It has long been known that free, ionic silver particles can be highly toxic to aquatic organisms. Yet we a lack of detailed knowledge about the doses required to trigger a response and how the organisms deal with the stress. To learn more about the cellular processes, scientists in Switzerland subjected algae to a range of silver concentrations. The results are reassuring, but the presence of other stressors could compound the problem.
Women with estrogen-responsive breast cancer who consume soy protein supplements containing isoflavones to alleviate the side effects of menopause may be accelerating progression of their cancer, changing it from a treatable subtype to a more aggressive, less treatable form of the disease, new research suggests.
Cells in our body are constantly dividing to maintain our body functions. At each division, our DNA code and a whole machinery of supporting components has to be faithfully duplicated to maintain the cell’s memory of its own identity. Researchers in Denmark have developed a new technology that reveal the dynamic events of this duplication process and the secrets of cellular memory.
Defective blood coagulation is one of the leading causes of preventable death in patients who have suffered trauma or undergone surgery. To provide caregivers with timely information about the clotting properties of a patient’s blood, researchers have developed an optical device that requires only a few drops of blood and a few minutes to measure the key coagulation parameters that can guide medical decisions.
Typically, researchers construct cell-building scaffolds from synthetic materials or natural animal or human substances. Until now, however, no scaffolds grown in a Petri dish have been able to mimic the highly organized structure of the matrix made by living things. Researchers in Michigan have used a nano-grate to persuade fibroblasts to grow a scaffold with fibers just 80 nm, similar to to fibers in a natural matrix.
To attach itself to surfaces, the marine sponge Monorhaphis chuni forms an unusual glass rod. Researchers have recently analyzed the nanostructure of the filament passing through the center of this glass rod and discovered that it is formed with a perfect periodic arrangement of nanopores. In this way, the sponge employs a similar method that is now used for fabrication of man-made mesoporous nanomaterials.
A light-activated drug delivery system for treating cancer is particularly promising to traditional chemotherapy methods because it can accomplish spatial and temporal control of drug release. To this end, scientists have developed a new type of nanoparticle that can absorb energy from tissue-penetrating light that releases drugs in cancer cells.
Scientists in the U.K. have developed a novel approach to enabling collaborations between researchers at conferences and academic meetings: Treat them like genes. Using mathematical algorithms, the team created a method of matching conference-goers according to pre-set criteria, bringing about unforeseen collaboration opportunities while also enabling “would-like-to-meet” match-ups across disciplines and knowledge areas.
An ancient chemical, present for billions of years, appears to have helped proteins function properly since time immemorial. Proteins are the body's workhorses, and like horses they often work in teams. There exists a modern day team of multiple chaperone proteins that help other proteins fold into the complex 3-D shapes they must achieve to function. This is necessary to avert many serious diseases caused when proteins misbehave.
In the battle against infection, immune cells are the body's offense and defense. It has long been known that a population of blood stem cells that resides in the bone marrow generates all of these immune cells. But most scientists have believed that blood stem cells participate in battles against infection in a delayed way, replenishing immune cells on the front line only after they become depleted.
Keep this in mind: Scientists say they’ve learned how your brain plucks information out of working memory when you decide to act. Brown Univ. cognitive scientists have identified specific brain regions that work together to allow us to choose from among the options we store in working memory.
The time and cost of sequencing an entire human genome has plummeted, but analyzing three billion base pairs from a single genome can take many months. However, a Univ. of Chicago-based team working with Beagle, one of the world's fastest supercomputers devoted to life sciences, reports that genome analysis can be radically accelerated. The Argonne National Laboratory computer is able to analyze 240 full genomes in about two days.
Univ. of Georgia (UGA) marine scientists are uncovering the mechanisms that regulate the natural production of an anti-greenhouse gas. A new $2 million National Science Foundation grant will allow the UGA-led research group to further document how genes in ocean microbes transform sulfur into clouds in the Earth's atmosphere.
Researchers have developed the technology for a catheter-based device that would provide forward-looking, real-time, 3-D imaging from inside the heart, coronary arteries and peripheral blood vessels. With its volumetric imaging, the new device could better guide surgeons working in the heart, and potentially allow more of patients’ clogged arteries to be cleared without major surgery.
Screening more than 100 spider toxins, Yale Univ. researchers identified a protein from the venom of the Peruvian green velvet tarantula that blunts activity in pain-transmitting neurons. The findings, reported in Current Biology, show the new screening method used by the scientists has the potential to search millions of different spider toxins for safe pain-killing drugs and therapies.
Tularemia is endemic in the northeastern U.S., and is considered to be a risk to biosecurity, much like anthrax or smallpox, because it has already been weaponized in various regions of the world. A postdoctoral researcher at Lawrence Livermore National Laboratory has recently described his work to uncover the secrets of the bacterium Francisella tularensis, which causes tularemia, also known as "rabbit fever."
Many vaccines consist of a killed or disabled version of a virus. However, for certain diseases, this type of vaccine is ineffective, or just too risky. An alternative, safer approach is a vaccine made of small fragments of proteins produced by a disease-causing virus or bacterium. This has worked for some diseases, but in many cases these vaccines don’t provoke a strong enough response. Until now.
Researchers have formed the first high-definition picture of the Cas9 complex, a key part of the CRISPR-Cas system used by scientists as a genome-editing tool to silence genes and probe the biology of cells. Their findingsare expected to help researchers refine and further engineer the tool to accelerate genomic research and bring the technology closer to use in the treatment of human genetic disease.
For four decades, polychlorinated biphenyls (PCBs) and heavy metals from nearby manufacturing plants flowed into New Bedford Harbor, creating one of the EPA’s largest Superfund cleanup sites. It’s also the site of an evolutionary puzzle: small Atlantic killifish are not only tolerating the toxic conditions in the harbor, they seem to be thriving there. In a new paper, researchers may have an explanation for their genetic resistance to PCBs.
Once the snow melts, the bee population will be back in business pollinating and making honey. A new study by scientists in Canada reveals that some these bees use bits of plastic bags and plastic building materials to construct their nests. The discovery reveals how urban bee populations have adapted to a human-dominated world.
Univ. of California, Berkeley researchers have shown that chronic stress generates long-term changes in the brain that may explain why people suffering chronic stress are prone to mental problems such as anxiety and mood disorders later in life. Their findings could lead to new therapies to reduce the risk of developing mental illness after stressful events.
These findings won’t appear on any Hallmark card, but romantic love tends to activate the same reward areas of the brain as cocaine, research has shown. Now Yale School of Medicine researchers studying meditators have found that a more selfless variety of love, a deep and genuine wish for the happiness of others without expectation of reward, actually turns off the same reward areas that light up when lovers see each other.
Researchers have introduced a unique microrobotic technique to assemble the components of complex materials, the foundation of tissue engineering and 3-D printing. Tissue engineering and 3-D printing have become vitally important to the future of medicine for many reasons. The shortage of available organs for transplantation, for example, leaves many patients on waiting lists for life-saving treatment.
Plant growth is orchestrated by a spectrum of signals from hormones within a plant. A major group of plant hormones called cytokinins originate in the roots of plants, and their journey to growth areas on the stem and in leaves stimulates plant development. Though these phytohormones have been identified in the past, the molecular mechanism responsible for their transportation within plants was previously poorly understood. Until now.
On the eve of the 25th World AIDS Day (December 2014), President Barack Obama expressed hope to our nation, proclaiming that an “AIDS-free generation is within our reach.” During his speech, Obama expressed how our nation has made significant strides toward strengthening scientific investments, building effective HIV/AIDS education and prevention programs and bringing together public and private stakeholders.