Computer chips of a type more commonly found in games consoles have been used by scientists at the University of Bristol to reveal how the flu virus resists antiflu drugs such as Relenza and Tamiflu.
For 50 years scientists have been unsure how the bacteria that gives humans cholera manages to resist one of our basic innate immune responses. That mystery has now been solved, thanks to research from biologists at The University of Texas at Austin. The answers may help clear the way for a new class of antibiotics that don't directly shut down pathogenic bacteria, but instead disable their defenses so that our own immune systems can do the killing.
Researchers at the U.S. Air Force Research Laboratory have invented a simple, inexpensive dip-and-dry treatment can convert ordinary silk into a fabric that kills disease-causing bacteria—even the armor-coated spores of microbes like anthrax—in minutes.
The highly pathogenic hantavirus causes a condition known as hantavirus pulmonary syndrome (HPS), which has a case fatality rate of 35-40%. To help the fight against a disease that has no vaccine, U.S. Army scientists and industry collaborators have successfully protected laboratory animals from lethal hantavirus disease using a novel approach that combines DNA vaccines and duck eggs.
Biomedical engineers at University of California, Davis have developed a microfluidic chip to test for latent tuberculosis. They hope the test will be cheaper, faster, and more reliable than current testing for the disease.
A biomedical informatics researcher who tracks dangerous viruses as they spread around the globe has restructured his innovative tracking software to promote even wider use of the program around the world.
Hundreds of tiny hollow needles stick out of the membrane of a bacteria that causes cholera. These are treacherous tools that makes bacterial pathogens so dangerous. Researchers in the U.S. and Germany have now seen this structure in 3D detail at atomic resolution. The images may help drug researchers.
A research team at Rutgers University has been able to take a new pharmacological approach to activate the immune cells to prevent cancer growth through stimulation of the opiate receptors found on immune cells.
Doctors have long known that treating patients with multiple cancer drugs often produces better results than treatment with just a single drug. Now, a study from Massachusetts Institute of Technology shows that the order and timing of drug administration can have a dramatic effect.
The superbugs have met their match. Conceived at Nanyang Technological University, it comes in the form of a coating which has a magnetic-like feature that attracts bacteria and kills them without the need for antibiotics.
In order to reactivate silenced genes, a cell needs to remove certain “off” markers called methyl groups from the DNA. Scientists have recently shown that this process involves an intermediate step and an enzyme that also plays a role in the development of blood cancer. The finding could lead to new ideas for cancer-fighting therapies.
Researchers at the University of Michigan have identified new targets for drugs that could potentially treat anthrax, the deadly infection caused by Bacillus anthracis . The team found a new way to block the bacteria's ability to capture iron, which is vital to its survival and its disease-causing properties.
A pill that has long been used to treat HIV has moved one step closer to becoming the first drug approved to prevent healthy people from becoming infected with the virus that causes AIDS. The Food and Drug Administration said Tuesday that Gilead Sciences' Truvada appears to be safe and effective for HIV prevention.
One exhale and a new device from researchers at Stony Brook University in New York could screen for anything from diabetes to lung cancer. Based on a sensor chip built from electrospun nanowires that can detect minute amounts of chemical compounds, the device has yet to reach clinical trials. But its inventors anticipate the device to someday cost only $20.
Over the past several decades, scientists have faced challenges in developing new antibiotics even as bacteria have become increasingly resistant to existing drugs. One strategy that might combat such resistance would be to overwhelm bacterial defenses by using highly targeted nanoparticles to deliver large doses of existing antibiotics. In a step toward that goal, researchers have developed a nanoparticle designed to evade the immune system and home in on infection sites, then unleash a focused antibiotic attack.
A new Agriculture Department program will begin tracing the source of potentially contaminated ground beef as soon as there is an initial positive test. Current procedures require USDA officials to wait until additional testing confirms E. coli before starting their investigation. Under the new process, the source could be traced 24 to 48 hours sooner.
Researchers have taken advantage of cells' physical properties to develop a new instrument that slams cells against a wall of fluid and quickly analyzes the physical response, allowing for the identification of cancer and other cell states without expensive chemical tags.
Two Cornell University innovators from Africa have created a body suit embedded at the molecular level with insecticides to ward off mosquitoes infected with deadly malaria. The outfit could provide daytime protection and the insecticide does not dissipate like skin- or net-based repellants.
A research team at Karolinska Institutet in Sweden has solved the puzzle of the skin barrier: They have succeeded in describing the structure and function of the outermost layer of the skin—the stratum corneum—at a molecular level. This could enable large-scale delivery of drugs through the skin, or offer a deeper understanding of skin diseases.
While microemulsions are now used for drug delivery, such as antibiotics and syrups, using them for vaccines is new area of research. A U.S. Army major has developed a microemulsion made from five ingredients that could be a stable, promising candidate delivering a variety of antigens against diseases such as influenza.
Penicillin and other antibiotics have revolutionized medicine, turning once-deadly diseases into easily treatable ailments. However, while antibiotics have been in use for more than 70 years, the exact mechanism by which they kill bacteria has remained a mystery. Now a new study reveals the killing mechanism behind all three major classes of antibiotics.
By developing software that uses 3D models of proteins involved in cystic fibrosis, a team of scientists at Duke University has identified several new molecules that may ease the symptoms of the disease.
Striking an estimated 1 million Americans each year, kidney stones produce an excruciating pain that is among the worst known to man (or woman). Some are more prone to developing the condition than others, but until recent research on kidneys in mice the cause of the stones remained a mystery. The culprit is in the genes.
Researchers at the Max Planck Institute in Germany have discovered promising anti-diabetic substance in the amorfrutin class of natural substances, which are found in licorice and Amorpha fruticosa bush found in North America. The binding of these molecules, the scientists say, reduces the plasma concentration of certain fatty acids and glucose associated with diabetes or fatty liver conditions.
An international team of scientists conducting a global search for hypervirulent strains of Salmonella , the most common cause of infection, hospitalization, and death due to foodborne illness in the U.S., have developed a way to force the normally stealthy bacteria to reveal its biological weaponry before infection.