Ebola fears began to ease for some Monday as a monitoring period passed for those who had close contact with a victim of the disease and after a cruise ship scare ended with the boat returning to port and a laboratory worker on board testing negative for the virus. Federal officials meanwhile ramped up readiness to deal with future cases.
Scientists perform genome sequences because want to know why individuals differ from each other and how these differences are encoded in the DNA. However, sequencing a complete genome still costs around $1,000, and sequencing hundreds of individuals would be costly. In two recent review papers, scientists discuss why DNA sequencing of entire groups, or pool sequencing, can be an efficient and cost-effective approach.
Scientists have used computer simulations to show how bacteria are able to destroy antibiotics, a breakthrough which will help develop drugs which can effectively tackle infections in the future. Researchers at the Univ. of Bristol focused on the role of enzymes in the bacteria, which split the structure of the antibiotic and stop it working, making the bacteria resistant.
Buoyed by several dramatic advances, Lawrence Livermore National Laboratory (LLNL) scientists think they can tackle biological science in a way that couldn't be done before. Over the past two years, LLNL researchers have expedited accelerator mass spectrometer sample preparation and analysis time from days to minutes and moved a complex scientific process requiring accelerator physicists into routine laboratory usage.
When Lawrence Livermore National Laboratory researchers invented the field of biological accelerator mass spectrometry (AMS) in the late 1980s, the process of preparing the samples was time-consuming and cumbersome. Physicists and biomedical researchers used torches, vacuum lines, special chemistries and high degrees of skill to convert biological samples into graphite targets that could then be run through the AMS system.
Researchers are exploring the usefulness of ultrasound imaging to study dangerous abdominal aortic aneurysms, a bulging of the aorta that is usually fatal when it ruptures and for which there is no effective medical treatment. Abdominal aortic aneurysms are the 13th leading cause of death in the U.S., killing about 15,000 annually.
Univ. of California, Berkeley scientists have taken proteins from nerve cells and used them to create a “smart” material that is extremely sensitive to its environment. This marriage of materials science and biology could give birth to a flexible, sensitive coating that is easy and cheap to manufacture in large quantities.
Researchers from the Univ. of Sheffield have found vital new evidence on how to target and reverse the effects caused by one of the most common genetic causes of Parkinson’s. Mutations in a gene called LRRK2 carry a well-established risk for Parkinson’s disease, however the basis for this link is unclear.
The proteins that drive DNA replication are some of the most complex machines on Earth and the process involves hundreds of atomic-scale moving parts that rapidly interact and transform. Now, scientists have pinpointed crucial steps in the beginning of the replication process, including surprising structural details about the enzyme that "unzips" and splits the DNA double helix so the two halves can serve as templates for DNA duplication.
Methane-breathing microbes that inhabit rocky mounds on the seafloor could be preventing large volumes of the potent greenhouse gas from entering the oceans and reaching the atmosphere, according to a new study. The rock-dwelling microbes represent a previously unrecognized biological sink for methane and as a result could reshape scientists' understanding of where this greenhouse gas is being consumed in subseafloor habitats.
The discovery of a cellular snooze button has allowed a team of Michigan State Univ. scientists to potentially improve biofuel production and offer insight on the early stages of cancer. The discovery finds the protein CHT7 is a likely repressor of cellular quiescence, or resting state. This cellular switch, which influences algae’s growth and oil production, also wields control of cellular growth—and tumor growth—in humans.
A new study by scientists from The Scripps Research Institute, Lawrence Berkeley National Laboratory and other institutions suggests a cause of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. The team's work supports a common theme whereby loss of protein stability leads to disease.
Some people might consider mucus an icky bodily secretion best left wrapped in a tissue, but to a group of researchers in North Carolina, snot is an endlessly fascinating subject. The team has developed a way to use gold nanoparticles and light to measure the stickiness of the slimy substance that lines our airways. The new method could help doctors better monitor and treat lung diseases such as cystic fibrosis.
Researchers at The Scripps Research Institute have created a synthetic molecule that mimics “good” cholesterol and have shown it can reduce plaque buildup in the arteries of animal models. The molecule, taken orally, improved cholesterol in just two weeks.
As befitting life’s blueprint, DNA is surrounded by an elaborate security system that assures crucial information is imparted without error. The security is provided by a double membrane perforated by protein channels that block unwanted material from entering the nucleus and promote entry of key messengers.
The Centers for Disease Control and Prevention has said that at least 2 million Americans are sickened by antibiotic resistant infections each year and survive. Twenty-three thousand die. These experiences leave deep impressions not just on the patients but on their family and friends.
A breach of infection control resulting in a Dallas health worker getting Ebola raises fresh questions about whether hospitals truly can safely take care of people with the deadly virus, as health officials insist is possible. Even in the U.S., with the best conditions and protective gear available, mistakes can happen that expose more people to Ebola, the new case reveals.
Autism is characterized by many different symptoms: difficulty interacting with others, repetitive behaviors and hypersensitivity to sound and other stimuli. Massachusetts Institute of Technology neuroscientists have put forth a new hypothesis that accounts for these behaviors and may provide a neurological foundation for many of the disparate features of the disorder.
Hepatitis C, an infectious disease of the liver caused by the hepatitis C virus (HCV), affects 160 million people worldwide. There’s no vaccine for HCV and the few treatments that are available do not work on all variants of the virus. Before scientists can develop potential vaccines and additional therapies they must first thoroughly understand the molecular-level activity that takes place when the virus infects a host cell.
Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard Univ. have unveiled a new method to form tiny 3-D metal nanoparticles in prescribed shapes and dimensions using DNA, nature's building block, as a construction mold. The ability to mold inorganic nanoparticles out of materials such as gold and silver in precisely designed 3-D shapes is a significant breakthrough.
HIV is adept at eluding immune system responses because the protein it uses to infect cells is constantly changing. Now a team of researchers including scientists from Yale Univ. have stripped the cloak from this master of disguise, providing a high-resolution image of this surface spike protein and monitoring how it constantly changes its shape, information that suggests new ways to attack the virus through drugs and vaccines.
New research involving scientists in the U.S. and Israel offers new insight into the lethal interaction between cancer cells and the immune system's communications network. The study authors devised a new computer program that models a specific channel of cell-to-cell communication involving exosomes that both cancer and immune cells harness to communicate with other cells. This “cyberwarfare” model reveals three distinct states of cancer.
Tuberculosis is caused by a bacterium that infects the lungs of an estimated 8.6 million people worldwide. The fight against the disease is hampered by the fact that treatment requires a long time and that the bacterium often develops multi-drug resistance. Scientists have used a sensitive screening assay to test new compounds that can be used against the bacterium, and have discovered two small molecules that show remarkable promise.
Within our fat lives a variety of cells with the potential to become bone, cartilage or more fat if properly prompted. This makes adipose tissue, in theory, a readily available reservoir for regenerative therapies such as bone healing if doctors can get enough of those cells and compel them to produce bone. In a new study, scientists demonstrate a new method for extracting a wide variety of potential bone-producing cells from human fat.
A proposal to develop a new way to remotely control brain cells from Sarah Stanley, a research associate in Rockefeller Univ.’s Laboratory of Molecular Genetics is among the first to receive funding from President Barack Obama’s BRAIN initiative. The project will make use of a technique called radiogenetics that combines the use of radio waves or magnetic fields with nanoparticles to turn neurons on or off.