Reducing the use of laboratory animals has been a long-term goal in biological research. Many in vivo assays, like rabbit endotoxin testing or mouse antibody production testing to detect viral contaminants have largely been replaced by in vitro enzyme or PCR-based assays.
Patients with sickle cell disease often suffer from painful attacks known as vaso-occlusive...
New York Univ. Polytechnic School of Engineering professors have been collaborating with...
Scientists have developed the first ultra-thin, flexible device that sticks to skin like a rub-...
Scientists from The Scripps Research Institute have identified a novel synthetic compound that sharply inhibits the activity of a protein that plays an important role in in the progression of breast and pancreatic cancers. In the new study the scientists showed that the compound, known as SR1848, reduces the activity and expression of the cancer-related protein called “liver receptor homolog-1” or LRH-1.
A group led by scientists has developed a new method for effectively extracting and analyzing cancer cells circulating in patients’ blood. Circulating tumor cells are cancer cells that break away from tumors and travel in the blood, looking for places in the body to grow new tumors called metastases. Capturing these rare cells would allow doctors to detect and analyze the cancer so they could tailor treatment for individual patients.
HIV can be treated, but not every infection responds the same way. Treatment requires monitoring and testing, a practice that can become expensive for health care systems in the developing world.
The project, “Testing Saves Lives,” asked community organizations that provide HIV testing services across China to submit videos on the importance of getting tested. The videos were judged based on whether they generated interest about HIV testing, proposed ways to reach untested individuals and engaged the community.
No methods currently exist for the early detection of Alzheimer’s disease, which affects one out of nine people over the age of 65. Now, an interdisciplinary team of Northwestern University scientists and engineers has developed a noninvasive MRI approach that can detect the disease in a living animal. And it can do so at the earliest stages of the disease, well before typical Alzheimer’s symptoms appear.
A team of scientists from Arizona State Univ.’s Biodesign Institute and IBM’s T.J. Watson Research Center have developed a prototype DNA reader that could make whole genome profiling an everyday practice in medicine. Such technology could help usher in the age of personalized medicine, where information from an individual’s complete DNA and protein profiles could be used to design treatments specific to their individual makeup.
Flexible electronic sensors based on paper have the potential to cut the price of a wide range of medical tools, from helpful robots to diagnostic tests. Scientists have now developed a fast, low-cost way of making these sensors by directly printing conductive ink on paper.
A new bloodstream infection test created by Univ. of California, Irvine researchers can speed up diagnosis times with unprecedented accuracy, allowing physicians to treat patients with potentially deadly ailments more promptly and effectively. The technology, called Integrated Comprehensive Droplet Digital Detection, or IC 3D, can detect bacteria in milliliters of blood with single-cell sensitivity in 90 mins; no cell culture is needed.
Researchers led by David Thompson, president of Aten Biotherapeutics and a professor in Purdue's Department of Chemistry, are developing controlled-release imaging agents that allow for a longer, safer imaging session.
Paramedics respond to a 911 call to find an elderly patient who’s having difficulty breathing. Anxious and disoriented, the patient has trouble remembering all the medications he’s taking, and with his shortness of breath, speaking is difficult. Is he suffering from acute emphysema or heart failure? Initiating the wrong treatment regimen will increase the patient’s risk of severe complications.
The condition of an athlete's heart has for the first time been accurately monitored throughout the duration of a marathon race. The real-time monitoring was achieved by continuous electrocardiogram (ECG) surveillance and data transfer over a public mobile phone network. The new development allows instantaneous diagnosis of potentially fatal rhythm disorders.
Cancer researchers have found that a simple blood test might help diagnose pancreatic cancer, one of the most deadly forms of the disease. In new research at Indiana Univ., scientists have found that several microRNAs, which are small RNA molecules, circulate at high levels in the blood of pancreatic cancer patients.
Starting Monday, millions of people who have avoided colon cancer screening can get a new home test that's noninvasive and doesn't require the icky preparation most other methods do. The test is the first to look for cancer-related DNA in stool. But deciding whether to get it is a more complex choice than ads for "the breakthrough test ... that's as easy as going to the bathroom" make it seem.
New achievements in synthetic biology, which will allow complex cellular recognition reactions to proceed outside of living cells, will dare scientists to dream big: There could one day be inexpensive, shippable and accurate test kits that use saliva or a drop of blood to identify specific disease or infection.
Researchers at the Univ. of Pennsylvania and The Children's Hospital of Philadelphia have used graphene to fabricate a new type of microelectrode that solves a major problem for investigators looking to understand the intricate circuitry of the brain. The see-through, one-atom-thick electrodes can obtain both high-resolution optical images and electrophysiological data for the first time.
Scientists have been laboring to detect cancer and a host of other diseases in people using promising new biomarkers called “exosomes.” Indeed, Popular Science magazine named exosome-based cancer diagnostics one of the 20 breakthroughs that will shape the world this year. Exosomes could lead to less invasive, earlier detection of cancer, and sharply boost patients’ odds of survival.
A U.S.-British scientist and a Norwegian husband-and-wife research team won the Nobel Prize in medicine for discovering the brain's navigation system—the inner GPS that helps us find our way in the world—a revelation that could lead to advances in diagnosing Alzheimer's. The research by John O'Keefe, May-Britt Moser and Edvard Moser represents a "paradigm shift" in neuroscience that could help researchers understand Alzheimer's disease.
Life Science researchers have become ever-more dependent on the industry for “kits” that are intended to execute research processes in the laboratory flawlessly. In recognition of this expectation, kit manufacturers now market nearly every product as “guaranteed” or “validated.” This practice has led the research community to feel secure that the products will perform as advertised.
Massachusetts Institute of Technology engineers have devised a way to rapidly test hundreds of different drug-delivery vehicles in living animals, making it easier to discover promising new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA and DNA, to human patients.
Almost all of today’s previously existing cell-sorting methods rely on what is called a single-cell analysis platform. A researcher in Hawaii took a different approach, inventing a bulk method that sorts different cell populations by tuning their solubility. Instead of targeting individual features, the measurement principle sorts cells by differentiating their characteristic surface free energies.
A new, ultrasensitive biosensor made from graphene has been used to detect molecules that indicate an increased risk of developing cancer. The biosensor has been shown to be more than five times more sensitive than bioassay tests currently in use, and was able to provide results in a matter of minutes, opening up the possibility of a rapid, point-of-care diagnostic tool for patients.
Fewer than half of all patients who are suspected of having a genetic disease actually receive a satisfactory diagnosis. To solve this problem, scientists have developed an innovative diagnostic procedure, called PhenIX, that combines the analysis of genetic irregularities with the patient's clinical presentation. The method involves a search for genes that cause disease and its related phenotypes to produce a short, testable list.
Things can go downhill fast when a patient has sepsis, a life-threatening condition in which bacteria or fungi multiply in a patient's blood—often too fast for antibiotics to help. A new device inspired by the human spleen and developed by a team at Harvard's Wyss Institute for Biologically Inspired Engineering may radically transform the way doctors treat sepsis.
A simple point-of-care testing device for anemia could provide more rapid diagnosis of the common blood disorder and allow inexpensive at-home self-monitoring of persons with chronic forms of the disease. The disposable self-testing device analyzes a single droplet of blood using a chemical reagent that produces visible color changes corresponding to different levels of anemia.
New research in Europe suggests that testing the temperature of breath could be a simple and noninvasive method to either confirm or reject the presence of lung cancer. Many research teams have been looking at the possibility of using breath tests for a number of cancers but this is the first study looking at breath temperature as a marker in lung cancer.
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