A new class of synthetic platelet-like particles could augment natural blood clotting for the emergency treatment of traumatic injuries. The clotting particles, which are based on soft and deformable hydrogel materials, are triggered by the same factor that initiates the body’s own clotting processes.
Univ. of California, Berkeley neuroscientists plan to use light to tweak the transmission of signals in the brain to learn more about how the mouse brain and presumably the human brain process information. Last month, the promising optogenetics research project was awarded one of 36 new $300,000, two-year grants from the National Science Foundation in support of the BRAIN Initiative.
It may look like fresh blood and flow like fresh blood, but the longer blood is stored, the less it can carry oxygen into the tiny microcapillaries of the body. Using advanced optical techniques, researchers measured the stiffness of the membrane surrounding red blood cells over time. They found that, even though the cells retain their shape and hemoglobin content, the membranes get stiffer, steadily decreasing the cells’ functionality.
Researchers have sequenced the genomes and transcriptomes of five species of African cichlid fishes and uncovered a variety of features that enabled the fishes to thrive in new habitats and ecological niches within the Great Lakes of East Africa. The study helps explain the genetic basis for the incredible diversity among cichlid fishes and provides new information about vertebrate evolution.
The increased visual realism of 3-D films is believed to offer viewers a more vivid and lifelike experience than 2-D because it more closely approximates real life. However, psychology researchers at the Univ. of Utah, among those who use film clips routinely in the laboratory to study patients’ emotional conditions, have found that there is no significant difference between the two formats.
It’s one of the highest-profile cases of scientific fraud in memory: In 2005, South Korean researcher Woo-Suk Hwang and colleagues made international news by claiming that they had produced embryonic stem cells from a cloned human embryo using nuclear transfer. But within a year, the work had been debunked, soon followed by findings of fraud. South Korea put a moratorium on stem cell research funding.
Up to 30% of people with the most common form of hemophilia develop antibodies that attack lifesaving protein injections, making it difficult to prevent or treat excessive bleeding. Now researchers have developed a way to thwart production of these antibodies by using plant cells to teach the immune system to tolerate rather than attack the clotting factors.
Scientists have for the first time mapped the atomic structure of a protein within a living cell. The technique, which peered into cells with an x-ray laser, could allow scientists to explore some components of living cells as never before.
The ability to accurately repair DNA damaged by spontaneous errors, oxidation or mutagens is crucial to the survival of cells. This repair is normally accomplished by using an identical or homologous intact sequence of DNA, but scientists have now shown that RNA produced within cells of a common budding yeast can serve as a template for repairing the most devastating DNA damage—a break in both strands of a DNA helix.
In a new study that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute (TSRI) have adapted a chemical approach to turn diseased cells into unique manufacturing sites for molecules that can treat a form of muscular dystrophy.
Yale Cancer Center researchers may have discovered a new way of harnessing lupus antibodies to sabotage cancer cells made vulnerable by deficient DNA repair. The study found that cancer cells with deficient DNA repair mechanisms (or the inability to repair their own genetic damage) were significantly more vulnerable to attack by lupus antibodies.
Scientists have made an important breakthrough in the fight against debilitating autoimmune diseases such as multiple sclerosis by revealing how to stop cells attacking healthy body tissue. Rather than the body’s immune system destroying its own tissue by mistake, researchers at the Univ. of Bristol have discovered how cells convert from being aggressive to actually protecting against disease.
Scientists have tapped oil and water to create scaffolds of self-assembling, synthetic proteins called peptoid nanosheets that mimic complex biological mechanisms and processes. The accomplishmentis expected to fuel an alternative design of the 2-D peptoid nanosheets that can be used in a broad range of applications. Among them could be improved chemical sensors and separators, and safer, more effective drug delivery vehicles.
Removing both breasts to treat cancer affecting only one side doesn't boost survival chances for most women, compared with surgery that removes just the tumor, a large study suggests. The results raise concerns about riskier, potentially unnecessary operations that increasing numbers of women are choosing.
Responding rapidly to the deadly outbreak of Ebola virus disease (EVD) in West Africa, a team of researchers from the Broad Institute and Harvard Univ., working with the Sierra Leone Ministry of Health and Sanitation and researchers elsewhere, has sequenced and analyzed many Ebola virus genomes. Their findings could have important implications for rapid field diagnostic tests.
Some people take stress in stride; others are done in by it. New research at Rockefeller Univ. has identified the molecular mechanisms of this so-called stress gap in mice with very similar genetic backgrounds—a finding that could lead researchers to better understand the development of psychiatric disorders such as anxiety and depression.
When you accidentally touch a hot oven, you rapidly pull your hand away. Although scientists know the basic neural circuits involved in sensing and responding to such painful stimuli, they are still sorting out the molecular players. Duke Univ. researchers have made a surprising discovery about the role of a key molecule involved in pain in worms, and have built a structural model of the molecule.
An experimental Ebola drug healed all 18 monkeys infected with the deadly virus in a study, boosting hopes that the treatment might help fight the outbreak raging through West Africa. Scientists gave the drug, called ZMapp, three to five days after infecting the monkeys in the laboratory. Most were showing symptoms by then, and all completely recovered.
Sorry, clean freaks. No matter how well you scrub your home, it's covered in bacteria from your own body. And if you pack up and move, new research shows, you'll rapidly transfer your unique microbial fingerprint to the doorknobs, countertops and floors in your new house, too.
Cartilage lesions in joints often appear in older people as a result of degenerative processes, and appear in younger people after injuries and accidents. Such defects are difficult to repair and often require complicated surgery and long rehabilitation times. Researchers in Switzerland have reported that cells taken from the nasal septum are able to adapt to the environment of the knee joint and can thus repair articular cartilage defects.
DARPA’s new Electrical Prescriptions (ElectRx) program was among the initiatives the White House highlighted this week as President Barack Obama addressed the need for new and more effective strategies for improving the health of service members, veterans and others. ElectRx goes beyond medication, aiming to explore neuromodulation of organ functions to help the human body heal itself.
Duke Univ. researchers have identified a gene that could help scientists engineer drought-resistant crops. The gene, called OSCA1, encodes a protein in the cell membrane of plants that senses changes in water availability and adjusts the plant’s water conservation machinery accordingly. The effect is similar to a thermostat.
Most memories have some kind of emotion associated with them. A new study from Massachusetts Institute of Technology neuroscientists reveals the brain circuit that controls how memories become linked with positive or negative emotions. Furthermore, the researchers found that they could reverse the emotional association of specific memories by manipulating brain cells with optogenetics.
The harmful and potentially deadly bacterium Listeria is extremely good at adapting to changes. Research from Denmark uncovers exactly how cunning Listeria is and why it is so hard to fight. The discovery could help develop more efficient ways to combat the bacteria.
Like a protective tent over a colony of harmful bacteria, biofilms make the treatment of skin infections especially difficult. Microorganisms protected in a biofilm pose a significant health risk due to their antibiotic resistance and recalcitrance to treatment, and biofilm-protected bacteria account for 80% of total bacterial infections in humans and are 50 to 1,000 times more resistant to antibiotics than simpler bacterial infections.