Fastening protein-based medical treatments to nanoparticles isn't easy. With arduous chemistry, scientists can do it. But like a doomed marriage, the fragile binding that holds them together often separates. This problem, which has limited how doctors can use proteins to treat serious disease, may soon change.
With a tag, an anchor and a cage that can be unlocked with light, chemists have devised a simple, modular system that can locate proteins at the membrane of a cell. The chemists fused proteins to molecules called SNAP-tags, modified enzymes that recognize a particular chemical group called a benzylguanine.
The editors of R&D Magazine have announced a deadline extension for the 2015 R&D 100 Awards entry process until May 18, 2015. The R&D 100 Awards have a 50 plus year history of awarding the 100 most technologically significant products of the year.
A Univ. of Otago scientist is a member of an international research team that has made an important discovery about the workings of a bacterial immune system. The finding could lead to the development of tailor-made RNA-editing tools. RNA is the molecule that translates DNA's genetic instructions into the production of the proteins that are the building blocks of cells.
By combining two highly innovative experimental techniques, scientists at the Univ. of Illinois at Urbana-Champaign have for the first time simultaneously observed the structure and the correlated function of specific proteins critical in the repair of DNA, providing definitive answers to some highly debated questions, and opening up new avenues of inquiry and exciting new possibilities for biological engineering.
Research on a modified protein around which DNA is wrapped sheds light on how gene regulation is linked to aging and longevity in nematodes, fruit flies and possibly humans. The research has implications for how gene expression is regulated, and could offer a new drug target for age-related diseases.
Researchers from North Carolina State Univ. and the Univ. of Colorado, Boulder, have developed a statistical model that allows them to tell where a dust sample came from within the continental U.S. based on the DNA of fungi found in the sample.
Pre-eclampsia is a disease that affects 5 to 8% of pregnancies in America. Complications from this disease can lead to emergency cesarean sections early in pregnancies to save the lives of the infants and mothers. Scientists believe pre-eclampsia is caused by a number of factors, including shallow placentas that are insufficiently associated with maternal blood vessels.
Nowhere is the adage "form follows function" more true than in the folded chain of amino acids that makes up a single protein macromolecule. But proteins are very sensitive to errors in their genetic blueprints. One single-letter DNA "misspelling" (called a point mutation) can alter a protein's structure or electric charge distribution enough to render it ineffective or even deleterious.
A newly developed spectroscopy method is helping to clarify the poorly understood molecular process by which an anti-HIV drug induces lethal mutations in the virus’ genetic material. The findings from the Univ. of Chicago and the Massachusetts Institute of Technology could bolster efforts to develop the next generation of anti-viral treatments.
NIST researchers have demonstrated the most precise method yet to measure the structural configuration of monoclonal antibodies, an important factor in determining the safety and efficacy of these biomolecules as medicines. Monoclonal antibodies are proteins manufactured in the laboratory that can target specific disease cells or antigens (proteins that trigger an immune reaction) for removal from the body.
Electrical charges not only move through wires, they also travel along lengths of DNA, the molecule of life. The property is known as charge transport. In a new study appearing in Nature Chemistry, researchers explore the ways in which electrical charges move along DNA bases affixed to a pair of electrodes.
The human immune system is poised to spring into action at the first sign of a foreign invader, but it often fails to eliminate tumors that arise from the body’s own cells. Cancer biologists hope to harness that untapped power using an approach known as cancer immunotherapy. Orchestrating a successful immune attack against tumors has proven difficult so far, until now.
Univ. of Michigan researchers have discovered a biomarker that may be a potentially important breakthrough in diagnosing and treating prostate cancer. Biomarkers in the body are analogous to the warning lights in cars that signal something might need repairing. In our bodies, they indicate if something's wrong or if we're about to get sick or if we're predisposed to certain illnesses.
Researchers have demonstrated a promising new way to increase the effectiveness of radiation in killing cancer cells. The approach involves gold nanoparticles tethered to acid-seeking compounds called pHLIPs. The pHLIPs (pH low-insertion peptides) home in on high acidity of malignant cells, delivering their nanoparticle passengers straight to the cells’ doorsteps.
Scientists are mapping the habits of cancer cells, turn by microscopic turn. Using advanced technology and an approach that merges engineering and medicine, a Yale Univ.-led team has compiled some of the most sophisticated data yet on the elaborate signaling networks directing highly invasive cancer cells. Think of it as a digital field guide for a deadly scourge.
Scientists are using stem cells from amniotic fluid to promote the growth of functional blood vessels in healing hydrogels. In new experiments, the scientists combined versatile amniotic stem cells with injectable hydrogels used as scaffolds in regenerative medicine and proved they enhance the development of vessels needed to bring blood to new tissue and carry waste products away.
Biologists have discovered a vulnerability of brain cancer cells that could be exploited to develop more-effective drugs against brain tumors. The study found that a subset of glioblastoma tumor cells is dependent on a particular enzyme that breaks down the amino acid glycine. Without this enzyme, toxic metabolic byproducts build up inside the tumor cells, and they die.
Just as some people seem built to run marathons and have an easier time going for miles without tiring, others are born with a knack for memorizing things, from times tables to trivia facts. These two skills are not so different as it turns out. Salk scientists and collaborators have discovered that physical and mental activities rely on a single metabolic protein that controls the flow of blood and nutrients throughout the body.
A great deal of public attention in the past couple of years has been showered on complexes of bacterial proteins known as “CRISPR-Cas” for their potential use as a tool for editing DNA. Now, researchers with the Lawrence Berkeley National Laboratory are reporting that CRISPR-Cas complexes could also serve as an engineering tool for RNA, the molecule that translates DNA’s genetic instructions into the production of proteins.
Yale Univ. scientists are using new chemical tools to identify and understand molecules in the human gut that alter DNA and regulate inflammatory bowel diseases and colorectal cancers. In a recent article, researchers describe the chemical structures of 32 such molecules from the bacterial colibactin pathway, found in select strains of E. coli in the gut.
The self-organization properties of DNA-like molecular fragments four billion years ago may have guided their own growth into repeating chemical chains long enough to act as a basis for primitive life, says a new study by the Univ. of Colorado Boulder and the Univ. of Milan.
Northwestern Medicine scientists have identified a small RNA molecule called miR-182 that can suppress cancer-causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor. While standard chemotherapy drugs damage DNA to stop cancer cells from reproducing, the new method stops the source that creates those cancer cells: genes that are overexpressing certain proteins.
There are few times in life when one should aim for suboptimal performance, but new research at Rice Univ. suggests scientists who study metabolism and its role in evolution should look for signs of just that. A study published in BMC Systems Biology details a computational method called corsoFBA.
Stem cells hold great promise for treating a number of diseases, in part because they have the unique ability to differentiate, specializing into any one of the hundreds of cell types that comprise the human body. Harnessing this potential, though, is difficult.