A new method allows for large-scale generation of human embryonic stem cells of high clinical quality. It also allows for production of such cells without destroying any human embryos. The discovery is a big step forward for stem cell research and for the high hopes for replacing damaged cells and thereby curing serious illnesses such as diabetes and Parkinson's disease.
Databanks containing information and biological materials from individuals are a crucial resource for research, but they are currently accessible only to researchers. In a recent paper published in Science, experts say that donors should have unrestricted access to data derived from their own material and that advanced technology means allowing such access is today a question of will rather than feasibility.
Some may think of turkeys as good for just lunch meat and holiday meals, but bioengineers at the Univ. of California (UC), Berkeley saw inspiration in the big birds for a new type of biosensor that changes color when exposed to chemical vapors. This feature makes the sensors valuable detectors of toxins or airborne pathogens.
Reaction Biology Corp. (RBC), a contract research organization providing early-stage drug discovery services, announced that it has signed an agreement for Cisbio Bioassays, a biotechnology company in the field of products and services for human in vitro diagnostics and pharmaceutical research, to distribute its epigenetic proteins.
An international research team led by Mount Sinai Heart at Icahn School of Medicine at Mount Sinai, is testing its novel sugar-based tracer contrast agent to be used with positron emission tomography (PET) imaging to help in the hunt for dangerous inflammation and high-risk vulnerable atherosclerotic plaque inside vessel walls that causes acute heart attacks and strokes.
A world of cloak-and-dagger pharmaceuticals has come a step closer with the development of stealth compounds programmed to spring into action when they receive the signal. Researchers in the U.K. have designed and tested large molecular complexes that will reveal their true identity only when they’ve reached their intended target, like disguised saboteurs working deep behind enemy lines.
Massachusetts Institute of Technology engineers have devised a way to measure the mass of particles with a resolution better than an attogram. Weighing these tiny particles, including both synthetic nanoparticles and biological components of cells, could help researchers better understand their composition and function.
A new porous structure under development in German possesses essential properties of natural bone marrow and can be used for the reproduction of stem cells in the laboratory. The specific reproduction of these hematopoietic cells outside the body might facilitate new therapies for leukemia in a few years.
As more reports appear of a grim “post-antibiotic era” ushered in by the rise of drug-resistant bacteria, a new strategy for fighting infection is emerging that targets a patient’s cells rather than those of the invading pathogens. The approach involves looking at a class of proteins called phosphatases that is crucial for bacterial but involves the use of the host cell’s machinery.
In the 2nd century BC, Indian surgeon Sushruta used autografted skin transplantation in nose reconstruction, also known as rhinoplasty. This was the first reasonable account of organ transplantation recorded. The first successful human corneal transplant was performed in 1905 in the Czech Republic, and the first steps to skin transplantation occurred during World War I. The first successful kidney transplant happened in 1962 in the U.S.
Researchers in Switzerland are developing electronic components that are thinner and more flexible than before. They can even be wrapped around a single hair without damaging the electronics. This opens up new possibilities for ultra-thin, transparent sensors that are literally easy on the eye.
Developed by a team of researchers in Massachusetts and California, “nanotraps” are nanoparticles that act as viral traps using specific molecules found naturally within the human body. Initial testing on the treatments, which each use tiny, non-toxic particles that can be injected, inhaled, or eaten, has shown them to be effective and safe against a multitude of strains of disease.
The ability to determine protein stoichiometry and monitor the ratio of protein types allows scientists to see the difference between a properly functioning cell and a diseased cell. Photoactivation fluorescences studies have resulted in undercounting of proteins, however, leading a science group to recently establish new methodology for determining protein stoichiometry.
Recently, a study team from the First Affiliated Hospital, Sun Yat-sen Univ. in China has verified that virtual reality training using the Kinect system from the Xbox 360 could promote the recovery of upper limb motor function in subacute stroke patients, and brain reorganization by Kinect-based virtual reality training may be linked to the contralateral sensorimotor cortex.
In a recent achievement, Cui Qiu, a researcher with the Chinese Academy of Sciences' Qingdao Institute of Bioenergy and Bioprocess Technology, turned a few shy members of the Clostridium germ family into highly productive workers. Some chewed up wood fiber and churned out sugar, while others ate the sugar and made ethanol. These small creatures could bring huge changes to the world, Cui says.
Solar Impulse pilot Bertrand Piccard put his mental and physiological limits to the test during a 72-hour simulated flight across the Atlantic Ocean which ended Friday. Scientists from the Swiss Federal Polytechnic Institute in Lausanne monitored his mental states and cardiac rhythm throughout the flight to test his mental and physiological boundaries during strenuous flight conditions.
Can an experimental drug developed to treat epilepsy block the AIDS virus? A preliminary lab study suggests it's possible, and researchers are eager to try it in people. When tested in human tissues in the laboratory, the drug "works beautifully" to prevent HIV from destroying key cells of the immune system.
In the quest to shrink motors so they can maneuver in tiny spaces like inside and between human cells, scientists have taken inspiration from millions of years of plant evolution and incorporated, for the first time, corkscrew structures from plants into a new kind of helical “microswimmer.” The low-cost development, which appears in ACS’ journal Nano Letters, could be used on a large scale in targeted drug delivery and other applications.
New collaborative work from computational biologists in Massachusetts and California combines computational and experimental approaches to identify biologically meaningful RNA folds. The work could open the door to a better understanding of RNA machinery, which includes the ribosome, microRNAs and riboswitches, and long noncoding RNAs whose diverse functions are only beginning to be understood.
A group of researchers from the U.K. have used inkjet printing technology to successfully print cells taken from the eye for the very first time. The breakthrough, detailed in Biofabrication, could lead to the production of artificial tissue grafts made from the variety of cells found in the human retina and may aid in the search to cure blindness.
Easily manufactured, low-cost artificial cells manufactured using microprinting may one day serve as drug and gene delivery devices, according to engineers at Penn State Univ. who are creating large arrays of artificial cells. Made of lipids and proteins, these uniformly sized cells can either remain attached to the substrate on which they grow, or become separated and used as freely moving vessels.
In a sort of biological "spooky action at a distance," water in a cell slows down in the tightest confines between proteins and develops the ability to affect other proteins much farther away, Univ. of Michigan researchers have discovered. The finding could provide insights into how and why proteins clump together in diseases such as Alzheimer's and Parkinson's.
Until recently, the microscopic study of complex membrane proteins has been restricted due to limitations of “force microscopes” that are available to researchers and the one-dimensional results these microscopes reveal. Now, researchers at the Univ. of Missouri have built a 3-D microscope that will yield unparalleled information on membrane proteins and how they interact in cells. The innovation could speed up drug development.
Researchers have created a new type of molecular motor made of DNA and demonstrated its potential by using it to transport a nanoparticle along the length of a carbon nanotube. The design was inspired by natural biological motors that have evolved to perform specific tasks critical to the function of cells.
Metal-organic frameworks (MOFs) are commanding considerable research attention because of their appetite for greenhouse gases. But now supramolecular organic frameworks (SOFs), held together by non-covalent bonds, have joined the field. Researchers have unveiled the first 2-D SOFs that self-assemble in solution, an important breakthrough that holds implications for sensing, separation technologies, and biomimetics.