The World Health Organization will start large-scale testing of an experimental Ebola vaccine in Guinea on Saturday to see how effective it might be in preventing future outbreaks of the deadly virus. The West African nations of Sierra Leone, Liberia and Guinea have been hardest hit in the yearlong Ebola outbreak, which is estimated to have left more than 9,800 people dead.
The miserable flu season is winding down but not quite over yet, health officials said Wednesday, even the government picked what it hoped would be a better vaccine recipe for next fall and winter. If it seems early to worry about the next flu season, well, producing 140 million doses of vaccine requires starting months in advance.
For the first time, researchers have produced a 3-D image revealing part of the inner structure of an intact, infectious virus, using a unique x-ray laser at the SLAC National Accelerator Laboratory. The virus, called Mimivirus, is in a curious class of “giant viruses” discovered just over a decade ago.
Tiny parasitic hookworms infect nearly half a billion people worldwide, almost exclusively in developing countries, causing health problems ranging from gastrointestinal issues to cognitive impairment and stunted growth in children. By sequencing and analyzing the genome of one particular hookworm species, Caltech researchers have uncovered new information that could aid the fight against these parasites.
Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back. A new nanodevice developed by Massachusetts Institute of Technology researchers can help overcome that by first blocking the gene that confers drug resistance, then launching a new chemotherapy attack against the disarmed tumors.
With antibiotic resistance on the rise, scientists are looking for innovative ways to combat bacterial infections. The pathogen that causes conditions from strep throat to flesh-eating disease is among them, but scientists have now found a tool that could help them fight it: a drug approved to treat HIV. Their work, appearing in ACS Chemical Biology, could someday lead to new treatments.
A chemical found in garlic can kill bacteria that cause life-threatening lung infections in people with cystic fibrosis, research suggests. The study is the first to show that the chemical, known as allicin, could be an effective treatment against a group of infectious bacteria that is highly resistant to most antibiotics.
Researchers at the Univ. of North Carolina School of Medicine have found that the blood platelet protein Rasa3 is critical to the success of the common anti-platelet drug Plavix, which breaks up blood clots during heart attacks and other arterial diseases. The discovery details how Rasa3 is part of a cellular pathway crucial for platelet activity during clot formation.
When diagnosing a case of Ebola, time is of the essence. However, existing diagnostic tests take at least a day or two to yield results, preventing health care workers from quickly determining whether a patient needs immediate treatment and isolation. A new test could change that: The device, a simple paper strip similar to a pregnancy test, can rapidly diagnose Ebola, as well as other viral hemorrhagic fevers.
An experimental antiviral drug shows some early, encouraging signs of effectiveness in its first human test against Ebola in West Africa, but only if patients get it when their symptoms first appear. A study of the drug, favipiravir, is still in early stages in West Africa, and too few people have been treated to really know whether the drug helps.
Case Western Reserve Univ. dental researcher Pushpa Pandiyan has discovered a new way to model how infection-fighting T cells cause inflammation in mice. The hope is that the discovery can lead to new therapies or drugs that jump-start weakened or poorly functioning immune systems. Pandiyan believes the process could lead to identifying and testing new drugs to replace antifungal medicines.
North Korean authorities are barring foreigners from this year's Pyongyang marathon, a popular tourist event, amid ongoing Ebola travel restrictions, the head of a travel agency that specializes in the country said Monday. Nick Bonner, co-founder of Beijing-based Koryo Tours, said more than 400 foreign runners had signed up with his agency alone for the event, which is to be held April 12.
In recent years, scientists have found a surprising a connection between some people with autism and certain cancer patients: They have mutations in the same gene, one that codes for a protein critical for normal cellular health. Now scientists have reported in Biochemistry that the defects reduce the activity and stability of the protein. Their findings could someday help lead to new treatments for both sets of patients.
Federal health officials are easing access to DNA tests used to screen parents for devastating genetic disorders that can be passed on to their children. The surprise announcement offers a path forward for Google-backed genetic testing firm 23andMe, which previously clashed with regulators over its direct-to-consumer technology.
Single-letter genetic variations within parts of the genome once dismissed as 'junk DNA' can increase cancer risk through wormhole-like effects on far-off genes, new research shows.
Our susceptibility to disease depends both on the genes that we inherit from our parents and on our lifetime experiences. These two components—nature and nurture—seem to affect very different processes in the context of Alzheimer's disease, according to a new study published in Nature.
A molecule that can block the progress of Alzheimer's disease at a crucial stage in its development has been identified by researchers in a new study, raising the prospect that more such molecules may now be found. The report shows that a molecular chaperone can play the role of an "inhibitor" part-way through the molecular process that's thought to cause Alzheimer's.
The appearance of infectious diseases in new places and new hosts, such as West Nile virus and Ebola, is a predictable result of climate change, says a noted zoologist affiliated with the Harold W. Manter Laboratory of Parasitology at the Univ. of Nebraska-Lincoln.
Rivers and streams could be a major source of antibiotic resistance in the environment. The discovery comes following a study on the Thames river by scientists at the Univ. of Warwick and the Univ. of Exeter. The study found that greater numbers of resistant bacteria exist close to some waste water treatment works, and that these plants are likely to be responsible for at least half of the increase observed.
A new report shows this winter's nasty flu season has peaked and is clearly retreating. The flu reached its highest levels around the beginning of January, and stayed there for weeks. The government report out Friday shows flu has become less widespread and less intense in the last couple of weeks in most parts of the country.
Viruses are masters of outsourcing, entrusting their fundamental function– reproduction– to the host cells they infect. But it turns out this highly economical approach also creates vulnerability. Researchers have found an unexpected way the immune system exploits the flu virus’ dependence on its host’s machinery to create new viruses capable of spreading infection.
Mice genetically deficient in serotonin, a crucial brain chemical implicated in clinical depression, are more vulnerable than their normal littermates to social stressors, according to a Duke Univ. study. Following exposure to stress, the serotonin-deficient mice also did not respond to a standard antidepressant, fluoxetine (Prozac), which works by boosting serotonin transmission between neighboring neurons.
For patients with diabetes, insulin is critical to maintaining good health and normal blood-sugar levels. However, it’s not an ideal solution because it can be difficult for patients to determine exactly how much insulin they need to prevent their blood sugar from swinging too high or too low. Massachusetts Institute of Technology engineers hope to improve treatment for diabetes patients with a new type of engineered insulin.
Applying lessons learned from autism to brain cancer, researchers at The Johns Hopkins Univ. have discovered why elevated levels of the protein NHE9 add to the lethality of the most common and aggressive form of brain cancer, glioblastoma. Their discovery suggests that drugs designed to target NHE9 could help to successfully fight the deadly disease.
It took 16 years of twists and turns. Over and over, Dr. Nancy Sullivan thought she was close to an Ebola vaccine, only to see the next experiment fail. "A case of resuscitation more than once," is how the National Institutes of Health researcher describes the journey.