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The Lead

High-speed drug screen

September 30, 2014 7:37 am | by Anne Trafton, MIT News Office | News | Comments

Massachusetts Institute of Technology engineers have devised a way to rapidly test hundreds of different drug-delivery vehicles in living animals, making it easier to discover promising new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA and DNA, to human patients.

Graphene sensor tracks down cancer biomarkers

September 19, 2014 4:33 pm | News | Comments

A new,...

New diagnostic method identifies genetic diseases

September 18, 2014 9:01 am | News | Comments

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Blood-cleansing biospleen device developed for sepsis therapy

September 15, 2014 8:21 am | by Kristen Kusek, Wyss Institute for Biologically Inspired Engineering, Harvard Univ. | News | Comments

Things can go downhill fast when a patient has sepsis, a life-threatening condition in which bacteria or fungi multiply in a patient's blood—often too fast for antibiotics to help. A new device inspired by the human spleen and developed by a team at Harvard's Wyss Institute for Biologically Inspired Engineering may radically transform the way doctors treat sepsis.

Rapid point-of-care anemia test shows promise

September 12, 2014 8:22 am | by John Toon, Georgia Institute of Technology | News | Comments

A simple point-of-care testing device for anemia could provide more rapid diagnosis of the common blood disorder and allow inexpensive at-home self-monitoring of persons with chronic forms of the disease. The disposable self-testing device analyzes a single droplet of blood using a chemical reagent that produces visible color changes corresponding to different levels of anemia.

Breath temperature test could identify lung cancer

September 8, 2014 8:43 am | News | Comments

New research in Europe suggests that testing the temperature of breath could be a simple and noninvasive method to either confirm or reject the presence of lung cancer. Many research teams have been looking at the possibility of using breath tests for a number of cancers but this is the first study looking at breath temperature as a marker in lung cancer.

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Ultrasensitive biosensor from molybdenite semiconductor outshines graphene

September 4, 2014 12:58 pm | News | Comments

A new atomically thin 2-D ultrasensitive semiconductor material developed by researchers California promises to push the boundaries of biosensing technology toward single-molecule detection. Based on molybdenum disulfide or molybdenite, the biosensor material which is used commonly as a dry lubricant, surpasses graphene’s already high sensitivity, offers better scalability and lends itself to high-volume manufacturing.

A new way to diagnose malaria

September 2, 2014 7:38 am | by Anne Trafton, MIT News Office | News | Comments

Over the past several decades, malaria diagnosis has changed very little. After taking a blood sample from a patient, a technician smears the blood across a glass slide, stains it with a special dye and looks under a microscope for the Plasmodium parasite, which causes the disease. This approach gives an accurate count of how many parasites are in the blood, but is not ideal because there is potential for human error.

New DARPA program aimed at developing customized therapies

August 28, 2014 9:11 am | News | Comments

DARPA’s new Electrical Prescriptions (ElectRx) program was among the initiatives the White House highlighted this week as President Barack Obama addressed the need for new and more effective strategies for improving the health of service members, veterans and others. ElectRx goes beyond medication, aiming to explore neuromodulation of organ functions to help the human body heal itself.

Eye implant could lead to better glaucoma treatments

August 26, 2014 8:21 am | by Bjorn Carey, Stanford News Service | News | Comments

For the 2.2 million Americans battling glaucoma, the main course of action for staving off blindness involves weekly visits to eye specialists who monitor increasing pressure within the eye. Now researchers have developed an eye implant that could help stave off blindness caused by glaucoma. The tiny eye implant developed at Stanford Univ. could enable patients to take more frequent readings from the comfort of home.

A glucose meter of a different color provides continuous monitoring

August 26, 2014 7:53 am | by Liz Ahlberg, Physical Sciences Editor, Univ. of Illinois, Urbana-Champaign | Videos | Comments

Univ. of Illinois engineers are bringing a touch of color to glucose monitoring. The researchers developed a new continuous glucose monitoring material that changes color as glucose levels fluctuate, and the wavelength shift is so precise that doctors and patients may be able to use it for automatic insulin dosing—something now possible using current point measurements like test strips.

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Sorting cells with sound waves

August 26, 2014 7:36 am | by Anne Trafton, MIT News Office | Videos | Comments

Researchers have devised a new way to separate cells by exposing them to sound waves as they flow through a tiny channel. Their device, about the size of a dime, could be used to detect the extremely rare tumor cells that circulate in cancer patients’ blood, helping doctors predict whether a tumor is going to spread.

Future phones to use blood, speech to monitor HIV, stress, nutrition

August 25, 2014 9:30 am | by Cornell Univ. | News | Comments

David Erickson, a professor at Cornell Univ., will receive a $3 million National Science Foundation grant over five years to adapt smartphones for health monitoring. The program, dubbed PHeNoM for Public Health, Nanotechnology, and Mobility, aims to deploy three systems that can have an immediate impact on personal healthcare.

LFA Technology Helps Sniff Out Anthrax

August 22, 2014 3:04 pm | Award Winners

To mitigate anthrax attack risks, Sandia National Laboratories developed a credit-card sized device based on the lateral flow assay for detection of B. anthracis in ultra-low resource environments: BaDx (Bacillus anthracis diagnostics). BaDx is a low-cost, disposable device that requires no power, instrumentation or equipment to operate, and no refrigeration to maintain efficacy.

Medical Tests for the Developing World

August 21, 2014 3:52 pm | Award Winners

Novilytic’s Noviplex Plasma Collection Card is a self-contained, blood-plasma sampling device used to volumetrically collect a plasma aliquot independent of whole blood application volumes. The Noviplex requires no power and circumvents requirements for venipuncture-phlebotomy training, needles, special vials and equipment, refrigeration and centrifugation normally associated with traditional plasma methods.

9/11 dust cloud may have caused widespread pregnancy issues

August 15, 2014 9:00 am | News | Comments

Previous research into the health impacts of in utero exposure to the 9/11 dust cloud on birth outcomes has shown little evidence of consistent effects. But according to a new paper pregnant women living near the World Trade Center during 9/11 experienced higher-than-normal negative birth outcomes. These mothers were more likely to give birth prematurely and deliver babies with low birth weights.

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Tattoo biobatteries produce power from sweat

August 13, 2014 12:45 pm | Videos | Comments

In the future, working up a sweat by exercising may not only be good for your health, but it could also power your small electronic devices. Researchers report that they have designed a sensor in the form of a temporary tattoo that can both monitor a person’s progress during exercise and produce power from their perspiration.

FDA approves first DNA-based test for colon cancer

August 11, 2014 5:22 pm | by Matthew Perrone - AP Health Writer - Associated Press | News | Comments

The Food and Drug Administration has approved the first screening test for colon cancer that uses patient DNA to help spot potentially deadly tumors and growths. The Cologuard test from Exact Sciences detects irregular mutations in a patient's stool sample that can be an early warning sign of cancer. Patients who test positive for the mutations should undergo a colonoscopy to confirm the results.

New handheld device uses lasers, sound for melanoma imaging

August 7, 2014 9:39 am | News | Comments

Melanoma is the fifth most common cancer type in the United States. A new handheld device may help diagnosis and treatment efforts for the disease. It uses lasers and sound waves and is the first that can be used directly on a patient to accurately measure how deep a melanoma tumor extends into the skin.

Technology translation engine launches “organs-on-chips” company

July 28, 2014 10:07 am | News | Comments

The Wyss Institute for Biologically Inspired Engineering at Harvard Univ. announced that its human “Organs-on-Chips” technology will be commercialized by a newly formed private company to accelerate development of pharmaceutical, chemical, cosmetic and personalized medicine products.

Reconstructing an animal’s development cell by cell

July 21, 2014 9:36 am | News | Comments

Janelia Research Campus experts have built a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell. Using image data obtaining using a sophisticated form of light sheet microscopy, the tool can track the movement of cells in an animal’s body in 3-D.

All HIV not created equal: Scientists can identify which viruses cause infection

July 21, 2014 8:07 am | by Laura Bailey, Univ. of Michigan | News | Comments

HIV-infected people carry many different HIV viruses and all have distinct personalities—some much more vengeful and infectious than others. Yet, despite the breadth of infectivity, roughly 76% of HIV infections arise from a single virus. Now, scientists believe they can identify the culprit with very specific measurements of the quantities of a key protein in the HIV virus.

HIV diagnosis rate fell by third in U.S. over decade

July 19, 2014 11:17 am | by Mike Stobbe - AP Medical Writer - Associated Press | News | Comments

The rate of HIV infections diagnosed in the U.S. each year fell by one-third over the past decade, a government study finds. Experts celebrated it as hopeful news that the AIDS epidemic may be slowing in the U.S. The reasons for the drop aren't clear. It might mean fewer new infections are occurring. Or that most infected people already have been diagnosed so more testing won't necessarily find many more cases.

Researchers create new method to draw molecules from live cells

July 18, 2014 12:30 pm | by Jeannie Kever, Univ. of Houston | News | Comments

Most current methods of identifying intracellular information result in the death of the individual cells, making it impossible to continue to gain information and assess change over time. Using magnetized carbon nanotubes, scientists in Texas have devised a new method for extracting molecules from live cells without disrupting cell development.

Bubble wrap serves as sheet of tiny test tubes in resource-limited regions

July 16, 2014 11:46 am | News | Comments

Popping the blisters on the bubble wrap might be the most enjoyable thing about moving. But now, researchers led by 2007 R&D Magazine Scientist of the Year George Whitesides propose a more productive way to reuse the popular packing material: as a sheet of small, test tube-like containers for medical and environmental samples. Analyses can take place right in the bubbles.

Researchers invent nanotech microchip to diagnose type-1 diabetes

July 14, 2014 9:22 am | News | Comments

A cheap, portable, microchip-based test for diagnosing type-1 diabetes could speed up diagnosis and enable studies of how the disease develops. Handheld microchips distinguish between the two main forms of diabetes mellitus, which are both characterized by high blood-sugar levels but have different causes. Until now, making the distinction has required a slow, expensive test available only in sophisticated healthcare settings.

Research may help prevent eye injury among soldiers

July 1, 2014 11:50 am | by K.C. Gonzalez, UTSA | News | Comments

In a basement laboratory at Fort Sam Houston military base in Texas, a research team has spent the last two years simulating improvised explosive device blasts on postmortem pig eyes using a high-powered shock tube. Their most striking discovery is that these blasts can damage the optic nerve, and these injuries can occur even at low pressures, causing visual defects that until now have been associated traumatic brain injuries.

New particle-sorting method breaks speed records

June 24, 2014 8:52 am | by David L. Chandler, MIT News Office | Videos | Comments

Researchers compare the processing of biological fluid samples with searching for a needle in a haystack—only in this case, the haystack could be diagnostic samples, and the needle might be tumor cells present in just ppm concentrations. Now, a new way of processing these samples could make such detections possible in real time.

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