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Chip placed under skin provides precise medicine

May 27, 2015 7:39 am | by EPFL | News | Comments

The future of medicine lies in ever greater precision, not only when it comes to diagnosis but also drug dosage. The blood work that medical staff rely on is generally a snapshot indicative of the moment the blood is drawn before it undergoes hours, or even days, of analysis. Several EPFL laboratories are working on devices allowing constant analysis over as long a period as possible.

New way to prevent diabetes-associated blindness

May 26, 2015 8:04 am | by Shawna Williams, Johns Hopkins Univ. | News | Comments

Reporting on their study with lab-grown human cells, researchers at The Johns Hopkins Univ. and...

Freshly squeezed vaccines

May 22, 2015 7:23 am | by Kevin Leonardi, Koch Institute | News | Comments

Massachusetts Institute of Technology researchers have shown that they can use a microfluidic...

Device captures rare circulating tumor cell clusters

May 21, 2015 7:41 am | by John Toon, Georgia Institute of Technology | Videos | Comments

The latest version of a microfluidic device for capturing rare circulating tumor cells is the...

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Designing better medical implants

May 19, 2015 7:51 am | by Anne Trafton, MIT News Office | News | Comments

Biomedical devices that can be implanted in the body for drug delivery, tissue engineering or sensing can help improve treatment for many diseases. However, such devices are often susceptible to attack by the immune system, which can render them useless. A team of Massachusetts Institute of Technology researchers has come up with a way to reduce that immune-system rejection.

Discovery paves way for homebrewed drugs

May 18, 2015 11:22 am | by Sarah Yang, Univ. of California, Berkeley | News | Comments

Fans of homebrewed beer and backyard distilleries already know how to employ yeast to convert sugar into alcohol. But a research team led by UC Berkeley bioengineers has gone much further by completing key steps needed to turn sugar-fed yeast into a microbial factory for producing morphine and potentially other drugs, including antibiotics and anti-cancer therapeutics.

Tolou Shokuhfar and colleagues are developing techniques using 3D bioprinting to generate human tissue.

Bioprinting in 3D: Looks like candy, could regenerate nerve cells

May 12, 2015 10:23 am | by Michigan Technological University | News | Comments

The printer looks like a toaster oven with the front and sides removed. Its metal frame is built up around a stainless steel circle lit by an ultraviolet light. Stainless steel hydraulics and thin black tubes line the back edge, which lead to an inner, topside box made of red plastic. All together, the gray metal frame is small enough to fit on top of an old-fashioned school desk, but nothing about this 3D printer is old school.

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Researchers in the University of Colorado Center for Neuroscience have developed an implantable microscope that will allow researchers to see deep into the brain and learn about small parts of the brain we've never been able to properly study.

Researchers create microscope allowing deep brain exploration

May 12, 2015 10:05 am | by David Kelly, University of Colorado | News | Comments

A team of neuroscientists and bioengineers a have created a miniature, fiber-optic microscope designed to peer deeply inside a living brain. The laser-scanning microscope, a prototype which will be further refined, uses fiber-optics and a tiny electrowetting lens. Compared to other small, focusing lenses, it’s fast and not sensitive to motion. This allows it to reliably focus on living tissue.

Faster, smaller, more informative

May 12, 2015 7:37 am | by Anne Trafton, MIT News Office | News | Comments

A new technique invented at Massachusetts Institute of Technology can measure the relative positions of tiny particles as they flow through a fluidic channel, potentially offering an easy way to monitor the assembly of nanoparticles, or to study how mass is distributed within a cell. With further advancements, this technology has the potential to resolve the shape of objects in flow as small as viruses, the researchers say.

Researchers develop custom artificial membranes

May 8, 2015 8:06 am | by Evan Lerner, Univ. of Pennsylvania | News | Comments

Decorating the outside of cells like tiny antenna, a diverse community of sugar molecules acts like a telecommunications system, sending and receiving information, recognizing and responding to foreign molecules and neighboring cells. This sugar part of biomembranes is as crucial to health as DNA, but not much is known about it.

Sounding out scaffolds for eardrum replacement

May 7, 2015 10:18 am | by Institute of Physics | News | Comments

An international team of researchers has created tiny, complex scaffolds that mimic the intricate network of collagen fibers that form the human eardrum. It is hoped the scaffolds can be used to replace eardrums when they become severely damaged, reducing the need for patients to have their own tissue used in reconstruction surgery.

A better way to build DNA scaffolds

May 6, 2015 12:47 pm | by Chris Chipello, McGill Univ. | Videos | Comments

Imagine taking strands of DNA and using it to build tiny structures that can deliver drugs to targets within the body or take electronic miniaturization to a whole new level. While it may still sound like science fiction to most of us, researchers have been piecing together and experimenting with DNA structures for decades.

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Producing jet fuel compounds from fungus

May 6, 2015 7:36 am | by Tina Hilding, Washington State Univ. | News | Comments

Washington State Univ. researchers have found a way to make jet fuel from a common black fungus found in decaying leaves, soil and rotting fruit. The researchers hope the process leads to economically viable production of aviation biofuels in the next five years. The researchers used Aspergillus carbonarius ITEM 5010 to create hydrocarbons, the chief component of petroleum, similar to those in aviation fuels.

Practical gel that simply “clicks” for biomedical applications

May 1, 2015 10:17 am | by Harvard Univ. | News | Comments

If you opt to wear soft contact lenses, chances are you are using hydrogels on a daily basis. Made up of polymer chains that are able to absorb water, hydrogels used in contacts are flexible and allow oxygen to pass through the lenses, keeping eyes healthy. Hydrogels can be up to 99% water and as a result are similar in composition to human tissues.

Cellular sensing platform supports next-gen bioscience, biotech applications

May 1, 2015 8:25 am | by John Toon, Georgia Institute of Technology | News | Comments

Researchers from the Georgia Institute of Technology have developed a novel cellular sensing platform that promises to expand the use of semiconductor technology in the development of next-generation bioscience and biotech applications. The research proposes and demonstrates the world’s first multi-modality cellular sensor arranged in a standard low-cost CMOS process.

The accelerator of the compact light source. Courtesy of Klaus Achterhold / TUM

Compact synchrotron makes tumors visible

April 30, 2015 11:39 am | by Technische Universität München | News | Comments

Soft tissue disorders like tumors are very difficult to recognize using normal X-ray machines. There is hardly any distinction between healthy tissue and tumors. Researchers at the Technische Universität München have now developed a technology using a compact synchrotron source that measures not only X-ray absorption, but also phase shifts and scattering. Tissue that is hardly recognizable using traditional X-ray machines is now visible.

3-D Method Aids Study of Proteins

April 27, 2015 11:08 am | by Universitat Autònoma de Barcelona | News | Comments

Researchers have developed AGGRESCAN3D, a new computational method which allows studying the structure of folded globular proteins and their propensity for forming toxic protein aggregates.

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A team of researchers using the Advanced Photon Source, above, a U.S. Department of Energy Office of Science User Facility at Argonne National Laboratory, demonstrated unparalleled sensitivity for measuring the distribution of trace elements in thicker sp

X-ray ptychography, fluorescence microscopy combo sheds new light on trace elements

April 24, 2015 10:44 am | by Angela Hardin, Argonne National Laboratory | News | Comments

Scientists have developed a new approach that combines ptychographic x-ray imaging and fluorescence microscopy to study the important role trace elements play in biological functions on hydrated cells. A team of researchers using the Advanced Photon Source demonstrated unparalleled sensitivity for measuring distribution of trace elements in thicker specimens at cryogenic temperatures, in this case at about 260 degrees below Fahrenheit.

A new wrinkle for cell culture

April 23, 2015 9:53 am | by Kevin Stacey, Brown Univ. | News | Comments

Using a technique that introduces tiny wrinkles into sheets of graphene, researchers from Brown Univ. have developed new textured surfaces for culturing cells in the lab that better mimic the complex surroundings in which cells grow in the body.

Technique can measure volumes of key lab-on-a-chip components

April 22, 2015 11:35 am | by NIST | News | Comments

Imagine shrinking tubes and beakers down to the size of a credit card. When engineers figured out how to do that two decades ago, they enabled complex tests to be performed with tiny "lab on a chip" technology. But until now, there has been no way to accurately measure the size of the tiny vessels they created. Now, scientists at NIST have found a potential solution to this longstanding manufacturing issue.

Deadline Extended for 2015 R&D 100 Award Entries

April 20, 2015 1:53 pm | by Lindsay Hock, Editor | News | Comments

The editors of R&D Magazine have announced a deadline extension for the 2015 R&D 100 Awards entry process until May 18, 2015. The R&D 100 Awards have a 50 plus year history of awarding the 100 most technologically significant products of the year.

Biofuel Struggles with Economics and the Environment

April 17, 2015 2:31 pm | by Tim Studt | Articles | Comments

Immediately following the passage of the Energy Independence and Security Act (EISA) of 2007, much research interest focused on the development of bio-based renewable energy sources (biofuels). EISA mandated increased production and use of biofuels for the long term. There also appeared to be substantial long-term government support for the implementation of a biofuel-based industry.

Self-assembling, bioinstructive collagen materials for research, medical applications

April 9, 2015 7:50 am | by Emil Venere, Purdue Univ. | News | Comments

A Purdue Univ. researcher and entrepreneur is commercializing her laboratory's innovative collagen formulations that self-assemble or polymerize to form fibrils that resemble those found in the body's tissues. These collagen building blocks can be used to create customized 3-D tissue and organs outside the body to support basic biological research, drug discovery and chemical toxicity testing.

Scientists coax stem cells to form 3-D mini lungs

March 24, 2015 10:17 am | by University of Michigan Health System | News | Comments

Scientists have coaxed stem cells to grow the first three-dimensional mini lungs. Previous research has focused on deriving lung tissue from flat cell systems or growing cells onto scaffolds made from donated organs.

Researchers create fast-growing trees that are easier to turn into fuel

March 19, 2015 7:50 am | by James Hataway, Univ. of Georgia | News | Comments

Researchers at the Univ. of Georgia have discovered that manipulation of a specific gene in a hardwood tree species not only makes it easier to break down the wood into fuel, but also significantly increases tree growth. In a paper, the researchers describe how decreasing the expression of a gene called GAUT12.1 leads to a reduction in xylan and pectin.

New technique to chart protein networks in living cells

March 16, 2015 3:29 pm | by European Molecular Biology Laboratory | News | Comments

A new approach for studying the behavior of proteins in living cells has been developed by an interdisciplinary team of biologists and physicists at the European Molecular Biology Laboratory in Heidelberg. Described in a new study, the approach allows scientists for the first time to follow the protein networks that drive a biological process in real time.

Just Released A Product At Pittcon? Enter It Into the R&D 100 Awards

March 11, 2015 8:42 am | by Lindsay Hock, Editor | News | Comments

The editors of R&D Magazine have announced an eligibility extension for products to be entered into the 2015 R&D 100 Awards. The 2015 R&D 100 Awards will honor products, technologies and services that have been introduced to the market between January 1, 2014 and March 31, 2015.

Injectable polymer could prevent bleeding to death

March 11, 2015 8:09 am | by Jennifer Langston, Univ. of Washington | News | Comments

Most military battlefield casualties die before ever reaching a surgical hospital. Of those soldiers who might potentially survive, most die from uncontrolled bleeding. In some cases, there’s not much medics can do. That’s why Univ. of Washington researchers have developed a new injectable polymer that strengthens blood clots, called PolySTAT.

Finger-mounted reading device for the blind

March 10, 2015 1:29 pm | by Larry Hardesty, MIT News Office | News | Comments

Researchers at the MIT Media Laboratory have built a prototype of a finger-mounted device with a built-in camera that converts written text into audio for visually impaired users.             

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