Scientists have discovered a natural temperature sensor in a type of bacteria that causes meningitis and sepsis. The sensor allows the bacteria to evade the body’s immune response, leading to life-threatening infections. The Oxford Univ. team found that increasing temperature causes the bacteria to make more of a protective layer that surrounds the bacterium like an 'invisibility cloak' and helps it evade detection by the immune system.
Many viruses infect humans through mucosal surfaces. To help fight these viruses, scientists are working on vaccines that can establish a defense at mucosal surfaces. Vaccines can be delivered to the lungs via an aerosol spray, but are often cleared away before they can provoke an immune response. To overcome that, engineers have developed a new type of nanoparticle that protects the vaccine long enough to generate a strong immune response.
Researchers at The Scripps Research Institute discovered that an antibody that binds and neutralizes HIV likely also targets the body’s own “self” proteins. This finding could complicate the development of HIV vaccines designed to elicit this protective antibody, called 4E10, and others like it, as doing so might be dangerous or inefficient.
Pinning down an effective way to combat the spread of HIV, the viral precursor to AIDS, has long been a challenge for scientists and physicians, because the virus is an elusive one that mutates frequently and, as a result, quickly becomes immune to medication. A team of Drexel Univ. researchers is trying to get one step ahead of the virus with a microbicide they’ve created that can trick HIV into “popping” itself into oblivion.
A Lawrence Livermore National Laboratory-developed biological detection technology has been employed as part of an international collaboration that has detected a virus in bladder cancers. The research is believed to be the first study to demonstrate an association between Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, and bladder cancers.
New research suggests it might be possible to spot early signs of multiple sclerosis in patients' spinal fluid, findings that offer a new clue about how this mysterious disease forms. The study released Tuesday was small and must be verified by additional research. But if it pans out, the finding suggests scientists should take a closer look at a different part of the brain than is usually linked to MS.
Yale Univ. School of Medicine researchers have discovered a protein that is the missing link in the complicated chain of events that lead to Alzheimer’s disease. They report the discovery in Neuron. Researchers also found that blocking the protein with an existing drug can restore memory in mice with brain damage that mimics the disease.
Flu vaccination is no longer merely a choice between a jab in the arm or a squirt in the nose. This fall, some brands promise a little extra protection. For the first time, certain vaccines will guard against four strains of flu rather than the usual three. Called quadrivalent vaccines, these brands may prove more popular for children than their parents. That's because kids tend to catch the newly added strain more often.
Scientists have found a compelling clue in the quest to learn what causes age-related memory problems. Wednesday's report offers evidence that age-related memory loss really is a distinct condition from pre-Alzheimer's—and offers a hint that what we now consider the normal forgetfulness of old age might eventually be treatable.
A new genome-wide association study (GWAS) estimates the number of different places in the human genome that are involved in schizophrenia. In particular, the study identifies 22 locations, including 13 that are newly discovered, that are believed to play a role in causing schizophrenia.
Univ. of California, Irvine infectious disease researchers have uncovered components of the SARS coronavirus that allow it to take over host cells in order to replicate. This insight is critical for a full understanding of any outbreaks caused by such viruses and may prove beneficial in the development of therapies not only for human coronavirus infections but for other pathogenic illnesses as well.
By any measure, tuberculosis (TB) is a wildly successful pathogen. It infects as many as two billion people in every corner of the world, with a new infection of a human host estimated to occur every second. Now, thanks to a new analysis of dozens of tuberculosis genomes gathered from around the world, scientists are getting a more detailed picture of why TB is so prevalent and how it evolves to resist countermeasures.
Anxiety disorders affect 40 million American adults in a given year. Currently available treatments, such as antianxiety drugs, are not always effective and have unwanted side effects. To develop better treatments, a more specific understanding of the brain circuits that produce anxiety is necessary. Researchers have now discovered a communication pathway between the amygdala and the ventral hippocampus that appears to control anxiety.
A new study by Rice Univ. biophysicists offers the most comprehensive picture yet of the molecular-level action of melittin, the principal toxin in bee venom. The research could aid in the development of new drugs that use a similar mechanism as melittin’s to attack cancer and bacteria.
Shares of Immunomedics jumped Wednesday after announcing that its treatment for a type of non-Hodgkin lymphoma helped to extend the lives of patients that used it in combination with another drug. The company said patients with newly diagnosed follicular lymphoma responded well to a combination of its epratuzumab and Roche's drug, Rituxan.
A new study from an international team led by Oak Ridge National Laboratory is guiding drug designers toward improved pharmaceuticals to treat HIV. The scientists used neutrons and x-rays to study the interactions between HIV protease, a protein produced by the HIV virus, and an antiviral drug commonly used to block virus replication.
For cancer patients, it’s not the primary tumor that is deadly, but the spread or “metastasis” of cancer cells from the primary tumor to secondary locations throughout the body that is the problem. That’s why a major focus of contemporary cancer research is how to stop or fight metastasis. Studies suggest that metastasizing cancer cells undergo a major molecular change when they leave the primary tumor—a process called EMT.
In 1998, scientists published the first complete genome of a multicellular organism—the worm Caenorhabditis elegans. At the same time, new technologies were emerging to help researchers manipulate genes and learn more about their functions.
Outbreaks such as the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome coronavirus (MERS) have afflicted people around the world, yet many people think these trends are on the decline. Quite the opposite is true. The efforts to combat this epidemic are being spearheaded by a team of Lawrence Livermore National Laboratory scientists.
Higher blood-sugar levels, even those well short of diabetes, seem to raise the risk of developing dementia, a major new study finds. Researchers say it suggests a novel way to try to prevent Alzheimer's disease—by keeping glucose at a healthy level.
Scientists who sparked an outcry by creating easier-to-spread versions of the bird flu want to try such experiments again using a worrisome new strain known as H7N9. Since it broke out in China in March, the bird flu strain has infected more than 130 people and killed 43. Researchers say that genetically engineering this virus in the lab could help track whether it's changing in the wild to become a bigger threat.
At Battelle, supporting America’s military personnel is woven into the fabric of its business. In that pursuit, a team consisting of Battelle, NxStage Medical Inc. and Aethlon Medical has won a contract from DARPA to develop an innovative, new medical device that may save the lives of soldiers—and civilians as well—by treating sepsis.
Univ. of Maryland Ventures announced agreements between Univ. of Maryland, Baltimore and five different life sciences companies across the Baltimore/Washington metropolitan region. The companies include Rexahn Pharmaceuticals, Plasmonix, IGI Technologies, A&G Pharmaceuticals and BioAssay Works.
“Are we there yet?” As anyone who has traveled with young children knows, maintaining focus on distant goals can be a challenge. A new study from Massachusetts Institute of Technology suggests how the brain achieves this task, and indicates that the neurotransmitter dopamine may signal the value of long-term rewards.
China and Russia have halted imports of some New Zealand dairy products in response to a botulism scare, according to New Zealand government officials. New Zealand dairy giant Fonterra announced Saturday that up to 1,000 tons of infant formula, sports drinks and other products sold in seven countries could be tainted after tests turned up bacteria in whey protein that could cause botulism.