Case Western Reserve Univ. dental researcher Pushpa Pandiyan has discovered a new way to model how infection-fighting T cells cause inflammation in mice. The hope is that the discovery can lead to new therapies or drugs that jump-start weakened or poorly functioning immune systems. Pandiyan believes the process could lead to identifying and testing new drugs to replace antifungal medicines.
North Korean authorities are barring foreigners from this year's Pyongyang marathon, a popular tourist event, amid ongoing Ebola travel restrictions, the head of a travel agency that specializes in the country said Monday. Nick Bonner, co-founder of Beijing-based Koryo Tours, said more than 400 foreign runners had signed up with his agency alone for the event, which is to be held April 12.
In recent years, scientists have found a surprising a connection between some people with autism and certain cancer patients: They have mutations in the same gene, one that codes for a protein critical for normal cellular health. Now scientists have reported in Biochemistry that the defects reduce the activity and stability of the protein. Their findings could someday help lead to new treatments for both sets of patients.
Federal health officials are easing access to DNA tests used to screen parents for devastating genetic disorders that can be passed on to their children. The surprise announcement offers a path forward for Google-backed genetic testing firm 23andMe, which previously clashed with regulators over its direct-to-consumer technology.
Single-letter genetic variations within parts of the genome once dismissed as 'junk DNA' can increase cancer risk through wormhole-like effects on far-off genes, new research shows.
Our susceptibility to disease depends both on the genes that we inherit from our parents and on our lifetime experiences. These two components—nature and nurture—seem to affect very different processes in the context of Alzheimer's disease, according to a new study published in Nature.
A molecule that can block the progress of Alzheimer's disease at a crucial stage in its development has been identified by researchers in a new study, raising the prospect that more such molecules may now be found. The report shows that a molecular chaperone can play the role of an "inhibitor" part-way through the molecular process that's thought to cause Alzheimer's.
The appearance of infectious diseases in new places and new hosts, such as West Nile virus and Ebola, is a predictable result of climate change, says a noted zoologist affiliated with the Harold W. Manter Laboratory of Parasitology at the Univ. of Nebraska-Lincoln.
Rivers and streams could be a major source of antibiotic resistance in the environment. The discovery comes following a study on the Thames river by scientists at the Univ. of Warwick and the Univ. of Exeter. The study found that greater numbers of resistant bacteria exist close to some waste water treatment works, and that these plants are likely to be responsible for at least half of the increase observed.
A new report shows this winter's nasty flu season has peaked and is clearly retreating. The flu reached its highest levels around the beginning of January, and stayed there for weeks. The government report out Friday shows flu has become less widespread and less intense in the last couple of weeks in most parts of the country.
Viruses are masters of outsourcing, entrusting their fundamental function– reproduction– to the host cells they infect. But it turns out this highly economical approach also creates vulnerability. Researchers have found an unexpected way the immune system exploits the flu virus’ dependence on its host’s machinery to create new viruses capable of spreading infection.
Mice genetically deficient in serotonin, a crucial brain chemical implicated in clinical depression, are more vulnerable than their normal littermates to social stressors, according to a Duke Univ. study. Following exposure to stress, the serotonin-deficient mice also did not respond to a standard antidepressant, fluoxetine (Prozac), which works by boosting serotonin transmission between neighboring neurons.
For patients with diabetes, insulin is critical to maintaining good health and normal blood-sugar levels. However, it’s not an ideal solution because it can be difficult for patients to determine exactly how much insulin they need to prevent their blood sugar from swinging too high or too low. Massachusetts Institute of Technology engineers hope to improve treatment for diabetes patients with a new type of engineered insulin.
Applying lessons learned from autism to brain cancer, researchers at The Johns Hopkins Univ. have discovered why elevated levels of the protein NHE9 add to the lethality of the most common and aggressive form of brain cancer, glioblastoma. Their discovery suggests that drugs designed to target NHE9 could help to successfully fight the deadly disease.
It took 16 years of twists and turns. Over and over, Dr. Nancy Sullivan thought she was close to an Ebola vaccine, only to see the next experiment fail. "A case of resuscitation more than once," is how the National Institutes of Health researcher describes the journey.
Through an investigation of a fundamental process that guides the maturation of immune cells, researchers have revealed new insights into possible ways to vaccinate people to generate potent antibodies of the type that are predicted to offer protection against diverse strains of the highly mutable HIV.
Drinking red grape juice or wine in moderation could improve the health of overweight people by helping them burn fat better, according to a new study coauthored by an Oregon State Univ. researcher. The findings suggest that consuming dark-colored grapes, whether eating them or drinking juice or wine, might help people better manage obesity and related metabolic disorders such as fatty liver.
In 2008, the World Health Organization announced a global effort to eradicate malaria, which kills about 800,000 people every year. As part of that goal, scientists are trying to develop new drugs that target the malaria parasite during the stage when it infects the human liver, which is crucial because some strains of malaria can lie dormant in the liver for several years before flaring up.
Bacteria have a sophisticated means of defending themselves, and they need it: more viruses infect bacteria than any other biological entity. Two experiments undertaken at the SLAC National Accelerator Laboratory provide new insight at the heart of bacterial adaptive defenses in a system called CRISPR, short for Clustered Regularly Interspaced Short Palindromic Repeat.
Federal health regulators on Tuesday approved a highly anticipated medicine from Pfizer Inc. to treat postmenopausal women with a certain type of advanced breast cancer who have not already taken other drugs. The Food and Drug Administration approved Ibrance for women who have tumors that do not contain a protein known as HER-2. Ibrance, known generically as palbociclib, works by blocking molecules linked to cancer cell growth.
Federal health officials are facing questioning about why this year's flu vaccine isn't giving good protection against the winter menace. This is a particularly bad flu season, and one reason is that the most common flu strain isn't a good match to this year's vaccine. Lawmakers on Tuesday asked why the Centers for Disease Control and Prevention didn't act months ago when concerns first arose to create a better-matched vaccine.
Moderate consumption of alcohol has been associated with health benefits in some, but not all, studies. Researchers at the Yale Univ. School of Medicine may have found an explanation, in part, for why non-smokers might benefit from a glass of wine.
A complex interplay of molecular components governs most aspects of biological sciences: healthy organism development, disease progression and drug efficacy are all dependent on the way life's molecules interact in the body. Understanding these biomolecular interactions is critical for the discovery of new therapeutics and diagnostics to treat diseases, but currently requires scientists to have access to expensive laboratory equipment.
President Barack Obama is calling for an investment to move away from one-size-fits-all-medicine, toward an approach that tailors treatment to your genes. The White House said Friday that Obama will ask Congress for $215 million for what he's calling a precision medicine initiative. The ambitious goal: Scientists will assemble databases of about a million volunteers to study their genetics to learn how to individualize care.
A gas that gives rotten eggs their distinctive odor could one day form the basis of new cardiovascular therapies. Research has indicated that a new compound, called AP39, which generates minute quantities of the gas hydrogen sulfide inside cells, could be beneficial in cases of high blood pressure and diseases of the blood vessels that occur with aging and diabetes.