Rice Univ. bioengineers are teaming with colleagues from Baylor College of Medicine and MD Anderson Cancer Center to apply the latest techniques in tissue engineering toward the study of one of the most common and deadly human illnesses: the stomach flu. The bacteria and viruses that cause acute gastroenteritis often come from contaminated food or water and result in cramps, nausea, diarrhea and vomiting.
Materials resulting from chemical bonding of glucosamine, a type of sugar, with fullerenes, kind of nanoparticles known as buckyballs, might help to reduce cell damage and inflammation occurring after stroke. A team from the Max Planck Institute in Germany has tested this on mice, opening the door to potential new drugs for the cerebrovascular accident.
Federal health officials are stepping up their oversight of medical scopes linked to potentially fatal "superbug" outbreaks. The Food and Drug Administration released stricter guidelines for manufacturers of reusable medical instruments, including specialized endoscopes used in about a half-million U.S. medical procedures each year.
Can a tetanus shot help treat brain cancer? A dose of tetanus vaccine let patients live longer when added to an experimental treatment for the most common and deadly kind of brain tumor, researchers report.
Since December, an outbreak of swine flu in India has killed more than 1,200 people, and a new study suggests that the strain has acquired mutations that make it more dangerous than previously circulating strains of H1N1 influenza. The findings contradict previous reports from Indian health officials that the strain has not changed from the version of H1N1 that emerged in 2009 and has been circulating around the world ever since.
Scientists have determined the basic structural organization of a molecular motor that hauls cargoes and performs other critical functions within cells. Biologists have long wanted to know how this molecular motor works. But the complex’s large size, myriad subunits and high flexibility have until now restricted structural studies to small pieces of the whole.
A new study has identified both where and how a protein in the brain, called Neuropeptide Y (NPY), can act to suppress binge alcohol drinking. The find suggests that restoring NPY may be useful for treating alcohol use disorders and may also protect some individuals from becoming alcohol dependent.
While today’s human body contains a variety of these proteins, a marine sciences professor believes they evolved from a single ancestor millions of years ago. This find is pivotal in unraveling the mysteries of DNA organization and regulation, and could someday lead to innovative biomonitoring strategies and therapies targeting a variety of diseases including cancer.
Bioengineers are presenting a network of pulsating cardiac muscle cells housed in an inch-long silicone device that effectively models human heart tissue. They have demonstrated the viability of this system as a drug-screening tool by testing it with cardiovascular medications.
The World Health Organization will start large-scale testing of an experimental Ebola vaccine in Guinea on Saturday to see how effective it might be in preventing future outbreaks of the deadly virus. The West African nations of Sierra Leone, Liberia and Guinea have been hardest hit in the yearlong Ebola outbreak, which is estimated to have left more than 9,800 people dead.
The miserable flu season is winding down but not quite over yet, health officials said Wednesday, even the government picked what it hoped would be a better vaccine recipe for next fall and winter. If it seems early to worry about the next flu season, well, producing 140 million doses of vaccine requires starting months in advance.
For the first time, researchers have produced a 3-D image revealing part of the inner structure of an intact, infectious virus, using a unique x-ray laser at the SLAC National Accelerator Laboratory. The virus, called Mimivirus, is in a curious class of “giant viruses” discovered just over a decade ago.
Tiny parasitic hookworms infect nearly half a billion people worldwide, almost exclusively in developing countries, causing health problems ranging from gastrointestinal issues to cognitive impairment and stunted growth in children. By sequencing and analyzing the genome of one particular hookworm species, Caltech researchers have uncovered new information that could aid the fight against these parasites.
Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back. A new nanodevice developed by Massachusetts Institute of Technology researchers can help overcome that by first blocking the gene that confers drug resistance, then launching a new chemotherapy attack against the disarmed tumors.
With antibiotic resistance on the rise, scientists are looking for innovative ways to combat bacterial infections. The pathogen that causes conditions from strep throat to flesh-eating disease is among them, but scientists have now found a tool that could help them fight it: a drug approved to treat HIV. Their work, appearing in ACS Chemical Biology, could someday lead to new treatments.
A chemical found in garlic can kill bacteria that cause life-threatening lung infections in people with cystic fibrosis, research suggests. The study is the first to show that the chemical, known as allicin, could be an effective treatment against a group of infectious bacteria that is highly resistant to most antibiotics.
Researchers at the Univ. of North Carolina School of Medicine have found that the blood platelet protein Rasa3 is critical to the success of the common anti-platelet drug Plavix, which breaks up blood clots during heart attacks and other arterial diseases. The discovery details how Rasa3 is part of a cellular pathway crucial for platelet activity during clot formation.
When diagnosing a case of Ebola, time is of the essence. However, existing diagnostic tests take at least a day or two to yield results, preventing health care workers from quickly determining whether a patient needs immediate treatment and isolation. A new test could change that: The device, a simple paper strip similar to a pregnancy test, can rapidly diagnose Ebola, as well as other viral hemorrhagic fevers.
An experimental antiviral drug shows some early, encouraging signs of effectiveness in its first human test against Ebola in West Africa, but only if patients get it when their symptoms first appear. A study of the drug, favipiravir, is still in early stages in West Africa, and too few people have been treated to really know whether the drug helps.
Case Western Reserve Univ. dental researcher Pushpa Pandiyan has discovered a new way to model how infection-fighting T cells cause inflammation in mice. The hope is that the discovery can lead to new therapies or drugs that jump-start weakened or poorly functioning immune systems. Pandiyan believes the process could lead to identifying and testing new drugs to replace antifungal medicines.
North Korean authorities are barring foreigners from this year's Pyongyang marathon, a popular tourist event, amid ongoing Ebola travel restrictions, the head of a travel agency that specializes in the country said Monday. Nick Bonner, co-founder of Beijing-based Koryo Tours, said more than 400 foreign runners had signed up with his agency alone for the event, which is to be held April 12.
In recent years, scientists have found a surprising a connection between some people with autism and certain cancer patients: They have mutations in the same gene, one that codes for a protein critical for normal cellular health. Now scientists have reported in Biochemistry that the defects reduce the activity and stability of the protein. Their findings could someday help lead to new treatments for both sets of patients.
Federal health officials are easing access to DNA tests used to screen parents for devastating genetic disorders that can be passed on to their children. The surprise announcement offers a path forward for Google-backed genetic testing firm 23andMe, which previously clashed with regulators over its direct-to-consumer technology.
Single-letter genetic variations within parts of the genome once dismissed as 'junk DNA' can increase cancer risk through wormhole-like effects on far-off genes, new research shows.
Our susceptibility to disease depends both on the genes that we inherit from our parents and on our lifetime experiences. These two components—nature and nurture—seem to affect very different processes in the context of Alzheimer's disease, according to a new study published in Nature.