Researchers report in Nature that they have made a breakthrough in understanding how a powerful antibiotic agent is made in nature. Their discovery solves a decades-old mystery, and opens up new avenues of research into thousands of similar molecules, many of which are likely to be medically useful.
Like a slumbering dragon, HIV can lay dormant in a person’s cells for years, evading medical treatments only to wake up and strike at a later time, quickly replicating itself and destroying the immune system. Scientists at the Salk Institute have uncovered a new protein that participates in active HIV replication. The new protein, called Ssu72, is part of a switch used to awaken HIV-1 from its slumber.
In early drug discovery, you need a starting point. In a new research paper published in PLOS-Neglected Tropical Diseases, a team of researchers present hundreds of such starting points for potentially treating Human African trypanosomiasis, or sleeping sickness, a deadly disease that affects thousands of people annually.
The governors of New York and New Jersey are at odds with scientists over Ebola as they back 21-day quarantines for medical workers returning from West Africa, while the nation's top infectious-disease expert warns that such restrictions are unnecessary and could discourage volunteers from aiding disease-ravaged countries.
New achievements in synthetic biology, which will allow complex cellular recognition reactions to proceed outside of living cells, will dare scientists to dream big: There could one day be inexpensive, shippable and accurate test kits that use saliva or a drop of blood to identify specific disease or infection.
The federal government is closing a gap in Ebola screening at airports while states from New York to Texas to California work to get hospitals and nurses ready in case another patient turns up somewhere in the U.S. with the deadly disease. Under the rule going into effect Wednesday, air travelers from the West African nations must enter the U.S. through one of five airports doing special screenings and fever checks for Ebola.
Scientists think of CD8 T cells as long-lived cells that become tuned to fight just one pathogen, but a new study finds that once CD8 T cells fight one pathogen, they also join the body’s “innate” immune system, ready to answer the calls of the cytokine signals that are set off by a wide variety of infections.
Rice Univ. bioengineers have found new evidence of a possible link between diabetes and the hardening of heart valves. A Rice laboratory, in collaboration with the Univ. of Texas Health Science Center at Houston Medical School, discovered that the interstitial cells that turn raw materials into heart valves need just the right amount of nutrients for proper metabolic function.
Federal health officials on Monday issued new guidelines to promote head-to-toe protection for health workers treating Ebola patients. Officials have been scrambling to come up with new advice for protective gear since two Dallas nurses became infected while caring for the first person diagnosed with the virus in the U.S.
European Union nations are working to reach 1 billion euros ($1.27 billion) in aid by the end of the week to fight Ebola in West Africa and are seeking a common approach to the crisis.EU foreign ministers began a week of talks Monday so their 28 leaders can agree by Friday on better measures to fight Ebola, anything from financial aid to common repatriation procedures, more Ebola treatment facilities and better training for health workers.
Ebola fears began to ease for some Monday as a monitoring period passed for those who had close contact with a victim of the disease and after a cruise ship scare ended with the boat returning to port and a laboratory worker on board testing negative for the virus. Federal officials meanwhile ramped up readiness to deal with future cases.
Scientists have used computer simulations to show how bacteria are able to destroy antibiotics, a breakthrough which will help develop drugs which can effectively tackle infections in the future. Researchers at the Univ. of Bristol focused on the role of enzymes in the bacteria, which split the structure of the antibiotic and stop it working, making the bacteria resistant.
The new Urban Dynamics Institute at Oak Ridge National Laboratory is working with the Bill & Melinda Gates Foundation to aid polio vaccination efforts in developing countries. Teams at the institute will apply big data analysis to population dynamics in Nigeria, allowing polio vaccination crews to better estimate the amount of vaccine needed and to target areas of priority, saving time and money in eradicating the disease.
Buoyed by several dramatic advances, Lawrence Livermore National Laboratory (LLNL) scientists think they can tackle biological science in a way that couldn't be done before. Over the past two years, LLNL researchers have expedited accelerator mass spectrometer sample preparation and analysis time from days to minutes and moved a complex scientific process requiring accelerator physicists into routine laboratory usage.
Researchers are exploring the usefulness of ultrasound imaging to study dangerous abdominal aortic aneurysms, a bulging of the aorta that is usually fatal when it ruptures and for which there is no effective medical treatment. Abdominal aortic aneurysms are the 13th leading cause of death in the U.S., killing about 15,000 annually.
Researchers from the Univ. of Sheffield have found vital new evidence on how to target and reverse the effects caused by one of the most common genetic causes of Parkinson’s. Mutations in a gene called LRRK2 carry a well-established risk for Parkinson’s disease, however the basis for this link is unclear.
A new study by scientists from The Scripps Research Institute, Lawrence Berkeley National Laboratory and other institutions suggests a cause of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. The team's work supports a common theme whereby loss of protein stability leads to disease.
President Barack Obama urged his top national security and public health officials on Monday to incorporate lessons from the most recent Texas Ebola infection into the U.S.'s response plans to the deadly virus. He also called on the international community to deliver assistance more quickly to the countries of West Africa that are struggling against the disease.
The Centers for Disease Control and Prevention has said that at least 2 million Americans are sickened by antibiotic resistant infections each year and survive. Twenty-three thousand die. These experiences leave deep impressions not just on the patients but on their family and friends.
A breach of infection control resulting in a Dallas health worker getting Ebola raises fresh questions about whether hospitals truly can safely take care of people with the deadly virus, as health officials insist is possible. Even in the U.S., with the best conditions and protective gear available, mistakes can happen that expose more people to Ebola, the new case reveals.
Autism is characterized by many different symptoms: difficulty interacting with others, repetitive behaviors and hypersensitivity to sound and other stimuli. Massachusetts Institute of Technology neuroscientists have put forth a new hypothesis that accounts for these behaviors and may provide a neurological foundation for many of the disparate features of the disorder.
Hepatitis C, an infectious disease of the liver caused by the hepatitis C virus (HCV), affects 160 million people worldwide. There’s no vaccine for HCV and the few treatments that are available do not work on all variants of the virus. Before scientists can develop potential vaccines and additional therapies they must first thoroughly understand the molecular-level activity that takes place when the virus infects a host cell.
HIV is adept at eluding immune system responses because the protein it uses to infect cells is constantly changing. Now a team of researchers including scientists from Yale Univ. have stripped the cloak from this master of disguise, providing a high-resolution image of this surface spike protein and monitoring how it constantly changes its shape, information that suggests new ways to attack the virus through drugs and vaccines.
Tuberculosis is caused by a bacterium that infects the lungs of an estimated 8.6 million people worldwide. The fight against the disease is hampered by the fact that treatment requires a long time and that the bacterium often develops multi-drug resistance. Scientists have used a sensitive screening assay to test new compounds that can be used against the bacterium, and have discovered two small molecules that show remarkable promise.
The first person diagnosed with Ebola in the U.S. died Wednesday despite intense but delayed treatment, and the government announced it was expanding airport examinations to guard against the spread of the deadly disease. The checks will include taking the temperatures of hundreds of travelers arriving from West Africa at five major American airports.