DNAnexus has announced a collaboration with Stanford Univ. that has resulted in a new 1000 Genomes Project data set of genetic variation. Launched in January 2008, the 1000 Genomes Project was the first international effort to sequence a large number of individual genomes with the goal of developing a comprehensive and freely accessible resource on human genetic variation.
Scientists are reporting development of a squishy...
An international multidisciplinary team including...
Scientists at Penn State Univ. have developed a...
Bruker Corp. has announced that it has been granted U.S. FDA clearance under Section 510(k) to market its MALDI Biotyper CA System in the United States for the identification of Gram negative bacterial colonies cultured from human specimens. The clearance marks progress in Bruker’s efforts to develop MALDI-TOF mass spectrometry into the most advanced platform for clinical microbiology identification.
Univ. of Arizona agricultural and biosystems engineering associate professor Jeong-Yeol Yoon and cardiology professor Dr. Marvin Slepian are testing nanotextured surfaces to improve how cardiovascular implant devices are attached in the body. The goal is to create a selectively sticky surface, favoring endothelial cell attachment, without favoring platelet attachment.
A new innovation may help us deal with post-Thanksgiving guilt: Biotechnologists have constructed a genetic regulatory circuit from human components that monitors blood-fat levels. In response to excessive levels, it produces a messenger substance that signals satiety to the body. Tests on obese mice reveal that this helps them to lose weight.
The Food and Drug Administration has ordered Google-backed genetic test maker 23andMe to halt sales of its personalized DNA test kits. In a warning letter posted online Monday, FDA regulators say that the Silicon Valley company has not shown that its tests are safe or effective despite "more than 14 face-to-face and teleconference meetings" and "hundreds of email exchanges."
Viruses can not only cause illnesses in humans, they also infect bacteria. Bacteria protect themselves with a kind of immune system that detects and “chops up” foreign DNA. Scientists have now shown that the dual-RNA guided enzyme Cas9 which is involved in the process has developed independently in various strains of bacteria. This enhances the potential of exploiting the bacterial immune system for genome engineering.
A team of researchers has uncovered critical information that could help scientists understand how protein polymers interact with other self-assembling biopolymers. The research helps explain naturally occurring nanomaterial within cells and could one day lead to engineered bio-composites for drug delivery, artificial tissue, bio-sensing, or cancer diagnosis.
In leaves, two proteins are responsible for photosynthesis, and they perform the conversion of carbon dioxide into oxygen and biomass very efficiently. Scientists have now harnessed this capability by embedding these proteins into complex molecules developed in the laboratory. Their bio-based solar cell creates electron current instead of biomass.
For 40 years, scientists thought they understood how certain bacteria work together to anaerobically digest biomass to produce methane gas. But now microbiologists have shown for the first time that one of the most abundant methane-producing microorganisms on Earth makes direct electrical connections with another species to produce the gas in a completely unexpected way.
One of the methods used for examining the molecules in a liquid consists in passing the fluid through a nano-sized hole so as to detect their passage. Researchers in Switzerland have found a way to improve this technique by using a material with unique properties: graphene.
Researchers at the University of Iowa have created a bio patch to regenerate missing or damaged bone by putting DNA into a nano-sized particle that delivers bone-producing instructions directly into cells. The bone-regeneration kit relies on a collagen platform seeded with particles containing the genes needed for producing bone.
Researchers at the Univ. of Chicago are developing computer-aided diagnosis and quantitative image analysis methods for mammograms, ultrasounds and magnetic resonance images to identify specific tumor characteristics, including size, shape and sharpness
Our brains have upwards of 86 billion neurons, connected by synapses that not only complete myriad logic circuits; they continuously adapt to stimuli, strengthening some connections while weakening others. Materials scientists have now created a new type of transistor that mimics the behavior of a synapse. The novel device simultaneously modulates the flow of information in a circuit and physically adapts to changing signals.
The ability to shrink laboratory-scale processes to automated chip-sized systems would revolutionize biotechnology and medicine. One of the challenges of lab-on-a-chip technology is the need for miniaturized pumps to move solutions through microchannels. A super-thin silicon membrane developed at the Univ. of Rochester could now make it possible to shrink the power source, paving the way for diagnostic devices the size of a credit card.
Accurate and rapid testing for drug toxicity just became easier, thanks to a half-dozen Rice Univ. student interns working at Houston-based startup Nano3D Biosciences (n3D). The bioengineering and nanoscale physics students just wrapped up a year-long effort to aid the company in developing a new method for conducting high-throughput, in vitro cytotoxicity assays.
Researchers in The Netherlands have recently unveiled their “photoacoustic mammoscope,” a new device that could someday be used for routine breast cancer screenings. Instead of x-rays, which are used in traditional mammography, the photoacoustic breast mammoscope uses a combination of infrared light and ultrasound to create a 3-D map of the breast.
Over the past three years, 300,000 gamers have helped scientists with genomic research by playing Phylo, an online puzzle game. Now, the McGill Univ. researchers who developed the game are making this crowd of players available to scientists around the globe. The idea is to put human talent to work to improve on what is already being done by computers in the field of comparative genomics.
Famed for its historic sites, its double-decker buses and its West End shows, London now has a more dubious distinction: Britain's public health agency says it has become the tuberculosis capital of Western Europe. In response, health officials are taking to the streets in an effort to stop the spread of the infectious lung disease.
In remote regions of the world where electricity is hard to come by and scientific instruments are even scarcer, conducting medical tests at a doctor’s office or medical laboratory is rarely an option. Scientists are now reporting progress toward an inexpensive point-of-care, paper-based device to fill that void with no electronics required.
For more a decade scientists have investigated microbial life under the seafloor off the coast of Peru. Traces of past microbial life in sediments reveal how these ecosystems have responded to climate change over hundreds of thousands of years. Little is known about how the “deep biosphere” developed over millennia and how microbial life influences the cycling of carbon in the oceans.
OnTarget Laboratories LLC has teamed with partners in academia to test a novel optical imaging technology developed at Purdue Univ. that could help surgeons see cancer tissue during surgery. The technology is based on the over-expression of specific receptors on solid cancerous tumors and enables illumination of the tumor tissue during surgery.
Everyone grows older, but scientists don't really understand why. Now a Univ. of California, Los Angeles study has uncovered a biological clock embedded in our genomes that may shed light on why our bodies age and how we can slow the process.
A research team including a Penn State chemical engineer was recently awarded a $3.9 million National Science Foundation grant to understand how blue-green algae convert nitrogen into oxygen. The objective is to learn how to "transplant" the nitrogen fixing capability of one species to another.
In two parallel projects, researchers at the Wyss Institute for Biologically Inspired Engineering have created new genomes inside the bacterium E. coli in ways that could open new possibilities for increasing flexibility, productivity and safety in biotechnology. In the first project, researchers created a novel genome, the first-ever entirely genomically recoded organism. They then greatly expanded genetic changes in the second project.
Massachusetts Institute of Technology researchers have developed a new microfluidic device that could speed the monitoring of bacterial infections associated with cystic fibrosis and other diseases. The new microfluidic chip is etched with tiny channels, each resembling an elongated hourglass with a pinched midsection. Researchers injected bacteria through one end of each channel, and observed how cells travel from one end to the other.
Human fingertips have several types of sensory neurons that are responsible for relaying touch signals to the central nervous system. Scientists have long believed these neurons followed a linear path to the brain with a "labeled-lines" structure. But new research on mouse whiskers reveals a surprise: At the fine scale, the sensory system's wiring diagram doesn't have a set pattern.
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