Researchers in Singapore and at IBM Research in California have discovered a new, potentially life-saving application for polyethylene terephthalate (PET), which is widely used to make plastic bottles. They have successfully converted PET into a non-toxic biocompatible material with superior fungal killing properties. This could help prevent and treat various fungus-induced diseases such as keratitis.
Medicated adhesive patches have become a preferred method of delivery for everything from nicotine to hormones to motion sickness medication. Drexel Univ. researchers are trying to expand the possibilities of this system, which is called transdermal delivery, with the help of a cleverly designed delivery vehicle and an ultrasonic "push," or pressure from sound waves.
An ultrasonic microscope emits a high frequency sound at an object, and the reflected sound captured by its lens is converted into a 2-D image of the object under scrutiny. Prof. Naohiro Hozumi in Japan is developing the technology to monitor living tissue and cell specimens for medical purposes.
As represented in this Forecast, the life science industry includes biopharmaceuticals, medical instruments and devices, animal/agricultural bioscience and commercial research and testing. However, the industry’s R&D spending is driven primarily by the mass and research intensity of the biopharmaceutical sector, which accounts for nearly 85% of all expenditures.
Researchers in China, working on the optimization of a third-generation sequencing technique based on nanopores, have found that long-chain DNA with low salt concentration is more conducive to the nanopore sequencing process. This finding may improve the efficiency of sequencing, and further low the cost of gene sequencing.
DNAnexus has announced a collaboration with Stanford Univ. that has resulted in a new 1000 Genomes Project data set of genetic variation. Launched in January 2008, the 1000 Genomes Project was the first international effort to sequence a large number of individual genomes with the goal of developing a comprehensive and freely accessible resource on human genetic variation.
Scientists are reporting development of a squishy gel that, when compressed at a key location such as a painful knee joint, releases anti-inflammatory medicine. The new material could someday deliver medications when and where osteoarthritis patients need it most.
An international multidisciplinary team including researchers at the Univ. of Illinois at Urbana/Champaign and the National Institute of Biomedical Imaging and Bioengineering has developed a sophisticated ”electronic skin” that adheres non-invasively to human skin, conforms well to contours, and provides a detailed temperature map of any surface of the body.
Scientists at Penn State Univ. have developed a method that enables a more accurate prediction of how ribonucleic acid molecules (RNAs) fold within living cells, shedding new light on how plants, as well as other living organisms, respond to environmental conditions. The advance was made possible by the ability to analyze more than 10,000 RNA molecules in a single cell.
Bruker Corp. has announced that it has been granted U.S. FDA clearance under Section 510(k) to market its MALDI Biotyper CA System in the United States for the identification of Gram negative bacterial colonies cultured from human specimens. The clearance marks progress in Bruker’s efforts to develop MALDI-TOF mass spectrometry into the most advanced platform for clinical microbiology identification.
Univ. of Arizona agricultural and biosystems engineering associate professor Jeong-Yeol Yoon and cardiology professor Dr. Marvin Slepian are testing nanotextured surfaces to improve how cardiovascular implant devices are attached in the body. The goal is to create a selectively sticky surface, favoring endothelial cell attachment, without favoring platelet attachment.
A new innovation may help us deal with post-Thanksgiving guilt: Biotechnologists have constructed a genetic regulatory circuit from human components that monitors blood-fat levels. In response to excessive levels, it produces a messenger substance that signals satiety to the body. Tests on obese mice reveal that this helps them to lose weight.
The Food and Drug Administration has ordered Google-backed genetic test maker 23andMe to halt sales of its personalized DNA test kits. In a warning letter posted online Monday, FDA regulators say that the Silicon Valley company has not shown that its tests are safe or effective despite "more than 14 face-to-face and teleconference meetings" and "hundreds of email exchanges."
Viruses can not only cause illnesses in humans, they also infect bacteria. Bacteria protect themselves with a kind of immune system that detects and “chops up” foreign DNA. Scientists have now shown that the dual-RNA guided enzyme Cas9 which is involved in the process has developed independently in various strains of bacteria. This enhances the potential of exploiting the bacterial immune system for genome engineering.
A team of researchers has uncovered critical information that could help scientists understand how protein polymers interact with other self-assembling biopolymers. The research helps explain naturally occurring nanomaterial within cells and could one day lead to engineered bio-composites for drug delivery, artificial tissue, bio-sensing, or cancer diagnosis.
In leaves, two proteins are responsible for photosynthesis, and they perform the conversion of carbon dioxide into oxygen and biomass very efficiently. Scientists have now harnessed this capability by embedding these proteins into complex molecules developed in the laboratory. Their bio-based solar cell creates electron current instead of biomass.
For 40 years, scientists thought they understood how certain bacteria work together to anaerobically digest biomass to produce methane gas. But now microbiologists have shown for the first time that one of the most abundant methane-producing microorganisms on Earth makes direct electrical connections with another species to produce the gas in a completely unexpected way.
One of the methods used for examining the molecules in a liquid consists in passing the fluid through a nano-sized hole so as to detect their passage. Researchers in Switzerland have found a way to improve this technique by using a material with unique properties: graphene.
Researchers at the University of Iowa have created a bio patch to regenerate missing or damaged bone by putting DNA into a nano-sized particle that delivers bone-producing instructions directly into cells. The bone-regeneration kit relies on a collagen platform seeded with particles containing the genes needed for producing bone.
Researchers at the Univ. of Chicago are developing computer-aided diagnosis and quantitative image analysis methods for mammograms, ultrasounds and magnetic resonance images to identify specific tumor characteristics, including size, shape and sharpness
Our brains have upwards of 86 billion neurons, connected by synapses that not only complete myriad logic circuits; they continuously adapt to stimuli, strengthening some connections while weakening others. Materials scientists have now created a new type of transistor that mimics the behavior of a synapse. The novel device simultaneously modulates the flow of information in a circuit and physically adapts to changing signals.
The ability to shrink laboratory-scale processes to automated chip-sized systems would revolutionize biotechnology and medicine. One of the challenges of lab-on-a-chip technology is the need for miniaturized pumps to move solutions through microchannels. A super-thin silicon membrane developed at the Univ. of Rochester could now make it possible to shrink the power source, paving the way for diagnostic devices the size of a credit card.
Accurate and rapid testing for drug toxicity just became easier, thanks to a half-dozen Rice Univ. student interns working at Houston-based startup Nano3D Biosciences (n3D). The bioengineering and nanoscale physics students just wrapped up a year-long effort to aid the company in developing a new method for conducting high-throughput, in vitro cytotoxicity assays.
Researchers in The Netherlands have recently unveiled their “photoacoustic mammoscope,” a new device that could someday be used for routine breast cancer screenings. Instead of x-rays, which are used in traditional mammography, the photoacoustic breast mammoscope uses a combination of infrared light and ultrasound to create a 3-D map of the breast.
Over the past three years, 300,000 gamers have helped scientists with genomic research by playing Phylo, an online puzzle game. Now, the McGill Univ. researchers who developed the game are making this crowd of players available to scientists around the globe. The idea is to put human talent to work to improve on what is already being done by computers in the field of comparative genomics.