A complex interplay of molecular components governs most aspects of biological sciences: healthy organism development, disease progression and drug efficacy are all dependent on the way life's molecules interact in the body. Understanding these biomolecular interactions is critical for the discovery of new therapeutics and diagnostics to treat diseases, but currently requires scientists to have access to expensive laboratory equipment.
Reducing the use of laboratory animals has been a long-term goal in biological research. Many...
When individuals wear their hearing aids for the first time, they are flooded with sounds they...
Researchers from North Carolina State Univ. have developed a new, wearable sensor that uses silver nanowires to monitor electrophysiological signals, such as electrocardiography (EKG) or electromyography (EMG). The new sensor is as accurate as the “wet electrode” sensors used in hospitals, but can be used for long-term monitoring and is more accurate than existing sensors when a patient is moving.
The human brain’s complexity makes it extremely challenging to study; not only because of its sheer size, but also because of the variety of signaling methods it uses simultaneously. Conventional neural probes are designed to record a single type of signaling, limiting the information that can be derived from the brain at any point in time. Now researchers at Massachusetts Institute of Technology may have found a way to change that.
Acute care nurse practitioner students, specializing in flight nursing at Case Western Reserve Univ., will soon be training in the nation’s first state-of-the-art simulator built in an actual helicopter. The simulator creates the sense of treating critically injured patients from takeoff to landing. The helicopter simulator was installed at the university’s Cedar Avenue Service Center.
Scientists have developed the first ultra-thin, flexible device that sticks to skin like a rub-on tattoo and can detect a person’s glucose levels. The sensor, reported in a proof-of-concept study in Analytical Chemistry, has the potential to eliminate finger-pricking for many people with diabetes.
Scientists from The Scripps Research Institute have identified a novel synthetic compound that sharply inhibits the activity of a protein that plays an important role in in the progression of breast and pancreatic cancers. In the new study the scientists showed that the compound, known as SR1848, reduces the activity and expression of the cancer-related protein called “liver receptor homolog-1” or LRH-1.
A group led by scientists has developed a new method for effectively extracting and analyzing cancer cells circulating in patients’ blood. Circulating tumor cells are cancer cells that break away from tumors and travel in the blood, looking for places in the body to grow new tumors called metastases. Capturing these rare cells would allow doctors to detect and analyze the cancer so they could tailor treatment for individual patients.
In a laboratory first, Duke Univ. researchers have grown human skeletal muscle that contracts and responds just like native tissue to external stimuli such as electrical pulses, biochemical signals and pharmaceuticals. The laboratory-grown tissue should soon allow researchers to test new drugs and study diseases in functioning human muscle outside of the human body.
Electroporation is a powerful technique in molecular biology. By using an electrical pulse to create a temporary nanopore in a cell membrane, researchers can deliver chemicals, drugs and DNA directly into a single cell. But existing electroporation methods require high electric field strengths and for cells to be suspended in solution, which disrupts cellular pathways and creates a harsh environment for sensitive primary cells.
A simple method to sense DNA, as well as potential biomarker proteins of cancer or other diseases such as Alzheimer's, may soon be within reach thanks to the work of a team of Yokohama National Univ. researchers in Japan. As the team reports in Applied Physics Letters, they created a photonic crystal nanolaser biosensor capable of detecting the adsorption of biomolecules based on the laser's wavelength shift.
The immune system is a complex network of many different cells working together to defend against invaders. Successfully fighting off an infection depends on the interactions between these cells. A new device developed by Massachusetts Institute of Technology engineers offers a much more detailed picture of that cellular communication.
Chemists have made a significant advancement to directly functionalize C-H bonds in natural products by selectively installing new carbon-carbon bonds into highly complex alkaloids and nitrogen-containing drug molecules. C-H functionalization is a much more streamlined process than traditional organic chemistry, holding the potential to greatly reduce the time and number of steps needed to create derivatives of natural products.
Proteins and other biomolecules are often analyzed exclusively in aqueous solutions in test tubes. But it is uncertain if these experimental studies can be transferred to the densely packed cellular environment. The Bochum-based researchers have developed a novel method which can be used to analyze the effects of the lack of space in living cells with the aid of a microscope for the first time.
Around 400 BC, Hippocrates was among the first people in recorded history to postulate the brain as the seat of sensation and intelligence. Yet only in the last 100 years have we identified, and closely studied, its key building block: the neuron. A highly specialized cell found in all but the simplest animals, like sponges, the neuron is one of the keys to understanding the brain.
The bionic age is no longer the workings of a far-fetched sci-fi movie; it’s here, now. We have experienced the first bionic eye and limbs. These technologies merge human capabilities with machines. They transform how we live, and who we are. They are improving quality of life. And there’s perhaps no greater example than R&D Magazine’s Innovator of the Year Prof. Hugh Herr.
Researchers at NYU Langone Medical Center have developed new technology that can assess the location and impact of a brain injury merely by tracking the eye movements of patients as they watch music videos for less than four minutes, according to a study published online in the Journal of Neurosurgery.
Researchers for the first time have developed a method to track through the human body the movement of polycyclic aromatic hydrocarbons, or PAHs, as extraordinarily tiny amounts of these potential carcinogens are biologically processed and eliminated.
Researchers have devised a way to replace the knee’s protective lining, called the meniscus, using a personalized 3D-printed implant, or scaffold, infused with human growth factors that prompt the body to regenerate the lining on its own. The therapy, successfully tested in sheep, could provide the first effective and long-lasting repair of damaged menisci.
Researchers at Yale Univ. have joined forces with a leading 3-D biology company, Organovo, to develop 3-D printed tissues for transplant research. As the number of donors for vital tissue and organ transplants decreases worldwide and the demand for transplants increases, 3-D bioprinting technology offers a solution to a long-standing and growing problem.
In a study in Neuron, scientists describe a new high data-rate, low-power wireless brain sensor. The technology is designed to enable neuroscience research that cannot be accomplished with current sensors that tether subjects with cabled connections. Experiments in the paper confirm that new capability.
A Univ. of Texas at Dallas professor applied robot control theory to enable powered prosthetics to dynamically respond to the wearer’s environment and help amputees walk. In recently published research, wearers of the robotic leg could walk on a moving treadmill almost as fast as an able-bodied person.
Los Alamos National Laboratory has released an updated version of powerful bioinformatics software that is now capable of identifying DNA from viruses and all parts of the Tree of Life—putting diverse problems such as identifying pathogen-caused diseases, selection of therapeutic targets for cancer treatment and optimizing yields of algae farms within relatively easy reach for health care professionals, researchers and others.
Researchers can now explore viruses, bacteria and components of the human body in more detail than ever before with software developed at The Scripps Research Institute. In a study published online in Nature Methods, the researchers demonstrated how the software, called cellPACK, can be used to model viruses such as HIV.
A team of scientists from Arizona State Univ.’s Biodesign Institute and IBM’s T.J. Watson Research Center have developed a prototype DNA reader that could make whole genome profiling an everyday practice in medicine. Such technology could help usher in the age of personalized medicine, where information from an individual’s complete DNA and protein profiles could be used to design treatments specific to their individual makeup.
Researchers at Tufts Univ., in collaboration with a team at the Univ. of Illinois at Urbana-Champaign, have demonstrated a resorbable electronic implant that eliminated bacterial infection in mice by delivering heat to infected tissue when triggered by a remote wireless signal. The silk and magnesium devices then harmlessly dissolved in the test animals. The technique had previously been demonstrated only in vitro.
Just in time for the holidays, Google is throwing its money, brain power and technology at the humble spoon. Of course these spoons (don't call them spoogles) are a bit more than your basic utensil: Using hundreds of algorithms, they allow people with essential tremors and Parkinson's disease to eat without spilling.
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