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Heart-therapy researchers develop nanobullet drug delivery system

October 31, 2014 9:52 am | News | Comments

Stanford Univ. School of Medicine researchers have developed a new formula for delivering the therapeutic peptide apelin to heart tissue for treatment of hypertrophy, a hereditary disease commonly attributed to sudden death in athletes. The nanoscale delivery system, which dramatically increases the peptide’s stability, shows promise for treating heart disease in humans, the researchers said.

Making lab-grown tissues stronger

October 31, 2014 8:54 am | by Andy Fell, UC Davis News Service | News | Comments

Lab-grown tissues could one day provide new treatments for injuries and damage to the joints,...

Identifying the source of stem cells

October 30, 2014 3:14 pm | News | Comments

When most animals begin life, cells immediately begin accepting assignments to become a head,...

Making lab-grown tissues stronger

October 30, 2014 3:09 pm | News | Comments

Cartilage, for example, is a hard material that caps the ends of bones and allows joints to work...

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Heart’s own immune cells can help it heal

October 30, 2014 2:55 pm | by Julia Evangelou Strait, Washington Univ. in St. Louis | News | Comments

The heart holds its own pool of immune cells capable of helping it heal after injury, according to new research in mice at Washington University School of Medicine in St. Louis. When the heart is injured, beneficial immune cells are often supplanted by bone marrow cells, which cause damaging inflammation. In a mouse model, researchers showed that blocking the bone marrow’s macrophages protects the organ’s beneficial pool of macrophages.

Afingen uses precision method to enhance plants

October 30, 2014 8:17 am | by Julie Chao, Lawrence Berkeley National Laboratory | News | Comments

Imagine being able to precisely control specific tissues of a plant to enhance desired traits without affecting the plant’s overall function. Thus a rubber tree could be manipulated to produce more natural latex. Trees grown for wood could be made with higher lignin content, making for stronger yet lighter-weight lumber.

Tiny nanopores make big impact

October 30, 2014 8:05 am | by Anne M. Stark, Lawrence Livermore National Laboraotry | News | Comments

A team led by the Lawrence Livermore National Laboratory scientists has created a new kind of ion channel consisting of short carbon nanotubes, which can be inserted into synthetic bilayers and live cell membranes to form tiny pores that transport water, protons, small ions and DNA. These carbon nanotube “porins” have significant implications for future health care and bioengineering applications.

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ECG on the run: Continuous surveillance of marathon athletes is feasible

October 29, 2014 9:40 am | News | Comments

The condition of an athlete's heart has for the first time been accurately monitored throughout the duration of a marathon race. The real-time monitoring was achieved by continuous electrocardiogram (ECG) surveillance and data transfer over a public mobile phone network. The new development allows instantaneous diagnosis of potentially fatal rhythm disorders.

Researchers prove mathematical models can predict cellular processes

October 29, 2014 9:33 am | News | Comments

A team led by Virginia Tech researchers studied cells found in breast and other types of connective tissue and discovered new information about cell transitions that take place during wound healing and cancer. They developed mathematical models to predict the dynamics of cell transitions, and by comparison gained new understanding of how a substance known as transforming growth factor triggers cell transformations.

Scientists discover exact receptor for DEET that repels mosquitoes

October 29, 2014 9:24 am | News | Comments

DEET has been the gold standard of insect repellents for more than six decades, and now researchers led by a Univ. of California, Davis, scientist have discovered the exact odorant receptor that repels them. They also have identified a plant defensive compound that might mimic DEET, a discovery that could pave the way for better and more affordable insect repellents.

Self-assembled membranes hint at biomedical applications

October 28, 2014 11:36 am | by David Lindley, Argonne National Laboratory | News | Comments

Techniques for self-assembling of molecules have grown increasingly sophisticated, but biological structures remain a challenge. Recently, scientists have used self-assembly under controlled conditions to create a membrane consisting of layers with distinctly different structures. At the Advanced Photon Source, the team has studied the structures and how they form, paving the way for hierarchical structures with biomedical applications.

Molecular beacons shine light on how cells "crawl"

October 24, 2014 12:40 pm | by Carol Clark, EScience Commons | News | Comments

Adherent cells, the kind that form the architecture of all multicellular organisms, are engineered with precise forces that allow them to move around and stick to things. When these cells are put into a petri dish with a variety of substrates they can sense the differences in the surfaces and they will “crawl” toward the stiffest one. Chemists have devised a method using DNA-based tension probes to measure and map these phenomena.

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Implantable device remotely releases therapeutic drugs, on Earth or in orbit

October 24, 2014 10:28 am | News | Comments

Houston Methodist Research Institute scientists will receive about $1.25 million from the Center for the Advancement of Science in Space to develop an implantable, nanochannel device that delivers therapeutic drugs at a rate guided by remote control. The device's effectiveness will be tested aboard the International Space Station and on Earth's surface.

Scientists to use tiny particles to fight big diseases

October 23, 2014 12:49 pm | Videos | Comments

A group of scientists in Florida have combined medicine and advanced nanotechnological engineering to create a smarter, more targeted therapy that could overcome the most lethal gynecologic cancer. The technology involves combining Taxol, a chemotherapy drug, with magneto-electric nanoparticles that can penetrate the blood-brain barrier.

Precise and programmable biological circuits

October 23, 2014 9:37 am | by Fabio Bergamin, ETH Zurich | News | Comments

Bio-engineers are working on the development of biological computers: biological material that can be integrated into cells to change their functions. Researchers in Europe have now developed a biological circuit that controls the activity of individual sensor components using internal "timer". This circuit prevents a sensor from being active when not required by the system; when required, it can be activated via a control signal.

Microscopic “walkers” find their way across cell surfaces

October 23, 2014 8:14 am | by David L. Chandler, MIT News Office | News | Comments

Nature has developed a wide variety of methods for guiding particular cells, enzymes and molecules to specific structures inside the body: White blood cells can find their way to the site of an infection, while scar-forming cells migrate to the site of a wound. But finding ways of guiding artificial materials within the body has proven more difficult.

See-through sensors open new window into the brain

October 22, 2014 11:22 am | by Renee Meiller, Univ. of Wisconsin-Madison | News | Comments

Developing invisible implantable medical sensor arrays, a team of Univ. of Wisconsin-Madison engineers has overcome a major technological hurdle in researchers’ efforts to understand the brain. The team described its technology, which has applications in fields ranging from neuroscience to cardiac care and even contact lenses, in Nature Communications.

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Researchers advance genome editing technique

October 22, 2014 7:41 am | by Mick Kulikowski, North Carolina State Univ. News Services | News | Comments

Customized genome editing has major potential for application in medicine, biotechnology, food and agriculture. Now, in a paper published in Molecular Cell, North Carolina State Univ. researchers and colleagues examine six key molecular elements that help drive this genome editing system, which is known as CRISPR-Cas.

Ultra-thin carbon electrodes are powerful tool for studying brain disorders

October 21, 2014 11:34 am | News | Comments

Researchers at the Univ. of Pennsylvania and The Children's Hospital of Philadelphia have used graphene to fabricate a new type of microelectrode that solves a major problem for investigators looking to understand the intricate circuitry of the brain. The see-through, one-atom-thick electrodes can obtain both high-resolution optical images and electrophysiological data for the first time.

High blood-sugar levels may harden heart valves

October 21, 2014 8:05 am | by Mike Williams, Rice Univ. | News | Comments

Rice Univ. bioengineers have found new evidence of a possible link between diabetes and the hardening of heart valves. A Rice laboratory, in collaboration with the Univ. of Texas Health Science Center at Houston Medical School, discovered that the interstitial cells that turn raw materials into heart valves need just the right amount of nutrients for proper metabolic function.

“Mega” cells control the growth of blood-producing cells

October 20, 2014 9:38 am | News | Comments

While megakaryocytes are best known for producing platelets that heal wounds, these "mega" cells found in bone marrow also play a critical role in regulating stem cells according to new research from the Stowers Institute for Medical Research. The study is the first to show that hematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes).

Geneticists evaluate cost-effective genome analysis

October 17, 2014 1:39 pm | News | Comments

Scientists perform genome sequences because want to know why individuals differ from each other and how these differences are encoded in the DNA. However, sequencing a complete genome still costs around $1,000, and sequencing hundreds of individuals would be costly. In two recent review papers, scientists discuss why DNA sequencing of entire groups, or pool sequencing, can be an efficient and cost-effective approach.

Biological sample prep time cut dramatically

October 16, 2014 8:40 am | by Stephen P Wampler, Lawrence Livermore National Laboratory | News | Comments

When Lawrence Livermore National Laboratory researchers invented the field of biological accelerator mass spectrometry (AMS) in the late 1980s, the process of preparing the samples was time-consuming and cumbersome. Physicists and biomedical researchers used torches, vacuum lines, special chemistries and high degrees of skill to convert biological samples into graphite targets that could then be run through the AMS system.

Scientists create new protein-based material with some nerve

October 15, 2014 9:24 am | by Sarah Yang, UC Berkeley | News | Comments

Univ. of California, Berkeley scientists have taken proteins from nerve cells and used them to create a “smart” material that is extremely sensitive to its environment. This marriage of materials science and biology could give birth to a flexible, sensitive coating that is easy and cheap to manufacture in large quantities.

Scientists map key moment in assembly of DNA-splitting molecular machine

October 15, 2014 8:22 am | News | Comments

The proteins that drive DNA replication are some of the most complex machines on Earth and the process involves hundreds of atomic-scale moving parts that rapidly interact and transform. Now, scientists have pinpointed crucial steps in the beginning of the replication process, including surprising structural details about the enzyme that "unzips" and splits the DNA double helix so the two halves can serve as templates for DNA duplication.

Scientists create mimic of “good” cholesterol to fight heart disease, stroke

October 13, 2014 10:28 am | News | Comments

Researchers at The Scripps Research Institute have created a synthetic molecule that mimics “good” cholesterol and have shown it can reduce plaque buildup in the arteries of animal models. The molecule, taken orally, improved cholesterol in just two weeks.

Bio-inspired “nano-cocoons” offer targeted drug delivery against cancer

October 13, 2014 8:39 am | by Matt Shipman, North Carolina State Univ. | News | Comments

Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs. The new system is DNA-based, which means it is biocompatible and less toxic to patients than systems that use synthetic materials.

DNA nanofoundries cast custom-shaped metal nanoparticles

October 10, 2014 7:50 am | by Kat J. McAlpine, Wyss Institute for Biologically Inspired Engineering | News | Comments

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard Univ. have unveiled a new method to form tiny 3-D metal nanoparticles in prescribed shapes and dimensions using DNA, nature's building block, as a construction mold. The ability to mold inorganic nanoparticles out of materials such as gold and silver in precisely designed 3-D shapes is a significant breakthrough.

Of bio-hairpins and polymer-spaghetti

October 9, 2014 11:02 am | News | Comments

When a sturdy material becomes soft and spongy, one usually suspects damage. But this is not always the case, especially in biological cells. By looking at microscopic biopolymer networks, researchers in Germany revealed that such materials soften by undergoing a transition from an entangled spaghetti of filaments to aligned layers of bow-shaped filaments that slide past each other. This finding may explain how other filaments flow.

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