When most animals begin life, cells immediately begin accepting assignments to become a head, tail or a vital organ. However, mammalian cells become the protective placenta or to commit to forming the baby. It’s during this critical first step that research from Michigan State Univ. has revealed key discoveries. The results provide insights into where stem cells come from, and could advance research in regenerative medicine.
Cartilage, for example, is a hard material that caps the ends of bones and allows joints to work smoothly, but engineered replacement tissue is, mechanically, far from native tissue. Researchers in California report the use of an enzyme that has greatly improved engineering cartilage built from cultures. It promotes cross-linking and makes the material stronger.
The heart holds its own pool of immune cells capable of helping it heal after injury, according to new research in mice at Washington University School of Medicine in St. Louis. When the heart is injured, beneficial immune cells are often supplanted by bone marrow cells, which cause damaging inflammation. In a mouse model, researchers showed that blocking the bone marrow’s macrophages protects the organ’s beneficial pool of macrophages.
People with muscular dystrophy could one day assess the effectiveness of their medication with the help of a smartphone-linked device, a new study in mice suggests. The study used a new method to process ultrasound imaging information that could lead to hand-held instruments that provide fast, convenient medical information.
Imagine being able to precisely control specific tissues of a plant to enhance desired traits without affecting the plant’s overall function. Thus a rubber tree could be manipulated to produce more natural latex. Trees grown for wood could be made with higher lignin content, making for stronger yet lighter-weight lumber.
An accumulation of amyloid-beta proteins deposits called plaques is known to cause Alzheimer’s disease. One aspect of this illness that has not received much attention is which role the structure of the brain environment plays. Researchers have discovered that macromolecules like astrocytes provide well-defined physical cues in the form of ruffles that have a crucial role in promoting healthy interactions between cells in the hippocampus.
The condition of an athlete's heart has for the first time been accurately monitored throughout the duration of a marathon race. The real-time monitoring was achieved by continuous electrocardiogram (ECG) surveillance and data transfer over a public mobile phone network. The new development allows instantaneous diagnosis of potentially fatal rhythm disorders.
A team led by Virginia Tech researchers studied cells found in breast and other types of connective tissue and discovered new information about cell transitions that take place during wound healing and cancer. They developed mathematical models to predict the dynamics of cell transitions, and by comparison gained new understanding of how a substance known as transforming growth factor triggers cell transformations.
DEET has been the gold standard of insect repellents for more than six decades, and now researchers led by a Univ. of California, Davis, scientist have discovered the exact odorant receptor that repels them. They also have identified a plant defensive compound that might mimic DEET, a discovery that could pave the way for better and more affordable insect repellents.
Cancer researchers have found that a simple blood test might help diagnose pancreatic cancer, one of the most deadly forms of the disease. In new research at Indiana Univ., scientists have found that several microRNAs, which are small RNA molecules, circulate at high levels in the blood of pancreatic cancer patients.
Nitrogen is an essential component of all living systems, playing important roles in everything from proteins and nucleic acids to vitamins. It is the most abundant element in Earth's atmosphere and is literally all around us, but in its gaseous state, N2, it is inert and useless to most organisms.
Rice Univ. researchers have delivered a scientific one-two punch with a pair of papers that detail how synthetic collagen fibers self-assemble via their sticky ends. Collagen is the most common protein in mammals, a major component of bone and the fibrous tissues that support cells and hold organs together. Discovering its secrets may lead to better synthetic collagen for tissue engineering and cosmetic and reconstructive medicine.
Researchers report in Nature that they have made a breakthrough in understanding how a powerful antibiotic agent is made in nature. Their discovery solves a decades-old mystery, and opens up new avenues of research into thousands of similar molecules, many of which are likely to be medically useful.
Like a slumbering dragon, HIV can lay dormant in a person’s cells for years, evading medical treatments only to wake up and strike at a later time, quickly replicating itself and destroying the immune system. Scientists at the Salk Institute have uncovered a new protein that participates in active HIV replication. The new protein, called Ssu72, is part of a switch used to awaken HIV-1 from its slumber.
In early drug discovery, you need a starting point. In a new research paper published in PLOS-Neglected Tropical Diseases, a team of researchers present hundreds of such starting points for potentially treating Human African trypanosomiasis, or sleeping sickness, a deadly disease that affects thousands of people annually.
Adherent cells, the kind that form the architecture of all multicellular organisms, are engineered with precise forces that allow them to move around and stick to things. When these cells are put into a petri dish with a variety of substrates they can sense the differences in the surfaces and they will “crawl” toward the stiffest one. Chemists have devised a method using DNA-based tension probes to measure and map these phenomena.
Bio-engineers are working on the development of biological computers: biological material that can be integrated into cells to change their functions. Researchers in Europe have now developed a biological circuit that controls the activity of individual sensor components using internal "timer". This circuit prevents a sensor from being active when not required by the system; when required, it can be activated via a control signal.
Though neurobiologists have tried for half a century to better understand the brains of jumping spiders, no one has succeeded. The liquid in spiders’ bodies is pressurized, and they move with hydraulic pressure and muscles. But with a new technique using a tiny tungsten recording electrode, researchers have made recordings of neurons associated with visual perception inside the poppy seed-sized brain the spider.
Customized genome editing has major potential for application in medicine, biotechnology, food and agriculture. Now, in a paper published in Molecular Cell, North Carolina State Univ. researchers and colleagues examine six key molecular elements that help drive this genome editing system, which is known as CRISPR-Cas.
Scientists think of CD8 T cells as long-lived cells that become tuned to fight just one pathogen, but a new study finds that once CD8 T cells fight one pathogen, they also join the body’s “innate” immune system, ready to answer the calls of the cytokine signals that are set off by a wide variety of infections.
New medications created by pharmaceutical companies have helped millions of Americans alleviate pain and suffering from their medical conditions. However, the drug creation process often misses many side effects that kill at least 100,000 patients a year, according to Nature.
Rice Univ. bioengineers have found new evidence of a possible link between diabetes and the hardening of heart valves. A Rice laboratory, in collaboration with the Univ. of Texas Health Science Center at Houston Medical School, discovered that the interstitial cells that turn raw materials into heart valves need just the right amount of nutrients for proper metabolic function.
Federal health officials on Monday issued new guidelines to promote head-to-toe protection for health workers treating Ebola patients. Officials have been scrambling to come up with new advice for protective gear since two Dallas nurses became infected while caring for the first person diagnosed with the virus in the U.S.
DNA has garnered attention for its potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, biology and more. Researchers have been working to master the ability to coax DNA molecules to self-assemble into the precise shapes and sizes needed in order to fully realize these nanotechnology dreams.
While megakaryocytes are best known for producing platelets that heal wounds, these "mega" cells found in bone marrow also play a critical role in regulating stem cells according to new research from the Stowers Institute for Medical Research. The study is the first to show that hematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes).