Univ. of California, Los Angeles researchers have developed a lens-free microscope that can be used to detect the presence of cancer or other cell-level abnormalities with the same accuracy as larger and more expensive optical microscopes. The invention could lead to less expensive and more portable technology for performing common examinations of tissue, blood and other biomedical specimens.
Around 400 BC, Hippocrates was among the first people in recorded history to postulate the brain...
Earlier this month, the NTSB released its...
A widely presumed problem of aging is that the brain becomes less flexible or plastic, and that...
Massachusetts Institute of Technology chemists have developed new nanoparticles that can simultaneously perform magnetic resonance imaging (MRI) and fluorescent imaging in living animals. Such particles could help scientists to track specific molecules produced in the body, monitor a tumor’s environment, or determine whether drugs have successfully reached their targets.
Researchers are close to commercializing a new type of medical imaging technology that could diagnose cardiovascular disease by measuring ultrasound signals from molecules exposed to a fast-pulsing laser. The system takes precise 3-D images of plaques lining arteries and identifies deposits that are likely to rupture and cause heart attacks.
The heart holds its own pool of immune cells capable of helping it heal after injury, according to new research in mice at Washington University School of Medicine in St. Louis. When the heart is injured, beneficial immune cells are often supplanted by bone marrow cells, which cause damaging inflammation. In a mouse model, researchers showed that blocking the bone marrow’s macrophages protects the organ’s beneficial pool of macrophages.
While megakaryocytes are best known for producing platelets that heal wounds, these "mega" cells found in bone marrow also play a critical role in regulating stem cells according to new research from the Stowers Institute for Medical Research. The study is the first to show that hematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes).
Researchers are exploring the usefulness of ultrasound imaging to study dangerous abdominal aortic aneurysms, a bulging of the aorta that is usually fatal when it ruptures and for which there is no effective medical treatment. Abdominal aortic aneurysms are the 13th leading cause of death in the U.S., killing about 15,000 annually.
The proteins that drive DNA replication are some of the most complex machines on Earth and the process involves hundreds of atomic-scale moving parts that rapidly interact and transform. Now, scientists have pinpointed crucial steps in the beginning of the replication process, including surprising structural details about the enzyme that "unzips" and splits the DNA double helix so the two halves can serve as templates for DNA duplication.
Two Americans and a German scientist won the 2014 Nobel Prize in chemistry Wednesday for finding ways to make microscopes more powerful than previously thought possible. Working independently of each other, U.S. researchers Eric Betzig and William Moerner and Stefan Hell of Germany shattered previous limits on the resolution of optical microscopes by using molecules that glow on command to peer inside tiny components of life.
A U.S.-British scientist and a Norwegian husband-and-wife research team won the Nobel Prize in medicine for discovering the brain's navigation system—the inner GPS that helps us find our way in the world—a revelation that could lead to advances in diagnosing Alzheimer's. The research by John O'Keefe, May-Britt Moser and Edvard Moser represents a "paradigm shift" in neuroscience that could help researchers understand Alzheimer's disease.
People who wish to know how memory works are forced to take a glimpse into the brain. They can now do so without bloodshed: Researchers have developed a new method for creating 3-D models of memory-relevant brain structures. The approach is unique because it enables automatic calculation of the neural interconnections in the brain on the basis of their position inside the space and their projection directions.
The National Institutes of Health this week announced its first research grants through President Barack Obama’s BRAIN Initiative, including three awards to the Univ. of California, Berkeley, totaling nearly $7.2 million over three years. The projects are among 58 funded in this initial wave of NIH grants, involving 100 researchers and a total of $46 million in fiscal year 2014 dollars alone.
Only a minority of suspicious mammograms actually leads to a cancer diagnosis, which results in lots of needless worry and spent time for women and their families. Ultrasound elastography could be an excellent screening tool but it requires a lot of skill and interpretation. In an effort to improve results, researchers in Michigan have developed a virtual “breast”, allowing medical professionals to practice in the laboratory.
Massachusetts Institute of Technology engineers have devised a way to rapidly test hundreds of different drug-delivery vehicles in living animals, making it easier to discover promising new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA and DNA, to human patients.
How the brain ages is still largely an open question because this organ is mostly insulated from direct contact with other systems in the body. In recent research, scientists in Israel found evidence of a unique “signature” that may be the “missing link” between cognitive decline and aging. The scientists believe that this discovery may lead, in the future, to treatments that can slow or reverse cognitive decline in older people.
For years, neuroscientists have been trying to develop tools that would allow them to clearly view the brain's circuitry in action. To get this complete picture, neuroscientists are working to develop a range of new tools to study the brain. Researchers at Caltech have developed one such tool that provides a new way of mapping neural networks in a living organism.
Researchers have developed an optical method that makes individual proteins, such as the proteins characteristic of some cancers, visible. Other methods that achieve this only work if the target biomolecules have first been labeled with fluorescent tags, but this approach is very difficult. By contrast, the new method allows scientists to directly detect the scattered light of individual proteins via their shadows.
A new $1.9 million study at the Univ. of Michigan seeks to make low-dose computed tomography scans a viable screening technique by speeding up the image reconstruction from half an hour or more to just five minutes. The advance could be particularly important for fighting lung cancers, as symptoms often appear too late for effective treatment.
Researchers have shown how to use a new imaging platform to map lipid metabolism in living cells, discovering specifically where cholesterol is stored and pointing toward further studies in obesity, diabetes and longevity. The imaging approach makes it possible to not only quantify the storage of cholesterol, but also the "desaturation" and oxidation of lipids, which may reduce the ability of cells to use insulin.
It may look like fresh blood and flow like fresh blood, but the longer blood is stored, the less it can carry oxygen into the tiny microcapillaries of the body. Using advanced optical techniques, researchers measured the stiffness of the membrane surrounding red blood cells over time. They found that, even though the cells retain their shape and hemoglobin content, the membranes get stiffer, steadily decreasing the cells’ functionality.
Cancerous brain tumors are notorious for growing back despite surgical attempts to remove them, and for leading to a dire prognosis for patients. But scientists are developing a new way to try to root out malignant cells during surgery so fewer or none get left behind to form new tumors. The technology relies on a Raman scanner that can read injected nanoprobes.
Scientists in Germany have managed to take a unique look at the membranes of human cells using a new technique called dSTORM: direct stochastic optical reconstruction microscopy. This is a specific form of high-resolution fluorescence microscopy, and it makes individual saccharified proteins and lipids visible at the molecular level.
Specialized cells can break through normal tissue boundaries and burrow into other tissues and organs. This crucial step in many normal developmental processes is guided by an extracellular cue called netrin, which orients the anchor cell so that it invades in the right direction. In a new study, researchers have shown how receptors on the invasive cells rove around the cell membrane ”hunting” for a missing netrin signal.
In 2012, more than 85 million computed tomography (CT) scans were performed in the U.S. Of these, 16% were thoracic scans. Up to now, this has been done manually and sequentially in what is a tedious, lengthy and error-prone process. Engineers at Siemens Corporate Technology and Siemens Healthcare, Computed Tomography have launched a new solution to save radiologists time and increase diagnostic confidence for thoracic bone assessment.
The human brain harbors far more copper, iron and zinc than anywhere else in the body. Abnormally high levels of these metals can lead to disorders such as Alzheimer’s and Parkinson’s diseases. Chris Chang, a faculty chemist with Berkeley Lab’s Chemical Sciences Div., has spent the past several years developing new probes and techniques for imaging the molecular activity of these metals in the brain.
Conventional wisdom holds that the cytoplasm of mammalian cells is a viscous fluid, with organelles and proteins suspended within it, jiggling against one another and drifting at random. However, a new biophysical study led by researchers at Harvard Univ. challenges this model and reveals that those drifting objects are subject to a very different type of environment.
The Univ. of California, San Diego’s Nanofabrication Cleanroom Facility (Nano3) is the first institution to obtain a new FEI Scios dual-beam microscope, with an adaptation for use at cryogenic temperatures. The new microscope allows biologists to nanomachine cells to reduce them to the thickness required for electron microscopy without creating any sample distortions and while maintaining cryogenic temperatures.
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