Massachusetts Institute of Technology researchers have developed a new microfluidic device that could speed the monitoring of bacterial infections associated with cystic fibrosis and other diseases. The new microfluidic chip is etched with tiny channels, each resembling an elongated hourglass with a pinched midsection. Researchers injected bacteria through one end of each channel, and observed how cells travel from one end to the other.
Life-threatening blood clots can form in anyone who sits on a plane for a long time, is confined to bed while recovering from surgery, or takes certain medications. There is no fast and easy way to diagnose these clots, which often remain undetected until they break free and cause a stroke or heart attack. However, new technology from Massachusetts Institute of Technology may soon change that.
Details have been released by IBM Research on Watson-related cognitive technologies that are expected to help physicians make more informed and accurate decisions faster and to cull new insights from electronic medical records (EMR). The new computing capabilities allow for a more natural interaction between physicians, data and EMRs.
You might not think to look to a urine test to diagnose an eye disease. But a new Duke Univ. study says it can link what is in a patient's urine to gene mutations that cause retinitis pigmentosa, or RP, an inherited, degenerative disease that results in severe vision impairment and often blindness.
Researchers are developing a system that uses tiny magnetic beads to quickly detect rare types of cancer cells circulating in a patient's blood, an advance that could help medical doctors diagnose cancer earlier than now possible and monitor how well a patient is responding to therapy.
There is certainly no shortage of lab-on-a-chip devices, but in most cases manufacturers have not yet found a cost-effective way to mass produce them. Scientists are now developing a platform for series production of these pocket laboratories. The first major step is moving away from the usual injection molding or wet chemical processing techniques in favor of roll-to-roll processing.
A microfluidic chip developed at the Univ. of Michigan is among the best at capturing elusive circulating tumor cells from blood—and it can support the cells' growth for further analysis. The device, believed to be the first to pair these functions, uses the advanced electronics material graphene oxide. In clinics, such a device could one day help doctors diagnose cancers.
At the U.S. Army Edgewood Chemical Biological Center, experts have been conducting research of “organs” on microchips. Unlike the few other laboratories conducting these types of studies, the Army is specifically looking at potential scenarios that will affect warfighters, especially chemical agent exposure.
An intriguing study led by the Univ. of Colorado Boulder may provide a powerful new tool in the quiver of forensic scientists attempting to determine the time of death in cases involving human corpses: a microbial clock. The clock is essentially the lock-step succession of bacterial changes that occur postmortem as bodies move through the decay process.
Cancer cells metastasize in several stages—first by invading surrounding tissue, then by infiltrating and spreading via the circulatory system. Some circulating cells work their way out of the vascular network, eventually forming a secondary tumor. Now researchers have developed a microfluidic device that mimics the flow of cancer cells through a system of blood vessels. High-resolution time-lapse imaging captures the moment of metastasis.
A team of researchers at NIST and Applied Research Associates, Inc. has demonstrated an improved microfluidic technique for recovering DNA from real-world, complex mixtures such as dirt. According to the researchers their technique delivers DNA from these crude samples with much less effort and in less time than conventional techniques and yields DNA concentrations optimal for human identification procedures.
A Lawrence Livermore National Laboratory-developed biological detection technology has been employed as part of an international collaboration that has detected a virus in bladder cancers. The research is believed to be the first study to demonstrate an association between Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, and bladder cancers.
Standard drug-testing methods have shortcomings. Animal testing is expensive and unreliable, and the static environment of cells and cultures don’t mimic the behavior of the entire organism. An interdisciplinary research team at Lehigh Univ. is using microscopy and optical tweezers to develop a new finger-sized chip that can study the activities of cells at the nanoscale, possibly offering an alternative to traditional drug testing.
Each year, millions of people in the U.S. get a tuberculosis skin test to see if they have the infection. But the standard diagnostic test is difficult to give, because a hypodermic needle must be inserted at a precise angle and depth in the arm to successfully check for tuberculosis. Now, a team has created a microneedle patch that can penetrate the skin and precisely deliver a tuberculosis test.
A lightweight and field-portable device invented at Univ. of California, Los Angeles that conducts kidney tests and transmits data through a smartphone attachment may significantly reduce the need for frequent office visits by people with diabetes and others with chronic kidney ailments.
Researchers at Massachusetts Institute of Technology have found a way to detect early-stage malarial infection of blood cells by measuring changes in the infected cells’ electrical properties. The team has built an experimental microfluidic device that takes a drop of blood and streams it across an electrode that measures a signal differentiating infected cells from uninfected cells.
Massachusetts Institute of Technology chemical engineers have discovered that arrays of billions of nanoscale sensors have unique properties that could help pharmaceutical companies produce drugs more safely and efficiently. Using these sensors, the researchers were able to characterize variations in the binding strength of antibody drugs, which hold promise for treating cancer and other diseases.
When people have a brain injury so severe that they can't squeeze a loved one's hand or otherwise respond, there are few good ways to tell if they have any lingering awareness or are in a vegetative state. Now researchers have created a technique using a magnetic coil and an electroencephalogram to allow them to peek inside the brain and measure varying levels of consciousness.
The Wyss Institute for Biologically Inspired Engineering at Harvard Univ. has received a $5.6 million grant award from the U.S. Food and Drug Administration to use its Organs-on-Chips technology to test human physiological responses to radiation. The project will investigate if the microfluidic devices lined by living human cells can be used instead of animals to evaluate the efficacy and safety of medical treatments for radiation sickness.
A recent invention at Purdue Univ. could improve therapy selection for personalized cancer care. Researchers have created a technique called BioDynamic Imaging that measures the activity inside cancer biopsies, or samples of cells. It allows technicians to assess the efficacy of drug combinations, called regimens, on personal cancers.
Lawrence Berkeley National Laboratory scientists have helped to develop a tiny chip that has big potential for quickly determining whether someone has been exposed to dangerous levels of ionizing radiation. The first-of-its-kind chip has an array of nanosensors that measure the concentrations of proteins that change after radiation exposure.
A team of researchers in Singapore and South Korea have developed a fluorescent caffeine detector and a detection kit that lights up like a traffic light when caffeine is present in various drinks and solutions. Based on a technology called “lab-on-a-disc”, the detection system identifies caffeine concentrations using laser light.
At Battelle, supporting America’s military personnel is woven into the fabric of its business. In that pursuit, a team consisting of Battelle, NxStage Medical Inc. and Aethlon Medical has won a contract from DARPA to develop an innovative, new medical device that may save the lives of soldiers—and civilians as well—by treating sepsis.
Univ. of Maryland Ventures announced agreements between Univ. of Maryland, Baltimore and five different life sciences companies across the Baltimore/Washington metropolitan region. The companies include Rexahn Pharmaceuticals, Plasmonix, IGI Technologies, A&G Pharmaceuticals and BioAssay Works.
Early in 2012, a team of scientists reported the development of a postage stamp-sized microchip capable of sorting cells through a technique, known as cell rolling, that mimics a natural mechanism in the body. The device successfully separated leukemia cells from cell cultures, but could not extract cells directly from blood. Now the group has developed a new microchip that can quickly separate white blood cells from samples of whole blood.