E. coli usually brings to mind food poisoning and beach closures, but researchers recently discovered a protein in E. coli that inhibits the accumulation of potentially toxic amyloids, a hallmark of diseases such as Parkinson's. Amyloids are formed by proteins that misfold and group together, and when amyloids assemble at the wrong place or time, they can damage brain tissue and cause cell death.
Ian Duncan is a Scotsman with the iron discipline and stamina of a competitive marathoner,...
Researchers report the first crystal structure of the cellular receptor CXCR4 bound to an immune...
Lori Simons took the bright orange pill at 3 a.m. Eight hours later, doctors sliced into her...
Two new drug compounds appear to be effective in treating endometriosis, a disorder that, like MS, is driven by estrogen and inflammation, scientists report in Science Translational Medicine. The researchers hope to eventually use the new compounds and others like them to treat a variety of disorders linked to estrogen signaling and inflammation.
San Francisco Bay Area officials have begun laboratory tests and necropsies on dead seabirds found coated with a mysterious substance that looks and feels like dirty rubber cement. More than 125 dead birds have been found along the bay's shorelines, said Andrew Hughan, spokesman for the California Dept. of Fish and Wildlife.
As predators go, cone snails are slow moving and lack the typical fighting parts. They’ve made up for it by producing a vast array of fast-acting toxins that target the nervous systems of prey. A new study reveals that some cone snails add a weaponized form of insulin to the venom cocktail they use to disable fish.
Patients with sickle cell disease often suffer from painful attacks known as vaso-occlusive crises, during which their sickle-shaped blood cells get stuck in tiny capillaries, depriving tissues of needed oxygen. Blood transfusions can sometimes prevent such attacks, but there are currently no good ways to predict when a vaso-occlusive crisis, which can last for several days, is imminent.
A new “microcapsule” treatment delivery method developed by researchers at Queen Mary Univ. of London could reduce inflammation in cartilage affected by osteoarthritis and reverse damage to tissue. A protein molecule called C-type natriuretic peptide (CNP), which occurs naturally in the body, is known to reduce inflammation and aid in the repair of damaged tissue.
As predicted, this year's flu vaccine is doing a pretty crummy job. It's only 23% effective, primarily because it doesn't include the bug that is making most people sick, according to a government study released today. That's one of the worst performances in the last decade, since U.S. health officials started routinely tracking how well vaccines work. In the best flu seasons, the vaccines were 50 to 60% effective.
Scientists have gained new insight into fragile X syndrome by studying the case of a person without the disorder, but with two of its classic symptoms. In patients with fragile X, a key gene is completely disabled, eliminating a protein that regulates electrical signals in the brain and causing a host of behavioral, neurological and physical symptoms.
A regime of anti-HIV drugs has the potential to protect against infection in the first place. But real life can interfere; the effectiveness of this prophylactic approach declines if the medications aren’t taken as prescribed. HIV researchers hope a new compound, known as cabotegravir, could make dosing easier for some because the drug would be administered by injection once every three months.
New York Univ. Polytechnic School of Engineering professors have been collaborating with researchers from Peking Univ. on a new test strip that is demonstrating great potential for the early detection of certain heart attacks. The new colloidal gold test strip can test for cardiac troponin I (cTn-I) detection.
Scientists have developed the first ultra-thin, flexible device that sticks to skin like a rub-on tattoo and can detect a person’s glucose levels. The sensor, reported in a proof-of-concept study in Analytical Chemistry, has the potential to eliminate finger-pricking for many people with diabetes.
Autism is a spectrum of closely related disorders diagnosed in patients who exhibit a shared core of symptoms, including delays in learning to communicate and interact socially. Early detection of autism in children is the key for treatments to be most effective and produce the best outcomes. Using advanced 3-D imaging and statistical analysis techniques, researchers identified facial measurements in children with autism.
Sometimes the response to the outbreak of a disease can make things worse. The ability to anticipate when such overreactions might occur could help public health officials take steps to limit the dangers. Now a new computer model could provide a way of making such forecasts, based on a combination of data collected from hospitals, social media and other sources.
A new study from Lund Univ. in Sweden indicates inherited viruses that are millions of years old play an important role in building up the complex networks that characterize the human brain. Researchers have long been aware endogenous retroviruses constitute around 5% of our DNA. For many years, they were considered junk DNA of no real use, a side effect of our evolutionary journey.
Washington State Univ. Spokane scientists have found a brain protein that boosts the healing power of sleep and speeds an animal's recovery from the flu. The research has determined that a brain-specific protein is uniquely involved in sleep responses triggered by the influenza virus in mice. Without the protein, animals develop more severe symptoms of infection and die at higher rates than regular or control mice.
In the midst of a worrisome flu season, health officials are pushing doctors to prescribe antiviral medicines. The Centers for Disease Control and Prevention on Friday sent a new alert to doctors, advising prompt use of Tamiflu and other antivirals for hospitalized flu patients and those at higher risk for complications like pneumonia.
A major barrier to finding a cure for HIV/AIDS is the presence of latent HIV in the cells of chronically infected individuals. But a team of Yale and Johns Hopkins researchers may have pinpointed a strategy for eliminating the residual virus. Despite treatment with antiretroviral therapy, HIV persists in patients in a latent reservoir.
The common cold virus can reproduce itself more efficiently in the cooler temperature found inside the nose than at core body temperature, according to a new Yale Univ.-led study. This finding may confirm the popular, yet contested, notion that people are more likely to catch a cold in cool-weather conditions.
Shortly after birth, human brains expand rapidly with the experience of an entirely new world. During this period, neurons in the newborn brain compete with one another to form lasting connections, called synapses. A new study by Duke Univ. researchers provides a close-up of synapse refinement and identifies a protein that is crucial in this process.
The flu is now widespread in all but seven states, and hospitalization rates match the dismal season two years ago. While health officials fear this will be an unusually bad year, it's too soon to say. The latest figures released Monday by the CDC show the flu hitting hard in most of the 43 states where the illness was widespread. But the flu was not yet rampant in populous states like California and New York.
The tics seen in Tourette syndrome may be caused by the loss of specific neurons in the brain, a Yale Univ. study has demonstrated. Previous postmortem studies of people with severe forms of the disease showed that there was a decrease in a rare but important type of neuron in the dorsal striatum, deep within the brain.
Researchers at Oregon State Univ. have developed a new way to selectively insert compounds into cancer cells—a system that will help surgeons identify malignant tissues and then, in combination with phototherapy, kill any remaining cancer cells after a tumor is removed. It’s about as simple as, “If it glows, cut it out.” And if a few malignant cells remain, they’ll soon die.
Vaccines designed to protect against HIV can backfire and lead to increased rates of infection. This unfortunate effect has been seen in more than one vaccine clinical trial. Scientists at Emory Univ. have newly published results that support a straightforward explanation for the backfire effect: vaccination may increase the number of immune cells that serve as viral targets.
New research findings point toward a class of compounds that could be effective in combating infections caused by enterovirus D68, which has stricken children with serious respiratory infections in the U.S. and elsewhere. The researchers used x-ray crystallography to learn the precise structure of the original strain of EV-D68 on its own and when bound to an anti-viral compound called "pleconaril."
With drug-resistant bacteria on the rise, even common infections that were easily controlled for decades are proving trickier to treat with standard antibiotics. New drugs are desperately needed, but so are ways to maximize the effective lifespan of these drugs. To accomplish that, Duke Univ. researchers used software they developed to predict a constantly evolving infectious bacterium's countermoves to one of these new drugs ahead of time.
A company that is developing new anti-viral drugs hopes it will have a cure for Ebola, which is still in the research phase, put on the fast track for development in the fight against the disease. NanoViricides, whose headquarters are in West Haven, opened its research and development lab in July. The company, with a net worth of $250 million, employs more than 20 and expects to double that in the next two years.
- Page 1