A research team led by Ali Javey of the Univ. of California, Berkeley, has created the first user-interactive sensor network on flexible plastic. The new electronic skin, or e-skin, responds to touch by instantly lighting up. The more intense the pressure, the brighter the light it emits.
Stem cells are key to the promise of regenerative medicine, but the formula for induced pluripotent stem cells (iPSCs), the cells that can be created from a patient’s own tissues, has limited variations. New research, however, says iPSCs are far more versatile than originally thought. For the first time, researchers have replace a gene once thought impossible to substitute, creating the potential for more flexible recipes.
This week Illumina, Inc. announced the availability of its Phasing Analysis Service. The new sample-to-answer service delivers human whole-genome phase information, empowering gene mapping studies with a more comprehensive view of genomic variation. With phase data, researchers can better understand the effect of genotype on phenotype and variant interaction within a gene.
Microbiologists in France are reinvigorating a way of battling C. difficile infections that they hope will help overcome the growing problem of antibiotic resistant superbugs in hospitals. Using a model human colon, the researchers showed that the administration of a specific bacteriophage significantly reduced toxins and the number of C. difficile cells produced without significantly affecting the other members of the gut microbiota.
Researchers in Switzerland have developed a live-cell fluorescent labeling that makes bacterial cell-to-cell communication pathways visible. The communication between bacterial cells is essential in the regulation of processes within bacterial populations, such as biofilm development.
Although malaria has been eradicated in many countries, including the United States, it still infects more than 200 million people worldwide, killing nearly a million every year. In a major step toward reducing that number, a team led by MIT researchers has now developed a way to grow liver tissue that can support the liver stage of the life cycle of the two most common species of malaria.
GOJO Industries, a maker of hand hygiene and skin health and inventors of Purell Hand Sanitizer, conducted an independent research study at the John Peter Smith Hospital in Fort Worth, Texas to determine the impact on hand hygiene compliance rates when the hospital hand hygiene program included an electronic compliance activity monitoring system. The research showed a 92% hand hygiene improvement.
A team of researchers from Case Western Reserve University School of Medicine have identified a mechanism that can prevent the normal prion protein from changing its molecular shape into the abnormal form responsible for neurodegenerative diseases. This finding offers new hope in the battle against a foe that until now has always proved fatal.
Biotechnology company Zero Gravity Solutiuons aims to utilize the unique effects of extended zero/micro gravity environments available on the International Space Station to promote gene expression and accelerate stem cell research. The company has completed filings required prior to trading of the company’s stock.
On Thursday, Sigma-Aldrich Corp.announced a partnership with The Scripps Research Institute (TSRI) to fund research and provide immediate, day-of-publication access to TSRI researchers’ discoveries for the synthesis and analysis of potential drugs. The partnership promises to eliminate months from the translation of cutting-edge chemistry into widespread applications for drug discovery.
Mathematician Marcus Roper and his research group at the Univ. of California was the first to measure and explain the dynamic movement of nuclei in the cells of a fungus. They have produced a video showing this activity, and though it resembles cars darting along the freeway the images show millions of nuclei flowing through the tube-like filaments of a single fungus cell.
Scientists have developed an "intelligent knife" that can tell surgeons immediately whether the tissue they are cutting is cancerous or not. In the first study to test the invention in the operating theatre, the "iKnife" diagnosed tissue samples from 91 patients with 100% accuracy, instantly providing information that normally takes up to half an hour to reveal using laboratory tests.
Researchers have developed a drug delivery technique for diabetes treatment in which a sponge-like material surrounds an insulin core. The sponge expands and contracts in response to blood sugar levels to release insulin as needed. The technique could also be used for targeted drug delivery to cancer cells.
By feeding stem cells tiny particles made of magnetized iron oxide, scientists at Emory Univ. and Georgia Tech have used magnets to attract the cells to a particular location in the body after intravenous injection. The method could become a tool for directing stem cells’ healing powers to treat conditions such as heart disease or vascular disease.
The ergodic theorem, proposed by mathematician George Birkhoff in 1931, holds that if you follow an individual particle over an infinite amount of time, it will go through all the states that are seen in an infinite population at an instant in time. Experiments by biochemists in California show for the first time that the ergodic theorem can be demonstrated by a collection of individual protein molecules.
The interior of a living cell is a crowded place, with proteins and other macromolecules packed tightly together. A team of scientists at Carnegie Mellon Univ. has approximated this molecular crowding in an artificial cellular system and found that tight quarters help the process of gene expression, especially when other conditions are less than ideal.
Scientists in the new but fast-growing field of computational genomics are facing a dilemma. These researchers have begun to assemble the chemical blueprints of the DNA found in humans, animals, plants and microbes. But a flood of unassembled genetic data is being produced much faster than current computers can turn it into useful information, two scholars in the field are warning.
With the help of a new biochemical technique, an international team of scientists has cracked the “RNA control code”, which dictates how the family of molecules that mediates DNA expression moves genetic information from DNA to create proteins. One of the proteins they examined may explain some of the symptoms in children with autism.
The Ranger supercomputer in Texas has recently been used to determine how to sculpt fluid flows by precisely placing tiny pillars in microfluidic channels. By altering fluid speed and stacking pillars, a wide arrays of controlled flows can be achieved. This could be a boon for clinicians who would like to separate white blood cells in a sample, or more quickly perform lab-on-a-chip-type operations.
A team of engineers has designed a telescopic contact lens that can switch between normal and magnified vision by using slightly modified off-the-shelf 3-D television glasses. The new lens could ultimately be used to improve vision for patients suffering from eye disease, including age-related macular degeneration.
Half a millennium after Johannes Gutenberg printed the Bible, researchers printed a 3-D splint that saved the life of an infant born with severe tracheobronchomalacia, a birth defect that causes the airway to collapse. While similar surgeries have been performed using tissue donations and windpipes created from stem cells, this is the first time 3-D printing has been used to treat tracheobronchomalacia—at least in a human.
Introductory chemistry students learn that oil and water repel each other. So do other hydrophobic substances, which carry no electric charge, and hydrophilic substances, which carry an electric charge that allows them to mix with water. In a recent study, a group of bioengineers have found a way to strongly adhere hydrogels to hydrophobic silicone substrates, an innovation that provides a valuable new tool for microscale biotechnology.
Univ. of Toronto researchers are helping demystify an important class of proteins associated with disease, a discovery that could lead to better treatments for cancer, cystic fibrosis and many other conditions. The team developed the first roadmap for ATP-binding cassette (ABC) transporter proteins. These proteins are crucial components of every cell, and are also involved in tumor resistance.
Human embryonic stem cells have the remarkable property that they can form all human cell types, a process that is facilitated by cell communication pathways. An international research team based in Singapore have discovered a molecular network in human embryonic stem cells that integrates cell communication signals to keep the cell in its stem cell state.
In new research, Biodesign Institute team members describe a pair of tweezers made using principles of DNA base-pairing. They are astonishingly small: When the jaws of these tools are in the open position, the distance between the two arms is about 16 nanometers—over 30,000 times smaller than a single grain of sand.