A unique method for delivering compounds that could positively impact the global battle against HIV and AIDS may be possible, thanks to researchers in Penn State's College of Agricultural Sciences. A semi-soft vaginal suppository made from the seaweed-derived food ingredient carrageenan and loaded with the antiviral drug Tenofovir provides a woman-initiated, drug delivery vehicle that can protect against the spread of STIs.
Federal researchers next week will start testing humans with an experimental vaccine to prevent...
Like a protective tent over a colony of harmful bacteria, biofilms make the treatment of skin...
Older adults losing vision as they age are more likely to face an increased mortality risk,...
For the 2.2 million Americans battling glaucoma, the main course of action for staving off blindness involves weekly visits to eye specialists who monitor increasing pressure within the eye. Now researchers have developed an eye implant that could help stave off blindness caused by glaucoma. The tiny eye implant developed at Stanford Univ. could enable patients to take more frequent readings from the comfort of home.
Coffee contains antioxidants. Antioxidants fight gum disease. Researchers in dental medicine have found that coffee consumption does not have an adverse effect on periodontal health, and may have protective effects against periodontal disease.
A multidisciplinary team of scientists from the Univ. of California, Los Angeles and Stanford Univ. has used a naturally occurring nanoparticle called a vault to create a novel drug delivery system that could lead to advances in the treatment of cancer and HIV. Their findings could lead to cancer treatments that are more effective with smaller doses and to therapies that could potentially eradicate the HIV virus.
Princeton Univ. researchers have developed a way to use a laser to measure people's blood sugar, and, with more work to shrink the laser system to a portable size, the technique could allow diabetics to check their condition without pricking themselves to draw blood.
As one of few Ebola survivors with medical expertise, Dr. Kent Brantly seems keenly aware of the position his painful experience has put him in. He hasn't spoken yet about his plans, but spent much of his first public appearance pleading for help for countries still struggling with the virus.
MDR-TB is a growing problem, estimated to kill 170,000 people annually and projected to infect more than two million people between 2011 and 2015. Janssen Research & Development LLC’s bedaquiline represents a significant scientific and public health advancement in the treatment of MDR-TB, as the first available medicine developed specifically for pulmonary MDR-TB treatment.
New research suggests a one-two punch could help battle polio in some of the world's most remote and strife-torn regions: Giving a single vaccine shot to children who've already swallowed drops of an oral polio vaccine greatly boosted their immunity. The World Health Organization officials said the combination strategy already is starting to be used in mass vaccination campaigns in some hard-hit areas.
Texas researchers are reporting that an experimental drug saved monkeys from a virus closely related to Ebola even after symptoms began. The drug targets a strain of Marburg virus that is even more lethal than the Ebola currently ravaging West Africa. Both viruses take time to multiply in the body before symptoms appear, and few studies have explored how late treatment might be effective.
British drugmaker AstraZeneca says the U.S. Dept. of Justice has closed its investigation into a clinical trial of the company's blood thinner Brilinta, and plans no further action. The company announced in October 2013 that federal officials were looking into the 18,000-patient study, which began in 2009.
Rice Univ. scientists have won a race to find the crystal structure of the first virus known to infect the most abundant animal on Earth. The Rice laboratories of structural biologist Yizhi Jane Tao and geneticist Weiwei Zhong, with help from researchers at Baylor College of Medicine and Washington Univ., analyzed the Orsay virus that naturally infects a certain type of nematode, the worms that make up 80% of the living animal population.
Disabilities among U.S. children have increased slightly, with a bigger rise in mental and developmental problems in those from wealthier families, a 10-year analysis found. Disadvantaged kids still bear a disproportionate burden. The increases may partly reflect more awareness and recognition that conditions, including autism, require a specific diagnosis to receive special services, the researchers said.
A scary problem lurks beyond the frenzied efforts to keep people from spreading Ebola: No one knows exactly where the virus comes from or how to stop it from seeding new outbreaks. Ebola has caused two dozen outbreaks in Africa since it first emerged in 1976. It is coming from somewhere—probably bats—but experts agree they need to pinpoint its origins in nature.
An investigation into a potentially dangerous blunder at a government lab found that a scientist kept silent about the accident and revealed it only after other employees noticed something fishy. Officials on Friday released the results of an internal probe into the accident, which happened in January at the Centers for Disease Control and Prevention in Atlanta.
Scientists are racing to begin the first human safety tests of two experimental Ebola vaccines, but it won't be easy to prove that the shots and other potential treatments in the pipeline really work. There are no proven drugs or vaccines for Ebola, a disease so rare that it's been hard to attract investments in countermeasures. But the current outbreak in West Africa is fueling new efforts to speed Ebola vaccine and drug development.
A federal panel says older Americans should start getting a new vaccine against bacteria that cause pneumonia. The Advisory Committee on Immunization Practices voted Wednesday to recommend a dose of the expensive new shot for people 65 and older. The panel said older adults should still get an older pneumococcal vaccine, too.
Surgical and trauma patients are at significant risk for morbidity and mortality from bleeding and/or leaking bodily fluids. With the number and complexity of surgeries rising, so is the need for better hemostatic agents to stop bleeding as quickly as possible. The history of approaches to hemostasis goes back to when people simply used their hands or a tool to apply to a wound to stop bleeding.
Plasmodium falciparum, the parasite that causes malaria, has proven notoriously resistant to scientists’ efforts to study its genetics. It can take up to a year to determine the function of a single gene, which has slowed efforts to develop new, more targeted drugs and vaccines. Biological engineers have now demonstrated a new genome-editing technique that can disrupt a single parasite gene in a matter of weeks.
The World Health Organization on Friday declared the Ebola outbreak in West Africa to be an international public health emergency that requires an extraordinary response to stop its spread. It is the largest and longest outbreak ever recorded of Ebola, which has a death rate of about 50% and has so far killed at least 961 people. WHO declared similar emergencies for the swine flu pandemic in 2009 and for polio in May.
Some of the most damaging brain diseases can be traced to irregular blood delivery in the brain. Now, Stanford Univ. chemists have employed lasers and carbon nanotubes to capture an unprecedented look at blood flowing through a living brain. The technique was developed for mice but could one day be applied to humans, potentially providing vital information in the study of stroke and migraines.
A Purdue Univ. study shows that Notch signaling, a key biological pathway tied to development and cell communication, also plays an important role in the onset of obesity and Type 2 diabetes, a discovery that offers new targets for treatment. The research team found that blocking Notch signaling in the fat tissue of mice caused white fat cells to transform into a "leaner" type of fat known as beige fat.
The current Ebola crisis in West Africa is on pace to sicken more people than all other previous outbreaks of the disease combined, a U.S. health official said Thursday. Dr. Tom Frieden, director of the Centers for Disease Control and Prevention, told a congressional hearing that the outbreak is unprecedented in part because it's in a region of Africa that never has dealt with Ebola before.
A bug can turn you into a vegetarian, or at least make you swear off red meat. Doctors across the nation are seeing a surge of sudden meat allergies in people bitten by a certain kind of tick. This bizarre problem was only discovered a few years ago but is growing as the ticks spread from the Southwest and the East to more parts of the United States.
Researchers at Yale School of Medicine have discovered a new drug compound that reverses the brain deficits of Alzheimer’s disease in an animal model. The compound, TC-2153, inhibits the negative effects of a protein called STtriatal-Enriched tyrosine Phosphatase (STEP), which is key to regulating learning and memory. These cognitive functions are impaired in Alzheimer’s.
Sequencing the genomes of tumor cells has revealed thousands of mutations associated with cancer. One way to discover the role of these mutations is to breed a strain of mice that carry the genetic flaw—but breeding such mice is an expensive, time-consuming process. Now, Massachusetts Institute of Technology researchers have found an alternative.
It's long been known that faulty BRCA genes greatly raise the risk for breast cancer. Now scientists say a more recently identified, less common gene can do the same. Mutations in the gene can make breast cancer up to nine times more likely to develop, an international team of researchers reports in the New England Journal of Medicine.
- Page 1