first time that the size of molecules penetrating the blood-brain barrier can be controlled using acoustic pressure. The innovative ultrasound approach uses acoustic pressure to let molecules through, and may help treatment for central nervous system diseases like Parkinson’s and Alzheimer’s.
By combining magnetic nanoparticles with one of the most common and effective chemotherapy drugs, Argonne National Laboratory researchers have created a way to deliver anti-cancer drugs directly into the nucleus of cancer cells. They have created nano-sized bubbles, or “micelles,” that contain magnetic nanoparticles of iron oxide and cisplatin, a conventional chemotherapy drug also known as “the penicillin of cancer.”