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Giant macrophages discovered in blood of cancer patients

March 20, 2014 11:44 am | News | Comments

When cancers become advanced, tumor cells from the primary tumor can enter the bloodstream and cause metastasis at another organ with deadly effect. While researching the biological implications of CTC spread, Creatv MicroTech researchers found a group of previously unreported cells associated with primary cancer spread. These macrophage-like cells could serve as biomarkers.

IBM's Watson to help in brain cancer research

March 19, 2014 3:20 pm | by Bree Fowler - AP Technology Writer - Associated Press | News | Comments

IBM is teaming up with the New York Genome Center to help fight brain cancer. The company said Wednesday that its Watson cloud computing system will be used in partnership with a New York-based genetic research center to help develop treatments for glioblastoma, the most common type of brain cancer in U.S. adults.

Cheaper, more aggressive prostate cancer treatment may also be riskier

March 12, 2014 11:40 am | by Karen N. Peart, Yale Univ. | News | Comments

A faster and less expensive form of radiotherapy for treating prostate cancer may come at a price, according to a new study by Yale School of Medicine researchers—a higher rate of urinary toxicity or urine poisoning. The standard therapy for prostate cancer is called intensity modulated radiation therapy (IMRT). Stereotactic body radiotherapy (SBRT) is a newer treatment that delivers a greater dose of radiation than IMRT.

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Technique uses ATP as trigger for targeted anti-cancer drug delivery

March 11, 2014 12:50 pm | News | Comments

Biomedical engineering researchers have developed a new technique that uses adenosine-5’-triphosphate (ATP), the so-called “energy molecule,” to trigger the release of anti-cancer drugs directly into cancer cells. Early laboratory tests show it increases the effectiveness of drugs targeting breast cancer. The technique was developed by researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill.

How tumors escape

March 11, 2014 7:43 am | by Anne Trafton, MIT News Office | News | Comments

About 90% of cancer deaths are caused by tumors that have spread from their original locations. This process, known as metastasis, requires cancer cells to break loose from their neighbors and from the supportive scaffold that gives tissues their structure. Cancer biologists have now discovered that certain proteins in this structure, known as the extracellular matrix, help cancer cells make their escape.

Earlier Detection of Cancer

February 28, 2014 1:55 pm | by Muneesh Tewari, Univ. of Michigan, and George Karlin-Neumann, Director of Scientific Affairs, Bio-Rad's Digital Biology Center | Articles | Comments

Finding treatments for advanced stage cancer isn’t easy. Therefore, early detection methods are paramount in the fight against the disease. Motivated by the opportunity to intervene as early as possible in the course of cancer, Dr. Muneesh Tewari, a Univ. of Michigan researcher, has been studying the diagnostic potential of blood-based biomarkers.

Finding a few foes among billions of friends

February 26, 2014 2:46 pm | by Steven Powell, Univ. of South Carolina | News | Comments

Beating cancer is all about early detection, and new research from the Univ. of South Carolina is another step forward in catching the disease early. A team of chemists is reporting a new way to detect just a few lurking tumor cells, which can be outnumbered a billion to one in the bloodstream by healthy cells.

Experimental treatment eradicates acute leukemia in mice

February 26, 2014 7:53 am | by Shaun Mason, Univ. of California, Los Angeles | News | Comments

A diverse team of scientists from Univ. of California, Los Angeles' Jonsson Comprehensive Cancer Center has developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread.

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Study: Personalized medicine best way to treat cancer

February 25, 2014 8:14 am | by Brett Israel, Georgia Institute of Technology | News | Comments

If a driver is traveling to New York City, I-95 might be their route of choice. But they could also take I-78, I-87 or any number of alternate routes. Most cancers begin similarly, with many possible routes to the same disease. A new study found evidence that assessing the route to cancer on a case-by-case basis might make more sense than basing a patient’s cancer treatment on commonly disrupted genes and pathways.

Soy supplements with isoflavones “reprogram” breast cancer cells

February 25, 2014 8:05 am | by Sharita Forrest, News Editor, Univ. of Illinois, Urbana-Champaign | News | Comments

Women with estrogen-responsive breast cancer who consume soy protein supplements containing isoflavones to alleviate the side effects of menopause may be accelerating progression of their cancer, changing it from a treatable subtype to a more aggressive, less treatable form of the disease, new research suggests.

FDA clears Pharmacyclics drug for new cancer use

February 12, 2014 2:09 pm | by The Associated Press | News | Comments

The Food and Drug Administration on Wednesday approved a cancer drug from Pharmacyclics and Janssen Biotech Inc. for a new use against a rare blood and bone marrow disease. The agency said it approved Imbruvica for patients with chronic lymphocytic leukemia who have already tried at least one other therapy.

Study disputes value of routine mammograms

February 12, 2014 12:09 pm | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

A Canadian study that many experts say has major flaws has revived a debate about the value of mammograms. The study suggests that these screening x-rays do not lower the risk of dying of breast cancer while finding many tumors that do not need treatment. The study gives longer follow-up on nearly 90,000 women who were given either a breast exam by a nurse to check for lumps plus a mammogram or the breast exam alone.

Targeted Healing of the Immune System

February 9, 2014 10:00 am | by Lindsay Hock, Managing Editor | Articles | Comments

In the U.S. about 12,500 women are diagnosed with cervical cancer a year. Out of these women, about 4,500 progress into invasive cervical cancer or the end stage of the disease. This leaves about 8,000 women a year in the U.S. that are cured through existing standard of care treatment: surgery or chemotherapy/radiation. However, chemotherapy/radiation have terrible side effects in some cases.

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Credit card-sized device could analyze biopsy

February 7, 2014 7:44 am | by Michelle Ma, Univ. of Washington | News | Comments

Pancreatic cancer is a particularly devastating disease. At least 94% of patients will die within five years, and in 2013 it was ranked as one of the top 10 deadliest cancers. Routine screenings for breast, colon and lung cancers have improved treatment and outcomes for patients with these diseases. But because little is known about how pancreatic cancer behaves, patients often receive a diagnosis when it’s already too late.

A microchip for metastasis

February 6, 2014 8:09 am | by Jennifer Chu, MIT News Office | News | Comments

Nearly 70% of patients with advanced breast cancer experience skeletal metastasis, in which cancer cells migrate from a primary tumor into bone. While scientists are attempting to better understand metastasis in general, not much is known about how and why certain cancers spread to specific organs. Now researchers have developed a 3-D microfluidic platform that mimics the spread of breast cancer cells into a bone-like environment.

How a shape-shifting DNA-repair machine fights cancer

February 4, 2014 10:44 am | by Dan Krotz, Lawrence Berkeley National Laboratory | News | Comments

Maybe you’ve seen the movies or played with toy Transformers, those shape-shifting machines that morph in response to whatever challenge they face. It turns out that DNA-repair machines in your cells use a similar approach to fight cancer and other diseases, according to research led by scientists from Lawrence Berkeley National Laboratory.

Genetic function discovered that could offer new avenue to cancer therapies

February 4, 2014 9:13 am | News | Comments

Researchers at Oregon State Univ. have discovered a genetic function that helps one of the most important “tumor suppressor” genes to do its job and prevent cancer. Finding ways to maintain or increase the effectiveness of this gene—called Grp1-associated scaffold protein, or Grasp—could offer an important new avenue for human cancer therapies, scientists said.

Report: Childhood cancer cases up, but deaths down

January 31, 2014 11:08 am | by Mike Stobbe - AP Medical Writer - Associated Press | News | Comments

A new report says childhood cancer cases continue to increase, but death rates have fallen by half. The American Cancer Society report—released Friday—is being called one of the most comprehensive looks at the types of cancer that most commonly affect children and adolescents.

Weapon fights drug-resistant tumors

January 31, 2014 9:16 am | by Anne Trafton, MIT News Office | News | Comments

Cancer drugs that recruit antibodies from the body’s own immune system to help kill tumors have shown much promise in treating several types of cancer. However, after initial success, the tumors often return. A new study from Massachusetts Institute of Technology reveals a way to combat these recurrent tumors with a drug that makes them more vulnerable to the antibody treatment.

Doctors: Too few cancer patients enroll in studies

January 28, 2014 5:08 pm | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

One of every 10 clinical trials for adults with cancer ends prematurely because researchers can't get enough people to test new treatments, scientists report. The surprisingly high rate reveals not just the scope and cost of wasted opportunities that deprive patients of potential advances, but also the extent of barriers such as money, logistics and even the mistaken fear that people won't get the best care if they join these experiments.

Researchers discover potential drug targets for early onset glaucoma

January 24, 2014 8:18 am | by Brett Israel, Georgia Institute of Technology | News | Comments

Using a novel high-throughput screening process, scientists have, for the first time, identified molecules with the potential to block the accumulation of a toxic eye protein that can lead to early onset of glaucoma. Glaucoma is a group of diseases that can damage the eye’s optic nerve and cause vision loss and blindness. Elevated eye pressure is the main risk factor for optic nerve damage.

Unwanted side effect becomes advantage in photoacoustic imaging

January 15, 2014 9:55 am | News | Comments

Biomedical engineer Lihong Wang and researchers in his laboratory work with lasers used in photoacoustic imaging for early cancer detection and a close look at biological tissue. But sometimes there are limitations to what they can do; and as engineers, they work to find a way around those limitations. The team found a novel way to use an otherwise unwanted side effect of the lasers they use—the photo bleaching effect—to their advantage.

Researchers develop artificial bone marrow

January 10, 2014 12:51 pm | News | Comments

A new porous structure under development in German possesses essential properties of natural bone marrow and can be used for the reproduction of stem cells in the laboratory. The specific reproduction of these hematopoietic cells outside the body might facilitate new therapies for leukemia in a few years.

Simple test can indicate cervical cancer

January 9, 2014 8:23 am | News | Comments

Researchers at the Univ. of Louisville have confirmed that using the heat profile from a person’s blood, called a plasma thermogram, can serve as an indicator for the presence or absence of cervical cancer, including the stage of cancer. To generate a plasma thermogram, a blood plasma sample is melted, producing a unique signature indicating a person’s health status.

Chemical imaging brings cancer tissue analysis into the digital age

January 8, 2014 9:33 am | News | Comments

A new method for analyzing biological samples' chemical makeup is set to transform the way medical scientists examine diseased tissue. When tests are carried out on a patient’s tissue today, such as to look for cancer, the test has to be interpreted by a histology specialist, and can take weeks to obtain a full result. Mass spectrometry imaging uses technologies that reveal how chemical components are distributed in a tissue sample.

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