Univ. of Michigan researchers are the first to use brain imaging procedures to track the clinical action of pregabalin, a drug known by the brand name Lyrica that is prescribed to patients suffering from fibromyalgia and neuropathic pain. The study suggests role of brain imaging in creating personalized treatment of chronic pain.
Arizona State University is teaming up with seven other research universities to establish a new Science and Technology Center (STC), sponsored by the National Science Foundation. The center will be based at the University at Buffalo. It is expected to transform the field of structural and dynamic molecular biology, including drug development, by using x-ray lasers to peer into biological molecules.
Scientists have developed a 3D filming technique that has brought fresh insights into the behavior of malaria sperm. They were able to see that malaria sperm move in an irregular, lopsided corkscrew motion. Understanding how malaria parasites mate could pave the way for improved prevention and control of this deadly disease.
Researchers at the Univ. of Chicago are developing computer-aided diagnosis and quantitative image analysis methods for mammograms, ultrasounds and magnetic resonance images to identify specific tumor characteristics, including size, shape and sharpness
Most people know about ultrasound through its role in prenatal imaging: those grainy, grey outlines of junior constructed from reflected sound waves. A new technology called an "acoustic diode” that would transmit sound in one direction may dramatically improve future ultrasound images by changing the way sound waves are transmitted.
Microbeam radiation therapy provides tremendous promise for cancer patients through its ability to destroy tumor cells while protecting surrounding healthy tissue. Yet research into its clinical use has been limited by the sheer size of the technology required to generate the beams. Until now.
The increasingly powerful microscopes used in biomedical imaging provide biologists with 3-D images of hundreds of cells, and cells in these images are often layered on each other. Under these conditions, it is impossible for traditional computational methods to determine the cells' properties. Researchers have developed a virtual tool that can analyze dozens of images in just an hour. This works out to hundreds of cells.
Researchers using transmission electron microscopy have examined the smallest building block of coral that can be identified: sphemlites. These studies have revealed three distinct regions whose formation could be directly correlated to the time of day. These findings could help scientists and environmentalists working to protect and conserve coral from the threats of acidification and rising water temperatures.
A lens with ten times the resolution of any current lens, making it a powerful new tool for the biological sciences, has been developed by researchers at the Univ. of Sydney. The lens was created using fiber-optic manufacturing technology, and is a metamaterial, or a material with completely new properties not found in nature.
Dendrites, the branch-like projections of neurons, were once thought to be passive wiring in the brain. But now researchers at the Univ. of North Carolina at Chapel Hill have shown that these dendrites do more than relay information from one neuron to the next. They actively process information, multiplying the brain's computing power.
Researchers in The Netherlands have recently unveiled their “photoacoustic mammoscope,” a new device that could someday be used for routine breast cancer screenings. Instead of x-rays, which are used in traditional mammography, the photoacoustic breast mammoscope uses a combination of infrared light and ultrasound to create a 3-D map of the breast.
OnTarget Laboratories LLC has teamed with partners in academia to test a novel optical imaging technology developed at Purdue Univ. that could help surgeons see cancer tissue during surgery. The technology is based on the over-expression of specific receptors on solid cancerous tumors and enables illumination of the tumor tissue during surgery.
Cell biologists and chemists in Switzerland have revealed how viral DNA moves in human cells. They have developed a new method to generate virus particles containing labeled viral DNA genomes, which has allowed them to visualize, for the first time, single viral genomes in the cytoplasm and the nucleus.
Human fingertips have several types of sensory neurons that are responsible for relaying touch signals to the central nervous system. Scientists have long believed these neurons followed a linear path to the brain with a "labeled-lines" structure. But new research on mouse whiskers reveals a surprise: At the fine scale, the sensory system's wiring diagram doesn't have a set pattern.
During open surgery, doctors rely on their sense of touch to identify anatomical structures: a procedure they call palpation. But this practice is not possible in minimally invasive surgery where surgeons work with small, specialized tools and miniature cameras. A small, wireless capsule has been developed that can restore the sense of touch that surgeons are losing as they shift increasingly from open to minimally invasive surgery.
In the search to understand memory, Wei Min is looking at cells at the most basic level, long before the formation of neurons and synapses. The asst. prof. of chemistry studies the synthesis of proteins, the building blocks of the body formed using genetic code from DNA. “We want to understand the molecular nature of memory, one of the key questions that remain in neuroscience,” he says.
Researchers have developed a new quantitative method of identifying pollen grains that is certainly nothing to sneeze at. Since the invention of the light microscopes, the classification of pollen and spores has been a highly subjective venture for those who use these tiny particles to study vegetation in their field, palynology. However, the limitations have kept researchers from classifying pollen and spores beyond a general level.
The microscopic technique, developed by researchers at Queen Mary Univ. of London, represents a major advance for cell biologists as it will allow them to investigate structures deep inside the cell, such as viruses, bacteria and parts of the nucleus in depth.
With high-tech optical tools and sophisticated mathematics, Rice Univ. researchers have found a way to pinpoint the location of specific sequences along single strands of DNA, a technique that could someday help diagnose genetic diseases. Proof-of-concept experiments in the Rice laboratory of chemist Christy Landes identified DNA sequences as short as 50 nucleotides at room temperature.
Autumn is usually not such a great time for big special effects movies as the summer blockbusters have faded and those for the holiday season have not yet opened. Fall is more often the time for thoughtful films about small subjects, which makes it perfect for the unveiling of a new movie produced by researchers at Lawrence Berkeley National Laboratory.
Scientists at Massachusetts Institute of Technology and the Univ. of Texas at Arlington have developed a new type of microscopy that can image cells through a silicon wafer, allowing them to precisely measure the size and mechanical behavior of cells behind the wafer. The new technology, which relies on near-infrared light, could help scientists learn more about diseased or infected cells as they flow through silicon microfluidic devices.
A team from the Univ. of Illinois at Urbana-Champaign and Northwestern Univ. has devised a novel nuclear magnetic resonance imaging (MRI) technique that delivers a roughly 10-nm spatial resolution. This represents a significant advance in MRI sensitivity as modern MRI techniques yield spatial resolutions on the millimeter length scale, with the highest-resolution experimental instruments giving spatial resolution of a few micrometers.
Tracking blood flow in the laboratory is an important tool for studying ailments and is usually measured in the clinic using professional imaging equipment and techniques like laser speckle contrast imaging. Now, developers have built a new biological imaging system 50 times less expensive than standard equipment, and suitable for imaging applications outside of the laboratory.
Inspired by how wireless communication networks use multiple radio frequencies to communicate with multiple users, researchers from the Univ. of California, Los Angeles have developed a new high-speed microscopy technique that is an order of magnitude faster than current fluorescence-imaging technologies.
Using a new and super-sensitive instrument, researchers have discovered where a protein binds to plant cell walls, a process that loosens the cell walls and makes it possible for plants to grow. Finding that binding target has been a major challenge for structural biologists because there are only tiny amounts of the protein involved in cell growth and cell walls are very complex.