Researchers at Yale School of Medicine have pinpointed a mechanism in part of the brain that is key to sensing glucose levels in the blood, linking it to both type 1 and type 2 diabetes. The findings are published in the Proceedings of the National Academies of Sciences.
Imagine you're fighting for your life but no matter how hard you hit, your opponent won't go down. The same can be said of highly treatment-resistant cancers, such as head and neck cancer, where during radiation and chemotherapy some cancer cells repair themselves, survive and thrive. Head and neck cancer is the sixth most common cancer in the world, but the late detection and treatment resistance result in a high mortality rate.
Soon, protection from HIV infection could be as simple as inserting a medicated, disappearing fabric minutes before having sex. Univ. of Washington bioengineers have discovered a potentially faster way to deliver a topical drug that protects women from contracting HIV. Their method spins the drug into silk-like fibers that quickly dissolve when in contact with moisture, releasing high doses of the drug.
Some people can handle stressful situations better than others, and it’s not all in their genes: Even identical twins show differences in how they respond. Researchers have identified a specific electrical pattern in the brains of genetically identical mice that predicts how well individual animals will fare in stressful situations. The findings may eventually help researchers prevent potential consequences of chronic stress.
A new stem cell discovery might one day lead to a more streamlined process for obtaining stem cells, which in turn could be used in the development of replacement tissue for failing body parts, according to Univ. of California, San Francisco scientists who reported the findings in Cell.
Fifteen years ago, Massachusetts Institute of Technology professor John Essigmann and colleagues from the Univ. of Washington had a novel idea for an HIV drug. They thought if they could induce the virus to mutate uncontrollably, they could force it to weaken and eventually die out—a strategy that our immune system uses against many viruses.
A $1,000-per-pill drug that insurers are reluctant to pay for has quickly become the treatment of choice for a liver-wasting viral disease that affects more than three million Americans. In less than six months, prescriptions for Sovaldi have eclipsed all other hepatitis C pills combined, according to new data from IMS Health.
There is no cure for Alzheimer’s disease and other forms of dementia, but the research community is one step closer to finding treatment. Univ. of Washington bioengineers have a designed a peptide structure that can stop the harmful changes of the body’s normal proteins into a state that’s linked to widespread diseases such as Alzheimer’s, Parkinson’s, heart disease, Type 2 diabetes and Lou Gehrig’s disease.
The Wyss Institute for Biologically Inspired Engineering at Harvard Univ. announced that its human “Organs-on-Chips” technology will be commercialized by a newly formed private company to accelerate development of pharmaceutical, chemical, cosmetic and personalized medicine products.
A costly drug given mostly to premature babies is at the center of a clash between the manufacturer and the nation's leading pediatrician's group, which recommends scaling back use of the medicine. The dispute involves new guidelines from the American Academy of Pediatrics, which say medical evidence shows the drug benefits few children other than very young preemies.
Virologists and biologists in California have identified a highly abundant, never-before-described virus that could play a major role in obesity, diabetes. The virus, named crAssphage, has about 10 times as many base pairs of DNA as HIV and infects one of the most common types of gut bacteria. This phylum of bacteria is thought to be connected with obesity, diabetes and other gut-related diseases.
The drought that has the entire country in its grip is affecting more than the color of people’s lawns. It may also be responsible for the proliferation of a heat-loving amoeba commonly found in warm freshwater bodies, such as lakes, rivers and hot springs, which the drought has made warmer than usual this year.
Fragile X syndrome (FXS) is a genetic disorder that causes obsessive compulsive and repetitive behaviors, and other behaviors on the autistic spectrum, as well as cognitive deficits. It’s the most common inherited cause of mental impairment and the most common cause of autism. Now biomedical scientists at the Univ. of California, Riverside have published a study that sheds light on the cause of autistic behaviors in FXS.
The U.S. Food and Drug Administration on Wednesday approved a new cancer drug from Gilead Sciences Inc. to treat three types of blood cancer. Regulators approved the drug for patients with forms of chronic lymphocytic leukemia, follicular lymphoma and small lymphocytic lymphoma. The cancers affect an estimated 200,000 patients in the U.S., according to Gilead.
If you’re allergic to dust mites, help may be on the way. Researchers at the Univ. of Iowa have developed a vaccine that can combat dust-mite allergies by naturally switching the body’s immune response. In animal tests, the nano-sized vaccine package lowered lung inflammation by 83% despite repeated exposure to the allergens.
There is more good news about HIV treatment pills used to prevent infection in people at high risk of getting the AIDS virus: Follow-up from a landmark study that proved the drug works now shows that it does not encourage risky sex and is effective even if people skip some doses.
HIV-infected people carry many different HIV viruses and all have distinct personalities—some much more vengeful and infectious than others. Yet, despite the breadth of infectivity, roughly 76% of HIV infections arise from a single virus. Now, scientists believe they can identify the culprit with very specific measurements of the quantities of a key protein in the HIV virus.
The rate of HIV infections diagnosed in the U.S. each year fell by one-third over the past decade, a government study finds. Experts celebrated it as hopeful news that the AIDS epidemic may be slowing in the U.S. The reasons for the drop aren't clear. It might mean fewer new infections are occurring. Or that most infected people already have been diagnosed so more testing won't necessarily find many more cases.
Veterans, medical marijuana activists and scientists welcomed the first federally approved research into pot as a treatment for post-traumatic stress disorder. But their hopes for the research were dashed when the Univ. of Arizona fired researcher Suzanne Sisley, who undertook the study after clearing four years of bureaucratic hurdles.
The repetitive facilitation exercise is one of the most common rehabilitation tactics for stroke patients attempting to regain wrist movement. Stroke hemiparesis individuals are not able to move that part of their body because they cannot create a strong enough neural signal that travels from the brain to the wrist.
The director of the Centers for Disease Control and Prevention acknowledged Wednesday that systemic safety problems have for years plagued federal public health laboratories that handle dangerous germs such as anthrax and bird flu. Testifying at a congressional hearing in Washington, CDC Director Dr. Tom Frieden said the agency had long thought of the lapses as unrelated accidents.
Researchers in Kentucky have developed a technology that uses male mosquitoes to effectively sterilize females through a naturally occurring bacterium. Called MosquitoMate, the new technology has been issued an experimental use permit for open field releases targeting the invasive Asian tiger mosquito, which is a vector for newly introduced pathogens like the Chikungunya virus.
A microbe detection array technology developed by Lawrence Livermore National Laboratory (LLNL) scientists could provide a new rapid method for public health authorities to conduct surveillance for emerging viral diseases. This possible use of the Lawrence Livermore Microbial Detection Array (LLMDA) was studied by an international team of researchers from eight nations in a paper published in the PLOS ONE.
Despite impressive medical strides, cancer remains a leading killer and overwhelming burden to healthcare systems, causing well over a half million fatalities per year with a projected cost of $174 billion by 2020, according to the National Cancer Institute. Reducing the human and economic toll will require diagnosis and intervention at early stages of illness, when the best prognosis for a cure exists.
The rate of Alzheimer's disease and other dementias is falling in the U.S. and some other rich countries—good news about an epidemic that is still growing simply because more people are living to an old age, new studies show. An American over age 60 today has a 44% lower chance of developing dementia than a similar-aged person did roughly 30 years ago, the longest study of these trends in the U.S. concluded.