Researchers at Columbia University and Stanford University have developed a computational method that enables scientists to visualize and interpret "high-dimensional" data produced by single-cell measurement technologies such as mass cytometry. A sophisticated algorithm converts difficult-to-interpret data into visual representations similar to two-dimensional "scatter plots".
Your brain often works on autopilot when it comes to grammar. That theory has been around for years, but University of Oregon neuroscientists have captured elusive hard evidence that people indeed detect and process grammatical errors with no awareness of doing so.
Despite the perceived advantages of foot protection, some runners in recent years have returned to barefoot running, believing it is a more natural way to run and therefore less injurious to the feet and legs. The difference results in a different running stride, and it affects how the muscles of the legs and feet respond and develop. A new study attempts to explain exactly how the muscles respond to this change.
Metal elements and molecules interact in the body, but visualizing them together has always been a challenge. Researchers at RIKEN in Japan have developed a new molecular imaging technology that enables them to image bio-metals and bio-molecules at the same time in a live mouse. This new technology will enable researchers to study the complex interactions between metal elements and molecules in living organisms.
Metal elements and molecules interact in the body but visualizing them together has always been a challenge. Researchers from the RIKEN Center for Life Science Technologies have developed a new molecular imaging technology that enables them to visualize biometals and biomolecules simultaneously in a live mouse. This new technology will enable researchers to study the complex interactions between metal elements and molecules.
Scientists at TU Delft have made an important advancement in a new microscopic technique that is widely used in medical research. They demonstrate what the resolution of this localization microscopy is and how the best resolution can be achieved as quickly as possible.
To get a better understanding of metastasis, more than 95 graduate students, post docs and professors in a variety of laboratories across the U.S. subjected two cell lines to a battery of tests and measurements using more than 20 different techniques. The work has enabled a comprehensive cataloging and comparison of the physical characteristics of non-malignant and metastatic cells.
Researchers have married two biological imaging technologies, creating a new way to learn how good cells go bad. Being able to study a cell's internal workings in fine detail would likely yield insights into the physical and biochemical responses to its environment. The technology, which combines an atomic force microscope and nuclear magnetic resonance system, could help researchers study individual cancer cells.
To understand the development of sensory representations within our brain, we have to comprehend how electrical activation is linked to the sensory experience. For this reason, researchers in Italy have analyzed the behavior and the activation of neural networks in rats while carrying out tactile object recognition tests. The study represents the first time that the activity of multiple neurons has been monitored.
A dye-based imaging technique known as two-photon microscopy can produce pictures of active neural structures in much finer detail than functional magnetic resonance imaging, but it requires expensive femtosecond lasers to fluoresce existing dyes. A research team at the University of Pennsylvania has developed a new kind dye that fluoresces easily and produces quality images with far less powerful lasers.
Scientists at the University of California, Berkeley, have discovered that when we embark on a targeted search, various visual and non-visual regions of the brain mobilize to track down a person, animal, or thing. That means that if we're looking for a youngster lost in a crowd, the brain areas usually dedicated to recognizing other objects shift their focus and join the search party.
A Purdue University-led team has revealed the proton transfer pathway responsible for a majority of energy storage in photosynthesis. The team used X-ray crystallography to describe the molecular structure of the cytochrome complex isolated from cyanobacteria, the most primitive photosynthetic organism. The findings contribute to the understanding of the function of photosynthesis and that of membrane proteins.
Much research has demonstrated that chronic stress elevates levels of glucocorticoid stress hormones, which impairs memory. And stress is associated with a lot of other physical ailments. But less is known about the effects of acute stress, and studies have been conflicting. Recent work shows that intense, short-lived stress causes the proliferation of new neurons, improving mental performance.
How do nerve cells—which can each be up to three feet long in humans—keep from rupturing or falling apart? Recent research reports that axons, the long, cable-like projections on neurons, are made stronger by a unique modification of the common molecular building block of the cell skeleton. The finding may help guide the search for treatments for neurodegenerative diseases.
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed a new tool to help surgeons use X-rays to track devices used in “minimally invasive” surgical procedures while also limiting the patient’s exposure to radiation from the X-rays.
A new class of tiny, injectable light-emitting diodes (LEDs) is illuminating the deep mysteries of the brain. Researchers at the University of Illinois at Urbana-Champaign and Washington University in St. Louis developed ultrathin, flexible optoelectronic devices—including LEDs the size of individual neurons—that are lighting the way for neuroscientists in the field of optogenetics and beyond.
In a provocative new study, scientists reported Wednesday that they were able to "see" pain on brain scans and, for the first time, measure its intensity and tell whether a drug was relieving it. Though the research is in its early stages, it opens the door to a host of possibilities. For example, scans might be used someday to tell when pain is hurting a baby, someone with dementia, or a paralyzed person unable to talk.
The NeuroBlate Thermal Therapy System is a new device that uses a minimally invasive, magnetic resonance imaging (MRI)-guided laser system to coagulate, or heat and kill, brain tumors. The MRI basically "cooks" brain tumors in a controlled fashion to destroy them. The first-in-human study of the system finds that it appears to provide a new, safe and minimally invasive procedure for treating recurrent glioblastoma, a malignant type of brain tumor.
A technology being developed at Oak Ridge National Laboratory promises to provide clear images of the brains of children, the elderly, and people with Parkinson's and other diseases without the use of uncomfortable or intrusive restraints. Awake imaging provides motion compensation reconstruction, which removes blur caused by motion, allowing physicians to get a transparent picture of the functioning brain without anesthetics that can mask conditions and alter test results.
Although bladder cancer is the sixth most common form of cancer in the U.S. and the most expensive to treat, the basic method that doctors use to treat it hasn’t changed much in more than 70 years. A research team may soon be changing that dramatically after having developed a prototype telerobotic platform designed to be inserted through natural orifices—in this case the urethra—that can provide surgeons with a much better view, making it easier to remove tumors.
Olympic swimmers aren’t the only ones who change their strokes to escape competitors. To escape from the jaws and claws of predators in cold, viscous water, marine copepods switch from a wave-like swimming stroke to big power strokes, a behavior that has now been revealed thanks to 3D high-speed digital holography.
Researchers from Georgia Tech and Children's Healthcare of Atlanta have developed a technique that assists in identifying tumors from normal brain tissue during surgery by staining tumor cells blue. The technique could be critically important for hospitals lacking sophisticated equipment in preserving the maximum amount of normal tissue and brain function during surgery.
University of Texas, Dallas researchers are developing a new low-light imaging method that could improve a number of scientific applications, including the microscopic imaging of single molecules in cancer research. The team's method minimizes the deterioration of images that can occur with conventional imaging approaches.
The biological sources of methane are wide-ranging. However, the conditions have to be always oxygen-free and the exact mechanism has been unclear. A team of researchers in Germany has gained insight into microbiological methane production by explaining the structure of a hydrogenase used by archaebacteria to split hydrogen to produce methane
New research offers a more comprehensive way of analyzing one cell’s unique behavior, using an array of colors to show patterns that could indicate why a cell will or won’t become cancerous. A University of Washington team has developed a new method for color-coding cells that allows them to illuminate 100 biomarkers, a ten-time increase from the current research standard