During each cell division, more than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to daughter cells. But what happens when the DNA template is damaged in such a way that the replication machinery gets stuck? To answer this question, a team of scientists have analyzed how the protein composition of the DNA replication machinery changes upon encountering damaged DNA.
New research has brought us closer to being able to understand the health benefits of coffee. Monash Univ. researchers, in collaboration with Italian coffee roasting company Illycaffè, have conducted the most comprehensive study to date on how free radicals and antioxidants behave during every stage of the coffee brewing process, from intact bean to coffee brew.
A type of immune cell that promotes inflammation during the immune response, TH17, can convert into another type of cell that reduces inflammation, Yale Univ. researchers have found. The finding, published in Nature, points to a possible therapeutic strategy for inflammation-mediated diseases, such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis.
The human body is a cross between a factory and a construction zone; at least on the cellular level. Certain proteins act as project managers, which direct a wide variety of processes and determine the fate of the cell as a whole. One group of proteins called the WD-repeat (WDR) family helps a cell choose which of the thousands of possible gene products it should manufacture.
Your employer may one day help determine if your genes are why your jeans have become too snug. Big companies are considering blending genetic testing with coaching on nutrition and exercise to help workers lose weight and improve their health before serious conditions like diabetes or heart disease develop.
Researchers from the University of Liverpool have used mathematical equations to shed new light on how flowing fluid hinders the movement of bacteria in their search for food. Mathematicians developed a new set of equations to study how flowing fluid affected the movement of bacteria and how the swimming behavior of the bacteria themselves affected their travel.
The researchers found that sinking particles of stressed and dying phytoplankton release chemicals that have a jolting, steroid-like effect on marine bacteria feeding on the particles. The chemicals juice up the bacteria’s metabolism causing them to more rapidly convert organic carbon in the particles back into CO2 before they can sink to the deep ocean.
Researchers have captured the first 3-D video of a living algal embryo turning itself inside out, from a sphere to a mushroom shape and back again. The results could help unravel the mechanical processes at work during a similar process in animals, which has been called the “most important time in your life.”
Researchers have developed AGGRESCAN3D, a new computational method which allows studying the structure of folded globular proteins and their propensity for forming toxic protein aggregates.
One in three Americans has high blood pressure, a long-term constriction of arteries that can lead to coronary heart disease, heart failure and stroke. Using a sophisticated x-ray analysis, a U.S.-German team of scientists revealed the molecular structure of the angiotensin receptor AT1R, an important regulator for blood pressure in the human body.
Scientists are getting their best look yet at the DNA code for the woolly mammoth, thanks to work that could be a step toward bringing back the extinct beast. Researchers deciphered the complete DNA code, or genomes, of two mammoths. The new genomes are far more refined than a previous one announced in 2008.
Much like magnetic resonance imaging is able to scan the interior of the human body, the emerging technique of "picosecond ultrasonics," a type of acoustic imaging, can be used to make virtual slices of biological tissues without destroying them. Now, a team of researchers in Japan and Thailand has shown that picosecond ultrasonics can achieve micron resolution of single cells, imaging their interiors in slices separated by 150 nm.
As baby boomers age, the number of people diagnosed with Parkinson's disease is expected to increase. Patients who develop this disease usually start experiencing symptoms around age 60 or older. Currently, there's no cure, but scientists are reporting a novel approach that reversed Parkinson's-like symptoms in rats. Their results, published in ACS Nano, could one day lead to a new therapy for human patients.
A fully extended strand of human DNA measures about five feet in length. Yet it occupies a space just one-tenth of a cell by wrapping itself around histones to form a dense hub of information called chromatin. Access to these meticulously packed genes is regulated by post-translational modifications, chemical changes to the structure of histones that act as on-off signals for gene transcription.
Scientists have, for the first time, captured live images of the process of taste sensation on the tongue. The international team imaged single cells on the tongue of a mouse with a specially designed microscope system.
Enzymes, the micro machines in our cells, can evolve to perform new tasks when confronted with novel situations. But what if you want an enzyme to do an entirely different job—one that it would never have to do in a cell? In a recent report published in ACS Central Science, researchers show that they can mimic nature and perform evolution in a test tube, developing enzymes that can perform brand-new chemical reactions.
Scientists have determined the 3-D structure of a key part of a protein that is associated with glaucoma and identified regions of this domain that correlate with severe forms of the disease. The new crystal structure is of the olfactomedin (OLF) domain in myocilin, a protein implicated in glaucoma. Many proteins have OLF domains, but mutations in the OLF domain of myocilin are linked to early-onset glaucoma.
Scientists are coming to grips with the superior grasping ability of humans and other primates throughout history. In a new study, a research team led by Yale Univ. found that even the oldest known human ancestors may have had precision grip capabilities comparable to modern humans. This includes Australopithecus afarensis, which appears in the fossil record a million years before the first evidence of stone tools.
Drugs that target insulin pathways to slow or stop the growth of brain tumors are going in the right direction, but appear to be on the wrong track, according to new research. Through detailed computer models and experiments on two distinct glioblastoma cell types, the researchers have found reason to believe therapies that attack the insulin signaling pathway thought to influence tumor development have had mixed results in trials.
Research on a modified protein around which DNA is wrapped sheds light on how gene regulation is linked to aging and longevity in nematodes, fruit flies and possibly humans. The research has implications for how gene expression is regulated, and could offer a new drug target for age-related diseases.
Zinc deficiency, long associated with numerous diseases like certain cancers, can lead to activation of the Hedgehog signaling pathway, a biomolecular pathway that plays essential roles in developing organisms and in diseases, according to new research at Rensselaer Polytechnic Institute.
Gel permeation/size exclusion chromatography (GPC/SEC) is a vital analytical technique used to characterize synthetic and natural polymers, including biologically important macromolecules such as proteins and DNA. Evolving challenges tax the capabilities of traditional GPC/SEC and invite advances in the technology.
Brain tumors are notoriously difficult for most drugs to reach, but Yale Univ. researchers have found a promising but unlikely new ally against brain cancers, portions of a deadly virus similar to Ebola. A virus containing proteins found in the Lassa virus not only passed through the formidable blood-brain barrier but destroyed brain tumors in mice, according to research released in the Journal of Virology.
Pre-eclampsia is a disease that affects 5 to 8% of pregnancies in America. Complications from this disease can lead to emergency cesarean sections early in pregnancies to save the lives of the infants and mothers. Scientists believe pre-eclampsia is caused by a number of factors, including shallow placentas that are insufficiently associated with maternal blood vessels.
Nowhere is the adage "form follows function" more true than in the folded chain of amino acids that makes up a single protein macromolecule. But proteins are very sensitive to errors in their genetic blueprints. One single-letter DNA "misspelling" (called a point mutation) can alter a protein's structure or electric charge distribution enough to render it ineffective or even deleterious.