The increasingly powerful microscopes used in biomedical imaging provide biologists with 3-D images of hundreds of cells, and cells in these images are often layered on each other. Under these conditions, it is impossible for traditional computational methods to determine the cells' properties. Researchers have developed a virtual tool that can analyze dozens of images in just an hour. This works out to hundreds of cells.
Accurate and rapid testing for drug toxicity just became easier, thanks to a half-dozen Rice Univ. student interns working at Houston-based startup Nano3D Biosciences (n3D). The bioengineering and nanoscale physics students just wrapped up a year-long effort to aid the company in developing a new method for conducting high-throughput, in vitro cytotoxicity assays.
Dendrites, the branch-like projections of neurons, were once thought to be passive wiring in the brain. But now researchers at the Univ. of North Carolina at Chapel Hill have shown that these dendrites do more than relay information from one neuron to the next. They actively process information, multiplying the brain's computing power.
The act of walking is seldom given a second thought, but upon closer inspection locomotion is less straightforward. In particular, the ankle is an anatomical jumble, and its role in maintaining stability and motion has not been well characterized. A device called the “Anklebot” could help matters by measuring the stiffness of the ankle in various directions.
Famed for its historic sites, its double-decker buses and its West End shows, London now has a more dubious distinction: Britain's public health agency says it has become the tuberculosis capital of Western Europe. In response, health officials are taking to the streets in an effort to stop the spread of the infectious lung disease.
In remote regions of the world where electricity is hard to come by and scientific instruments are even scarcer, conducting medical tests at a doctor’s office or medical laboratory is rarely an option. Scientists are now reporting progress toward an inexpensive point-of-care, paper-based device to fill that void with no electronics required.
For those wanting to keep their distance from health threats like E. coli-contaminated lettuce or the flu, there are two upcoming apps for that. Pacific Northwest National Laboratory hosted a competition last summer where graduate students used Android development tools and web-based analytics to design mobile apps that could help fight the threats of food-related illnesses and the flu.
Everyone grows older, but scientists don't really understand why. Now a Univ. of California, Los Angeles study has uncovered a biological clock embedded in our genomes that may shed light on why our bodies age and how we can slow the process.
Massachusetts Institute of Technology researchers have developed a new microfluidic device that could speed the monitoring of bacterial infections associated with cystic fibrosis and other diseases. The new microfluidic chip is etched with tiny channels, each resembling an elongated hourglass with a pinched midsection. Researchers injected bacteria through one end of each channel, and observed how cells travel from one end to the other.
Life-threatening blood clots can form in anyone who sits on a plane for a long time, is confined to bed while recovering from surgery, or takes certain medications. There is no fast and easy way to diagnose these clots, which often remain undetected until they break free and cause a stroke or heart attack. However, new technology from Massachusetts Institute of Technology may soon change that.
Details have been released by IBM Research on Watson-related cognitive technologies that are expected to help physicians make more informed and accurate decisions faster and to cull new insights from electronic medical records (EMR). The new computing capabilities allow for a more natural interaction between physicians, data and EMRs.
You might not think to look to a urine test to diagnose an eye disease. But a new Duke Univ. study says it can link what is in a patient's urine to gene mutations that cause retinitis pigmentosa, or RP, an inherited, degenerative disease that results in severe vision impairment and often blindness.
Researchers are developing a system that uses tiny magnetic beads to quickly detect rare types of cancer cells circulating in a patient's blood, an advance that could help medical doctors diagnose cancer earlier than now possible and monitor how well a patient is responding to therapy.
There is certainly no shortage of lab-on-a-chip devices, but in most cases manufacturers have not yet found a cost-effective way to mass produce them. Scientists are now developing a platform for series production of these pocket laboratories. The first major step is moving away from the usual injection molding or wet chemical processing techniques in favor of roll-to-roll processing.
A microfluidic chip developed at the Univ. of Michigan is among the best at capturing elusive circulating tumor cells from blood—and it can support the cells' growth for further analysis. The device, believed to be the first to pair these functions, uses the advanced electronics material graphene oxide. In clinics, such a device could one day help doctors diagnose cancers.
At the U.S. Army Edgewood Chemical Biological Center, experts have been conducting research of “organs” on microchips. Unlike the few other laboratories conducting these types of studies, the Army is specifically looking at potential scenarios that will affect warfighters, especially chemical agent exposure.
An intriguing study led by the Univ. of Colorado Boulder may provide a powerful new tool in the quiver of forensic scientists attempting to determine the time of death in cases involving human corpses: a microbial clock. The clock is essentially the lock-step succession of bacterial changes that occur postmortem as bodies move through the decay process.
Cancer cells metastasize in several stages—first by invading surrounding tissue, then by infiltrating and spreading via the circulatory system. Some circulating cells work their way out of the vascular network, eventually forming a secondary tumor. Now researchers have developed a microfluidic device that mimics the flow of cancer cells through a system of blood vessels. High-resolution time-lapse imaging captures the moment of metastasis.
A team of researchers at NIST and Applied Research Associates, Inc. has demonstrated an improved microfluidic technique for recovering DNA from real-world, complex mixtures such as dirt. According to the researchers their technique delivers DNA from these crude samples with much less effort and in less time than conventional techniques and yields DNA concentrations optimal for human identification procedures.
A Lawrence Livermore National Laboratory-developed biological detection technology has been employed as part of an international collaboration that has detected a virus in bladder cancers. The research is believed to be the first study to demonstrate an association between Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, and bladder cancers.
Standard drug-testing methods have shortcomings. Animal testing is expensive and unreliable, and the static environment of cells and cultures don’t mimic the behavior of the entire organism. An interdisciplinary research team at Lehigh Univ. is using microscopy and optical tweezers to develop a new finger-sized chip that can study the activities of cells at the nanoscale, possibly offering an alternative to traditional drug testing.
Each year, millions of people in the U.S. get a tuberculosis skin test to see if they have the infection. But the standard diagnostic test is difficult to give, because a hypodermic needle must be inserted at a precise angle and depth in the arm to successfully check for tuberculosis. Now, a team has created a microneedle patch that can penetrate the skin and precisely deliver a tuberculosis test.
A lightweight and field-portable device invented at Univ. of California, Los Angeles that conducts kidney tests and transmits data through a smartphone attachment may significantly reduce the need for frequent office visits by people with diabetes and others with chronic kidney ailments.
Researchers at Massachusetts Institute of Technology have found a way to detect early-stage malarial infection of blood cells by measuring changes in the infected cells’ electrical properties. The team has built an experimental microfluidic device that takes a drop of blood and streams it across an electrode that measures a signal differentiating infected cells from uninfected cells.
Massachusetts Institute of Technology chemical engineers have discovered that arrays of billions of nanoscale sensors have unique properties that could help pharmaceutical companies produce drugs more safely and efficiently. Using these sensors, the researchers were able to characterize variations in the binding strength of antibody drugs, which hold promise for treating cancer and other diseases.