In a new study that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute (TSRI) have adapted a chemical approach to turn diseased cells into unique manufacturing sites for molecules that can treat a form of muscular dystrophy.
Duke Univ. researchers have identified a gene that could help scientists engineer drought-resistant crops. The gene, called OSCA1, encodes a protein in the cell membrane of plants that senses changes in water availability and adjusts the plant’s water conservation machinery accordingly. The effect is similar to a thermostat.
Laboratory-grown replacement organs have moved a step closer with the completion of a new study. Scientists have grown a fully functional organ from transplanted laboratory-created cells in a living animal for the first time. They have created a thymus, an organ next to the heart that produces immune cells known as T cells that are vital for guarding against disease.
Lawrence Berkeley National Laboratory’s Tissue-Specific Cell-Wall Engineering is a powerful new method for rapidly transforming crops into biological factories. The technology, a suite of high-precision genetic tools and procedures, makes it possible to change plant traits in a highly selective, tissue-specific fashion.
Massachusetts Institute of Technology chemical engineers have devised a new implantable tissue scaffold coated with bone growth factors that are released slowly over a few weeks. When applied to bone injuries or defects, this coated scaffold induces the body to rapidly form new bone that looks and behaves just like the original tissue.
Researchers in Texas have successfully used a new gene editing method to correct a mutation that leads to Duchenne muscular dystrophy (DMD) in a mouse model of the condition. The technique is called CRISPR/Cas9-mediated genome editing, and can precisely remove a mutation in DNA, allowing the body’s DNA repair mechanisms to replace it with a normal copy of the gene.
To help them further the study of cell function, a team of Stanford Univ. bioengineers has designed a suite of protein motors that can be controlled remotely by light. Splicing together DNA from different organisms such as pig, slime mold and oat, which has a light-detecting module, the team created DNA codes for each of their protein motors. When exposed to light, the new protein motors change direction or speed.
Researchers at Rice Univ. and the Univ. of Kansas Medical Center are making genetic circuits that can perform more complex tasks by swapping protein building blocks. The modular genetic circuits engineered from parts of otherwise unrelated bacterial genomes can be set up to handle multiple chemical inputs simultaneously with a minimum of interference from their neighbors.
DNA mutations had been thought to be rare events that occur randomly throughout the genome. However, recent studies have shown that cancer development frequently involves the formation of multiple mutations that arise simultaneously and in close proximity to each other. These groups of clustered mutations are frequently found in regions where chromosomal rearrangements take place.
DNA–protein conjugates can be used in diagnostic techniques, nanotechnology and other disciplines, but controlling the conjugation of these macromolecules can be a challenge. Scientists in Denmark have pioneered an easier method that makes it possible to direct the tagging of proteins with DNA to a particular site on the protein without genetically modifying the protein beforehand.
More than 100 researchers from around the world have collaborated in the biggest-ever genomic mapping of schizophrenia, for which scientists had previously uncovered only about a couple of dozen risk-related genes. Since this research began, scientists have linked more than 100 spots in our DNA to the risk of developing schizophrenia, casting light on the mystery of what makes the disease tick.
Using two thin, tiny gold nanorods 10,000 times thinner than a human hair, researchers from the U.S. and Germany have succeeded in creating an adjustable filter for so-called circularly polarized light. This switch for nano-optics is made from two tiny gold rods that reversibly change their optical properties when specific DNA molecules are added.
Many organisms that hold potential for proteomic analysis do not yet have a completely sequenced genome because the costs are prohibitive. Xenopus laevis, the African clawed frog, is one such species. Researchers at the Marine Biological Laboratory have found a work-around. Instead of relying on DNA, they used mRNA sequences to more efficiently create a reference database that can be used for proteomic analysis of Xenopus.
Researchers in Sweden have headed a study that provides new knowledge about the EphA2 receptor, which is significant in several forms of cancer. The researchers employed the method of DNA origami, in which a DNA molecule is shaped into a nanostructure, and used these structures to test theories about cell signalling.
Researchers have already used molecular rotors as viscosity sensor probes in live cells, but a recent study in Singapore is the first to report on the use of fluorescent molecular rotors to study critical protein interactions.
Researchers have developed new methods to trace the life history of individual cells back to their origins in the fertilized egg. By looking at the copy of the human genome present in healthy cells, and by looking at the numbers and types of mutations in a cell's DNA, biologists in the U.K. have been able to build a picture of each cell's development from the early embryo on its journey to become part of an adult organ.
Optogenetics relies on light-sensitive proteins that can suppress or stimulate electrical signals within cells. This technique requires a light source to be implanted in the brain, where it can reach the cells to be controlled. Massachusetts Institute of Technology engineers have now developed the first light-sensitive molecule that enables neurons to be silenced noninvasively, using a light source outside the skull.
Genomic sequencing is supposed to reveal the entire genetic makeup of an organism. The technology can be used to analyze a disease-causing bacterium to determine how much harm it is capable of causing. But new research at Rockefeller Univ. suggests that current sequencing protocols overlook crucial bits of information: isolated pieces of DNA floating outside the bacterial chromosome, the core of a cell’s genetic material.
An international collaboration of researchers have sequenced and analyzed the genome of the common bean to begin to identify genes involved in critical traits such as size, flavor, disease resistance and drought tolerance. They learned that, unlike most other food crops, the common bean was domesticated twice by humans about 8,000 years ago. The results of the study may help guide modern breeding programs.
A dash of clay, a dab of fiber from crab shells, and a dollop of DNA: This strange group of materials are actually the ingredients of promising green fire retardants invented by researchers at NIST. Applied to polyurethane foam, the bio-based coatings greatly reduced the flammability of the common furniture padding after it was exposed to an open flame.
In the last few years, the benefits of short, intense workouts have been extolled by both researchers and exercise fans as something of a metabolic panacea capable of providing greater overall fitness. Now, a new study from scientists at The Scripps Research Institute in Florida confirm that there is something molecularly unique about intense exercise: the activation of a single protein.
A new technology developed in Denmark uses the HIV virus as a tool in the fight against hereditary diseases and, in the long term, against HIV infection as well. The technology repairs the genome in a new and safer manner by using the virus as nanoparticles to manage the “cut and paste” approach to modifying the genome.
Researchers at the Univ. of Massachusetts will lead an international team of scientists in the development and implementation of a new optogenetic platform that can remotely activate neurons inside a free-moving organism. Using a new class of nanoparticles they propose to selectively turn on non-image forming photoreceptors inside mice and Drosophila, unencumbered by the fiber optic wires currently used in optogenetic technologies.
The final step in the production of a biotech medicine is finishing with the correct sugar structure. This step is essential for the efficacy of the medicine, but it also makes the production process very complex and expensive. Researchers in Belgium have developed a technology that shortens the sugar structures whilst retaining the therapeutic efficiency. This technology could make production of biotech medicines simpler and cheaper.
A new study shows that lowering temperatures for two hours each day reduces the height of corn without affecting its seed yield. The technique could be used to grow crops in controlled-environment facilities in caves and former mines.