Using a simple "drag-and-drop" computer interface and DNA self-assembly techniques, researchers with Parabon NanoLabs of Reston, Va.,have developed a new approach for drug development that could drastically reduce the time required to create and test medications. Parabon has partnered with Janssen Research & Development to use this technology to create and test the efficacy of a new prostate cancer drug.
The spread of cancer cells from primary tumors to other parts of the body remains the leading cause of cancer-related deaths. Using atomic force microscopy, a research group in Europe has recently shown how the unique nanomechanical properties of breast cancer cells are fundamental to the process of metastasis.
Logic circuits can be built from just about anything, including billiard balls, pipes of water, or animals in a maze. Tae Seok Moon, a professor at Washington University in St. Louis, intends to build logic gates out of genes, and has already built the largest such device yet reported. But the purpose of these circuits is not to crunch numbers.
Researchers from Johns Hopkins and Northwestern universities have discovered how to control the shape of nanoparticles that move DNA through the body and have shown that the shapes of these carriers may make a big difference in how well they work in treating cancer and other diseases. The technique is noteworthy because it does not use a virus to carry DNA into cells.
Using in silico computational tools to complement the results of in vivo and in vitro experiments, researchers at Pacific Northwest National Laboratory have revealed an atomic-level understanding of the mechanism by which nanoparticles inhibit the growth and metastasis of pancreatic tumors. The findings are promising for the development of particle-based therapies.
Many tumor cells have a defective cellular equipment. It is only by a special trick that they manage to distribute their chromosomes correctly to their daughter cells during cell division. Researchers have now developed a substance that thwarts this trick and forces cancer cells into death during cell division.
It's a medical nightmare: a 24-year-old man endures 350 surgeries since childhood to remove growths that keep coming back in his throat and have spread to his lungs, threatening his life. A new discovery, however, allows doctors to grow "mini tumors" from each patient's cancer in a lab dish, then test various drugs or combinations on them to see which works best.
It's a medical nightmare: a 24-year-old man endures 350 surgeries since childhood to remove growths that keep coming back in his throat and have spread to his lungs, threatening his life. Now doctors have found a way to help him by way of a scientific coup that holds promise for millions of cancer...
Malignant cells that leave a primary tumor, travel the bloodstream and grow out of control in new locations cause the vast majority of cancer deaths. New nanotechnology developed at Case Western Reserve University detects these metastases in mouse models of breast cancer far earlier than current methods, a step toward earlier, life-saving diagnosis and treatment.
Scientists reported Sunday that they have completed a major analysis of the genetics of breast cancer, finding four major classes of the disease. The new finding, which is the latest example of research into the biological details of tumors, offers hints that one type of breast cancer might be vulnerable to drugs that already work against ovarian cancer.
In their quest for a cancer cure, researchers at the Duke Cancer Institute made a serendipitous discovery: a molecule necessary for cheaper and greener way to produce nylon. The finding arose from an intriguing notion that some of the genetic and chemical changes in cancer tumors might be harnessed for beneficial uses.
Researchers have long known that individual diseases are associated with genes in specific locations of the genome. Now, genetics researchers have shown definitively that a small number of places in the human genome are associated with a large number and variety of diseases. In particular, several diseases of aging are associated with a locus which is more famous for its role in preventing cancer.
In a pre-clinical non-small-cell lung cancer metastasis model in mice, a research team at the University of Massachusetts, Amherst uses a sensor array system of gold nanoparticles and proteins to “smell” different cancer types in much the same way our noses identify and remember different odors.
In a new study, University of Missouri medicinal chemists have taken an existing drug that is being developed for use in fighting certain types of cancer and added a special cluster of three elements: boron, carbon, and hydrogen. This structure, called a carborane, has multiplied the binding force of the drug. Clinical could start within two years.
Cancer metastasis, the escape and spread of primary tumor cells, is a common cause of cancer-related deaths. But metastasis remains poorly understood, and only recently have studies indicate that blood’s “stickiness” actually tears off tumor cells. Using a statistical technique employed by animators, scientists created a new computer simulation that reveals how cancer cells enter the bloodstream and the physical forces involved.
Like ravenous monsters, cancer tumors need plentiful supplies of cellular building blocks such as amino acids and nucleotides to keep growing at a rapid pace. This process has not been fully understood, but now chemists at the California Institute of Technology have shown for the first time that a specific sugar, known as GlcNAc ("glick-nack"), plays a key role in keeping the cancerous monsters "fed."
A nanoparticle developed at Rice University and tested in collaboration with Baylor College of Medicine may bring great benefits to the emergency treatment of brain-injury victims, even those with mild injuries. Combined polyethylene glycol-hydrophilic carbon clusters (PEG-HCC), already being tested to enhance cancer treatment, are also adept antioxidants. In animal studies, injections of PEG-HCC during initial treatment after an injury helped restore balance to the brain's vascular system.
Scientists at Los Alamos National Laboratory have observed, for the first time, how a laser penetrates dense, electron-rich plasma to generate ions. The process has applications for developing next generation particle accelerators and new cancer treatments.
Cancers release chemicals that confuse the immune system. Countering this effect, researchers led by Tarek Fahmy of Yale University have recently developed a system to simultaneously deliver a sustained dose of both an immune-system booster and a chemical to block the cancer's secretions. In mice this therapy has delayed tumor growth and even sent tumors into remission.
By sequencing cancer-cell genomes, scientists have discovered vast numbers of genes that are mutated, deleted, or copied in cancer cells. This treasure trove is a boon for researchers seeking new drug targets, but it is nearly impossible to test them all in a timely fashion. To help speed up the process, Massachusetts Institute of Technology researchers have developed RNA-delivering nanoparticles that allow for rapid screening of new drug targets in mice.
As the medical community continues to make positive strides in personalized cancer therapy, scientists know some dead ends are unavoidable. Drugs that target specific genes in cancerous cells are effective, but not all proteins are targetable. In fact, it has been estimated that as few as 10% to 15% of human proteins are potentially targetable by drugs. For this reason, Georgia Institute of Technology researchers are focusing on ways to fight cancer by attacking defective genes before they are able to make proteins.
Surprisingly, 90% of cancer deaths are caused from metastasis,the migration of cancer cells from a primary tumor to other parts of the body, not from the primary tumor alone. To better understand what happens to cells affected by this process, Johns Hopkins University researchers have fabricated a microfluidic-based cell migration chamber that has already yielded surprising results.
Yale University Cancer Center scientists have developed a new class of proteins that inhibit HIV infection in cell cultures and may open the way to new strategies for treating and preventing infection by the virus that causes AIDS.
Tumorous cancer cells are full of ultraviolet-induced genetic damage caused by sunlight exposure, but which mutations drive this cancer? By creating a method to spot the changes, scientists from several U.S. institutions have identified six genes responsible for mutations in melanoma, three of which of which are the result of damage inflicted by light.
Cancers are notorious for secreting chemicals that confuse the immune system and thwart biological defenses. Some treatments try to neutralize the cancer's chemical arsenal and boost immune response but are rarely successful. Researchers at Yale University have recently developed a system to simultaneously deliver both an immune-system booster and a chemical to counter the cancer's secretions.