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Genomics & Proteomics
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The Lead

Zeroing in on a silent killer

April 24, 2015 8:16 am | by Robert Perkins, Univ. of Southern California | News | Comments

One in three Americans has high blood pressure, a long-term constriction of arteries that can lead to coronary heart disease, heart failure and stroke. Using a sophisticated x-ray analysis, a U.S.-German team of scientists revealed the molecular structure of the angiotensin receptor AT1R, an important regulator for blood pressure in the human body.

New DNA codes for mammoths: Step toward bringing them back?

April 23, 2015 2:05 pm | by Malcolm Ritter, AP Science Writer, Associated Press | News | Comments

Scientists are getting their best look yet at the DNA code for the woolly mammoth, thanks to...

A new wrinkle for cell culture

April 23, 2015 9:53 am | by Kevin Stacey, Brown Univ. | News | Comments

Using a technique that introduces tiny wrinkles into sheets of graphene, researchers from Brown...

Scientists use nanoscale building blocks and DNA “glue” to shape 3-D superlattices

April 23, 2015 8:17 am | by Karen McNulty Walsh, Brookhaven National Laboratory | News | Comments

Taking child's play with building blocks to a whole new level, the nanometer scale, scientists...

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Decoding the cell’s genetic filing system

April 22, 2015 11:09 am | by Princeton Univ. | News | Comments

A fully extended strand of human DNA measures about five feet in length. Yet it occupies a space just one-tenth of a cell by wrapping itself around histones to form a dense hub of information called chromatin. Access to these meticulously packed genes is regulated by post-translational modifications, chemical changes to the structure of histones that act as on-off signals for gene transcription.

Engineering the P450 enzyme to perform new reactions

April 22, 2015 8:24 am | by American Chemical Society | News | Comments

Enzymes, the micro machines in our cells, can evolve to perform new tasks when confronted with novel situations. But what if you want an enzyme to do an entirely different job—one that it would never have to do in a cell? In a recent report published in ACS Central Science, researchers show that they can mimic nature and perform evolution in a test tube, developing enzymes that can perform brand-new chemical reactions.

3-D structure solved for vulnerable region of glaucoma-causing protein

April 22, 2015 7:53 am | by Brett Israel, Georgia Institute of Technology | News | Comments

Scientists have determined the 3-D structure of a key part of a protein that is associated with glaucoma and identified regions of this domain that correlate with severe forms of the disease. The new crystal structure is of the olfactomedin (OLF) domain in myocilin, a protein implicated in glaucoma. Many proteins have OLF domains, but mutations in the OLF domain of myocilin are linked to early-onset glaucoma.

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Happily ever after

April 21, 2015 8:20 am | by Cory Nealon, Univ. at Buffalo | News | Comments

Fastening protein-based medical treatments to nanoparticles isn't easy. With arduous chemistry, scientists can do it. But like a doomed marriage, the fragile binding that holds them together often separates. This problem, which has limited how doctors can use proteins to treat serious disease, may soon change.

Chemists create modular system for placing proteins on membranes

April 21, 2015 8:12 am | by Susan Brown, Univ. of California, San Diego | News | Comments

With a tag, an anchor and a cage that can be unlocked with light, chemists have devised a simple, modular system that can locate proteins at the membrane of a cell. The chemists fused proteins to molecules called SNAP-tags, modified enzymes that recognize a particular chemical group called a benzylguanine.

Deadline Extended for 2015 R&D 100 Award Entries

April 20, 2015 1:53 pm | by Lindsay Hock, Editor | News | Comments

The editors of R&D Magazine have announced a deadline extension for the 2015 R&D 100 Awards entry process until May 18, 2015. The R&D 100 Awards have a 50 plus year history of awarding the 100 most technologically significant products of the year.

Key element in bacterial immune system discovered

April 20, 2015 7:53 am | by Univ. of Otago | News | Comments

A Univ. of Otago scientist is a member of an international research team that has made an important discovery about the workings of a bacterial immune system. The finding could lead to the development of tailor-made RNA-editing tools. RNA is the molecule that translates DNA's genetic instructions into the production of the proteins that are the building blocks of cells.

New lab technique reveals structure, function of proteins critical in DNA repair

April 17, 2015 12:32 pm | by Univ. of Illinois, Urbana-Champaign | News | Comments

By combining two highly innovative experimental techniques, scientists at the Univ. of Illinois at Urbana-Champaign have for the first time simultaneously observed the structure and the correlated function of specific proteins critical in the repair of DNA, providing definitive answers to some highly debated questions, and opening up new avenues of inquiry and exciting new possibilities for biological engineering.

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DNA “spool” modification affects aging, longevity

April 17, 2015 10:01 am | by Krishan Ramujan, Cornell Univ. | News | Comments

Research on a modified protein around which DNA is wrapped sheds light on how gene regulation is linked to aging and longevity in nematodes, fruit flies and possibly humans. The research has implications for how gene expression is regulated, and could offer a new drug target for age-related diseases.

Tracing dust samples using fungal DNA

April 16, 2015 12:33 pm | by Matt Shipman, News Services, North Carolina State Univ. | News | Comments

Researchers from North Carolina State Univ. and the Univ. of Colorado, Boulder, have developed a statistical model that allows them to tell where a dust sample came from within the continental U.S. based on the DNA of fungi found in the sample.

New transitional stem cells discovered

April 16, 2015 11:19 am | by Nathan Hurst, Univ. of Missouri | News | Comments

Pre-eclampsia is a disease that affects 5 to 8% of pregnancies in America. Complications from this disease can lead to emergency cesarean sections early in pregnancies to save the lives of the infants and mothers. Scientists believe pre-eclampsia is caused by a number of factors, including shallow placentas that are insufficiently associated with maternal blood vessels.

Inhibitor for abnormal protein points way to more selective cancer drugs

April 16, 2015 8:20 am | by Dave Zobel, Caltech | News | Comments

Nowhere is the adage "form follows function" more true than in the folded chain of amino acids that makes up a single protein macromolecule. But proteins are very sensitive to errors in their genetic blueprints. One single-letter DNA "misspelling" (called a point mutation) can alter a protein's structure or electric charge distribution enough to render it ineffective or even deleterious.

Shape-shifting molecule tricks viruses into mutating themselves to death

April 15, 2015 9:36 am | by Steve Koppes, Univ. of Chicago | News | Comments

A newly developed spectroscopy method is helping to clarify the poorly understood molecular process by which an anti-HIV drug induces lethal mutations in the virus’ genetic material. The findings from the Univ. of Chicago and the Massachusetts Institute of Technology could bolster efforts to develop the next generation of anti-viral treatments.

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NMR “fingerprinting” for monoclonal antibodies

April 15, 2015 8:49 am | by NIST | News | Comments

NIST researchers have demonstrated the most precise method yet to measure the structural configuration of monoclonal antibodies, an important factor in determining the safety and efficacy of these biomolecules as medicines. Monoclonal antibodies are proteins manufactured in the laboratory that can target specific disease cells or antigens (proteins that trigger an immune reaction) for removal from the body.

Study shows novel pattern of electrical charge movement through DNA

April 15, 2015 8:03 am | by Richard Harth, Biodesign Institute | News | Comments

Electrical charges not only move through wires, they also travel along lengths of DNA, the molecule of life. The property is known as charge transport. In a new study appearing in Nature Chemistry, researchers explore the ways in which electrical charges move along DNA bases affixed to a pair of electrodes.

Recruiting the entire immune system to attack cancer

April 14, 2015 11:30 am | by Anne Trafton, MIT News Office | News | Comments

The human immune system is poised to spring into action at the first sign of a foreign invader, but it often fails to eliminate tumors that arise from the body’s own cells. Cancer biologists hope to harness that untapped power using an approach known as cancer immunotherapy. Orchestrating a successful immune attack against tumors has proven difficult so far, until now.

Researchers find protein that may signal more aggressive prostate cancers

April 14, 2015 8:13 am | by Nicole Casal Moore, Univ. of Michigan | News | Comments

Univ. of Michigan researchers have discovered a biomarker that may be a potentially important breakthrough in diagnosing and treating prostate cancer. Biomarkers in the body are analogous to the warning lights in cars that signal something might need repairing. In our bodies, they indicate if something's wrong or if we're about to get sick or if we're predisposed to certain illnesses.

Gold by special delivery intensifies cancer-killing radiation

April 14, 2015 7:47 am | by Kevin Stacey, Brown Univ. | News | Comments

Researchers have demonstrated a promising new way to increase the effectiveness of radiation in killing cancer cells. The approach involves gold nanoparticles tethered to acid-seeking compounds called pHLIPs. The pHLIPs (pH low-insertion peptides) home in on high acidity of malignant cells, delivering their nanoparticle passengers straight to the cells’ doorsteps.

A digital field guide to cancer cells

April 9, 2015 10:10 am | by Jim Shelton, Yale Univ. | News | Comments

Scientists are mapping the habits of cancer cells, turn by microscopic turn. Using advanced technology and an approach that merges engineering and medicine, a Yale Univ.-led team has compiled some of the most sophisticated data yet on the elaborate signaling networks directing highly invasive cancer cells. Think of it as a digital field guide for a deadly scourge.

Amniotic stem cells demonstrate healing potential

April 9, 2015 7:41 am | by Mike Williams, Rice Univ. | News | Comments

Scientists are using stem cells from amniotic fluid to promote the growth of functional blood vessels in healing hydrogels. In new experiments, the scientists combined versatile amniotic stem cells with injectable hydrogels used as scaffolds in regenerative medicine and proved they enhance the development of vessels needed to bring blood to new tissue and carry waste products away.

Biologists identify brain tumor weakness

April 9, 2015 7:31 am | by Anne Trafton, MIT News Office | News | Comments

Biologists have discovered a vulnerability of brain cancer cells that could be exploited to develop more-effective drugs against brain tumors. The study found that a subset of glioblastoma tumor cells is dependent on a particular enzyme that breaks down the amino acid glycine. Without this enzyme, toxic metabolic byproducts build up inside the tumor cells, and they die.

Food for thought: Master protein enhances learning and memory

April 8, 2015 8:54 am | by The Salk Institute | News | Comments

Just as some people seem built to run marathons and have an easier time going for miles without tiring, others are born with a knack for memorizing things, from times tables to trivia facts. These two skills are not so different as it turns out. Salk scientists and collaborators have discovered that physical and mental activities rely on a single metabolic protein that controls the flow of blood and nutrients throughout the body.

Possible new RNA engineering tool

April 8, 2015 7:50 am | by Lynn Yarris, Lawrence Berkeley National Laboratory | News | Comments

A great deal of public attention in the past couple of years has been showered on complexes of bacterial proteins known as “CRISPR-Cas” for their potential use as a tool for editing DNA. Now, researchers with the Lawrence Berkeley National Laboratory are reporting that CRISPR-Cas complexes could also serve as an engineering tool for RNA, the molecule that translates DNA’s genetic instructions into the production of proteins.

Spotting a molecular warhead for disease in the human gut

April 7, 2015 12:20 pm | by Jim Shelton, Yale Univ. | News | Comments

Yale Univ. scientists are using new chemical tools to identify and understand molecules in the human gut that alter DNA and regulate inflammatory bowel diseases and colorectal cancers. In a recent article, researchers describe the chemical structures of 32 such molecules from the bacterial colibactin pathway, found in select strains of E. coli in the gut.

Study hints at spontaneous appearance of primordial DNA

April 7, 2015 10:51 am | by Jim Scott, CU-Boulder Media Relations | News | Comments

The self-organization properties of DNA-like molecular fragments four billion years ago may have guided their own growth into repeating chemical chains long enough to act as a basis for primitive life, says a new study by the Univ. of Colorado Boulder and the Univ. of Milan.

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