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Genomics & Proteomics
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The Lead

Researchers advance genome editing technique

October 22, 2014 7:41 am | by Mick Kulikowski, North Carolina State Univ. News Services | News | Comments

Customized genome editing has major potential for application in medicine, biotechnology, food and agriculture. Now, in a paper published in Molecular Cell, North Carolina State Univ. researchers and colleagues examine six key molecular elements that help drive this genome editing system, which is known as CRISPR-Cas.

If CD8 T cells take on one virus, they’ll fight others too

October 21, 2014 10:36 am | by David Orenstein, Brown Univ. | News | Comments

Scientists think of CD8 T cells as long-lived cells that become tuned to fight just one pathogen...

Supercomputers link proteins to drug side effects

October 21, 2014 8:48 am | by Kenneth Ma, LLNL | News | Comments

New medications created by pharmaceutical companies have helped millions of Americans alleviate...

High blood-sugar levels may harden heart valves

October 21, 2014 8:05 am | by Mike Williams, Rice Univ. | News | Comments

Rice Univ. bioengineers have found new evidence of a possible link between diabetes and the...

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Geneticists evaluate cost-effective genome analysis

October 17, 2014 1:39 pm | News | Comments

Scientists perform genome sequences because want to know why individuals differ from each other and how these differences are encoded in the DNA. However, sequencing a complete genome still costs around $1,000, and sequencing hundreds of individuals would be costly. In two recent review papers, scientists discuss why DNA sequencing of entire groups, or pool sequencing, can be an efficient and cost-effective approach.

Designing antibiotics of the future

October 17, 2014 9:48 am | News | Comments

Scientists have used computer simulations to show how bacteria are able to destroy antibiotics, a breakthrough which will help develop drugs which can effectively tackle infections in the future. Researchers at the Univ. of Bristol focused on the role of enzymes in the bacteria, which split the structure of the antibiotic and stop it working, making the bacteria resistant. 

Scientists create new protein-based material with some nerve

October 15, 2014 9:24 am | by Sarah Yang, UC Berkeley | News | Comments

Univ. of California, Berkeley scientists have taken proteins from nerve cells and used them to create a “smart” material that is extremely sensitive to its environment. This marriage of materials science and biology could give birth to a flexible, sensitive coating that is easy and cheap to manufacture in large quantities.

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Effects of high-risk Parkinson’s mutation are reversible

October 15, 2014 9:01 am | by Amy Pullan, Media Relations Office, University of Sheffield | News | Comments

Researchers from the Univ. of Sheffield have found vital new evidence on how to target and reverse the effects caused by one of the most common genetic causes of Parkinson’s. Mutations in a gene called LRRK2 carry a well-established risk for Parkinson’s disease, however the basis for this link is unclear.  

Scientists map key moment in assembly of DNA-splitting molecular machine

October 15, 2014 8:22 am | News | Comments

The proteins that drive DNA replication are some of the most complex machines on Earth and the process involves hundreds of atomic-scale moving parts that rapidly interact and transform. Now, scientists have pinpointed crucial steps in the beginning of the replication process, including surprising structural details about the enzyme that "unzips" and splits the DNA double helix so the two halves can serve as templates for DNA duplication.

Discovery of cellular snooze button advances cancer and biofuel research

October 14, 2014 12:53 pm | by Michigan State Univ. Media Communications | News | Comments

The discovery of a cellular snooze button has allowed a team of Michigan State Univ. scientists to potentially improve biofuel production and offer insight on the early stages of cancer. The discovery finds the protein CHT7 is a likely repressor of cellular quiescence, or resting state. This cellular switch, which influences algae’s growth and oil production, also wields control of cellular growth—and tumor growth—in humans.

ALS progression linked to increased protein instability

October 14, 2014 8:14 am | by Jon Weiner, Lawrence Berkeley National Laboratory | News | Comments

A new study by scientists from The Scripps Research Institute, Lawrence Berkeley National Laboratory and other institutions suggests a cause of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. The team's work supports a common theme whereby loss of protein stability leads to disease.

DNA’s security system unveiled

October 13, 2014 9:04 am | by Bill Hathaway, Yale Univ. | Videos | Comments

As befitting life’s blueprint, DNA is surrounded by an elaborate security system that assures crucial information is imparted without error. The security is provided by a double membrane perforated by protein channels that block unwanted material from entering the nucleus and promote entry of key messengers.

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Bio-inspired “nano-cocoons” offer targeted drug delivery against cancer

October 13, 2014 8:39 am | by Matt Shipman, North Carolina State Univ. | News | Comments

Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs. The new system is DNA-based, which means it is biocompatible and less toxic to patients than systems that use synthetic materials.

Molecular structure of Hep C envelope protein unveiled

October 10, 2014 9:09 am | by Laura Mgrdichian, Brookhaven National Laboratory | News | Comments

Hepatitis C, an infectious disease of the liver caused by the hepatitis C virus (HCV), affects 160 million people worldwide. There’s no vaccine for HCV and the few treatments that are available do not work on all variants of the virus. Before scientists can develop potential vaccines and additional therapies they must first thoroughly understand the molecular-level activity that takes place when the virus infects a host cell.

Charged graphene gives DNA a stage to perform molecular gymnastics

October 10, 2014 8:12 am | by Liz Ahlberg, Physical Sciences Editor, Univ. of Illinois, Urbana-Champaign | News | Comments

When Illinois researchers set out to investigate a method to control how DNA moves through a tiny sequencing device, they didn’t know they were about to witness a display of molecular gymnastics. Fast, accurate and affordable DNA sequencing is the first step toward personalized medicine.

DNA nanofoundries cast custom-shaped metal nanoparticles

October 10, 2014 7:50 am | by Kat J. McAlpine, Wyss Institute for Biologically Inspired Engineering | News | Comments

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard Univ. have unveiled a new method to form tiny 3-D metal nanoparticles in prescribed shapes and dimensions using DNA, nature's building block, as a construction mold. The ability to mold inorganic nanoparticles out of materials such as gold and silver in precisely designed 3-D shapes is a significant breakthrough.

Researchers capture images of elusive protein HIV uses to infect cells

October 9, 2014 11:00 am | by Bill Hathaway, Yale Univ. | News | Comments

HIV is adept at eluding immune system responses because the protein it uses to infect cells is constantly changing. Now a team of researchers including scientists from Yale Univ. have stripped the cloak from this master of disguise, providing a high-resolution image of this surface spike protein and monitoring how it constantly changes its shape, information that suggests new ways to attack the virus through drugs and vaccines.

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“Cyberwar” against cancer gets boost from intelligent nanocarriers

October 9, 2014 10:48 am | News | Comments

New research involving scientists in the U.S. and Israel offers new insight into the lethal interaction between cancer cells and the immune system's communications network. The study authors devised a new computer program that models a specific channel of cell-to-cell communication involving exosomes that both cancer and immune cells harness to communicate with other cells. This “cyberwarfare” model reveals three distinct states of cancer.

New way to extract bone-making cells from fat tissue

October 9, 2014 8:23 am | by David Orenstein, Brown Univ. | News | Comments

Within our fat lives a variety of cells with the potential to become bone, cartilage or more fat if properly prompted. This makes adipose tissue, in theory, a readily available reservoir for regenerative therapies such as bone healing if doctors can get enough of those cells and compel them to produce bone. In a new study, scientists demonstrate a new method for extracting a wide variety of potential bone-producing cells from human fat.

“Bellhops” in cell walls can double as hormones

October 8, 2014 9:29 am | by SLAC Office of Communications | Videos | Comments

Researchers have discovered that some common messenger molecules in human cells double as hormones when bound to a protein that interacts with DNA. The finding could bring to light a class of previously unknown hormones and lead to new ways to target diseases—including cancers and a host of hormone-related disorders.

Lab-on-a-chip for early diagnosis of cancer

October 8, 2014 8:09 am | by Brendan M. Lynch, KU News Service | News | Comments

Scientists have been laboring to detect cancer and a host of other diseases in people using promising new biomarkers called “exosomes.” Indeed, Popular Science magazine named exosome-based cancer diagnostics one of the 20 breakthroughs that will shape the world this year. Exosomes could lead to less invasive, earlier detection of cancer, and sharply boost patients’ odds of survival.

Getting metabolism right

October 8, 2014 7:59 am | by Larry Hardesty, MIT News Office | News | Comments

Metabolic networks are mathematical models of every possible sequence of chemical reactions available to an organ or organism, and they’re used to design microbes for manufacturing processes or to study disease. Based on both genetic analysis and empirical study, they can take years to assemble. Unfortunately, a new analytic tool suggests that many of those models may be wrong.

DNA linked to how much coffee you drink

October 7, 2014 2:15 pm | by Malcolm Ritter, AP Science Writer | News | Comments

Scientists have long known that your DNA influences how much java you consume. Now a huge study has identified some genes that may play a role. Their apparent effect is quite small. But variations in such genes may modify coffee's effect on a person's health, and so genetic research may help scientists explore that.

Validation: Recognizing A Problem With Real-Time PCR Kits

October 7, 2014 7:49 am | by Keith Cockrum, Bio-Rad Laboratories | Bio-Rad Laboratories | Articles | Comments

Life Science researchers have become ever-more dependent on the industry for “kits” that are intended to execute research processes in the laboratory flawlessly. In recognition of this expectation, kit manufacturers now market nearly every product as “guaranteed” or “validated.” This practice has led the research community to feel secure that the products will perform as advertised.

Liquid DNA behind virus attacks

October 6, 2014 11:48 am | News | Comments

According to two recent studies, viruses can convert their DNA from solid to fluid form, explaining how viruses manage to eject DNA into the cells of their victims. The researchers in one study, which focused on herpes infections, say the discovery was surprising: No one was previously aware of the “phase transition” from solid to fluid form in virus DNA.

A protein approach to halve and to whole

October 6, 2014 8:12 am | by Mike Williams, Rice Univ. | News | Comments

Rice Univ. scientists have developed a plug-and-play approach to detect interactions between proteins they say could greatly improve understanding of basic biological functions. The Rice team, in collaboration with Baylor College of Medicine, split and added sticky tags to fluorescent proteins that become biosensors when inserted into living cells.

First pictures of BRCA2 protein show how it works to repair DNA

October 6, 2014 8:07 am | by Sam Wong, Imperial College London | News | Comments

Mutations in the gene that encodes BRCA2 are well known for raising the risk of breast cancer and other cancers. Although the protein was known to be involved in DNA repair, its shape and mechanism have been unclear, making it impossible to target with therapies. Researchers in the U.K. purified the protein and used electron microscopy to reveal its structure and how it interacts with other proteins and DNA.

NIH awards UC Berkeley $7.2 million to advance brain initiative

October 2, 2014 8:28 am | by Robert Sanders, UC Berkeley | News | Comments

The National Institutes of Health this week announced its first research grants through President Barack Obama’s BRAIN Initiative, including three awards to the Univ. of California, Berkeley, totaling nearly $7.2 million over three years. The projects are among 58 funded in this initial wave of NIH grants, involving 100 researchers and a total of $46 million in fiscal year 2014 dollars alone.

Agilent to collaborate with Univ. of Toronto on metabolomics solutions

October 2, 2014 7:57 am | News | Comments

A collaboration has been announced between Agilent Technologies and the Univ. of Toronto’s Donnelly Centre for Cellular and Biomolecular Research to produce a comprehensive metabolomics multiple-reaction monitoring library and methodology, using Agilent’s Infinity 1290 UHPLC, 6460 triple quadrupole mass spectrometry system, and MassHunter Software. The goal is to accelerate quantification of hundreds of metabolically important compounds.

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