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New study aims to rapidly test lung cancer drugs

June 16, 2014 2:16 pm | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

A bold new way to test cancer drugs started Monday. Like a medical version of speed dating, doctors will sort through multiple experimental drugs and match patients to the one most likely to succeed based on each person's unique tumor gene profile. Five drug companies, the government, private foundations and advocacy groups are taking part.

Antibodies from the desert act as guides to disease cells

June 13, 2014 8:19 am | News | Comments

Researchers have developed nanoparticles that not only bypass the body’s defence system, but also find their way to the diseased cells. The procedure uses fragments from a particular type of antibody that only occurs in camels and llamas. The small particles were even successful under conditions which are very similar to the situation within potential patients’ bodies.

Study: Red meat possibly linked to breast cancer

June 11, 2014 9:22 am | by Maria Cheng - AP Medical Writer - Associated Press | News | Comments

Women who often indulge their cravings for hamburgers, steaks and other red meat may have a slightly higher risk of breast cancer, a new study suggests. Doctors have long warned that a diet loaded with red meat is linked to cancers including those of the colon and pancreas, but there has been less evidence for its role in breast cancer.

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Scientists reveal details of calcium “safety valve” in cells

June 9, 2014 8:18 am | by Karen McNulty Walsh, Brookhaven National Laboratory | News | Comments

Sometimes a cell has to die—when it's done with its job or inflicted with injury that could otherwise harm an organism. Conversely, cells that refuse to die when expected can lead to cancer. So scientists interested in fighting cancer have been keenly interested in learning the details of "programmed cell death." They want to understand what happens when this process goes awry and identify new targets for anticancer drugs.

New clues to why older women are more vulnerable to breast cancer

June 6, 2014 10:56 am | by Dan Krotz, Lawrence Berkeley National Laboratory | News | Comments

Scientists from Lawrence Berkeley National Laboratory have gained more insights into why older women are more susceptible to breast cancer. They found that as women age, the cells responsible for maintaining healthy breast tissue stop responding to their immediate surroundings, including mechanical cues that should prompt them to suppress nearby tumors.

Short nanotubes target pancreatic cancer

June 6, 2014 10:45 am | by Mike Williams, Rice Univ. | News | Comments

Short, customized carbon nanotubes have the potential to deliver drugs to pancreatic cancer cells and destroy them from within, according to researchers at Rice Univ. and the Univ. of Texas MD Anderson Cancer Center. Pristine nanotubes produced through a new process developed at Rice can be modified to carry drugs to tumors through gaps in blood-vessel walls that larger particles cannot fit through.

Tech Aids Cancer Research

June 4, 2014 2:32 pm | by Lindsay Hock, Managing Editor | Thermo Fisher Scientific | Articles | Comments

Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. The disease can be caused by both external and internal factors; and, if the spread isn’t controlled, it can result in death. The annual cancer statistics report from the American Cancer Society estimates there will be 1,885,540 new cancer cases and 585,720 cancer deaths in the U.S. for 2014.

“Quadrapeutics” works in preclinical study of hard-to-treat tumors

June 2, 2014 7:52 am | Videos | Comments

The first preclinical study of a new Rice Univ.-developed anticancer technology found that a novel combination of existing clinical treatments can instantaneously detect and kill only cancer cells without harming surrounding normal organs. The research reports that Rice’s “quadrapeutics” technology was 17 times more efficient than conventional chemoradiation therapy against aggressive, drug-resistant head and neck tumors.

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Cancer, bioelectrical signals and the microbiome connected

May 28, 2014 8:37 am | by Kim Thurler, Tufts Univ. | News | Comments

Developmental biologists at Tufts Univ., using a tadpole model, have shown that bioelectrical signals from distant cells control the incidence of tumors arising from cancer-causing genes and that this process is impacted by levels of a common fatty acid produced by bacteria found in the tadpole and also in humans. 

“Nanodaisies” deliver drug cocktail to cancer cells

May 28, 2014 8:16 am | by Matt Shipman, News Services, North Carolina State Univ. | News | Comments

Biomedical engineering researchers have developed daisy-shaped, nanoscale structures that are made predominantly of anticancer drugs and are capable of introducing a “cocktail” of multiple drugs into cancer cells. The researchers are all part the joint biomedical engineering program at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill.

How the anticancer drug Taxol works

May 23, 2014 8:08 am | by Lynn Yarris, Lawrence Berkeley National Laboratory | News | Comments

A pathway to the design of even more effective versions of the powerful anticancer drug Taxol has been opened with the most detailed look ever at the assembly and disassembly of microtubules, tiny fibers of tubulin protein that form the cytoskeletons of living cells and play a crucial role in mitosis.

Chemists discover structure of cancer drug candidate

May 20, 2014 7:43 am | News | Comments

Chemists at The Scripps Research Institute have determined the correct structure of a highly promising anticancer compound approved by the U.S. Food and Drug Administration for clinical trials in cancer patients. The new report, published in Angewandte Chemie, focuses on a compound called TIC10.

Ultra-sensitive nanochip detects cancer early

May 19, 2014 1:02 pm | News | Comments

A new  “lab-on-a-chip” platform developed at the Institute of Photonic Sciences in Spain is capable of detecting detect very low concentrations of protein cancer markers, enabling diagnoses of the disease in its earliest stages. The device, just a few square centimeters in size, uses recent advances in plasmonics, nano-fabrication, microfluids and surface chemistry.

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Herpes-loaded stem cells used to kill brain tumors

May 16, 2014 2:09 pm | News | Comments

Harvard Stem Cell Institute scientists have a potential solution for how to more effectively kill tumor cells using cancer-killing viruses. The investigators report that trapping virus-loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

Going beyond the surface

May 16, 2014 8:00 am | by Cory Nealon, Univ. of Buffalo | News | Comments

Photodynamic therapy (PDT) is an effective treatment for easily accessible tumors such as oral and skin cancer. But the procedure, which uses lasers to activate special drugs called photosensitizing agents, isn’t adept at fighting cancer deep inside the body. That could change because of a new technology that could bring PDT into areas of the body which were previously inaccessible.

The Bright Side of Fluorescence

May 14, 2014 8:49 am | by Takeharu Nagai, PhD, Osaka Univ., Japan | Photometrics | Articles | Comments

Fluorescent proteins have helped researchers open doors to countless molecular imaging applications and deepened our understanding of biological processes. Without fluorescence, advancements in oncology, drug discovery and any field that requires single-cell to whole-body imaging would be substantially limited.

Method sneaks drugs into cancer cells before triggering release

May 9, 2014 10:11 am | by Matt Shipman, News Services, North Carolina State Univ. | News | Comments

Biomedical engineering researchers have developed an anti-cancer drug delivery method that essentially smuggles the drug into a cancer cell before triggering its release. The method can be likened to keeping a cancer-killing bomb and its detonator separate until they are inside a cancer cell, where they then combine to destroy the cell.

Chemotherapy timing is key to success

May 8, 2014 4:00 pm | by Anne Trafton, MIT News Office | News | Comments

Massachusetts Institute of Technology researchers have devised a novel cancer treatment that destroys tumor cells by first disarming their defenses, then hitting them with a lethal dose of DNA damage. In studies with mice, the research team showed that this one-two punch, which relies on a nanoparticle that carries two drugs and releases them at different times, dramatically shrinks lung and breast tumors.

Where DNA’s copy machine pauses, cancer could be next

May 6, 2014 9:13 am | News | Comments

From time to time, genetic codes aren’t copied and collated properly, leaving gaps or breaks. A comprehensive mapping of these “fragile sites” in yeast by a team of Duke Univ. researchers shows that errors appear in specific areas of the genome where the DNA-copying machinery is slowed or stalled. The study could shed light on abnormalities seen in solid tumors.

Two-lock box delivers cancer therapy

May 6, 2014 7:37 am | News | Comments

Rice Univ. scientists have designed a tunable virus that works like a safe deposit box. It takes two keys to open it and release its therapeutic cargo. The Rice team developed an adeno-associated virus (AAV) that unlocks only in the presence of two selected proteases, enzymes that cut up other proteins for disposal. Because certain proteases are elevated at tumor sites, the viruses can be designed to target and destroy the cancer cells.

Cancer researchers to create live tumors with 3-D printer

April 25, 2014 1:31 pm | News | Comments

Using a mixture of cervical cancer cells and a hydrogel substance that resembles an ointment balm, Drexel Univ.’s Wei Sun can print out a tumor model that can be used for studying their growth and response to treatment. This living model will give cancer researchers a better look at how tumors behave and a more accurate measure of how they respond to treatment.

U.S. approves first-ever DNA alternative to Pap smear

April 24, 2014 5:22 pm | by Matthew Perrone - AP Health Writer - Associated Press | News | Comments

Federal health regulators have cleared a genetic test from Roche as the first ever U.S.-approved alternative to the Pap smear, the decades-old mainstay of cervical cancer screening. The U.S. Food and Drug Administration approved Swiss-based Roche's cobas HPV test to detect the human Papillomavirus, or HPV, in women 25 and up. HPV causes nearly all cases of cervical cancer.

Gold nanoparticles help target, quantify breast cancer gene segments in a living cell

April 23, 2014 8:59 am | by Natalie van Hoose, Purdue Univ. | News | Comments

A team at Purdue Univ. has used gold nanoparticles to target and bind to fragments of genetic material known as BRCA1 messenger RNA splice variants, which can indicate the presence and stage of breast cancer. The number of these synthetic DNA “tails” in a cell can be determined in a living cell by examining the specific signal that light produces when it interacts with the gold nanoparticles.

Study identifies enzymes that help fix cancer-causing DNA defects

April 23, 2014 7:47 am | by Natalie van Hoose, Purdue Univ. | News | Comments

Purdue Univ. researchers have identified an important enzyme pathway that helps prevent new cells from receiving too many or too few chromosomes, a condition that has been directly linked to cancer and other diseases. The team found that near the end of cell division, the enzyme Cdc14 activates Yen1, an enzyme that ensures any breaks in DNA are fully repaired before the parent cell distributes copies of the genome to daughter cells.

Tracking oxygen in the body

April 22, 2014 7:34 am | by Anne Trafton, MIT News Office | News | Comments

Unlike healthy cells, cancer cells thrive when deprived of oxygen. Tumors in low-oxygen environments tend to be more resistant to therapy and spread more aggressively to other parts of the body. Measuring tumors’ oxygen levels could help doctors make decisions about treatments, but there’s currently no way to make such measurements. However, a new sensor developed at Massachusetts Institute of Technology could change that.

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