For years, neuroscientists have been trying to develop tools that would allow them to clearly view the brain's circuitry in action. To get this complete picture, neuroscientists are working to develop a range of new tools to study the brain. Researchers at Caltech have developed one such tool that provides a new way of mapping neural networks in a living organism.
A new $1.9 million study at the Univ. of Michigan seeks to make low-dose computed tomography...
Researchers have shown how to use a new imaging platform to map lipid metabolism in living cells...
It may look like fresh blood and flow like fresh blood, but the longer blood is stored, the less it can carry oxygen into the tiny microcapillaries of the body. Using advanced optical techniques, researchers measured the stiffness of the membrane surrounding red blood cells over time. They found that, even though the cells retain their shape and hemoglobin content, the membranes get stiffer, steadily decreasing the cells’ functionality.
Cancerous brain tumors are notorious for growing back despite surgical attempts to remove them, and for leading to a dire prognosis for patients. But scientists are developing a new way to try to root out malignant cells during surgery so fewer or none get left behind to form new tumors. The technology relies on a Raman scanner that can read injected nanoprobes.
Scientists in Germany have managed to take a unique look at the membranes of human cells using a new technique called dSTORM: direct stochastic optical reconstruction microscopy. This is a specific form of high-resolution fluorescence microscopy, and it makes individual saccharified proteins and lipids visible at the molecular level.
Specialized cells can break through normal tissue boundaries and burrow into other tissues and organs. This crucial step in many normal developmental processes is guided by an extracellular cue called netrin, which orients the anchor cell so that it invades in the right direction. In a new study, researchers have shown how receptors on the invasive cells rove around the cell membrane ”hunting” for a missing netrin signal.
In 2012, more than 85 million computed tomography (CT) scans were performed in the U.S. Of these, 16% were thoracic scans. Up to now, this has been done manually and sequentially in what is a tedious, lengthy and error-prone process. Engineers at Siemens Corporate Technology and Siemens Healthcare, Computed Tomography have launched a new solution to save radiologists time and increase diagnostic confidence for thoracic bone assessment.
The human brain harbors far more copper, iron and zinc than anywhere else in the body. Abnormally high levels of these metals can lead to disorders such as Alzheimer’s and Parkinson’s diseases. Chris Chang, a faculty chemist with Berkeley Lab’s Chemical Sciences Div., has spent the past several years developing new probes and techniques for imaging the molecular activity of these metals in the brain.
Conventional wisdom holds that the cytoplasm of mammalian cells is a viscous fluid, with organelles and proteins suspended within it, jiggling against one another and drifting at random. However, a new biophysical study led by researchers at Harvard Univ. challenges this model and reveals that those drifting objects are subject to a very different type of environment.
The Univ. of California, San Diego’s Nanofabrication Cleanroom Facility (Nano3) is the first institution to obtain a new FEI Scios dual-beam microscope, with an adaptation for use at cryogenic temperatures. The new microscope allows biologists to nanomachine cells to reduce them to the thickness required for electron microscopy without creating any sample distortions and while maintaining cryogenic temperatures.
Some of the most damaging brain diseases can be traced to irregular blood delivery in the brain. Now, Stanford Univ. chemists have employed lasers and carbon nanotubes to capture an unprecedented look at blood flowing through a living brain. The technique was developed for mice but could one day be applied to humans, potentially providing vital information in the study of stroke and migraines.
Melanoma is the fifth most common cancer type in the United States. A new handheld device may help diagnosis and treatment efforts for the disease. It uses lasers and sound waves and is the first that can be used directly on a patient to accurately measure how deep a melanoma tumor extends into the skin.
Brain tumors fly under the radar of the body’s defense forces by coating their cells with extra amounts of a specific protein, new research at the Univ. of Michigan shows. The findings, made in mice and rats, show the key role of a protein called galectin-1 in some of the most dangerous brain tumors, called high grade malignant gliomas. The stealth approach lets the tumors hide until it’s too late for the body to defeat them.
In 2012, a team of researchers in London imaged, for the first time, the structure of the DNA double helix. James Watson and Francis Crick discovered DNA 60 years ago by laboriously studying x-ray diffraction images of millions of DNA molecules. However, Dr. Bart Hoogenboom and Dr. Carl Leung used atomic force microscopy (AFM) to directly “feel” the molecule’s structure in a fraction of the time.
Using cryo-electron microscopy technology from FEI Corp., researchers at the NIH-FEI Living Lab for Structural Biology have determined the structural mechanism by which glutamate receptors participate in the transmission of signals between neurons in the brain. The findings suggest a major breakthrough: that the determination of membrane proteins may no longer be limited by size or the need for crystallization.
Magnetic resonance imaging (MRI) is best-known for its use in medicine, but because MRI operates by quantum principles it translates to other quantum systems. Recently, physicists at the Joint Quantum Institute have executed an MRI-like diagnostic on a crystal of interacting quantum spins. The technique reveals many features of their system, such as the spin-spin interaction strengths and the energies of various spin configurations.
Neurons communicate with each other through electrical signals that are generated by chemicals, which bind to structures on neurons called neuroreceptors. One neuroreceptor, called 5HT3-R, is involved in a variety of neurological disorders. Scientists in Switzerland have revealed for the first time the 3-D structure of this crucial neuroreceptor.
In the same week that the U.S. surgeon general issued a lengthy report about the dangers of skin cancer, researchers at Montana State Univ. published a paper breaking new ground on how DNA responds when exposed to ultraviolet (UV) light. The study, made possible by femtosecond lasers used for ultrafast spectroscopy, showed how DNA transfers electrons when excited by UV light.
What if computer screens had glasses instead of the people staring at the monitors? That concept is not too far afield from technology being developed by UC Berkeley computer and vision scientists. They are developing computer algorithms to compensate for an individual’s visual impairment, and creating vision-correcting displays that enable users to see text and images clearly without wearing eyeglasses or contact lenses.
The best way to cure most cases of cancer is to surgically remove the tumor. The Achilles heel of this approach, however, is that the surgeon may fail to extract the entire tumor, leading to a local recurrence. With a new technique based on injectable dye and infrared light, researchers in Pennsylvania have established a new strategy to help surgeons see the entire tumor in the patient, increasing the likelihood of a positive outcome.
The medical practice of Dr. Robert Howe, a reproductive endocrinologist in Massachusetts, introduced him to how computerized tomography could make precise 3-D images of body parts. As a student of music history, he realized the same technology could help him study delicate musical instruments from the past. With the help of engineers, these rare instruments are now being both imaged and printed printed in 3-D.
When it comes to swimming, the bodies of some bacteria are more than just dead weight, according to new research from Brown Univ. Many bacteria swim using flagella, corkscrew-like appendages that push or pull bacterial cells like tiny propellers. It's long been assumed that the flagella do all the work during swimming, while the rest of the cell body is just along for the ride.
Janelia Research Campus experts have built a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell. Using image data obtaining using a sophisticated form of light sheet microscopy, the tool can track the movement of cells in an animal’s body in 3-D.
Scientists have designed a new self-assembling nanoparticle that targets tumors, to help doctors diagnose cancer earlier. The new nanoparticle, developed by researchers in the U.K., boosts the effectiveness of magnetic resonance imaging scanning by specifically seeking out receptors that are found in cancerous cells.
Prothrombin is an inactive precursor for thrombin, a key blood-clotting protein, and is essential for life because of its ability to coagulate blood. Using x-ray crystallography, researchers have published the first image of this important protein. By removing disordered sections of the protein’s structure, scientists have revealed its underlying molecular mechanism for the first time.
Developmental processes in all living organisms are controlled by genes. At the same time there is a continuous metabolism taking place. Recent research in Austria has analyzed this interaction in flowering plants. For the first time, changes in metabolism were linked to 3-D morphometric data using micro-computed tomography (micro-CT) for the first time.
Scientists succeeded in obtaining an unprecedented view of a type of brain cell receptor that is implicated in a range of neurological illnesses. The team of biologists at Cold Spring Harbor Laboratory used the Advanced Photon Source at Argonne National Laboratory to get an atomic-level picture of the intact NMDA (N-methyl, D-aspartate) receptor should serve as template and guide for the design of therapeutic compounds.
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