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Simple catalyst helps to construct complex biological scaffolds

February 18, 2015 11:01 am | by Technical Univ. Munich | News | Comments

Terpenes and their derivatives exert important biological and pharmaceutical functions. Starting out from a few basic building blocks nature elegantly builds up complex structures. Chemically particularly challenging are bridged ring systems such as eucalyptol. Chemists at the Technical Univ. Munich have developed a catalyst that initiates the formation of such compounds.

KSU researchers develop heat-tolerant wheat

February 15, 2015 4:43 pm | by The Associated Press | News | Comments

Two Kansas State Univ. researchers are developing a type of wheat that will tolerate hotter...

Non-stick material joins portfolio of slippery surface technologies

February 10, 2015 4:16 pm | by Kat J. McAlpine, Wyss Institute for Biologically Inspired Engineering | News | Comments

More than 80% of microbial infections in the human body are caused by a build–up of bacteria,...

DNA “cage” could improve nanopore technology

February 10, 2015 10:51 am | by Kevin Stacey, Brown Univ. | News | Comments

Despite having a diameter tens of thousands of times smaller than a human hair, nanopores could...

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Microfluidics enables production of shape-controllable microgels

February 10, 2015 10:41 am | by Emil Venere, Purdue Univ. | News | Comments

A new, relatively simple process makes it possible to create biocompatible particles called shape-controllable microgels that could be custom designed for specific roles such as drug delivery vehicles, tissue engineering building blocks and biomedical research. The particles are made of two distinctly different materials: polymers called polyNIPAAm and sodium alginate, used in drug delivery.

Bioengineered miniature structures could prevent heart failure

February 4, 2015 4:10 pm | by Medical College of Wisconsin | News | Comments

The delivery of tiny biodegradable microstructures to heart tissue damaged by heart attack may help repair the tissue and prevent future heart failure. A team led by cardiovascular researchers at the Medical College of Wisconsin bioengineered the microstructures to be the same size, shape and stiffness as adult heart muscle cells, or cardiomyocytes, with the goal of releasing biologically active peptides that act as cardioprotective agents.

Biologists partner bacterium with nitrogen gas to produce more, cleaner bioethanol

February 3, 2015 7:56 am | by Stephen Chaplin, Indiana Univ. | News | Comments

Indiana Univ. biologists believe they have found a faster, cheaper and cleaner way to increase bioethanol production by using nitrogen gas, the most abundant gas in Earth’s atmosphere, in place of more costly industrial fertilizers. The discovery could save the industry millions of dollars and make cellulosic ethanol more competitive with corn ethanol and gasoline.

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Cyanobacterium found in algae collection holds promise for biotech applications

February 2, 2015 10:53 am | by Diana Lutz, Washington Univ. in St. Louis | News | Comments

Cyanobacteria, bacteria that obtain their energy through photosynthesis, are of considerable interest as bio-factories, organisms that could be harnessed to generate a range of industrially useful products. Part of their appeal is that they can grow on sunlight and carbon dioxide alone and thus could contribute to lowering greenhouse gas emissions and moving away from a petrochemical-based economy.

DNA nanoswitches reveal how life’s molecules connect

January 30, 2015 8:17 am | by Kat J. McAlpine, Wyss Institute for Biologically Inspired Engineering | News | Comments

A complex interplay of molecular components governs most aspects of biological sciences: healthy organism development, disease progression and drug efficacy are all dependent on the way life's molecules interact in the body. Understanding these biomolecular interactions is critical for the discovery of new therapeutics and diagnostics to treat diseases, but currently requires scientists to have access to expensive laboratory equipment.

Researchers design tailored tissue adhesives

January 29, 2015 8:17 am | by Anne Trafton, MIT News Office | News | Comments

After undergoing surgery to remove diseased sections of the colon, up to 30% of patients experience leakage from their sutures, which can cause life-threatening complications. Many efforts are under way to create new tissue glues that can help seal surgical incisions and prevent such complications; now, a new study reveals that the effectiveness of such glues hinges on the state of the tissue in which they are being used.

Synthetic amino acid enables safe, new biotechnology solutions

January 26, 2015 12:13 pm | by Bill Hathaway, Yale Univ. | News | Comments

Scientists from Yale Univ. have devised a way to ensure genetically modified organisms (GMOs) can be safely confined in the environment, overcoming a major obstacle to widespread use of GMOs in agriculture, energy production, waste management and medicine.

Chemists find a way to unboil eggs

January 26, 2015 9:25 am | by Janet Wilson, Univ. of California, Irvine | News | Comments

Univ. of California, Irvine and Australian chemists have figured out how to unboil egg whites, an innovation that could dramatically reduce costs for cancer treatments, food production and other segments of the $160 billion global biotechnology industry, according to findings published in ChemBioChem.

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Biological safety lock for genetically modified organisms

January 22, 2015 1:17 pm | by Stephanie Dutchen, Harvard Medical School | News | Comments

The creation of genetically modified and entirely synthetic organisms continues to generate excitement as well as worry. Such organisms are already churning out insulin and other drug ingredients, helping produce biofuels and teaching scientists about human disease. While the risks can be exaggerated to frightening effect, modified organisms do have the potential to upset natural ecosystems if they were to escape.

New way to model sickle cell behavior

January 20, 2015 10:49 am | by Anne Trafton, MIT News Office | Videos | Comments

Patients with sickle cell disease often suffer from painful attacks known as vaso-occlusive crises, during which their sickle-shaped blood cells get stuck in tiny capillaries, depriving tissues of needed oxygen. Blood transfusions can sometimes prevent such attacks, but there are currently no good ways to predict when a vaso-occlusive crisis, which can last for several days, is imminent.

“Microcapsules” have potential to repair damage caused by osteoarthritis

January 20, 2015 8:29 am | by Queen Mary Univ. of London | News | Comments

A new “microcapsule” treatment delivery method developed by researchers at Queen Mary Univ. of London could reduce inflammation in cartilage affected by osteoarthritis and reverse damage to tissue. A protein molecule called C-type natriuretic peptide (CNP), which occurs naturally in the body, is known to reduce inflammation and aid in the repair of damaged tissue.

Hydrogels deliver on blood-vessel growth

January 20, 2015 7:50 am | by Mike Williams, Rice Univ. | Videos | Comments

Rice Univ. scientists have found the balance necessary to aid healing with high-tech hydrogel. The team created a new version of the hydrogel that can be injected into an internal wound and help it heal while slowly degrading as it is replaced by natural tissue. Hydrogels are used as a scaffold upon which cells can build tissue. The new hydrogel overcomes a host of issues that have kept them from reaching their potential to treat injuries.

New fibers can deliver many simultaneous stimuli

January 20, 2015 7:33 am | by David L. Chandler, MIT News Office | Videos | Comments

The human brain’s complexity makes it extremely challenging to study; not only because of its sheer size, but also because of the variety of signaling methods it uses simultaneously. Conventional neural probes are designed to record a single type of signaling, limiting the information that can be derived from the brain at any point in time. Now researchers at Massachusetts Institute of Technology may have found a way to change that.

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New tech keeps bacteria from sticking to surfaces

January 15, 2015 9:44 am | by Krishna Ramanujan, Cornell Univ. | News | Comments

Just as the invention of non-stick pans was a boon for chefs, a new type of nanoscale surface that bacteria can’t stick to holds promise for applications in the food processing, medical and even shipping industries. The technology uses an electrochemical process called anodization to create nanoscale pores that change the electrical charge and surface energy of a metal surface.

DNA “glue” could be used to build tissues, organs

January 14, 2015 10:23 am | by American Chemical Society | News | Comments

DNA molecules provide the "source code" for life in humans, plants, animals and some microbes. But now researchers report an initial study showing that the strands can also act as a glue to hold together 3-D-printed materials that could someday be used to grow tissues and organs in the laboratory.

First contracting human muscle grown in laboratory

January 14, 2015 8:28 am | by Ken Kingery, Duke Univ. | Videos | Comments

In a laboratory first, Duke Univ. researchers have grown human skeletal muscle that contracts and responds just like native tissue to external stimuli such as electrical pulses, biochemical signals and pharmaceuticals. The laboratory-grown tissue should soon allow researchers to test new drugs and study diseases in functioning human muscle outside of the human body.

Device allows manipulation of differentiating stem cells

January 14, 2015 8:20 am | by Amanda Morris, Northwestern Univ. | News | Comments

Electroporation is a powerful technique in molecular biology. By using an electrical pulse to create a temporary nanopore in a cell membrane, researchers can deliver chemicals, drugs and DNA directly into a single cell. But existing electroporation methods require high electric field strengths and for cells to be suspended in solution, which disrupts cellular pathways and creates a harsh environment for sensitive primary cells.

Photonic crystal nanolaser biosensor simplifies DNA detection

January 13, 2015 12:01 pm | by American Institute of Physics | News | Comments

A simple method to sense DNA, as well as potential biomarker proteins of cancer or other diseases such as Alzheimer's, may soon be within reach thanks to the work of a team of Yokohama National Univ. researchers in Japan. As the team reports in Applied Physics Letters, they created a photonic crystal nanolaser biosensor capable of detecting the adsorption of biomolecules based on the laser's wavelength shift.

Responsive material could be the “golden ticket” of sensing

January 7, 2015 7:45 am | by Univ. of Cambridge | News | Comments

Researchers from the Univ. of Cambridge have developed a new self-assembled material, which, by changing its shape, can amplify small variations in temperature and concentration of biomolecules, making them easier to detect. The material, which consists of synthetic spheres “glued” together with short strands of DNA, could be used to underpin a new class of biosensors, or form the basis for new drug delivery systems.

DNA origami could lead to nano “transformers” for biomedical applications

January 5, 2015 3:59 pm | by Pam Frost Gorder, Ohio State Univ. | Videos | Comments

If the new nanomachines built at The Ohio State Univ. look familiar, it’s because they were designed with full-size mechanical parts such as hinges and pistons in mind. The project is the first to prove that the same basic design principles that apply to typical full-size machine parts can also be applied to DNA; and can produce complex, controllable components for future nanorobots.

Sensor demonstrates lack of space in living cells

January 5, 2015 10:12 am | by Ruhr-Univ. Bochum | News | Comments

Proteins and other biomolecules are often analyzed exclusively in aqueous solutions in test tubes. But it is uncertain if these experimental studies can be transferred to the densely packed cellular environment. The Bochum-based researchers have developed a novel method which can be used to analyze the effects of the lack of space in living cells with the aid of a microscope for the first time.

Landmark discovery in gold nanorod instability

December 18, 2014 3:14 pm | News | Comments

Researchers at Swinburne University of Technology have discovered an instability in gold nanoparticles that is critical for their application in future technology. Gold nanorods are important building blocks for future applications in solar cells, cancer therapy and optical circuitry.

Molecular “hats” allow in vivo activation of disguised signaling peptides

December 15, 2014 11:42 am | by John Toon, Georgia Institute of Technology | News | Comments

When someone you know is wearing an unfamiliar hat, you might not recognize them. Georgia Institute of Technology researchers are using just such a disguise to sneak biomaterials containing peptide signaling molecules into living animals. When the disguised peptides are needed to launch biological processes, the researchers shine ultraviolet light onto the molecules through the skin, causing the "hat" structures to come off.

New technology tracks carcinogens as they move through the body

December 11, 2014 12:17 pm | by Oregon State University | News | Comments

Researchers for the first time have developed a method to track through the human body the movement of polycyclic aromatic hydrocarbons, or PAHs, as extraordinarily tiny amounts of these potential carcinogens are biologically processed and eliminated.

Injectable 3-D vaccines could fight cancer, infectious diseases

December 8, 2014 4:13 pm | by Kat J. McAlpine, Wyss Institute for Biologically Inspired Engineering | News | Comments

One of the reasons cancer is so deadly is that it can evade attack from the body's immune system, which allows tumors to flourish and spread. Scientists can try to induce the immune system, known as immunotherapy, to go into attack mode to fight cancer and to build long lasting immune resistance to cancer cells. Now, researchers have developed a non–surgical injection of programmable biomaterial to do so.

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