Inexpensive, portable devices that can rapidly screen cells for leukemia or HIV may soon be possible thanks to a chip that can produce 3D focusing of a stream of cells, according to Pennsylvania State University researchers.
Biomedical engineers at University of California, Davis have developed a microfluidic chip to test for latent tuberculosis. They hope the test will be cheaper, faster, and more reliable than current testing for the disease.
University of Iowa neuroscientist John Wemmie is interested in the effect of acid in the brain. His studies using new magnetic resonance imaging techniques suggest that increased acidity or low pH, in the brain is linked to panic disorders, anxiety, and depression. But his work also suggests that changes in acidity are important for normal brain activity too.
Researchers have created an ultrasensitive biosensor that could open up new opportunities for early detection of cancer and "personalized medicine" tailored to the specific biochemistry of individual patients. The device, which could be several hundred times more sensitive than other biosensors, combines the attributes of two distinctly different types of sensors.
Scientists at Weill Cornell Medical College have discovered that the single protein, alpha 2 delta, exerts a spigot-like function that controls the volume of neurotransmitters and other chemicals that flow between the synapses of brain neurons. The surprising finding tells us not only how brain cells communicate, but also how a certain pain drug works.
As medical researchers and engineers try to shrink diagnostics to fit in a person's pocket, one question is how to easily move and mix small samples of liquid. University of Washington researchers have built and patented a surface that, when shaken, moves drops along certain paths to conduct medical or environmental tests.
His DNA had been decoded; samples from his stomach and intestines have allowed us to reconstruct his very last meal. The circumstances of his violent death appear to have been explained. However, what had, until now, eluded scientists was identifying any traces of blood in Ötzi, the 5,000 year old glacier mummy.
As valuable as X-ray mammography is, it has certain drawbacks, such as exposure to ionizing radiation and the potential for false results. In the first phase of clinical testing is a new imaging device built around the principle of photoacoustics, or light-induced sound, that can detect and visualize breast tumors with a high degree of targetting accuracy.
One exhale and a new device from researchers at Stony Brook University in New York could screen for anything from diabetes to lung cancer. Based on a sensor chip built from electrospun nanowires that can detect minute amounts of chemical compounds, the device has yet to reach clinical trials. But its inventors anticipate the device to someday cost only $20.
When the DNA double helix breaks, the broken end goes searching for the similar sequence and uses that as a template for repair. Using a new dual-molecule technique, a research group in the Netherlands has found out how the DNA molecule is able to perform this search and recognition process in such an efficient way.
A new Agriculture Department program will begin tracing the source of potentially contaminated ground beef as soon as there is an initial positive test. Current procedures require USDA officials to wait until additional testing confirms E. coli before starting their investigation. Under the new process, the source could be traced 24 to 48 hours sooner.
Online crowd-sourcing—in which a task is presented to the public, who respond, for free, with various solutions and suggestions—has been used to evaluate potential consumer products, develop software algorithms, and solve vexing research and development challenges. But diagnosing infectious diseases?
Researchers at McMaster University have developed a rapid testing method using a simple paper strip that can detect E. coli in recreational water within minutes. The new tool can close the gap between outbreak and detection, improving public safety.
With the development of synchrotron infrared spectroscopy, scientists at Lawrence Berkeley National Laboratory have observed, in real time the process of protein phosphorylation—a chemical interaction that controls everything from cell proliferation to differentiation to metabolism—in living cells stimulated by nerve growth factor.
New research suggests that the 5-lipoxygenase enzyme plays an important role in the microgravity-induced cell death that affects astronauts’ immune systems. Forced inhibition of this enzyme’s activity could help astronauts and also lead to therapeutics for the elderly.
A newly developed cell phone-based platform lets health workers accurately read diagnostic tests in the field and chart the spread of diseases worldwide.
Until the development of a new nanomaterial-based sensor in Germany, the brain’s magnetic field was measurable only under technical laboratory conditions. This prevented the technology’s use in medical applications. The new sensors, however, operate at normal conditions. Neither cooling nor external magnetic bias fields are required.
Researchers at Northwestern University's Department of Radiation Oncology and Argonne National Laboratory recently deployed a new non-destructive X-ray microscopy solution from Xradia to image cryogenically preserved cells and advance studies of intra-cellular biology.
Mount Everest has attracted climbers and adventurers for nearly 100 years. Now, a team of U.S. scientists have set up a laboratory at the base of the world’s highest mountain to study the effects of high altitude on humans. A team from the Mayo Clinic in Minnesota says it plans to monitor nine climbers attempting to scale Everest to learn more about the physiology of humans at high altitudes in order to help patients with heart conditions and other ailments.
Nearly half of the 12 million babies born prematurely in developing countries experience episodes of apnea, a sudden stoppage of breathing. Working from that knowledge, five bioengineering students from Rice University created the Babalung Apnea Monitor, which can restart a baby's breathing and raises a flag if it can't.
A new quantum mechanical-based biosensor designed by a team at University of California, Santa Barbara offers potential for detecting biomolecules at ultra-low concentrations. The research team’s technology beats the fundamental limits of a conventional field-effect transistor (FET) designing a Tunnel-FET sensor that is faster and four orders of magnitude more sensitive.
Technological advances have produced implantable, electronic solutions for dosing and therapeutic functions in humans. However, these medical devices use probes, actuators, and electronic controls that need power. Researchers at the Fraunhofer Institute for Ceramic Technologies have recently succeeded in wirelessly transmitting power from a portable transmitter module to a receiver, offering the possibility of wirelessly-powered medical devices.
Using genetic engineering techniques, researchers in Germany have generated cells that emit green fluorescent light when stimulated by the binding of a cognate antigen. Previously antigens, which induce destructive immune responses, could not be identified directly without some prior knowledge of their structure.
Today, scientists map entire genomes mostly for research, but as genome mapping gets faster and cheaper, scientists and consumers have wondered about possible broader use: Would finding all the glitches hidden in your DNA predict which diseases you'll face decades later? Unfortunately, it’s not that simple, say experts.
Microfluidic devices have the potential to be fast, cheap, and portable diagnostic tools. But for the most part, the technology hasn't yet made it to the marketplace. While scientists have made successful prototypes in the laboratory, microfluidic devices—particularly for clinical use—have yet to be manufactured on a wider scale. However, Massachusetts Institute of Technology's David Hardt is working to move microfluidics from the laboratory to the factory.