DNA mutations had been thought to be rare events that occur randomly throughout the genome. However, recent studies have shown that cancer development frequently involves the formation of multiple mutations that arise simultaneously and in close proximity to each other. These groups of clustered mutations are frequently found in regions where chromosomal rearrangements take place.
We have long known that cancer cells monopolize large amounts of sugar. More recently, it became clear that some tumor cells are also characterized by a series of features such as mobility or unlikeliness to join in an ordered set. Researchers are calling this behavior “mesenchymal,” and they suspect it promotes metastasis.
With the help of conventional inkjet printers, scientists are reporting new understanding about the dynamics of 3-D bioprinting that takes them a step closer to realizing their goal of making working tissues and organs on-demand. Their recent work in testing bioinks filled with hydrogel and different concentrations of mouse fibroblasts shed light on how the inks behave when they’re dispensed through printer nozzles.
The best way to cure most cases of cancer is to surgically remove the tumor. The Achilles heel of this approach, however, is that the surgeon may fail to extract the entire tumor, leading to a local recurrence. With a new technique based on injectable dye and infrared light, researchers in Pennsylvania have established a new strategy to help surgeons see the entire tumor in the patient, increasing the likelihood of a positive outcome.
DNA–protein conjugates can be used in diagnostic techniques, nanotechnology and other disciplines, but controlling the conjugation of these macromolecules can be a challenge. Scientists in Denmark have pioneered an easier method that makes it possible to direct the tagging of proteins with DNA to a particular site on the protein without genetically modifying the protein beforehand.
A powerful new tool that could help advance the genetic engineering of “fuel” crops bioenergy, has been developed by researchers with the Joint BioEnergy Institute. Their new, unique assay enabled them to analyze nucleotide sugar transporter activities in Arabidopsis, a promising source of plant biomass, and characterize a family of six nucleotide sugar transporters that has never before been described.
The Wyss Institute for Biologically Inspired Engineering at Harvard Univ. announced that its human “Organs-on-Chips” technology will be commercialized by a newly formed private company to accelerate development of pharmaceutical, chemical, cosmetic and personalized medicine products.
Cancerous tumors protect themselves by tricking the immune system into accepting everything as normal, even while cancer cells are dividing and spreading. One pioneering approach to combat this effect is to use nanoparticles to jumpstart the body's ability to fight tumors. Recent combines these therapeutic nanoparticles with heat to stimulate the immune system.
Virologists and biologists in California have identified a highly abundant, never-before-described virus that could play a major role in obesity, diabetes. The virus, named crAssphage, has about 10 times as many base pairs of DNA as HIV and infects one of the most common types of gut bacteria. This phylum of bacteria is thought to be connected with obesity, diabetes and other gut-related diseases.
A new study has shown that it is possible to predict long-term cancer risk from a chemical exposure by measuring the short-term effects of that same exposure. The findings could make it possible to develop simpler and cheaper tests to screen chemicals for their potential cancer causing risk.
When a foreign material like a medical device or surgical implant is put inside the human body, the body usually reacts negatively. For the first time ever, researchers at Northwestern Univ. have created a biodegradable biomaterial that is inherently antioxidant. The material can be used to create elastomers, liquids that turn into gels, or solids for building devices that are more compatible with cells and tissues.
Actin is the most abundant protein in the body, and is the basis of most movement in the body. Adding to the growing fundamental understanding of the machinery of muscle cells, a group of biophysicists in Pennsylvania have published work that describes in minute detail how actin filaments are stabilized at one of their ends to form a basic muscle structure called the sarcomere.
More than a decade ago, news of a Namibian desert beetle’s efficient water collection system inspired engineers to try and reproduce these surfaces in the laboratory. Small-scale advances in fluid physics, materials engineering and nanoscience since that time have brought them close to succeeding. And their work could have impact on a wide range of industries at the macroscale.
Janelia Research Campus experts have built a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell. Using image data obtaining using a sophisticated form of light sheet microscopy, the tool can track the movement of cells in an animal’s body in 3-D.
In the U.K., researchers have revealed the structure of one of the most important and complicated proteins in cell division, the anaphase-promoting complex. Electron microscopy and software has produced images of the gigantic protein in unprecedented detail and could transform scientists' understanding of exactly how cells copy their chromosomes and divide. It could also reveal binding sites for future cancer drugs.
Using two thin, tiny gold nanorods 10,000 times thinner than a human hair, researchers from the U.S. and Germany have succeeded in creating an adjustable filter for so-called circularly polarized light. This switch for nano-optics is made from two tiny gold rods that reversibly change their optical properties when specific DNA molecules are added.
Most current methods of identifying intracellular information result in the death of the individual cells, making it impossible to continue to gain information and assess change over time. Using magnetized carbon nanotubes, scientists in Texas have devised a new method for extracting molecules from live cells without disrupting cell development.
Many organisms that hold potential for proteomic analysis do not yet have a completely sequenced genome because the costs are prohibitive. Xenopus laevis, the African clawed frog, is one such species. Researchers at the Marine Biological Laboratory have found a work-around. Instead of relying on DNA, they used mRNA sequences to more efficiently create a reference database that can be used for proteomic analysis of Xenopus.
Lawrence Livermore National Laboratory scientists are developing electrode array technology for monitoring brain activity as part of a collaborative research project with the Univ. of California San Francisco (UC San Francisco) to better understand how the neural circuitry of the brain works during memory retrieval.
The common pencil squid may hold the key to a new generation of medical technologies that could communicate more directly with the human body. Materials science researchers in California have discovered that reflectin, a protein in the tentacled creature’s skin, can conduct positive electrical charges, or protons, making it a promising material for building biologically inspired devices.
Popping the blisters on the bubble wrap might be the most enjoyable thing about moving. But now, researchers led by 2007 R&D Magazine Scientist of the Year George Whitesides propose a more productive way to reuse the popular packing material: as a sheet of small, test tube-like containers for medical and environmental samples. Analyses can take place right in the bubbles.
Researchers in Kentucky have developed a technology that uses male mosquitoes to effectively sterilize females through a naturally occurring bacterium. Called MosquitoMate, the new technology has been issued an experimental use permit for open field releases targeting the invasive Asian tiger mosquito, which is a vector for newly introduced pathogens like the Chikungunya virus.
Prothrombin is an inactive precursor for thrombin, a key blood-clotting protein, and is essential for life because of its ability to coagulate blood. Using x-ray crystallography, researchers have published the first image of this important protein. By removing disordered sections of the protein’s structure, scientists have revealed its underlying molecular mechanism for the first time.
Tamoxifen is an oral drug that is used for breast cancer prevention and as therapy for non-invasive breast cancer and invasive cancer. Seema Khan, a professor of surgery at Northwestern Univ., has found that is tamoxifen is used in gel form, it reduces the growth of cancer cells while minimizing dangerous side effects such as blood clots and uterine cancer.
A cheap, portable, microchip-based test for diagnosing type-1 diabetes could speed up diagnosis and enable studies of how the disease develops. Handheld microchips distinguish between the two main forms of diabetes mellitus, which are both characterized by high blood-sugar levels but have different causes. Until now, making the distinction has required a slow, expensive test available only in sophisticated healthcare settings.