R&D Magazine introduced its annual Scientist of the Year Award winner, Dr. Karl Deisseroth, and its Innovator of the Year Award winner, Dr. Hugh Herr. As R&D Magazine's 49th Scientist of the Year Award winner, Dr. Deisseroth is one of the United States’ leading researchers in the rapidly growing field of optogenetics, having invented several new technologies in support of efforts to understand neural functions in the human brain.
The human brain remains one of the least understood organs in the human body, because of its complexity and the difficulty of studying its physiology in the living body. Tufts Univ. researchers announced development of the first reported complex 3-D model made of brain-like cortical tissue that exhibits biochemical and electrophysiological responses and can function in the laboratory for months.
Researchers from the University of Texas at Austin and five other institutions have created a molecule that can cause cancer cells to self-destruct by ferrying sodium and chloride ions into the cancer cells. These synthetic ion transporters confirm a two-decades-old hypothesis that could point the way to new anticancer drugs while also benefitting patients with cystic fibrosis.
The Food and Drug Administration has approved the first screening test for colon cancer that uses patient DNA to help spot potentially deadly tumors and growths. The Cologuard test from Exact Sciences detects irregular mutations in a patient's stool sample that can be an early warning sign of cancer. Patients who test positive for the mutations should undergo a colonoscopy to confirm the results.
Wrapping wound dressings around fingers and toes can be tricky, but for burn victims, guarding them against infection is critical. At the National Meeting & Exposition of the American Chemical Society scientists have reported the development of new ultra-thin coatings called nanosheets that can cling to the body's contours and keep bacteria at bay. The super-thin sheets have been tested on mice and could help transform burn treatment.
Visual impairment comes in many forms, and it's on the rise in America. A Univ. of Cincinnati experiment aimed at this diverse and growing population could spark development of advanced tools to help all the aging baby boomers, injured veterans, diabetics and white-cane-wielding pedestrians navigate the blurred edges of everyday life.
Some of the most damaging brain diseases can be traced to irregular blood delivery in the brain. Now, Stanford Univ. chemists have employed lasers and carbon nanotubes to capture an unprecedented look at blood flowing through a living brain. The technique was developed for mice but could one day be applied to humans, potentially providing vital information in the study of stroke and migraines.
Graphene has excellent biocompatibility thanks to its great flexibility and chemical durability, and its conducting properties suggest uses for prosthetic devices in humans. Physicists are now developing key components of an artificial retina made of graphene. These retina implants may one day serve as optical prostheses for blind people whose optical nerves are still intact.
Brain tumors fly under the radar of the body’s defense forces by coating their cells with extra amounts of a specific protein, new research at the Univ. of Michigan shows. The findings, made in mice and rats, show the key role of a protein called galectin-1 in some of the most dangerous brain tumors, called high grade malignant gliomas. The stealth approach lets the tumors hide until it’s too late for the body to defeat them.
An outline of Marilyn Monroe's iconic face appeared on the clear, plastic film when a researcher fogs it with her breath. Terry Shyu, a doctoral student in chemical engineering at the Univ. of Michigan, was demonstrating a new high-tech label for fighting drug counterfeiting. While the researchers don't envision movie stars on medicine bottles, they used Monroe's image to prove their concept.
About one in four older adults suffers from chronic pain. Many of those people take medication, usually as pills. But this is not an ideal way of treating pain: Patients must take medicine frequently, and can suffer side effects, since the contents of pills spread through the bloodstream to the whole body. Now researchers have refined a technique that could enable pain medication to be released directly to specific parts of the body.
Neurons communicate with each other through electrical signals that are generated by chemicals, which bind to structures on neurons called neuroreceptors. One neuroreceptor, called 5HT3-R, is involved in a variety of neurological disorders. Scientists in Switzerland have revealed for the first time the 3-D structure of this crucial neuroreceptor.
DNA mutations had been thought to be rare events that occur randomly throughout the genome. However, recent studies have shown that cancer development frequently involves the formation of multiple mutations that arise simultaneously and in close proximity to each other. These groups of clustered mutations are frequently found in regions where chromosomal rearrangements take place.
Soon, protection from HIV infection could be as simple as inserting a medicated, disappearing fabric minutes before having sex. Univ. of Washington bioengineers have discovered a potentially faster way to deliver a topical drug that protects women from contracting HIV. Their method spins the drug into silk-like fibers that quickly dissolve when in contact with moisture, releasing high doses of the drug.
With the help of conventional inkjet printers, scientists are reporting new understanding about the dynamics of 3-D bioprinting that takes them a step closer to realizing their goal of making working tissues and organs on-demand. Their recent work in testing bioinks filled with hydrogel and different concentrations of mouse fibroblasts shed light on how the inks behave when they’re dispensed through printer nozzles.
What if computer screens had glasses instead of the people staring at the monitors? That concept is not too far afield from technology being developed by UC Berkeley computer and vision scientists. They are developing computer algorithms to compensate for an individual’s visual impairment, and creating vision-correcting displays that enable users to see text and images clearly without wearing eyeglasses or contact lenses.
The best way to cure most cases of cancer is to surgically remove the tumor. The Achilles heel of this approach, however, is that the surgeon may fail to extract the entire tumor, leading to a local recurrence. With a new technique based on injectable dye and infrared light, researchers in Pennsylvania have established a new strategy to help surgeons see the entire tumor in the patient, increasing the likelihood of a positive outcome.
The medical practice of Dr. Robert Howe, a reproductive endocrinologist in Massachusetts, introduced him to how computerized tomography could make precise 3-D images of body parts. As a student of music history, he realized the same technology could help him study delicate musical instruments from the past. With the help of engineers, these rare instruments are now being both imaged and printed printed in 3-D.
The Wyss Institute for Biologically Inspired Engineering at Harvard Univ. announced that its human “Organs-on-Chips” technology will be commercialized by a newly formed private company to accelerate development of pharmaceutical, chemical, cosmetic and personalized medicine products.
A new study has shown that it is possible to predict long-term cancer risk from a chemical exposure by measuring the short-term effects of that same exposure. The findings could make it possible to develop simpler and cheaper tests to screen chemicals for their potential cancer causing risk.
HIV-infected people carry many different HIV viruses and all have distinct personalities—some much more vengeful and infectious than others. Yet, despite the breadth of infectivity, roughly 76% of HIV infections arise from a single virus. Now, scientists believe they can identify the culprit with very specific measurements of the quantities of a key protein in the HIV virus.
The repetitive facilitation exercise is one of the most common rehabilitation tactics for stroke patients attempting to regain wrist movement. Stroke hemiparesis individuals are not able to move that part of their body because they cannot create a strong enough neural signal that travels from the brain to the wrist.
Lawrence Livermore National Laboratory scientists are developing electrode array technology for monitoring brain activity as part of a collaborative research project with the Univ. of California San Francisco (UC San Francisco) to better understand how the neural circuitry of the brain works during memory retrieval.
No batteries required: Scientists are creating a biological pacemaker by injecting a gene into the hearts of sick pigs that changed ordinary cardiac cells into a special kind that induces a steady heartbeat. The study, published Wednesday, is one step toward developing an alternative to electronic pacemakers that are implanted into 300,000 Americans a year.
Scientists have designed a new self-assembling nanoparticle that targets tumors, to help doctors diagnose cancer earlier. The new nanoparticle, developed by researchers in the U.K., boosts the effectiveness of magnetic resonance imaging scanning by specifically seeking out receptors that are found in cancerous cells.