A team at Purdue Univ. has used gold nanoparticles to target and bind to fragments of genetic material known as BRCA1 messenger RNA splice variants, which can indicate the presence and stage of breast cancer. The number of these synthetic DNA “tails” in a cell can be determined in a living cell by examining the specific signal that light produces when it interacts with the gold nanoparticles.
You can trace the genetic makeup of most corn grown in the U.S., and in many other places around the world, to Hawaii. The tiny island state 2,500 miles from the nearest continent is so critical to the nation's modern corn-growing business that the industry's leading companies all have farms here, growing new varieties genetically engineered for desirable traits like insect and drought resistance.
A type of single-cell green algae called Chlamydomonas reinhardtii is a leading subject for photosynthesis research, but few tools are available for characterizing the functions of its genes. A team including Carnegie Institution's Martin Jonikas has developed a highly sophisticated tool that will transform the work of plant geneticists by making large-scale genetic characterization of Chlamydomonas mutants possible for the first time.
Synthetic collagen invented at Rice Univ. may help wounds heal by directing the natural clotting of blood. The material, KOD, mimics natural collagen, a fibrous protein that binds cells together into organs and tissues. It could improve upon commercial sponges or therapies based on naturally derived porcine or bovine-derived collagen now used to aid healing during or after surgery.
In a north London hospital, scientists are growing noses, ears and blood vessels in a bold attempt to make body parts in the laboratory. It's far from the only laboratory in the world that is growing organs for potential transplant. But the London work was showcased this week hints at the availability of more types of body parts, including what would be the world's first nose made partly from stem cells.
Synthetic genetic circuitry created by researchers at Rice Univ. is helping them see, for the first time, how to regulate cell mechanisms that degrade the misfolded proteins implicated in Parkinson’s, Huntington’s and other diseases. The Rice team has designed a sophisticated circuit that signals increases in the degradation of proteins by the cell’s ubiquitin proteasome system (UPS).
Researchers have reported they can generate human motor neurons from stem cells much more quickly and efficiently than previous methods allowed. The new method involves adding critical signaling molecules to precursor cells a few days earlier than previous methods specified. This increases the proportion of healthy motor neurons derived from stem cells (from 30 to 70%) and cuts in half the time required to do so.
As the Earth’s human population marches toward 9 billion, the need for hardy new varieties of grain crops has never been greater. It won’t be enough to yield record harvests under perfect conditions; new grains must also be able to handle stress from climate changes. Researchers in Michigan have recently identified a set of genes that could be key to the development of the next generation of super rice.
Adopted a common technique used in biochemistry, called agarose gel electrophoresis, researchers have investigated the damage to DNA that might have been caused by use of an atmospheric pressure plasma jet. This qualitative and quantitative study could ultimately lead to plasma-based tools for cancer therapy or hospital hygiene and other purposes.
Massachusetts Institute of Technology engineers have coaxed bacterial cells to produce biofilms that can incorporate non-living materials, such as gold nanoparticles and quantum dots. These “living materials” combine the advantages of live cells, which respond to their environment and produce complex biological molecules, with the benefits of nonliving materials, which add functions such as conducting electricity or emitting light.
Genetically modifying a key protein complex in plants could lead to improved crops for the production of cellulosic biofuels, a Purdue Univ. study says. The researchers generated a mutant Arabidopsis plant whose cell walls can be converted easily into fermentable sugars, but doesn't display the stunted growth patterns of similar mutants.
It's a jungle in there. In the tightly woven ecosystem of the human gut, trillions of bacteria compete with each other on a daily basis while they sense and react to signals from the immune system, ingested food and other bacteria. Problems arise when bad gut bugs overtake friendly ones, or when the immune system is thrown off balance.
Biophysicists at Rice Univ. have used a miniscule machine, a protease called an FtsH-AAA hexameric peptidase, as a model to test calculations that combine genetic and structural data. Their goal is to solve one of the most compelling mysteries in biology: how proteins perform the regulatory mechanisms in cells upon which life depends.
Move over, nanotechnologists, and make room for the biggest of the small. Scientists at the Harvard's Wyss Institute have built a set of self-assembling DNA cages one-tenth as wide as a bacterium. The structures are some of the largest and most complex structures ever constructed solely from DNA.
A computer-aided design tool has been used by researchers at Virginia Tech and the Massachusetts Institute of Technology to create genetic languages to guide the design of biological systems. Known as GenoCAD, the open-source software was developed to help synthetic biologists capture biological rules to engineer organisms that produce useful products or health-care solutions from inexpensive, renewable materials.
Sometimes it only takes a quick jolt of electricity to get a swarm of cells moving in the right direction. Researchers at the Univ. of California, Berkeley found that an electrical current can be used to orchestrate the flow of a group of cells, an achievement that could establish the basis for more controlled forms of tissue engineering.
The Riken Center for Development Biology in Kobe, Japan, has been looking into questions raised over images and wording in a research paper describing a simple way of turning ordinary cells from mice into stem cells. Riken said Tuesday that it may retract the paper because of credibility and ethics issues, even though an investigation is continuing.
Fresh banana, a waft of flowers, blueberry: the scents in Shota Atsumi's laboratory in the Univ. of California, Davis Dept. of Chemistry are a little sweeter than most. That's because Atsumi and his team are engineering bacteria to make esters, molecules widely used as scents and flavorings, and also as basic feedstock for chemical processes from paints to fuels.
In a significant advance for the growing field of synthetic biology, Rice Univ. bioengineers have created a toolkit of genes and hardware that uses colored lights and engineered bacteria to bring both mathematical predictability and cut-and-paste simplicity to the world of genetic circuit design.
At a recent two-day meeting, the Food and Drug Administration heard from supporters and opponents of a provocative new technique meant to prevent children from inheriting debilitating diseases. The method creates babies from the DNA of three people, and the agency is considering whether to greenlight testing in women who have defective genes.
Scientists in the U.K. have developed a novel approach to enabling collaborations between researchers at conferences and academic meetings: Treat them like genes. Using mathematical algorithms, the team created a method of matching conference-goers according to pre-set criteria, bringing about unforeseen collaboration opportunities while also enabling “would-like-to-meet” match-ups across disciplines and knowledge areas.
The time and cost of sequencing an entire human genome has plummeted, but analyzing three billion base pairs from a single genome can take many months. However, a Univ. of Chicago-based team working with Beagle, one of the world's fastest supercomputers devoted to life sciences, reports that genome analysis can be radically accelerated. The Argonne National Laboratory computer is able to analyze 240 full genomes in about two days.
A new bioprinting method developed at the Wyss Institute for Biologically Inspired Engineering at Harvard Univ. creates intricately patterned 3-D tissue constructs with multiple types of cells and tiny blood vessels. The work represents a major step toward a longstanding goal of tissue engineers: creating human tissue constructs realistic enough to test drug safety and effectiveness.
Researchers have introduced a unique microrobotic technique to assemble the components of complex materials, the foundation of tissue engineering and 3-D printing. Tissue engineering and 3-D printing have become vitally important to the future of medicine for many reasons. The shortage of available organs for transplantation, for example, leaves many patients on waiting lists for life-saving treatment.
A team of physicists have used statistical mechanics and mathematical modeling to shed light on something known as epigenetic memory, which allows an organism to create a biological memory of some variable condition, such as quality of nutrition or temperature. The model highlights the "engineering" challenge a cell must constantly face during molecular recognition.