The gap between stem cell research and regenerative medicine just became a lot narrower, thanks to a new technique that coaxes stem cells, with potential to become any tissue type, to take the first step to specialization. It is the first time this critical step has been demonstrated in a laboratory.
A fast and cost-effective genetic test to determine the correct dosage of blood thinning drugs for the treatment of stroke, heart problems and deep vein thrombosis has been developed by researchers in Singapore. The new test, which uses gold nanoparticles mixed with DNA samples in solution, can quickly recognize three of the most common genetic variations associated with warfarin response.
New research by an international consortium may help physicians better understand the chronological development of a brain aneurysm. Using radiocarbon dating to date samples of ruptured and unruptured cerebral aneurysm tissue, the team, led by neurosurgeon Nima Etminan, found that the main structural constituent and protein—collagen type I—in cerebral aneurysms is distinctly younger than once thought.
Traumatic bone injuries are often so severe that the body can’t effectively repair the damage on its own. To aid the recovery, clinicians inject patients with growth factors. The treatment is costly, requiring large amounts of expensive growth factors. The growth factors also disperse, creating unwanted bone formation around the injury. A new technology could provide more efficient delivery of the bone regenerating growth factors.
A team of researchers has successfully tracked single molecules inside living cells with carbon nanotubes. Through this new method, the researchers found that cells stir their interiors using the same motor proteins that serve in muscle contraction. The study, which sheds new light on biological transport mechanisms in cells, appears in Science.
A Harvard Univ.-led team is the first to demonstrate the ability to use low-power light to trigger stem cells inside the body to regenerate tissue, an advance they reported in Science Translational Medicine. The research lays the foundation for a host of clinical applications in restorative dentistry and regenerative medicine more broadly, such as wound healing, bone regeneration and more.
Every once in a while in the U.S., bacterial meningitis seems to crop up out of nowhere, claiming a young life. Part of the disease’s danger is the ability of the bacteria to evade the body’s immune system, but scientists are now figuring out how the pathogen hides in plain sight. Their findings, which could help defeat these bacteria and others like it, appear in the Journal of the American Chemical Society.
Developmental biologists at Tufts Univ., using a tadpole model, have shown that bioelectrical signals from distant cells control the incidence of tumors arising from cancer-causing genes and that this process is impacted by levels of a common fatty acid produced by bacteria found in the tadpole and also in humans.
A new technology developed in Denmark uses the HIV virus as a tool in the fight against hereditary diseases and, in the long term, against HIV infection as well. The technology repairs the genome in a new and safer manner by using the virus as nanoparticles to manage the “cut and paste” approach to modifying the genome.
Research linking New Zealand's diminutive kiwi with a giant extinct bird from Africa is prompting scientists to rethink how flightless birds evolved. Instead, it's more likely their chicken-size, flight-capable ancestors enjoyed a window of evolutionary ascendancy about 60 million years ago, after dinosaurs died out and before mammals grew big. The study contradicts earlier theories about the evolution of flightless birds.
Using molecules of DNA like an architectural scaffold, Arizona State Univ. scientists, in collaboration with colleagues at the Univ. of Michigan, have developed a 3-D artificial enzyme cascade that mimics an important biochemical pathway that could prove important for future biomedical and energy applications.
Taking a moment to pause and relax can help if you find yourself in a tight spot. This strategy can work for molecules as well as people, it turns out. Researchers at the Univ. of California, San Diego have found that DNA packs more easily into the tight confines of a virus when given a chance to relax.
Researchers at the Univ. of Massachusetts will lead an international team of scientists in the development and implementation of a new optogenetic platform that can remotely activate neurons inside a free-moving organism. Using a new class of nanoparticles they propose to selectively turn on non-image forming photoreceptors inside mice and Drosophila, unencumbered by the fiber optic wires currently used in optogenetic technologies.
A pathway to the design of even more effective versions of the powerful anticancer drug Taxol has been opened with the most detailed look ever at the assembly and disassembly of microtubules, tiny fibers of tubulin protein that form the cytoskeletons of living cells and play a crucial role in mitosis.
A new study reveals how T cells, the immune system’s foot soldiers, respond to an enormous number of potential health threats. X-ray studies at the SLAC National Accelerator Laboratory, combined with Stanford Univ. biological studies and computational analysis, revealed remarkable similarities in the structure of binding sites which allow a given T cell to recognize many different invaders that provoke an immune response.
Widespread application of manufactured liposomes as artificial drug carriers has been hindered by factors such as inconsistency in size, structural instability, and high production costs. Researchers have designed a new liposome production system from bundled capillary tubes. It costs less than a $1 to make, requires no special fabrication technology, and consistently yields large quantities of uniform and sturdy vesicles.
North Carolina State Univ. entomologists are part of a research team that has for the first time sequenced the genome of a member of the termite order, the dampwood termite (Zootermopsis nevadensis). The findings on the genetic blueprint of the dampwood termite, one of the world’s most primitive social insects, highlight key differences and similarities with other social insects and provide insight into how social insects evolved.
Inspired by fictional cyborgs like Terminator, a team of researchers at the Univ. of Michigan and the Univ. of Pittsburgh has made the first bionic particles from semiconductors and proteins. These particles recreate the heart of the process that allows plants to turn sunlight into fuel.
A new “lab-on-a-chip” platform developed at the Institute of Photonic Sciences in Spain is capable of detecting detect very low concentrations of protein cancer markers, enabling diagnoses of the disease in its earliest stages. The device, just a few square centimeters in size, uses recent advances in plasmonics, nano-fabrication, microfluids and surface chemistry.
Researchers at Massachusetts Institute of Technology and the Univ. of Vienna have created an imaging system that reveals neural activity throughout the brains of living animals. This technique, the first that can generate 3-D movies of entire brains at the millisecond timescale, could help scientists discover how neuronal networks process sensory information and generate behavior.
Univ. of Utah researchers devised a way to watch newly forming AIDS virus particles emerging or “budding” from infected human cells without interfering with the process. The method shows a protein named ALIX gets involved during the final stages of virus replication, not earlier, as was believed previously.
A new study could help resolve a longstanding debate about the origins of the first people to inhabit the Americas, researchers report in Science. The study relies on genetic information extracted from the tooth of an adolescent girl who fell into a sinkhole in the Yucatan 12,000 to 13,000 years ago.
If studying a single gene or a diet that might extend longevity is like searching for a fountain of youth, then a new study calls for looking at something more like the whole watershed. Brown Univ. biologists who experimentally throttled three such factors in fruit flies found that lifespan depended more on interactions among the factors than on the factors themselves.
A new study reveals that a protein of the Ebola virus can transform into three distinct shapes, each with a separate function that is critical to the virus’s survival. Each shape offers a potential target for developing drugs against Ebola virus disease, a hemorrhagic fever that kills up to nine out of 10 infected patients in outbreaks such as the current one in West Africa.
Researchers at the National Physical Laboratory and the London Centre for Nanotechnology have determined the structure of DNA from measurements on a single molecule using atomic force microscopy (AFM), and found significant variations in the well-known double helix.