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Two-lock box delivers cancer therapy

May 6, 2014 7:37 am | News | Comments

Rice Univ. scientists have designed a tunable virus that works like a safe deposit box. It takes two keys to open it and release its therapeutic cargo. The Rice team developed an adeno-associated virus (AAV) that unlocks only in the presence of two selected proteases, enzymes that cut up other proteins for disposal. Because certain proteases are elevated at tumor sites, the viruses can be designed to target and destroy the cancer cells.

Cancer researchers to create live tumors with 3-D printer

April 25, 2014 1:31 pm | News | Comments

Using a mixture of cervical cancer cells and a hydrogel substance that resembles an ointment balm, Drexel Univ.’s Wei Sun can print out a tumor model that can be used for studying their growth and response to treatment. This living model will give cancer researchers a better look at how tumors behave and a more accurate measure of how they respond to treatment.

U.S. approves first-ever DNA alternative to Pap smear

April 24, 2014 5:22 pm | by Matthew Perrone - AP Health Writer - Associated Press | News | Comments

Federal health regulators have cleared a genetic test from Roche as the first ever U.S.-approved alternative to the Pap smear, the decades-old mainstay of cervical cancer screening. The U.S. Food and Drug Administration approved Swiss-based Roche's cobas HPV test to detect the human Papillomavirus, or HPV, in women 25 and up. HPV causes nearly all cases of cervical cancer.

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Gold nanoparticles help target, quantify breast cancer gene segments in a living cell

April 23, 2014 8:59 am | by Natalie van Hoose, Purdue Univ. | News | Comments

A team at Purdue Univ. has used gold nanoparticles to target and bind to fragments of genetic material known as BRCA1 messenger RNA splice variants, which can indicate the presence and stage of breast cancer. The number of these synthetic DNA “tails” in a cell can be determined in a living cell by examining the specific signal that light produces when it interacts with the gold nanoparticles.

Study identifies enzymes that help fix cancer-causing DNA defects

April 23, 2014 7:47 am | by Natalie van Hoose, Purdue Univ. | News | Comments

Purdue Univ. researchers have identified an important enzyme pathway that helps prevent new cells from receiving too many or too few chromosomes, a condition that has been directly linked to cancer and other diseases. The team found that near the end of cell division, the enzyme Cdc14 activates Yen1, an enzyme that ensures any breaks in DNA are fully repaired before the parent cell distributes copies of the genome to daughter cells.

Tracking oxygen in the body

April 22, 2014 7:34 am | by Anne Trafton, MIT News Office | News | Comments

Unlike healthy cells, cancer cells thrive when deprived of oxygen. Tumors in low-oxygen environments tend to be more resistant to therapy and spread more aggressively to other parts of the body. Measuring tumors’ oxygen levels could help doctors make decisions about treatments, but there’s currently no way to make such measurements. However, a new sensor developed at Massachusetts Institute of Technology could change that.

Targeting cancer with a triple threat

April 15, 2014 7:38 am | by Anne Trafton, MIT News Office | News | Comments

Delivering chemotherapy drugs in nanoparticle form could help reduce side effects by targeting the drugs directly to the tumors. In recent years, scientists have developed nanoparticles that deliver one or two chemotherapy drugs, but it has been difficult to design particles that can carry any more than that in a precise ratio. Now Massachusetts Institute of Technology chemists have devised a new way to build such nanoparticles.

Obama signs cancer research bill in memory of girl

April 4, 2014 9:37 am | by Associated Press | News | Comments

A 10-year-old girl who died of brain cancer is leaving a legacy for other sick children in a new law signed by President Barack Obama. The legislation calls for eliminating taxpayer funding for political conventions and redirecting it to pediatric research at the National Institutes of Health.

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Nanoparticles cause cancer cells to self-destruct

April 3, 2014 2:04 pm | Videos | Comments

Using magnetically controlled nanoparticles to force tumor cells to "self-destruct" sounds like science fiction, but could be a future part of cancer treatment, according to new research.                  

Fighting cancer with lasers and nanoballoons that pop

April 3, 2014 9:11 am | by University at Buffalo | News | Comments

Chemotherapeutic drugs excel at fighting cancer, but they're not so efficient at getting where they need to go. Now, researchers are developing a better delivery method by encapsulating the drugs in nanoballoons – which are tiny modified liposomes that, upon being struck by a red laser, pop open and deliver concentrated doses of medicine.

Cancer researchers find key protein link

March 27, 2014 12:58 pm | News | Comments

A new understanding of proteins at the nexus of a cell’s decision to survive or die has implications for researchers who study cancer and age-related diseases, according to biophysicists at the Rice Univ.-based Center for Theoretical Biological Physics. Experiments and computer analysis of two key proteins revealed a previously unknown binding interface that could be addressed by medication.

Study ties breast gene to high-risk uterine cancer

March 24, 2014 11:19 am | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

Women with a faulty breast cancer gene might face a greater chance of rare but deadly uterine tumors despite having their ovaries removed to lower their main cancer risks, doctors are reporting. A study of nearly 300 women with bad BRCA1 genes found four cases of aggressive uterine cancers years after they had preventive surgery to remove their ovaries. That rate is 26 times greater than expected.

Key link between tumors and healthy tissue identified

March 21, 2014 8:43 am | by Bill Hathaway, Yale Univ. | News | Comments

The delicate balance between development of normal tissue and tumors depends in part upon a key molecular switch within cells, Yale School of Medicine researchers report in Science. Their findings reveal a potential mechanism used by cancer cells to recruit healthy cells to promote tumor growth and suggest new strategies to generate healthy tissue.

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Giant macrophages discovered in blood of cancer patients

March 20, 2014 11:44 am | News | Comments

When cancers become advanced, tumor cells from the primary tumor can enter the bloodstream and cause metastasis at another organ with deadly effect. While researching the biological implications of CTC spread, Creatv MicroTech researchers found a group of previously unreported cells associated with primary cancer spread. These macrophage-like cells could serve as biomarkers.

IBM's Watson to help in brain cancer research

March 19, 2014 3:20 pm | by Bree Fowler - AP Technology Writer - Associated Press | News | Comments

IBM is teaming up with the New York Genome Center to help fight brain cancer. The company said Wednesday that its Watson cloud computing system will be used in partnership with a New York-based genetic research center to help develop treatments for glioblastoma, the most common type of brain cancer in U.S. adults.

Cheaper, more aggressive prostate cancer treatment may also be riskier

March 12, 2014 11:40 am | by Karen N. Peart, Yale Univ. | News | Comments

A faster and less expensive form of radiotherapy for treating prostate cancer may come at a price, according to a new study by Yale School of Medicine researchers—a higher rate of urinary toxicity or urine poisoning. The standard therapy for prostate cancer is called intensity modulated radiation therapy (IMRT). Stereotactic body radiotherapy (SBRT) is a newer treatment that delivers a greater dose of radiation than IMRT.

Technique uses ATP as trigger for targeted anti-cancer drug delivery

March 11, 2014 12:50 pm | News | Comments

Biomedical engineering researchers have developed a new technique that uses adenosine-5’-triphosphate (ATP), the so-called “energy molecule,” to trigger the release of anti-cancer drugs directly into cancer cells. Early laboratory tests show it increases the effectiveness of drugs targeting breast cancer. The technique was developed by researchers at North Carolina State Univ. and the Univ. of North Carolina at Chapel Hill.

How tumors escape

March 11, 2014 7:43 am | by Anne Trafton, MIT News Office | News | Comments

About 90% of cancer deaths are caused by tumors that have spread from their original locations. This process, known as metastasis, requires cancer cells to break loose from their neighbors and from the supportive scaffold that gives tissues their structure. Cancer biologists have now discovered that certain proteins in this structure, known as the extracellular matrix, help cancer cells make their escape.

Earlier Detection of Cancer

February 28, 2014 1:55 pm | by Muneesh Tewari, Univ. of Michigan, and George Karlin-Neumann, Director of Scientific Affairs, Bio-Rad's Digital Biology Center | Articles | Comments

Finding treatments for advanced stage cancer isn’t easy. Therefore, early detection methods are paramount in the fight against the disease. Motivated by the opportunity to intervene as early as possible in the course of cancer, Dr. Muneesh Tewari, a Univ. of Michigan researcher, has been studying the diagnostic potential of blood-based biomarkers.

Finding a few foes among billions of friends

February 26, 2014 2:46 pm | by Steven Powell, Univ. of South Carolina | News | Comments

Beating cancer is all about early detection, and new research from the Univ. of South Carolina is another step forward in catching the disease early. A team of chemists is reporting a new way to detect just a few lurking tumor cells, which can be outnumbered a billion to one in the bloodstream by healthy cells.

Experimental treatment eradicates acute leukemia in mice

February 26, 2014 7:53 am | by Shaun Mason, Univ. of California, Los Angeles | News | Comments

A diverse team of scientists from Univ. of California, Los Angeles' Jonsson Comprehensive Cancer Center has developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread.

Study: Personalized medicine best way to treat cancer

February 25, 2014 8:14 am | by Brett Israel, Georgia Institute of Technology | News | Comments

If a driver is traveling to New York City, I-95 might be their route of choice. But they could also take I-78, I-87 or any number of alternate routes. Most cancers begin similarly, with many possible routes to the same disease. A new study found evidence that assessing the route to cancer on a case-by-case basis might make more sense than basing a patient’s cancer treatment on commonly disrupted genes and pathways.

Soy supplements with isoflavones “reprogram” breast cancer cells

February 25, 2014 8:05 am | by Sharita Forrest, News Editor, Univ. of Illinois, Urbana-Champaign | News | Comments

Women with estrogen-responsive breast cancer who consume soy protein supplements containing isoflavones to alleviate the side effects of menopause may be accelerating progression of their cancer, changing it from a treatable subtype to a more aggressive, less treatable form of the disease, new research suggests.

FDA clears Pharmacyclics drug for new cancer use

February 12, 2014 2:09 pm | by The Associated Press | News | Comments

The Food and Drug Administration on Wednesday approved a cancer drug from Pharmacyclics and Janssen Biotech Inc. for a new use against a rare blood and bone marrow disease. The agency said it approved Imbruvica for patients with chronic lymphocytic leukemia who have already tried at least one other therapy.

Study disputes value of routine mammograms

February 12, 2014 12:09 pm | by Marilynn Marchione - AP Chief Medical Writer - Associated Press | News | Comments

A Canadian study that many experts say has major flaws has revived a debate about the value of mammograms. The study suggests that these screening x-rays do not lower the risk of dying of breast cancer while finding many tumors that do not need treatment. The study gives longer follow-up on nearly 90,000 women who were given either a breast exam by a nurse to check for lumps plus a mammogram or the breast exam alone.

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