Protein activity is strictly regulated. Incorrect or poor protein regulation can lead to uncontrolled growth and thus cancer or chronic inflammation. Researchers in Switzerland have identified enzymes that can regulate the activity of medically important proteins. Their discovery enables these proteins to be manipulated very selectively, opening up new treatment methods.
A research team in Europe has developed a new line of transgenic "Enviropigs." Enviropigs have genetically modified salivary glands, which help them digest phosphorus in feedstuffs and reduce phosphorus pollution in the environment. After developing the initial line of Enviropigs, researchers found that the line had certain genes that could be unstable. The new line of pigs is called the Cassie line, and it is known for passing genes on more reliably.
Scientists have long known that the young and old brains are very different. Adolescent brains are more malleable or plastic. The flip of a single molecular switch helps create the mature neuronal connections that allow the brain to bridge the gap between adolescent impressionability and adult stability. Now Yale School of Medicine researchers have reversed the process, recreating a youthful brain that facilitated both learning and healing in the adult mouse.
Scientists at the University of Massachusetts Amherst, including assistant professor Peter Chien, recently gained new insight into how protein synthesis and degradation help to regulate the delicate ballet of cell division. In particular, they reveal how two proteins shelter each other in “mutually assured cleanup” to insure that division goes smoothly and safely.
Just like electronics, living cells use electrons for energy and information transfer. But cell membranes have thus far prevented us from “plugging” in cells to our computers. To get around this barrier that tightly controls charge balance, a research group at Lawrence Berkeley National Laboratory’s Molecular Foundry has engineered <em>E. coli</em> as a testbed for cellular-electrode communication. They have now demonstrated that these bacterial strains can generate measurable current at an anode.
Researchers at Michigan State University have used use an algae gene involved in oil production to engineer a plant that stores lipids or vegetable oil in its leaves—an uncommon occurrence for most plants. To confirm that the improved plants were more nutritious and contained more energy, the research team fed them to caterpillar larvae. The larvae that were fed oily leaves from the enhanced plants gained more weight than worms that ate regular leaves.
When it comes to healing the terrible wounds of war, success may hinge on the first blood clot—the one that begins forming on the battlefield right after an injury. Researchers exploring the complex stream of cellular signals produced by the body in response to a traumatic injury believe the initial response—formation of a blood clot—may control subsequent healing. Using that information, they're developing new biomaterials, including artificial blood platelets laced with regulatory chemicals that could be included in an injector device the size of an iPhone.
According to Michigan State University plant biologist Carolyn Malmstrom, when we start combining the qualities of different types of plants into one, there can be unanticipated results. In the domestication of wild plants for bioenergy, for example, long-lived plants are being selected for fast growth like annuals. In contrast, perennial plants in nature grow slower, but are usually better equipped to fight off invading viruses. When wild-growing perennials do get infected they can serve as reservoirs for viruses.
Digesting lignin, a highly stable polymer that accounts for up to a third of biomass, is a limiting step to producing a variety of biofuels. Researchers at Brown have figured out the microscopic chemical switch that allows Streptomyces bacteria to get to work, breaking lignin down into its constituent parts.
A new study from engineers at Rensselaer Polytechnic Institute and the University of California, Berkeley, pairs light and genetics to give researchers a powerful new tool for manipulating cells. The optogenetics breakthrough shows how blue light can be used as a switch to prompt targeted proteins to accumulate into large clusters. This clustering, or oligomerization, is commonly employed by nature to turn on or turn off specific signaling pathways used in cells’ complex system of communications.
Calcium plays a major role in orchestrating normal heart pump function. The condition known as diastolic heart failure occurs when the calcium signaling process is slowed, preventing the heart from relaxing. Scientists in Minnesota have utilized molecular genetic engineering to optimize heart performance in models of diastolic heart failure by creating an optimized protein that can aid in high-speed relaxation similar to fast twitching muscles.
Plant and animal cells contain two genomes: one in the nucleus and one in the mitochondria. When mutations occur in each, they can become incompatible, leading to disease. To increase understanding of such illnesses, scientists at Brown University and Indiana University have traced one example in fruit flies down to the individual errant nucleotides and the mechanism by which the flies become sick.
Scientists in the U.K. have reported that they have developed a method that cuts down the time it takes to make new “parts” for microscopic biological factories from two days to only six hours. The technique does away with the need to re-engineer a cell’s DNA every time a new part is needed. The researchers say their research brings them another step closer to a new kind of industrial revolution, where parts for these biological factories could be mass-produced.
In a development that could lead to faster and more effective toxicity tests for airborne chemicals, scientists from Rice University and the Rice spinoff company Nano3D Biosciences have used magnetic levitation to grow some of the most realistic lung tissue ever produced in a laboratory.
Using genetic material as their medium, researchers reported Wednesday that they had stored all 154 Shakespeare sonnets, a photo, a scientific paper, and a 26-second sound clip from Martin Luther King Jr.'s "I Have a Dream" speech. That all fit in a barely visible bit of DNA in a test tube.
The purpose of cell division is to evenly distribute the genome between two daughter cells. But this process is highly prone to interaction errors between chromosomes and spindles. Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases
The principle of direct lineage reprogramming of differentiated cells within the body was first proven by Harvard Stem Cell Institute (HSCI) co-director Doug Melton and colleagues five years ago, when they reprogrammed exocrine pancreatic cells directly into insulin producing beta cells. Now, the same scientists have proven that neurons, too, can change their mind
Scientists in Germany and Switzerland have developed an implant that is able to genetically modify specific nerve cells, control them with light stimuli, and measure their electrical activity all at the same time. This new tool relies on an innovative genetic technique that forces nerve cells to change their activity by shining light of different colors onto them.
Tufts University School of Engineering researchers have developed a novel method for fabricating collagen structures that maintains the collagen's natural strength and fiber structure, making it useful for a number of biomedical applications.
It has been known since the 1970s that excessive salt causes DNA to reverse its twist, from a right-handed spiral to a left-handed one. The complexity of the DNA molecule has prevented a theoretical explanation which correctly predicts the amount of salt to do this. In a recent publication, however, researchers achieved new accuracy in the ability to measure energy differences between states of molecules, thus predicting which states will be observed.
Scientists from The Scripps Research Institute have developed a way to alter the function of RNA in living cells by designing molecules that recognize and disable RNA targets. As a proof of principle, the team designed a molecule that disabled the RNA causing myotonic dystrophy. This small molecule is cell-permeable, offering benefits over traditional methods of targeting RNAs for degradation.
A painstaking effort to create a biocompatible patch to heal infant hearts is paying off at Rice University and Texas Children’s Hospital. The proof is in a petri dish in Jeffrey Jacot's laboratory, where a small slab of gelatinous material beats with the rhythm of a living heart.
It has recently been possible to resolve biological structures down to the molecular scale with light microscopy, termed super-resolution microscopy. However, there have been limits to the technique. So far, it has been difficult to distinguish between sample-specific and microscope-specific error sources if the images were blurry. Researchers in Germany have recently resolved this issue.
Mosquito control officials in the Florida Keys are waiting for the federal government to sign off on an experiment that would release hundreds of thousands of genetically modified mosquitoes to reduce the risk of dengue fever in the tourist town of Key West. If approved by the Food and Drug Administration, it would be the first such experiment in the U.S. Some residents, however, are worried about the risks.
After weathering concerns about everything from the safety of humans eating the salmon to their impact on the environment, Aquabounty was in a position to become the world's first company to sell fish whose DNA has been altered to speed up growth. But after positive feedback from the U.S. Food and Drug Administration in 2010, the agency still has not approved the fish and the company could soon run out of money.