Scientists from the Florida campus of The Scripps Research Institute have uncovered the unique mechanism of a powerful natural product with wide-ranging antifungal, antibacterial antimalaria and anticancer effects. The new study sheds light on the natural small molecule known as borrelidin.
An experimental drug rapidly shrinks most tumors in a mouse model of human breast cancer,...
Imaging tests like mammograms or CT scans can detect tumors, but figuring out whether a growth...
Saccharin, the artificial sweetener that is the main ingredient in Sweet 'N Low, Sweet Twin and...
The prices of leading cancer drugs have risen at rates far outstripping inflation over the last two decades, according to a new study co-authored by an Massachusetts Institute of Technology economist. But the exact reasons for the cost increases are unclear. Since 1995, a group of 58 leading cancer drugs has increased in price by 10% annually, even when adjusted for inflation and incremental health benefits, the study finds.
Cancer cells crowded tightly together suddenly surrender their desire to spread, and this change of heart is related to a cellular pathway that controls organ size. These two observations are reported by researchers at Georgetown Lombardi Comprehensive Cancer Center in Oncogene.
Scientists from Lawrence Berkeley National Laboratory have uncovered new clues about the risk of cancer from low-dose radiation, which in this research they define as equivalent to 100 millisieverts or roughly the dose received from ten full-body CT scans. They studied mice and found their risk of mammary cancer from low-dose radiation depends a great deal on their genetic makeup.
An extraordinary self-regulating heating effect that can be achieved in a particular type of magnetic material may open the doors to a new strategy for hyperthermia cancer treatment. Temperatures that can be tolerated by healthy body cells have long been known to destroy cancerous cells. An approach that uses magnetic particles introduced into tissue and heated remotely has found some success in treating cancer.
Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back. A new nanodevice developed by Massachusetts Institute of Technology researchers can help overcome that by first blocking the gene that confers drug resistance, then launching a new chemotherapy attack against the disarmed tumors.
A new drug that prompts cancer cells to self-destruct while sparing healthy cells is now entering phase I clinical trials in humans. The drug, called PAC-1, first showed promise in the treatment of pet dogs with spontaneously occurring cancers, and is still in clinical trials in dogs with osteosarcoma.
Univ. of Manchester scientists have used graphene to target and neutralize cancer stem cells while not harming other cells. This new development opens up the possibility of preventing or treating a broad range of cancers, using a non-toxic material.
A protein found in pancreatic tumors may lead to a new chemotherapy that is effective against many different kinds of cancers, but turning the discovery into a new drug has required a bit of chemistry know-how.
In recent years, scientists have found a surprising a connection between some people with autism and certain cancer patients: They have mutations in the same gene, one that codes for a protein critical for normal cellular health. Now scientists have reported in Biochemistry that the defects reduce the activity and stability of the protein. Their findings could someday help lead to new treatments for both sets of patients.
Single-letter genetic variations within parts of the genome once dismissed as 'junk DNA' can increase cancer risk through wormhole-like effects on far-off genes, new research shows.
Scientists have shown that gold nanotubes have many applications in fighting cancer: internal nanoprobes for high-resolution imaging, drug delivery vehicles and agents for destroying cancer cells. The study, published in Advanced Functional Materials, details the first successful demonstration of the biomedical use of gold nanotubes in a mouse model of human cancer.
Applying lessons learned from autism to brain cancer, researchers at The Johns Hopkins Univ. have discovered why elevated levels of the protein NHE9 add to the lethality of the most common and aggressive form of brain cancer, glioblastoma. Their discovery suggests that drugs designed to target NHE9 could help to successfully fight the deadly disease.
Federal health regulators on Tuesday approved a highly anticipated medicine from Pfizer Inc. to treat postmenopausal women with a certain type of advanced breast cancer who have not already taken other drugs. The Food and Drug Administration approved Ibrance for women who have tumors that do not contain a protein known as HER-2. Ibrance, known generically as palbociclib, works by blocking molecules linked to cancer cell growth.
Low doses of metformin, a widely used diabetes medication and a gene inhibitor known as BI2536 can successfully halt the growth of late-stage prostate cancer tumors, a Purdue Univ. study finds. Prostate cancer causes the second-highest number of cancer-related deaths in men in the U.S., and methods of treating advanced prostate cancer are limited.
A new study by Univ. of Kentucky Markey Cancer Center researchers suggests that targeting a key enzyme and its associated metabolic programming may lead to novel drug development to treat lung cancer. Cancer cells undergo metabolic alterations to meet the increased energy demands that support their excess growth and survival.
Cancer uses a little-understood element of cell signaling to hijack the communication process and spread, according to Rice Univ. researchers. A new computational study by researchers at the Rice-based Center for Theoretical Biological Physics shows how cancer cells take advantage of the system by which cells communicate with their neighbors as they pass messages to “be like me” or “be not like me.”
Eastern Montana residents rushed to stock up on bottled water Tuesday after authorities detected a cancer-causing component of oil in public water supplies downstream of a Yellowstone River pipeline spill. Elevated levels of benzene were found in water samples from a treatment plant that serves about 6,000 people in the agricultural community of Glendive, near North Dakota.
A new study from Massachusetts Institute of Technology reveals one reason why people who suffer from chronic inflammatory diseases such as colitis have a higher risk of mutations that cause cancer. The researchers also found that exposure to DNA-damaging chemicals after a bout of inflammation boosts these mutations even more, further increasing cancer risk.
Scientists from The Scripps Research Institute have identified a novel synthetic compound that sharply inhibits the activity of a protein that plays an important role in in the progression of breast and pancreatic cancers. In the new study the scientists showed that the compound, known as SR1848, reduces the activity and expression of the cancer-related protein called “liver receptor homolog-1” or LRH-1.
A group led by scientists has developed a new method for effectively extracting and analyzing cancer cells circulating in patients’ blood. Circulating tumor cells are cancer cells that break away from tumors and travel in the blood, looking for places in the body to grow new tumors called metastases. Capturing these rare cells would allow doctors to detect and analyze the cancer so they could tailor treatment for individual patients.
New research has identified one of the key cancer-fighting mechanisms for sulforaphane, and suggests that this phytochemical may be able to move beyond cancer prevention and toward therapeutic use for advanced prostate cancer. Scientists said that pharmacologic doses in the form of supplements would be needed for actual therapies, beyond the amount of sulforaphane that would ordinarily be obtained from dietary sources such as broccoli.
An international team of researchers has developed a drug delivery technique that utilizes graphene strips as “flying carpets” to deliver two anticancer drugs sequentially to cancer cells, with each drug targeting the distinct part of the cell where it will be most effective. The technique was found to perform better than either drug in isolation when tested in a mouse model targeting a human lung cancer tumor.
Researchers at Oregon State Univ. have developed a new way to selectively insert compounds into cancer cells—a system that will help surgeons identify malignant tissues and then, in combination with phototherapy, kill any remaining cancer cells after a tumor is removed. It’s about as simple as, “If it glows, cut it out.” And if a few malignant cells remain, they’ll soon die.
In a development that could lead to a deeper understanding of cancer and better early-stage treatment of the disease, University of Michigan researchers have devised a reliable way to grow a certain type of cancer cells from patients outside the body for study.
Researchers at Swinburne University of Technology have discovered an instability in gold nanoparticles that is critical for their application in future technology. Gold nanorods are important building blocks for future applications in solar cells, cancer therapy and optical circuitry.
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